carboxylate

• カルボン酸の、カルボン酸塩

関

carboxylic acid

　

WordNet

1. treat (a chemical compound) with carboxyl or carboxylic acid

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/28 09:20:32」(JST)

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Carboxylate ion

Acrylate ion

A carboxylate is a salt or ester of a carboxylic acid. Carboxylate salts have the general formula M(RCOO)_n, where M is a metal and n is 1,2,...; carboxylate esters have the general formula RCOOR'. R and R' are organic groups; R'≠H.

A carboxylate ion is the conjugate base of a carboxylic acid, RCOO⁻. It is an ion with negative charge.

Resonance stabilization of the carboxylate ion

Carboxylic acids easily dissociate into a carboxylate anion and a positively charged hydrogen ion (proton), much more readily than alcohols do (into an alkoxide ion and a proton), because the carboxylate ion is stabilized by resonance. The negative charge that is left after deprotonation of the carboxyl group is delocalized between the two electronegative oxygen atoms in a resonance structure.

This delocalization of the electron cloud means that both of the oxygen atoms are less strongly negatively charged; the positive proton is therefore less strongly attracted back to the carboxylate group once it has left; the carboxylate ion is more stable . In contrast, an alkoxide ion, once formed, would have a strong negative charge on the oxygen atom, which would make it difficult for the proton to escape. Carboxylic acids have a lower pH than alcohols: the higher the number of protons in solution, the lower the pH.

Examples

• Formate ion, HCOO⁻
• Acetate ion, CH₃COO⁻
• Lactate ion, CH₃CH(OH)COO⁻
• Oxalate ion, (COO)₂²⁻
• Citrate ion, C₃H₅O(COO)₃³⁻

References

UpToDate Contents

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• 1. 成人におけるエタノール 中毒 ethanol intoxication in adults
• 2. ビタミンＫおよびγカルボキシグルタミン酸の合成 vitamin k and the synthesis of gamma carboxyglutamic acid
• 3. ビタミンＫ、γカルボキシグルタミン酸、および凝固剤と他の蛋白質の機能 vitamin k gamma carboxyglutamic acid and the function of coagulation and other proteins
• 4. インスリン受容体の構造および機能 structure and function of the insulin receptor
• 5. 化学療法関連腎毒性および腎不全患者における用量調整 chemotherapy related nephrotoxicity and dose modification in patients with renal insufficiency

English Journal

• Investigating the Role of Protein UnkG from the Pseudomonas putida UW4 in the Ability of the Bacterium to Facilitate Plant Growth.

• Jiang W, Cheng Z, McConkey BJ, Glick BR.SourceDepartment of Biology, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada.
• Current microbiology.Curr Microbiol.2013 Apr;66(4):331-6. doi: 10.1007/s00284-012-0279-0. Epub 2012 Dec 2.
• A previous study showed that overexpressing protein UnkG decreased the ability of the plant growth-promoting bacterium Pseudomonas putida UW4 to facilitate plant growth and an unkG knockout mutant of P. putida UW4 displayed increased plant growth promotion. When activities of wild-type and the UnkG
• PMID 23212206

• Absolute bioavailability studies of a new oral topotecan formulation in Chinese patients using UHPLC-MS/MS.

• Li N, Han X, Yang J, Gui L, Song Y, Du P, Shi Y.SourceBeijing Key Laboratory of Clinical Study on Antitumor Molecular Target Drugs, Department of Medical Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
• Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Mar 25;76:252-6. doi: 10.1016/j.jpba.2012.12.033. Epub 2013 Jan 4.
• Xinze(®) is a new capsule formulation of topotecan being made in China which is similar to Hycamtin(®), the currently available oral formulation approved in 2007 for the treatment of relapsed small cell lung cancer (SCLC). As topotecan bioavailability and pharmacokinetic data for Chinese patients
• PMID 23354352

• Ionic semiconductor: DC and AC conductivity of anilinium tetrathiafulvalene-2-carboxylate.

• Kobayashi Y, Sumi S, Terauchi T, Hashizume D.SourceAdvanced Key Technologies Division, National Institute for Materials Science (NIMS), Sengen 1-2-1, Tsukuba, Ibaraki 305-0047, Japan. kobayashi.yuka@nims.go.jp.
• Dalton transactions (Cambridge, England : 2003).Dalton Trans.2013 Mar 21;42(11):3821-6. doi: 10.1039/c2dt32464d. Epub 2013 Jan 10.
• A single crystal of anilinium tetrathiafulvalene-2-carboxylate exhibits a characteristic electrical conduction; it is a semiconductor with activation-type transport above 200 K; σ(rt) = 0.16 S cm(-1) with an activation energy of 0.11 eV. On the other hand, below 200 K, it does not obey the Arrheniu
• PMID 23302820

Japanese Journal

• A MICROWAVE ASSISTED SYNTHESIS OF HIGHLY SUBSTITUTED 7-METHYL-5H-THIAZOLO[3,2-a]PYRIMIDINE-6-CARBOXYLATE DERIVATIVES VIA ONE-POT REACTION OF AMINOTHIAZOLE, ALDEHYDE AND ETHYL ACETOACETATE

• Zhao Bing,Jiang Li-Li,Liu Zhuo [他]
• Heterocycles : an international journal for reviews and communications in heterocyclic chemistry 87(10), 2093-2102, 2013-10-01
• NAID 40019802969

• Thermal solid-state polymerization of a divalent metal salt of an unsaturated carboxylic acid and the effects of additives

• Tsuchida Junki,Saito Yosuke,Sato Saki [他]
• Polymer journal 45(10), 1007-1012, 2013-10
• NAID 40019809393

• タンニン酸,フッ化ストロンチウム,フッ化亜鉛,タンニン・フッ化物合剤を配合した試作カルボキシレート系仮着用セメントの抗菌性について

• 會田 悦子,鈴木 英明,若見 昌信,庫山 未希,池見 宅司,會田 雅啓
• 日本歯科理工学会誌 32(4), 300-305, 2013-07-25
• 本研究はHY剤,フッ化亜鉛,フッ化ストロンチウム,タンニン酸を配合したカルボキシレート系仮着用セメントを試作し,S. mutans, A. naeslundiiに対する抗菌性を検討した.その結果,すべての試作セメントにおいて抗菌性が示された.また,これらを含んでいない試作カルボキシレート系仮着用セメントと比較して,これらを含んだ試作仮着用セメントの抗菌性が高かった.特に,S. mutansに対する …
• NAID 110009635028

Related Links

• carboxylateの意味・用例｜英辞郎 on the WEB：アルク

carboxylate 【名】カルボン酸塩 - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。 ... ピロリドンカルボン酸 グルタミン酸を加熱脱水 ...

• Carboxylate - definition of carboxylate by The Free Dictionary

At the lower degree of neutralization, the carboxylate group is protonated, eliminating the main anion-anion repulsive forces and leads to a decreased osmotic pressure difference between polymeric network and external solution, which ...

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★リンクテーブル★

リンク元	「カルボン酸塩」「carboxylic acid」
拡張検索	「1-pyrroline-5-carboxylate dehydrogenase」「dicarboxylate」「carboxylate ester」
関連記事	「carboxylated」

「カルボン酸塩」

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英

carboxylate

関

カルボン酸

「carboxylic acid」

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カルボン酸

関

carboxylate

「1-pyrroline-5-carboxylate dehydrogenase」

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1-ピロリン-5-カルボン酸脱水素酵素、1-ピロリン-5-カルボン酸デヒドロゲナーゼ

関

P5CDH

「dicarboxylate」

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ジカルボン酸、カルボン酸塩、ジカルボン酸エステル

関

dicarboxylic acid

「carboxylate ester」

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カルボン酸エステル

「carboxylated」

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• カルボキシル化された

関

carboxylation