1. sulfonylurea; an oral antidiabetic drug (trade name Orinase) used in the treatment of adult-onset diabetes mellitus (同)Orinase

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/25 21:40:34」(JST)

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English Journal

  • Polysaccharide isolated from Triticum aestivum stimulates insulin release from pancreatic cells via the ATP-sensitive K+ channel.
  • Lee SH, Lim SW, Lee YM, Lee HS, Kim DK.SourceDepartment of Immunology and Institute of Medical Sciences, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-180, Republic of Korea.
  • International journal of molecular medicine.Int J Mol Med.2012 May;29(5):913-9. doi: 10.3892/ijmm.2012.905. Epub 2012 Feb 6.
  • Traditional natural plants have been used throughout the world for their antidiabetic effects. The aim of the present study was to investigate the stimulating activity of a polysaccharide extract derived from T. aestivum sprout (TASP) on insulin secretion in vit
  • PMID 22322245
  • Can a cocktail designed for phenotyping pharmacokinetics and metabolism enzymes in human be used efficiently in rat?
  • Videau O, Pitarque S, Troncale S, Hery P, Thévenot E, Delaforge M, Bénech H.SourceCEA, DSV/iBiTecS/Pharmacology and Immunoanalysis Unit , CEA/Saclay, Gif-Sur-Yvette cedex , France.
  • Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2012 Apr;42(4):349-54. Epub 2012 Feb 9.
  • We recently designed the CIME cocktail consisting of 10 drugs to assess the activity of the major human CYPs (CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A), a phase II enzyme (UGT1A1/6/9), two drug transporters (P-gp and OATP1B1) and a component of the renal function ( Videau et al. 2010 ). The
  • PMID 22321050

Japanese Journal

  • 噴霧急速凍結乾燥法(Spray Freeze Drying)により調製した複合粒子の溶出性
  • 近藤 真弘,丹羽 敏幸,檀上 和美
  • YAKUGAKU ZASSHI 131(5), 711-719, 2011
  • Tolbutamide (TBM)and Eudragit S were used as model drugs and pH-dependent carrier, respectively. …
  • NAID 130000678853
  • Nateglinide Stimulates Glucagon-Like Peptide-1 Release by Human Intestinal L Cells via a KATP Channel-Independent Mechanism
  • Kitahara Yoshiro,Miura Kyoko,Yasuda Reiko,Kawanabe Haruka,Ogawa Shimpei,Eto Yuzuru
  • Biological & Pharmaceutical Bulletin 34(5), 671-676, 2011
  • … In addition, the major metabolite of nateglinide, tolbutamide, and mitiglinide, all of which augment insulin secretion by the pancreatic islets, had no effect on GLP-1 release by this cell line. …
  • NAID 130000657778

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tolbutamideとは。意味や和訳。[名][U]トルブタミド:糖尿病用の薬. - goo辞書は国語、英和、和英、中国語、百科事典等からまとめて探せる辞書検索サービスです。 ... gooのお知らせ gooヘルスケア「おもいやり食堂」 「さばの唐揚げ野菜 ...
Do not use this medication if you are allergic to tolbutamide, or if you are in a state of diabetic ketoacidosis. Call your doctor for treatment with insulin. Before taking tolbutamide, tell your doctor if you have kidney or liver disease, a ...

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拡張検索intravenous tolbutamide test





スルフォニル尿酸系薬 sulfonylurea

  • -作用弱
  • -作用中
  • -作用強
  • -新薬



  • GOO.1634
  • ATP感受性KチャネルのSUR1サブユニットに結合し、チャネルを阻害する。膜が脱分極し、電位依存性Ca2+チャネルが開口する。




  • 以下の全てを満たす場合
  • 1. NIDDM
  • 2. 高度の肥満がない
  • 3. 食事療法、運動療法で満足な血糖コントロールが得られない
  • 4. 膵インスリン分解能をある程度保持 (尿中Cペプチド>20μg/day)
  • 5. 低血糖を理解し対応できる
  • 6. 妊婦ではない



  • 1. IDDM
  • 2. 重篤な感染症を繰り返す場合
  • 3. 大きな外科手術を受ける場合
  • 4. 高度の肝・腎障害がある場合
  • 5. 妊婦
  • 6. アレルギーなど副作用の発現を満たすもの




intravenous tolbutamide test」

  [★] トルブタミド静脈負荷試験