Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/01 03:14:59」(JST)

wiki en

Diabetes mellitus type 2 (also known as type 2 diabetes) is a long term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.^[3] Common symptoms include increased thirst, frequent urination, and unexplained weight loss. Symptoms may also include increased hunger, feeling tired, and sores that do not heal.^[4] Often symptoms come on slowly.^[3] Long-term complications from high blood sugar include heart disease, strokes, diabetic retinopathy which can result in blindness, kidney failure, and poor blood flow in the limbs which may lead to amputations.^[1] The sudden onset of hyperosmolar hyperglycemic state may occur; however, ketoacidosis is uncommon.^[5]^[6]

Type 2 diabetes primarily occurs as a result of obesity and not enough exercise.^[1] Some people are more genetically at risk than others.^[3] Type 2 diabetes makes up about 90% of cases of diabetes, with the other 10% due primarily to diabetes mellitus type 1 and gestational diabetes.^[1] In diabetes mellitus type 1 there is an absolute lack of insulin due to breakdown of islet cells in the pancreas.^[7] Diagnosis of diabetes is by blood tests such as fasting plasma glucose, oral glucose tolerance test, or A1C.^[4]

Type 2 diabetes is partly preventable by staying a normal weight, exercising regularly, and eating properly. Treatment involves exercise and dietary changes.^[1] If blood sugar levels are not adequately lowered, the medication metformin is typically recommended.^[8]^[9] Many people may eventually also require insulin injections.^[10] In those on insulin, routinely checking blood sugar levels is advised; however, this may not be needed in those taking pills.^[11] Bariatric surgery often improves diabetes in those who are obese.^[12]^[13]

Rates of type 2 diabetes have increased markedly since 1960 in parallel with obesity.^[14] As of 2013 there were approximately 368 million people diagnosed with the disease compared to around 30 million in 1985.^[15]^[16] Typically it begins in middle or older age,^[3] although rates of type 2 diabetes are increasing in young people.^[17]^[18] Type 2 diabetes is associated with a ten-year-shorter life expectancy.^[19] Diabetes was one of the first diseases described.^[20] The importance of insulin in the disease was determined in the 1920s.^[21]

Play media

Video explanation of the various types of diabetes

Signs and symptoms

Overview of the most significant symptoms of diabetes.

The classic symptoms of diabetes are polyuria (frequent urination), polydipsia (increased thirst), polyphagia (increased hunger), and weight loss.^[22] Other symptoms that are commonly present at diagnosis include a history of blurred vision, itchiness, peripheral neuropathy, recurrent vaginal infections, and fatigue.^[7] Many people, however, have no symptoms during the first few years and are diagnosed on routine testing.^[7] A small number of people with type 2 diabetes mellitus can develop a hyperosmolar hyperglycemic state (a condition of very high blood sugar associated with a decreased level of consciousness and low blood pressure).^[7]

Complications

Type 2 diabetes is typically a chronic disease associated with a ten-year-shorter life expectancy.^[19] This is partly due to a number of complications with which it is associated, including: two to four times the risk of cardiovascular disease, including ischemic heart disease and stroke; a 20-fold increase in lower limb amputations, and increased rates of hospitalizations.^[19] In the developed world, and increasingly elsewhere, type 2 diabetes is the largest cause of nontraumatic blindness and kidney failure.^[23] It has also been associated with an increased risk of cognitive dysfunction and dementia through disease processes such as Alzheimer's disease and vascular dementia.^[24] Other complications include acanthosis nigricans, sexual dysfunction, and frequent infections.^[22]

Cause

The development of type 2 diabetes is caused by a combination of lifestyle and genetic factors.^[23]^[25] While some of these factors are under personal control, such as diet and obesity, other factors are not, such as increasing age, female gender, and genetics.^[19] A lack of sleep has been linked to type 2 diabetes.^[26] This is believed to act through its effect on metabolism.^[26] The nutritional status of a mother during fetal development may also play a role, with one proposed mechanism being that of altered DNA methylation.^[27] The intestinal bacteriæ Prevotella copri and Bacteroides vulgatus have been connected with type 2 diabetes.^[28]

Lifestyle

Lifestyle factors are important to the development of type 2 diabetes, including obesity and being overweight (defined by a body mass index of greater than 25), lack of physical activity, poor diet, stress, and urbanization.^[19]^[29] Excess body fat is associated with 30% of cases in those of Chinese and Japanese descent, 60–80% of cases in those of European and African descent, and 100% of cases in Pima Indians and Pacific Islanders.^[7] Among those who are not obese, a high waist–hip ratio is often present.^[7] Smoking appears to increase the risk of type 2 diabetes mellitus.^[30]

Dietary factors also influence the risk of developing type 2 diabetes. Consumption of sugar-sweetened drinks in excess is associated with an increased risk.^[31]^[32] The type of fats in the diet are important, with saturated fats and trans fatty acids increasing the risk, and polyunsaturated and monounsaturated fat decreasing the risk.^[25] Eating a lot of white rice appears to play a role in increasing risk.^[33] A lack of exercise is believed to cause 7% of cases.^[34] Persistent organic pollutants may play a role.^[35]

Genetics

Most cases of diabetes involve many genes, with each being a small contributor to an increased probability of becoming a type 2 diabetic.^[19] If one identical twin has diabetes, the chance of the other developing diabetes within his lifetime is greater than 90%, while the rate for nonidentical siblings is 25–50%.^[7] As of 2011, more than 36 genes had been found that contribute to the risk of type 2 diabetes.^[36] All of these genes together still only account for 10% of the total heritable component of the disease.^[36] The TCF7L2 allele, for example, increases the risk of developing diabetes by 1.5 times and is the greatest risk of the common genetic variants.^[7] Most of the genes linked to diabetes are involved in beta cell functions.^[7]

There are a number of rare cases of diabetes that arise due to an abnormality in a single gene (known as monogenic forms of diabetes or "other specific types of diabetes").^[7]^[19] These include maturity onset diabetes of the young (MODY), Donohue syndrome, and Rabson-Mendenhall syndrome, among others.^[19] Maturity onset diabetes of the young constitute 1–5% of all cases of diabetes in young people.^[37]

Medical conditions

There are a number of medications and other health problems that can predispose to diabetes.^[38] Some of the medications include: glucocorticoids, thiazides, beta blockers, atypical antipsychotics,^[39] and statins.^[40] Those who have previously had gestational diabetes are at a higher risk of developing type 2 diabetes.^[22] Other health problems that are associated include: acromegaly, Cushing's syndrome, hyperthyroidism, pheochromocytoma, and certain cancers such as glucagonomas.^[38] Testosterone deficiency is also associated with type 2 diabetes.^[41]^[42]

Pathophysiology

Type 2 diabetes is due to insufficient insulin production from beta cells in the setting of insulin resistance.^[7] Insulin resistance, which is the inability of cells to respond adequately to normal levels of insulin, occurs primarily within the muscles, liver, and fat tissue.^[43] In the liver, insulin normally suppresses glucose release. However, in the setting of insulin resistance, the liver inappropriately releases glucose into the blood.^[19] The proportion of insulin resistance versus beta cell dysfunction differs among individuals, with some having primarily insulin resistance and only a minor defect in insulin secretion and others with slight insulin resistance and primarily a lack of insulin secretion.^[7]

Other potentially important mechanisms associated with type 2 diabetes and insulin resistance include: increased breakdown of lipids within fat cells, resistance to and lack of incretin, high glucagon levels in the blood, increased retention of salt and water by the kidneys, and inappropriate regulation of metabolism by the central nervous system.^[19] However, not all people with insulin resistance develop diabetes, since an impairment of insulin secretion by pancreatic beta cells is also required.^[7]

Diagnosis

WHO diabetes diagnostic criteria^[44]^[45] edit
Condition	2 hour glucose	Fasting glucose	HbA_1c
Unit	mmol/l(mg/dl)	mmol/l(mg/dl)	mmol/mol	DCCT %
Normal	<7.8 (<140)	<6.1 (<110)	<42	<6.0
Impaired fasting glycaemia	<7.8 (<140)	≥6.1(≥110) & <7.0(<126)	42-46	6.0–6.4
Impaired glucose tolerance	≥7.8 (≥140)	<7.0 (<126)	42-46	6.0–6.4
Diabetes mellitus	≥11.1 (≥200)	≥7.0 (≥126)	≥48	≥6.5

The World Health Organization definition of diabetes (both type 1 and type 2) is for a single raised glucose reading with symptoms, otherwise raised values on two occasions, of either:^[46]

fasting plasma glucose ≥ 7.0 mmol/l (126 mg/dl)

or

with a glucose tolerance test, two hours after the oral dose a plasma glucose ≥ 11.1 mmol/l (200 mg/dl)

A random blood sugar of greater than 11.1 mmol/l (200 mg/dL) in association with typical symptoms^[22] or a glycated hemoglobin (HbA_1c) of ≥ 48 mmol/mol (≥ 6.5 DCCT %) is another method of diagnosing diabetes.^[19] In 2009 an International Expert Committee that included representatives of the American Diabetes Association (ADA), the International Diabetes Federation (IDF), and the European Association for the Study of Diabetes (EASD) recommended that a threshold of ≥ 48 mmol/mol (≥ 6.5 DCCT %) should be used to diagnose diabetes.^[47] This recommendation was adopted by the American Diabetes Association in 2010.^[48] Positive tests should be repeated unless the person presents with typical symptoms and blood sugars >11.1 mmol/l (>200 mg/dl).^[47]

Threshold for diagnosis of diabetes is based on the relationship between results of glucose tolerance tests, fasting glucose or HbA_1c and complications such as retinal problems.^[19] A fasting or random blood sugar is preferred over the glucose tolerance test, as they are more convenient for people.^[19] HbA_1c has the advantages that fasting is not required and results are more stable but has the disadvantage that the test is more costly than measurement of blood glucose.^[49] It is estimated that 20% of people with diabetes in the United States do not realize that they have the disease.^[19]

Diabetes mellitus type 2 is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency.^[50] This is in contrast to diabetes mellitus type 1 in which there is an absolute insulin deficiency due to destruction of islet cells in the pancreas and gestational diabetes mellitus that is a new onset of high blood sugars associated with pregnancy.^[7] Type 1 and type 2 diabetes can typically be distinguished based on the presenting circumstances.^[47] If the diagnosis is in doubt antibody testing may be useful to confirm type 1 diabetes and C-peptide levels may be useful to confirm type 2 diabetes,^[51] with C-peptide levels normal or high in type 2 diabetes, but low in type 1 diabetes.^[52]

Screening

No major organization recommends universal screening for diabetes as there is no evidence that such a program improve outcomes.^[53]^[54] Screening is recommended by the United States Preventive Services Task Force (USPSTF) in adults without symptoms whose blood pressure is greater than 135/80 mmHg.^[55] For those whose blood pressure is less, the evidence is insufficient to recommend for or against screening.^[55] There is no evidence that it changes the risk of death in this group of people.^[54] They also recommend screening among those who are overweight and between the ages of 40 and 70.^[56]

The World Health Organization recommends testing those groups at high risk^[53] and in 2014 the USPSTF is considering a similar recommendation.^[57] High-risk groups in the United States include: those over 45 years old; those with a first degree relative with diabetes; some ethnic groups, including Hispanics, African-Americans, and Native-Americans; a history of gestational diabetes; polycystic ovary syndrome; excess weight; and conditions associated with metabolic syndrome.^[22] The American Diabetes Association recommends screening those who have a BMI over 25 (in people of Asian descent screening is recommending for a BMI over 23.^[58]

Prevention

Onset of type 2 diabetes can be delayed or prevented through proper nutrition and regular exercise.^[59]^[60] Intensive lifestyle measures may reduce the risk by over half.^[23]^[61] The benefit of exercise occurs regardless of the person's initial weight or subsequent weight loss.^[62] High levels of physical activity reduce the risk of diabetes by about 28%.^[63] Evidence for the benefit of dietary changes alone, however, is limited,^[64] with some evidence for a diet high in green leafy vegetables^[65] and some for limiting the intake of sugary drinks.^[31] In those with impaired glucose tolerance, diet and exercise either alone or in combination with metformin or acarbose may decrease the risk of developing diabetes.^[23]^[66] Lifestyle interventions are more effective than metformin.^[23] While low vitamin D levels are associated with an increased risk of diabetes, correcting the levels by supplementing vitamin D3 does not improve that risk.^[67]

Management

Management of type 2 diabetes focuses on lifestyle interventions, lowering other cardiovascular risk factors, and maintaining blood glucose levels in the normal range.^[23] Self-monitoring of blood glucose for people with newly diagnosed type 2 diabetes may be used in combination with education,^[68] however the benefit of self monitoring in those not using multi-dose insulin is questionable.^[23]^[69] In those who do not want to measure blood levels, measuring urine levels may be done.^[68] Managing other cardiovascular risk factors, such as hypertension, high cholesterol, and microalbuminuria, improves a person's life expectancy.^[23] Decreasing the systolic blood pressure to less than 140 mmHg is associated with a lower risk of death and better outcomes.^[70] Intensive blood pressure management (less than 130/80 mmHg) as opposed to standard blood pressure management (less than 140/85–100 mmHg) results in a slight decrease in stroke risk but no effect on overall risk of death.^[71]

Intensive blood sugar lowering (HbA_1c<6%) as opposed to standard blood sugar lowering (HbA_1c of 7–7.9%) does not appear to change mortality.^[72]^[73] The goal of treatment is typically an HbA_1c of around 7% or a fasting glucose of less than 7.2 mmol/L (130 mg/dL); however these goals may be changed after professional clinical consultation, taking into account particular risks of hypoglycemia and life expectancy.^[74]^[58] Despite guidelines recommending that intensive blood sugar control be based on balancing immediate harms with long-term benefits, many people—for example people with a life expectancy of less than nine years who will not benefit, are over-treated.^[75]

It is recommended that all people with type 2 diabetes get regular eye examination.^[7] Treating gum disease in those with diabetes may result in a small improvement in blood sugar levels.^[76]^{[needs update]}

Lifestyle

A proper diet and exercise are the foundations of diabetic care,^[22] with a greater amount of exercise yielding better results.^[77] Aerobic exercise leads to a decrease in HbA_1c and improved insulin sensitivity.^[77] Resistance training is also useful and the combination of both types of exercise may be most effective.^[77] A diabetic diet that promotes weight loss is important.^[78] While the best diet type to achieve this is controversial,^[78] a low glycemic index diet or low carbohydrate diet has been found to improve blood sugar control.^[79]^[80] Culturally appropriate education may help people with type 2 diabetes control their blood sugar levels, for up to six months at least.^[81]^{[needs update]} If changes in lifestyle in those with mild diabetes has not resulted in improved blood sugars within six weeks, medications should then be considered.^[22] There is not enough evidence to determine if lifestyle interventions affect mortality in those who already have DM2.^[61] Vegetarian diets in general have been related to lower diabetes risk, but do not offer advantages compared with diets which allow moderate amounts of animal products.^[82] There is not enough evidence to suggest that cinnamon improves blood sugar levels in people with type 2 diabetes.^[83]

Medications

Metformin 500mg tablets.

There are several classes of anti-diabetic medications available. Metformin is generally recommended as a first line treatment as there is some evidence that it decreases mortality;^[9]^[23]^[84] however, this conclusion is questioned.^[85] Metformin should not be used in those with severe kidney or liver problems.^[22]

A second oral agent of another class or insulin may be added if metformin is not sufficient after three months.^[74] Other classes of medications include: sulfonylureas, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, SGLT2 inhibitors, and glucagon-like peptide-1 analogs.^[74] There is no significant difference between these agents.^[74] Rosiglitazone, a thiazolidinedione, has not been found to improve long-term outcomes even though it improves blood sugar levels.^[86] Additionally it is associated with increased rates of heart disease and death.^[87] Angiotensin-converting enzyme inhibitors (ACEIs) prevent kidney disease and improve outcomes in those with diabetes.^[88]^[89] The similar medications angiotensin receptor blockers (ARBs) do not.^[89] A 2016 review recommended treating to a systolic blood pressure of 140 to 150 mmHg.^[90]

Injections of insulin may either be added to oral medication or used alone.^[23] Most people do not initially need insulin.^[7] When it is used, a long-acting formulation is typically added at night, with oral medications being continued.^[22]^[23] Doses are then increased to effect (blood sugar levels being well controlled).^[23] When nightly insulin is insufficient, twice daily insulin may achieve better control.^[22] The long acting insulins glargine and detemir are equally safe and effective,^[91] and do not appear much better than neutral protamine Hagedorn (NPH) insulin, but as they are significantly more expensive, they are not cost effective as of 2010.^[92] In those who are pregnant insulin is generally the treatment of choice.^[22]

Surgery

Weight loss surgery in those who are obese is an effective measure to treat diabetes.^[93] Many are able to maintain normal blood sugar levels with little or no medications following surgery^[94] and long-term mortality is decreased.^[95] There however is some short-term mortality risk of less than 1% from the surgery.^[96] The body mass index cutoffs for when surgery is appropriate are not yet clear.^[95] It is recommended that this option be considered in those who are unable to get both their weight and blood sugar under control.^[97]^[98]

Epidemiology

Prevalence of diabetes worldwide in 2000. World average was 28 per 1000 inhabitants.

no data

≤ 7.5

7.5–15

15–22.5

22.5–30

30–37.5

37.5–45

45–52.5

52.5–60

60–67.5

67.5–75

75–82.5

≥ 82.5

Globally as of 2010 it was estimated that there were 285 million people with type 2 diabetes making up about 90% of diabetes cases.^[19] This is equivalent to about 6% of the world's adult population.^[99] Diabetes is common both in the developed and the developing world.^[19] It remains uncommon, however, in the underdeveloped world.^[7]

Women seem to be at a greater risk as do certain ethnic groups,^[19]^[100] such as South Asians, Pacific Islanders, Latinos, and Native Americans.^[22] This may be due to enhanced sensitivity to a Western lifestyle in certain ethnic groups.^[101] Traditionally considered a disease of adults, type 2 diabetes is increasingly diagnosed in children in parallel with rising obesity rates.^[19] Type 2 diabetes is now diagnosed as frequently as type 1 diabetes in teenagers in the United States.^[7]

Rates of diabetes in 1985 were estimated at 30 million, increasing to 135 million in 1995 and 217 million in 2005.^[15] This increase is believed to be primarily due to the global population aging, a decrease in exercise, and increasing rates of obesity.^[15] The five countries with the greatest number of people with diabetes as of 2000 are India having 31.7 million, China 20.8 million, the United States 17.7 million, Indonesia 8.4 million, and Japan 6.8 million.^[102] It is recognized as a global epidemic by the World Health Organization.^[1]

History

Diabetes is one of the first diseases described^[20] with an Egyptian manuscript from c. 1500 BCE mentioning "too great emptying of the urine."^[103] The first described cases are believed to be of type 1 diabetes.^[103] Indian physicians around the same time identified the disease and classified it as madhumeha or honey urine noting that the urine would attract ants.^[103] The term "diabetes" or "to pass through" was first used in 230 BCE by the Greek Apollonius Of Memphis.^[103] The disease was rare during the time of the Roman empire with Galen commenting that he had only seen two cases during his career.^[103]

Type 1 and type 2 diabetes were identified as separate conditions for the first time by the Indian physicians Sushruta and Charaka in 400–500 AD with type 1 associated with youth and type 2 with being overweight.^[103] The term "mellitus" or "from honey" was added by the Briton John Rolle in the late 1700s to separate the condition from diabetes insipidus which is also associated with frequent urination.^[103] Effective treatment was not developed until the early part of the 20th century when the Canadians Frederick Banting and Charles Best discovered insulin in 1921 and 1922.^[103] This was followed by the development of the long acting NPH insulin in the 1940s.^[103]

References

^ ^a ^b ^c ^d ^e ^f "Diabetes Fact sheet N°312". World Health Organization. August 2011. Archived from the original on 26 August 2013. Retrieved 2012-01-09.
^ "Diabetes Blue Circle Symbol". International Diabetes Federation. 17 March 2006. Archived from the original on 5 August 2007.
^ ^a ^b ^c ^d "Causes of Diabetes". National Institute of Diabetes and Digestive and Kidney Diseases. June 2014. Archived from the original on 2 February 2016. Retrieved 10 February 2016.
^ ^a ^b "Diagnosis of Diabetes and Prediabetes". National Institute of Diabetes and Digestive and Kidney Diseases. June 2014. Archived from the original on 6 March 2016. Retrieved 10 February 2016.
^ Pasquel, FJ; Umpierrez, GE (November 2014). "Hyperosmolar hyperglycemic state: a historic review of the clinical presentation, diagnosis, and treatment.". Diabetes Care. 37 (11): 3124–31. doi:10.2337/dc14-0984. PMC 4207202. PMID 25342831.
^ Fasanmade, OA; Odeniyi, IA; Ogbera, AO (June 2008). "Diabetic ketoacidosis: diagnosis and management". African journal of medicine and medical sciences. 37 (2): 99–105. PMID 18939392.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r Gardner, David G.; Shoback, Dolores, eds. (2011). "Chapter 17: Pancreatic hormones & diabetes mellitus". Greenspan's basic & clinical endocrinology (9th ed.). New York: McGraw-Hill Medical. ISBN 0-07-162243-8. OCLC 613429053.
^ Saenz A, Fernandez-Esteban I, Mataix A, Ausejo M, Roque M, Moher D (20 July 2005). "Metformin monotherapy for type 2 diabetes mellitus.". The Cochrane database of systematic reviews (3): CD002966. doi:10.1002/14651858.CD002966.pub3. PMID 16034881. (subscription required (help)).
^ ^a ^b Maruthur, NM; Tseng, E; Hutfless, S; Wilson, LM; Suarez-Cuervo, C; Berger, Z; Chu, Y; Iyoha, E; Segal, JB; Bolen, S (19 April 2016). "Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis". Annals of Internal Medicine. 164: 740–51. doi:10.7326/M15-2650. PMID 27088241. (subscription required (help)).
^ Krentz AJ, Bailey CJ (February 2005). "Oral antidiabetic agents: current role in type 2 diabetes mellitus.". Drugs. 65 (3): 385–411. doi:10.2165/00003495-200565030-00005. PMID 15669880. (subscription required (help)).
^ Malanda UL, Welschen LM, Riphagen II, Dekker JM, Nijpels G, Bot SD (18 January 2012). "Self-monitoring of blood glucose in patients with type 2 diabetes mellitus who are not using insulin.". The Cochrane database of systematic reviews. 1: CD005060. doi:10.1002/14651858.CD005060.pub3. PMID 22258959. (subscription required (help)).
^ Cetinkunar, S; Erdem, H; Aktimur, R; Sozen, S (16 June 2015). "Effect of bariatric surgery on humoral control of metabolic derangements in obese patients with type 2 diabetes mellitus: How it works.". World journal of clinical cases. 3 (6): 504–9. doi:10.12998/wjcc.v3.i6.504. PMC 4468896. PMID 26090370.
^ Ganguly, S; Tan, HC; Lee, PC; Tham, KW (April 2015). "Metabolic bariatric surgery and type 2 diabetes mellitus: an endocrinologist's perspective.". Journal of biomedical research. 29 (2): 105–11. doi:10.7555/JBR.29.20140127. PMC 4389109. PMID 25859264.
^ Moscou, Susan (2013). "Getting the word out: advocacy, social marketing, and policy development and enforcement". In Truglio-Londrigan, Marie; Lewenson, Sandra B. Public health nursing: practicing population-based care (2nd ed.). Burlington, MA: Jones & Bartlett Learning. p. 317. ISBN 978-1-4496-4660-8. OCLC 758391750.
^ ^a ^b ^c Smyth, S; Heron, A (January 2006). "Diabetes and obesity: the twin epidemics". Nature Medicine. 12 (1): 75–80. doi:10.1038/nm0106-75. PMID 16397575. (subscription required (help)).
^ Global Burden of Disease Study 2013 Collaborators (22 August 2015). "Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013". The Lancet. 386 (9995): 743–800. doi:10.1016/S0140-6736(15)60692-4. PMC 4561509. PMID 26063472.
^ Tfayli, H; Arslanian, S (March 2009). "Pathophysiology of type 2 diabetes mellitus in youth: the evolving chameleon". Arquivos brasileiros de endocrinologia e metabologia. 53 (2): 165–74. doi:10.1590/s0004-27302009000200008. PMC 2846552. PMID 19466209.
^ Imperatore, Giuseppina; Boyle, James P.; Thompson, Theodore J.; Case, Doug; Dabelea, Dana; Hamman, Richard F.; Lawrence, Jean M.; Liese, Angela D.; Liu, Lenna L. (December 2012). "Projections of Type 1 and Type 2 Diabetes Burden in the U.S. Population Aged <20 Years Through 2050". Diabetes Care. 35 (12): 2515–2520. doi:10.2337/dc12-0669. ISSN 0149-5992. PMC 3507562. PMID 23173134.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r Melmed, Shlomo; Polonsky, Kenneth S.; Larsen, P. Reed; Kronenberg, Henry M. (eds.). Williams textbook of endocrinology. (12th ed.). Philadelphia: Elsevier/Saunders. pp. 1371–1435. ISBN 978-1-4377-0324-5.
^ ^a ^b Leutholtz, Brian C.; Ripoll, Ignacio (2011). "Diabetes". Exercise and disease management (2nd ed.). Boca Raton: CRC Press. p. 25. ISBN 978-1-4398-2759-8. OCLC 725919496.
^ Zaccardi F, Webb DR, Yates T, Davies MJ (February 2016). "Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective.". Postgraduate Medical Journal. 92 (1084): 63–9. doi:10.1136/postgradmedj-2015-133281. PMID 26621825. (subscription required (help)).
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Vijan, S (2010-03-02). "Type 2 diabetes". Annals of Internal Medicine. 152 (5): ITC31–15; quiz ITC316. doi:10.7326/0003-4819-152-5-201003020-01003. PMID 20194231.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Ripsin CM, Kang H, Urban RJ (January 2009). "Management of blood glucose in type 2 diabetes mellitus". Am Fam Physician. 79 (1): 29–36. PMID 19145963.
^ Pasquier, F (October 2010). "Diabetes and cognitive impairment: how to evaluate the cognitive status?". Diabetes & metabolism. 36 Suppl 3: S100–5. doi:10.1016/S1262-3636(10)70475-4. PMID 21211730.
^ ^a ^b Risérus U, Willett WC, Hu FB (January 2009). "Dietary fats and prevention of type 2 diabetes". Progress in Lipid Research. 48 (1): 44–51. doi:10.1016/j.plipres.2008.10.002. PMC 2654180. PMID 19032965.
^ ^a ^b Touma, C; Pannain, S (August 2011). "Does lack of sleep cause diabetes?". Cleveland Clinic journal of medicine. 78 (8): 549–58. doi:10.3949/ccjm.78a.10165. PMID 21807927.
^ Christian, P; Stewart, CP (March 2010). "Maternal micronutrient deficiency, fetal development, and the risk of chronic disease". The Journal of Nutrition. 140 (3): 437–45. doi:10.3945/jn.109.116327. PMID 20071652.
^ Pedersen HK, Gudmundsdottir V, Nielsen HB, et al. (21 July 2016). "Human gut microbes impact host serum metabolome and insulin sensitivity". Nature. 535 (7612): 376–381. doi:10.1038/nature18646. PMID 27409811.
^ Abdullah, A; Peeters, A; de Courten, M; Stoelwinder, J (September 2010). "The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of prospective cohort studies.". Diabetes research and clinical practice. 89 (3): 309–19. doi:10.1016/j.diabres.2010.04.012. PMID 20493574.
^ Pan, A; Wang, Y; Talaei, M; Hu, FB; Wu, T (17 September 2015). "Relation of active, passive, and quitting smoking with incident type 2 diabetes: a systematic review and meta-analysis.". The Lancet. Diabetes & endocrinology. 3: 958–67. doi:10.1016/S2213-8587(15)00316-2. PMID 26388413.
^ ^a ^b Malik, VS; Popkin, BM; Bray, GA; Després, JP; Hu, FB (2010-03-23). "Sugar Sweetened Beverages, Obesity, Type 2 Diabetes and Cardiovascular Disease risk". Circulation. 121 (11): 1356–64. doi:10.1161/CIRCULATIONAHA.109.876185. PMC 2862465. PMID 20308626.
^ Malik, VS; Popkin, BM; Bray, GA; Després, JP; Willett, WC; Hu, FB (November 2010). "Sugar-Sweetened Beverages and Risk of Metabolic Syndrome and Type 2 Diabetes: A meta-analysis". Diabetes Care. 33 (11): 2477–83. doi:10.2337/dc10-1079. PMC 2963518. PMID 20693348.
^ Hu, EA; Pan, A; Malik, V; Sun, Q (2012-03-15). "White rice consumption and risk of type 2 diabetes: meta-analysis and systematic review". BMJ (Clinical research ed.). 344: e1454. doi:10.1136/bmj.e1454. PMC 3307808. PMID 22422870.
^ Lee, I-Min; Shiroma, Eric J; Lobelo, Felipe; Puska, Pekka; Blair, Steven N; Katzmarzyk, Peter T (1 July 2012). "Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy". The Lancet. 380 (9838): 219–29. doi:10.1016/S0140-6736(12)61031-9. PMC 3645500. PMID 22818936.
^ Lind, L; Lind, PM (Jun 2012). "Can persistent organic pollutants and plastic-associated chemicals cause cardiovascular disease?". Journal of internal medicine. 271 (6): 537–53. doi:10.1111/j.1365-2796.2012.02536.x. PMID 22372998.
^ ^a ^b Herder, C; Roden, M (June 2011). "Genetics of type 2 diabetes: pathophysiologic and clinical relevance". European journal of clinical investigation. 41 (6): 679–92. doi:10.1111/j.1365-2362.2010.02454.x. PMID 21198561.
^ "Monogenic Forms of Diabetes: Neonatal Diabetes Mellitus and Maturity-onset Diabetes of the Young". National Diabetes Information Clearinghouse (NDIC). National Institute of Diabetes and Digestive and Kidney Diseases, NIH. March 2007. Retrieved 2008-08-04.
^ ^a ^b Funnell, Martha M.; Anderson, Robert M. (2008). "Influencing self-management: from compliance to collaboration". In Feinglos, Mark N.; Bethel, M. Angelyn. Type 2 diabetes mellitus: an evidence-based approach to practical management. Contemporary endocrinology. Totowa, NJ: Humana Press. p. 462. ISBN 978-1-58829-794-5. OCLC 261324723.
^ Izzedine, H; Launay-Vacher, V; Deybach, C; Bourry, E; Barrou, B; Deray, G (November 2005). "Drug-induced diabetes mellitus". Expert opinion on drug safety. 4 (6): 1097–109. doi:10.1517/14740338.4.6.1097. PMID 16255667. (subscription required (help)).
^ Sampson, UK; Linton, MF; Fazio, S (July 2011). "Are statins diabetogenic?". Current Opinion in Cardiology. 26 (4): 342–7. doi:10.1097/HCO.0b013e3283470359. PMC 3341610. PMID 21499090.
^ Saad F, Gooren L (March 2009). "The role of testosterone in the metabolic syndrome: a review". The Journal of Steroid Biochemistry and Molecular Biology. 114 (1–2): 40–3. doi:10.1016/j.jsbmb.2008.12.022. PMID 19444934. (subscription required (help)).
^ Farrell JB, Deshmukh A, Baghaie AA (2008). "Low testosterone and the association with type 2 diabetes". The Diabetes Educator. 34 (5): 799–806. doi:10.1177/0145721708323100. PMID 18832284.
^ Diabetes mellitus a guide to patient care. Philadelphia: Lippincott Williams & Wilkins. 2007. p. 15. ISBN 978-1-58255-732-8.
^ Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation (PDF). Geneva: World Health Organization. 2006. p. 21. ISBN 978-92-4-159493-6.
^ Vijan, S (March 2010). "Type 2 diabetes". Annals of Internal Medicine. 152 (5): ITC31-15. doi:10.7326/0003-4819-152-5-201003020-01003. PMID 20194231.
^ World Health Organization. "Definition, diagnosis and classification of diabetes mellitus and its complications: Report of a WHO Consultation. Part 1. Diagnosis and classification of diabetes mellitus". Retrieved 2007-05-29.
^ ^a ^b ^c International Expert, Committee (July 2009). "International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes". Diabetes Care. 32 (7): 1327–34. doi:10.2337/dc09-9033. PMC 2699715. PMID 19502545.
^ "Diagnosis and classification of diabetes mellitus". Diabetes Care. American Diabetes Association. 33 Suppl 1 (Supplement_1): S62–9. January 2010. doi:10.2337/dc10-S062. PMC 2797383. PMID 20042775.
^ "Diagnosis and classification of diabetes mellitus". Diabetes Care. American Diabetes Association. 35 Suppl 1 (Suppl 1): S64–71. January 2012. doi:10.2337/dc12-s064. PMC 3632174. PMID 22187472.
^ Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Cotran, Ramzi S.; Robbins, Stanley L. (2005). Robbins and Cotran Pathologic Basis of Disease (7th ed.). Philadelphia, Pa.: Saunders. pp. 1194–1195. ISBN 0-7216-0187-1.
^ Diabetes mellitus a guide to patient care. Philadelphia: Lippincott Williams & Wilkins. 2007. p. 201. ISBN 978-1-58255-732-8.
^ Vivian, Eva M.; Blackorbay, Brady (2013). "Chapter 13: Endocrine Disorders". In Lee, Mary. Basic Skills in Interpreting Laboratory Data (5th ed.). Bethesda, MD: American Society of Health-System Pharmacists. ISBN 978-1-58528-345-3. OCLC 859778842.
^ ^a ^b Valdez R (2009). "Detecting Undiagnosed Type 2 Diabetes: Family History as a Risk Factor and Screening Tool". J Diabetes Sci Technol. 3 (4): 722–6. doi:10.1177/193229680900300417. PMC 2769984. PMID 20144319.
^ ^a ^b Selph, S; Dana, T; Blazina, I; Bougatsos, C; Patel, H; Chou, R (22 June 2015). "Screening for Type 2 Diabetes Mellitus: A Systematic Review for the U.S. Preventive Services Task Force". Annals of Internal Medicine. 162 (11): 765–76. doi:10.7326/M14-2221. PMID 25867111.
^ ^a ^b "Archived: Diabetes Mellitus (Type 2) in Adults: Screening". U.S. Preventive Services Task Force. June 2008. Retrieved 2014-03-16.
^ Siu, AL (27 October 2015). "Screening for Abnormal Blood Glucose and Type 2 Diabetes Mellitus: U.S. Preventive Services Task Force Recommendation Statement.". Annals of Internal Medicine. 163: 861–8. doi:10.7326/M15-2345. PMID 26501513.
^ "Draft Recommendation Statement Screening for Abnormal Glucose and Type 2 Diabetes Mellitus". U.S. Preventive Services Task Force. Archived from the original on 9 October 2014. Retrieved 7 October 2014.
^ ^a ^b "Standards of Medical Care in Diabetes—2015: Summary of Revisions". Diabetes Care. 54 (38): S4. 2015. doi:10.2337/dc15-S003. PMID 25537706.
^ Raina Elley C, Kenealy T (December 2008). "Lifestyle interventions reduced the long-term risk of diabetes in adults with impaired glucose tolerance". Evid Based Med. 13 (6): 173. doi:10.1136/ebm.13.6.173. PMID 19043031.
^ Orozco LJ, Buchleitner AM, Gimenez-Perez G, Roqué I Figuls M, Richter B, Mauricio D (2008). Mauricio, Didac, ed. "Exercise or exercise and diet for preventing type 2 diabetes mellitus". Cochrane Database Syst Rev (3): CD003054. doi:10.1002/14651858.CD003054.pub3. PMID 18646086.
^ ^a ^b Schellenberg, ES.; Dryden, DM.; Vandermeer, B.; Ha, C.; Korownyk, C. (October 2013). "Lifestyle Interventions for Patients With and at Risk for Type 2 Diabetes: A Systematic Review and Meta-analysis". Ann Intern Med. 159 (8): 543–51. doi:10.7326/0003-4819-159-8-201310150-00007. PMID 24126648.
^ O'Gorman, DJ; Krook, A (September 2011). "Exercise and the treatment of diabetes and obesity". The Medical clinics of North America. 95 (5): 953–69. doi:10.1016/j.mcna.2011.06.007. PMID 21855702.
^ Kyu, Hmwe H.; Bachman, Victoria F.; Alexander, Lily T.; Mumford, John Everett; Afshin, Ashkan; Estep, Kara; Veerman, J. Lennert; Delwiche, Kristen; Iannarone, Marissa L.; Moyer, Madeline L.; Cercy, Kelly; Vos, Theo; Murray, Christopher J.L.; Forouzanfar, Mohammad H. (9 August 2016). "Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013". BMJ. 354: i3857. doi:10.1136/bmj.i3857. PMC 4979358. PMID 27510511.
^ Nield L, Summerbell CD, Hooper L, Whittaker V, Moore H (2008). Nield, Lucie, ed. "Dietary advice for the prevention of type 2 diabetes mellitus in adults". Cochrane Database Syst Rev (3): CD005102. doi:10.1002/14651858.CD005102.pub2. PMID 18646120.
^ Carter, P; Gray, LJ; Troughton, J; Khunti, K; Davies, MJ (2010-08-18). "Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis". BMJ (Clinical research ed.). 341: c4229. doi:10.1136/bmj.c4229. PMC 2924474. PMID 20724400.
^ Santaguida PL, Balion C, Hunt D, et al. (August 2005). "Diagnosis, prognosis, and treatment of impaired glucose tolerance and impaired fasting glucose" (PDF). Evid Rep Technol Assess (Summ) (128): 1–11. PMID 16194123.
^ Seida, Jennifer C.; Mitri, Joanna; Colmers, Isabelle N.; Majumdar, Sumit R.; Davidson, Mayer B.; Edwards, Alun L.; Hanley, David A.; Pittas, Anastassios G.; Tjosvold, Lisa; Johnson, Jeffrey A. (Oct 2014). "Effect of Vitamin D3 Supplementation on Improving Glucose Homeostasis and Preventing Diabetes: A Systematic Review and Meta-Analysis". The Journal of Clinical Endocrinology & Metabolism. 99 (10): 3551–3560. doi:10.1210/jc.2014-2136. PMC 4483466. PMID 25062463.
^ ^a ^b "Type 2 diabetes: The management of type 2 diabetes". May 2009.
^ Farmer, AJ; Perera, R; Ward, A; Heneghan, C; Oke, J; Barnett, AH; Davidson, MB; Guerci, B; Coates, V; Schwedes, U; O'Malley, S (27 February 2012). "Meta-analysis of individual patient data in randomised trials of self monitoring of blood glucose in people with non-insulin treated type 2 diabetes". BMJ (Clinical research ed.). 344: e486. doi:10.1136/bmj.e486. PMID 22371867.
^ Emdin, CA; Rahimi, K; Neal, B; Callender, T; Perkovic, V; Patel, A (10 February 2015). "Blood pressure lowering in type 2 diabetes: a systematic review and meta-analysis.". JAMA. 313 (6): 603–15. doi:10.1001/jama.2014.18574. PMID 25668264.
^ McBrien, K; Rabi, DM; Campbell, N; Barnieh, L; Clement, F; Hemmelgarn, BR; Tonelli, M; Leiter, LA; Klarenbach, SW; Manns, BJ (6 August 2012). "Intensive and Standard Blood Pressure Targets in Patients With Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis". Archives of Internal Medicine. 172 (17): 1–8. doi:10.1001/archinternmed.2012.3147. PMID 22868819.
^ Boussageon, R; Bejan-Angoulvant, T; Saadatian-Elahi, M; Lafont, S; Bergeonneau, C; Kassaï, B; Erpeldinger, S; Wright, JM; Gueyffier, F; Cornu, C (2011-07-26). "Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials". BMJ (Clinical research ed.). 343: d4169. doi:10.1136/bmj.d4169. PMC 3144314. PMID 21791495.
^ Webster, MW (July 2011). "Clinical practice and implications of recent diabetes trials". Current Opinion in Cardiology. 26 (4): 288–93. doi:10.1097/HCO.0b013e328347b139. PMID 21577100.
^ ^a ^b ^c ^d Inzucchi, SE; Bergenstal, RM; Buse, JB; Diamant, M; Ferrannini, E; Nauck, M; Peters, AL; Tsapas, A; Wender, R; Matthews, DR (March 2015). "Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes.". Diabetologia. 58 (3): 429–42. doi:10.1007/s00125-014-3460-0. PMID 25583541.
^ Makam, AN; Nguyen, OK (10 January 2017). "An Evidence-Based Medicine Approach to Antihyperglycemic Therapy in Diabetes Mellitus to Overcome Overtreatment.". Circulation. 135 (2): 180–195. doi:10.1161/CIRCULATIONAHA.116.022622. PMID 28069712.
^ Simpson, TC.; Needleman, I.; Wild, SH.; Moles, DR.; Mills, EJ. (2010). Simpson, Terry C, ed. "Treatment of periodontal disease for glycaemic control in people with diabetes". Cochrane Database Syst Rev (5): CD004714. doi:10.1002/14651858.CD004714.pub2. PMID 20464734.
^ ^a ^b ^c Zanuso S, Jimenez A, Pugliese G, Corigliano G, Balducci S (March 2010). "Exercise for the management of type 2 diabetes: a review of the evidence". Acta Diabetol. 47 (1): 15–22. doi:10.1007/s00592-009-0126-3. PMID 19495557.
^ ^a ^b Davis N, Forbes B, Wylie-Rosett J (June 2009). "Nutritional strategies in type 2 diabetes mellitus". Mt. Sinai J. Med. 76 (3): 257–68. doi:10.1002/msj.20118. PMID 19421969.
^ Thomas D, Elliott EJ (2009). Thomas, Diana, ed. "Low glycaemic index, or low glycaemic load, diets for diabetes mellitus". Cochrane Database Syst Rev (1): CD006296. doi:10.1002/14651858.CD006296.pub2. PMID 19160276.
^ Feinman, RD; Pogozelski, WK; Astrup, A; Bernstein, RK; Fine, EJ; Westman, EC; Accurso, A; Frassetto, L; Gower, BA; McFarlane, SI; Nielsen, JV; Krarup, T; Saslow, L; Roth, KS; Vernon, MC; Volek, JS; Wilshire, GB; Dahlqvist, A; Sundberg, R; Childers, A; Morrison, K; Manninen, AH; Dashti, HM; Wood, RJ; Wortman, J; Worm, N (January 2015). "Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base.". Nutrition (Burbank, Los Angeles County, Calif.). 31 (1): 1–13. doi:10.1016/j.nut.2014.06.011. PMID 25287761.
^ Hawthorne, K.; Robles, Y.; Cannings-John, R.; Edwards, A. G. K.; Robles, Yolanda (2008). Robles, Yolanda, ed. "Culturally appropriate health education for Type 2 diabetes mellitus in ethnic minority groups". Cochrane Database Syst Rev (3): CD006424. doi:10.1002/14651858.CD006424.pub2. PMID 18646153. CD006424.
^ Glick-Bauer M, Yeh MC (2014). "The health advantage of a vegan diet: exploring the gut microbiota connection". Nutrients (Review). 6 (11): 4822–38. doi:10.3390/nu6114822. PMC 4245565. PMID 25365383.
^ Leach, Matthew J.; Kumar, Saravana (2012-09-12). "Cinnamon for diabetes mellitus". The Cochrane Database of Systematic Reviews (9): CD007170. doi:10.1002/14651858.CD007170.pub2. ISSN 1469-493X. PMID 22972104.
^ Palmer, Suetonia C.; Mavridis, Dimitris; Nicolucci, Antonio; Johnson, David W.; Tonelli, Marcello; Craig, Jonathan C.; Maggo, Jasjot; Gray, Vanessa; De Berardis, Giorgia; Ruospo, Marinella; Natale, Patrizia; Saglimbene, Valeria; Badve, Sunil V.; Cho, Yeoungjee; Nadeau-Fredette, Annie-Claire; Burke, Michael; Faruque, Labib; Lloyd, Anita; Ahmad, Nasreen; Liu, Yuanchen; Tiv, Sophanny; Wiebe, Natasha; Strippoli, Giovanni F.M. (19 July 2016). "Comparison of Clinical Outcomes and Adverse Events Associated With Glucose-Lowering Drugs in Patients With Type 2 Diabetes". JAMA. 316 (3): 313–24. doi:10.1001/jama.2016.9400. PMID 27434443.
^ Boussageon, R; Supper, I; Bejan-Angoulvant, T; Kellou, N; Cucherat, M; Boissel, JP; Kassai, B; Moreau, A; Gueyffier, F; Cornu, C (2012). Groop, Leif, ed. "Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials". PLOS Medicine. 9 (4): e1001204. doi:10.1371/journal.pmed.1001204. PMC 3323508. PMID 22509138.
^ Richter, B; Bandeira-Echtler, E; Bergerhoff, K; Clar, C; Ebrahim, SH (18 July 2007). Richter, Bernd, ed. "Rosiglitazone for type 2 diabetes mellitus". The Cochrane database of systematic reviews (3): CD006063. doi:10.1002/14651858.CD006063.pub2. PMID 17636824.
^ Chen, X; Yang, L; Zhai, SD (December 2012). "Risk of cardiovascular disease and all-cause mortality among diabetic patients prescribed rosiglitazone or pioglitazone: a meta-analysis of retrospective cohort studies". Chinese medical journal. 125 (23): 4301–6. PMID 23217404.
^ Lv, J; Perkovic, V; Foote, CV; Craig, ME; Craig, JC; Strippoli, GF (12 December 2012). Strippoli, Giovanni FM, ed. "Antihypertensive agents for preventing diabetic kidney disease". The Cochrane database of systematic reviews. 12: CD004136. doi:10.1002/14651858.CD004136.pub3. PMID 23235603.
^ ^a ^b Cheng, J; Zhang, W; Zhang, X; Han, F; Li, X; He, X; Li, Q; Chen, J (May 2014). "Effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on all-cause mortality, cardiovascular deaths, and cardiovascular events in patients with diabetes mellitus: a meta-analysis.". JAMA internal medicine. 174 (5): 773–85. doi:10.1001/jamainternmed.2014.348. PMID 24687000.
^ Brunström, Mattias; Carlberg, Bo (24 February 2016). "Effect of antihypertensive treatment at different blood pressure levels in patients with diabetes mellitus: systematic review and meta-analyses". BMJ. 352: i717. doi:10.1136/bmj.i717. PMC 4770818. PMID 26920333.
^ Swinnen, SG.; Simon, AC.; Holleman, F.; Hoekstra, JB.; Devries, JH. (2011). Simon, Airin CR, ed. "Insulin detemir versus insulin glargine for type 2 diabetes mellitus". Cochrane Database Syst Rev (7): CD006383. doi:10.1002/14651858.CD006383.pub2. PMID 21735405.
^ Waugh, N; Cummins, E; Royle, P; Clar, C; Marien, M; Richter, B; Philip, S (July 2010). "Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation". Health technology assessment (Winchester, England). 14 (36): 1–248. doi:10.3310/hta14360. PMID 20646668.
^ Picot, J; Jones, J; Colquitt, JL; Gospodarevskaya, E; Loveman, E; Baxter, L; Clegg, AJ (September 2009). "The clinical effectiveness and cost-effectiveness of bariatric (weight loss) surgery for obesity: a systematic review and economic evaluation". Health technology assessment (Winchester, England). 13 (41): 1–190, 215–357, iii–iv. doi:10.3310/hta13410. PMID 19726018.
^ Frachetti, KJ; Goldfine, AB (April 2009). "Bariatric surgery for diabetes management". Current Opinion in Endocrinology, Diabetes and Obesity. 16 (2): 119–24. doi:10.1097/MED.0b013e32832912e7. PMID 19276974.
^ ^a ^b Schulman, AP; del Genio, F; Sinha, N; Rubino, F (September–October 2009). ""Metabolic" surgery for treatment of type 2 diabetes mellitus". Endocrine Practice. 15 (6): 624–31. doi:10.4158/EP09170.RAR. PMID 19625245.
^ Colucci, RA (January 2011). "Bariatric surgery in patients with type 2 diabetes: a viable option". Postgraduate Medicine. 123 (1): 24–33. doi:10.3810/pgm.2011.01.2242. PMID 21293081.
^ Dixon, JB; le Roux, CW; Rubino, F; Zimmet, P (16 June 2012). "Bariatric surgery for type 2 diabetes". Lancet. 379 (9833): 2300–11. doi:10.1016/S0140-6736(12)60401-2. PMID 22683132.
^ Rubino, F; Nathan, DM; Eckel, RH; Schauer, PR; Alberti, KG; Zimmet, PZ; Del Prato, S; Ji, L; Sadikot, SM; Herman, WH; Amiel, SA; Kaplan, LM; Taroncher-Oldenburg, G; Cummings, DE; Delegates of the 2nd Diabetes Surgery, Summit (June 2016). "Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations.". Diabetes Care. 39 (6): 861–77. doi:10.2337/dc16-0236. PMID 27222544.
^ Meetoo, D; McGovern, P; Safadi, R (13–27 September 2007). "An epidemiological overview of diabetes across the world". British journal of nursing (Mark Allen Publishing). 16 (16): 1002–7. PMID 18026039.
^ Abate N, Chandalia M (2001). "Ethnicity and type 2 diabetes: focus on Asian Indians". J. Diabetes Complicat. 15 (6): 320–7. doi:10.1016/S1056-8727(01)00161-1. PMID 11711326.
^ Carulli, L; Rondinella, S; Lombardini, S; Canedi, I; Loria, P; Carulli, N (November 2005). "Review article: diabetes, genetics and ethnicity". Alimentary pharmacology & therapeutics. 22 Suppl 2: 16–9. doi:10.1111/j.1365-2036.2005.02588.x. PMID 16225465.
^ Wild S, Roglic G, Green A, Sicree R, King H (May 2004). "Global prevalence of diabetes: estimates for the year 2000 and projections for 2030". Diabetes Care. 27 (5): 1047–53. doi:10.2337/diacare.27.5.1047. PMID 15111519.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Zajac, Jacek; Shrestha, Anil; Patel, Parini; Poretsky, Leonid (2009). "The Main Events in the History of Diabetes Mellitus". In Poretsky, Leonid. Principles of diabetes mellitus (2nd ed.). New York: Springer. pp. 3–16. ISBN 978-0-387-09840-1. OCLC 663097550.

External links

Diabetes mellitus type 2 at DMOZ
IDF Diabetes Atlas 2015
National Diabetes Information Clearinghouse
Centers for Disease Control (Endocrine pathology)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 2型糖尿病の治療のためのジペプチジルペプチダーゼ4（DPP-4）阻害剤 dipeptidyl peptidase 4 dpp 4 inhibitors for the treatment of type 2 diabetes mellitus
2. 成人の2型糖尿病における血糖の初期マネージメント initial management of blood glucose in adults with type 2 diabetes mellitus
3. 小児および思春期における2型糖尿病の疫学、症状、および診断 epidemiology presentation and diagnosis of type 2 diabetes mellitus in children and adolescents
4. 成人における糖尿病に対する治療の概要 overview of medical care in adults with diabetes mellitus
5. 2型糖尿病における持続性高血糖のマネージメント management of persistent hyperglycemia in type 2 diabetes mellitus

English Journal

Small dense LDL is more susceptible to glycation than more buoyant LDL in Type 2 diabetes.

Younis NN, Soran H, Pemberton P, Charlton-Menys V, Elseweidy MM, Durrington PN.Source*Cardiovascular Research Group, School of Biomedicine, University of Manchester, Manchester, U.K.
Clinical science (London, England : 1979).Clin Sci (Lond).2013 Mar 1;124(5):343-9. doi: 10.1042/CS20120304.
Glycation of apoB (apolipoprotein B) of LDL (low-density lipoprotein) increases its atherogenicity. Concentrations of both serum glyc-apoB (glycated apoB) and SD-LDL (small dense LDL) (syn LDL3; D=1.044-1.063 g/ml) are increased in diabetes and are closely correlated. We studied whether SD-LDL is m
PMID 22985435

Does uric acid qualify as an independent risk factor for cardiovascular mortality?

Jeemon P, Prabhakaran D.AbstractUA (uric acid) is the final product of purine metabolism in humans and is implicated in many disease conditions. Sustained hyperuricaemia has putative adverse roles in cardiovascular diseases. Despite strong evidence emerging from large epidemiological studies supporting the hypothesis that UA independently influences cardiovascular disease outcomes and mortality, a causal role is yet to be established. Serum UA is also considered as a useful biomarker for mortality in high-risk patients with acute coronary syndromes, heart failure and hypertension and in patients with Type 2 diabetes mellitus. Post-hoc analyses of clinical trial data suggest beneficial effects of reducing serum UA. However, these findings are inconclusive and are only hypothesis-generating. In the present issue of Clinical Science, Ndrepepa and co-workers have investigated the prognostic role of UA in high-risk Type 2 diabetic patients with established coronary artery disease in predicting 1-year survival and cardiovascular mortality. These results support the independent role of serum UA in predicting survival in Type 2 diabetic patients. However, long-term follow-up studies are required with serial UA measurement to establish the time-dependent association of UA with mortality outcomes.
Clinical science (London, England : 1979).Clin Sci (Lond).2013 Feb 1;124(4):255-7. doi: 10.1042/CS20120524.
UA (uric acid) is the final product of purine metabolism in humans and is implicated in many disease conditions. Sustained hyperuricaemia has putative adverse roles in cardiovascular diseases. Despite strong evidence emerging from large epidemiological studies supporting the hypothesis that UA indep
PMID 23043434

Japanese Journal

糖尿病薬の心血管作用 (特集血糖・尿酸と循環器の連関)

尿酸と血糖 = Journal of uricemia & glycemic research 1(3), 123-127, 2015-10
NAID 40020774505

腎臓移植患者の原疾患特異的HLA対立遺伝子頻度の検討

医学検査 63(2), 173-180, 2014
NAID 130005057046

糖尿病合併症において血管平滑筋細胞機能に影響する因子

昭和大学薬学雑誌 3(2), 115-128, 2012-12
NAID 120005537024

Related Pictures

★リンクテーブル★

リンク元	「糖尿病」「スルホニル尿酸系薬」「インシュリン非依存性糖尿病」「adult-onset diabetes mellitus」「maturity-onset diabetes mellitus」

「糖尿病」

Diabetes mellitus type 2
Synonyms	noninsulin-dependent diabetes mellitus (NIDDM), adult-onset diabetes
	Universal blue circle symbol for diabetes
Pronunciation	/daɪəbiːtiːs/
Classification and external resources
Specialty	Endocrinology
ICD-10	E11
ICD-9-CM	250.00, 250.02
OMIM	125853
DiseasesDB	3661
MedlinePlus	000313
eMedicine	article/117853
MeSH	D003924
	[edit on Wikidata]

　　[★]

英: diabetes mellitus (SP), DM
関: 糖尿病治療薬

first aid step1 2006 p.first aid step1 2006 p.256,423

定義

グルコースに関連した糖質代謝障害

インスリンの不足

病型

1型糖尿病(インスリン依存性糖尿病(IDDM)):自己免疫性、特発性(劇症1型糖尿病、緩徐進行1型糖尿病)

インスリン分泌の低下

血中インスリン濃度：低

遺伝や生活習慣病に関係なく発症。治療はインスリンの注射

2型糖尿病(インスリン非依存型糖尿病(NIDDM))

インスリン受容体や細胞内情報伝達系の質的・量的変化

一般に血中インスリン濃度：高

肥満、喫煙、運増などが関連

中高年に多い

運動療法と食事療法

参考1

NIDDM：インスリン不要
NIDDM：高血糖是正にインスリン必要
IDDM：ケトーシス防止や生存にインスリン必要

DM type1

治療にインスリンが必要～生存にインスリンが必要

DM type2

境界領域～インスリン不要～治療にインスリンが必要

症状

慢性的な高血糖状態

尿糖陽性

血糖値が170-180mg/dl以上で尿糖陽性となる。

血糖150mg/dlでも尿糖陽性であれば腎性尿糖が疑われる

口渇、多飲、多尿
ケトーシス、アシドーシス体重減少

合併症

多発神経障害(広汎性左右対称性神経障害)
単神経障害

栄養血管の閉塞による脳神経障害
外眼筋(動眼神経、滑車神経、外転神経)麻痺、顔面神経麻痺

糖尿病足病変
歯周病
動脈硬化性病変

冠動脈硬化症(広義には冠動脈疾患(CAD))
脳血管障害
下肢閉塞性動脈硬化症

認知症
皮膚病変

直接デルマドローム：糖尿病性壊疽、糖尿病性浮腫性硬化症、糖尿病性黄色腫、リポイド類壊死症、糖尿病性水疱、デュピュイトラン拘縮、前脛骨部色素斑、播種状環状肉芽腫
間接デルマドローム：皮膚真菌症

糖尿病性ケトアシドーシス(type 1 DM)
高浸透圧性非ケトン性昏睡(type 2 DM)

医療系の雑誌より(日経カデット11月？)

表5　糖尿病患者にみられる筋骨格系症状を呈する疾患と臨床的特徴

糖尿病との関係	疾患	臨床的特徴
糖尿病が直接病因に関与する疾患	糖尿病性手関節症(diabetic cheiroarthropathy)	コントロール不良の糖尿病に多い。原因不明の皮膚硬化が徐々に進行し、手指の屈曲拘縮を来し手全体に及び、強皮症と誤診される。手指を合わせることができない(Prayer徴候)。
	シャルコー関節	頻度は低い(1%)が、長期糖尿病コントロール不良患者に多い。通常、足根中足関節などの中足部が多く、足底表面、前足部、中足部に潰瘍形成の合併を認めることがあり、骨髄炎との鑑別が困難な例あり。
	糖尿病性骨溶解(diabetic osteolysis)	原因不明の足趾の末節骨や基節骨の骨吸収が起こリ、足痛の原因となる。X線ではickedcandy変形を呈し、骨髄炎との鑑別が困難。
	糖尿病性筋梗塞	外傷、感染、腫瘍がなく大腿部などに急激に増大する疼痛を伴う腫瘤を認める。生検は出血の危険があるため行わない。通常1～2カ月で自然寛解する
	糖尿病性筋萎縮症(diabetic amyotrophy)	糖尿病性末梢神経障害の一型。大腿前部の痛みで、時に脱力や萎縮が非対称性に起きる。CPKの上昇はなく、脳脊髄液で軽度蛋白上昇以外の有意な所見はない。神経伝導速度.筋電図では神経原性変化を認め、筋生検では炎症細胞浸潤を伴わない筋線経の萎縮あり。
直接の関係は不明だが糖尿病患者に頻度が高い疾患	癒着性関節包炎(凍結肩または五十肩)	糖尿病患者の10-33%にみられる。長期2型糖尿病を有する女性に多く、肩の痛みと可動域障害を呈する。約半数が両側性だが非利き手側で症状が強い。炎症反応やX線異常を認めず、数週～数カ月で自然寛解する。
	複合性局所疼痛症候群1型(complex regional pain syndrome CRPS)	四肢の疼痛、皮膚色変化、皮膚温の変化、浮腫、可動域制限などの症候を呈するまれな症候群。
	手掌屈筋鍵炎	糖尿病患者の5-33%に認められる。長期に罹患した女性に多く、利き手側の母指に頻度(75%)が高いが、どの指にもみられる。
	Dupuytren拘縮	手掌筋膜の短縮と肥厚(有痛性結節)を生じ、第4、5指の屈曲拘縮を呈する。1型糖尿病で長期に罹患した患者に多いが、血糖コントロールとの関係はない。
	手根管症候群	手根管症候群の全患者の最大15%に糖尿病を認める。
	広汎性特発性骨増殖症(diffuse idiopathic skeletal hyperostosis DISH)	2型糖尿病患者の約20%にみられ、50才以上の肥満患者に多い。頭部、腰部のこわばリ、関節の可動域制限を呈する。全身の腱付着部痛を呈することもある。
その他	感染性関節炎や骨髄炎	血糖上昇による免疫力低下が感染症リスクを上昇させることによる

診断

血糖値検査による分類

　　　　　　　　　　　　　正常　　　　　　　　　　　糖尿病型
　空腹時血糖値 　　　　　＜110mg/dL　　　　　　　　　≧126mg/dL
                         and                        or
　75g OGTT2時間値　　　＜140mg/dL　　　　　　　　　≧200mg/dL

正常型、境界型、糖尿病型に分類する

正常型であっても、食後1時間値が180mg/dL(10.0mmol/l)以上の場合には、180mg/dl未満のものに比べて糖尿病に進展する可能性が高いので、境界型に準じた取り扱い(経過観察)を行う(参考1)。

診断基準

参考2-4

1) 初回検査で、①空腹時血糖値≧126mg/dl、②75gOGTT2時間値≧200mg/dl、③随時血糖値≧200mg/dl、④HbA1c(国際標準値)≧ 6.5%のうちいずれかを認めた場合は、「糖尿病型」と判定する。別の日に再検査を行い、再び「糖尿病型」が確認されれば糖尿病と診断する。但し、HbA1cのみの反復検査による診断は不可とする。また、血糖値とHbA1cが同一採血で糖尿病型を示すこと(①～③のいずれかと④)が確認されれば、初回検査だけでも糖尿病と診断してよい。
2)血糖値が糖尿病型(①～③のいずれか)を示し、かつ次のいずれかの条件がみたされた場合は、初回検査だけでも糖尿病と診断できる。

糖尿病の典型的症状(口渇、多飲、多尿、体重減少)の存在
確実な糖尿病網膜症の存在

3)過去において、上記1)ないしは2)の条件がみたされていたことが確認できる場合には、現在の検査値が上記の条件に合致しなくても、糖尿病と診断するか、糖尿病の疑いを持って対応する必要がある。
4)上記1)～ 3)によっても糖尿病の判定が困難な場合には、糖尿病の疑いをもって患者を追跡し、時期をおいて再検査する。
5)初回検査と再検査における判定方法の選択には、以下に留意する。

初回検査の判定にHbA1cを用いた場合、再検査ではそれ以外の判定方法を含めることが診断に必須である。検査においては、原則として血糖値とHbA1cの双方を測定するものとする。
初回検査の判定が随時血糖値≧200mg/dlで行われた場合、再検査は他の検査方法によることが望ましい。
HbA1cが見かけ上低値になり得る疾患・状況の場合には、必ず血糖値による診断を行う。

[show details]

予後

糖尿病の死因の一位は心筋梗塞(Q book p.259)。

USMLE

Q book p.245 38(死因)

高血圧と糖尿病を合併する病態

クッシング症候群：糖質コルチコイドによる糖新生亢進・インスリン拮抗作用と鉱質コルチコイド様作用による。
先端巨大症：成長ホルモンの抗インスリン作用と電解質代謝作用(Na,K,Cl濃度増加、細胞外液増加)
褐色細胞腫：交感神経緊張亢進によるα1,β1作用による血圧上昇、α2, β2作用による血糖上昇
原発性アルドステロン症：過量のアルドステロンによるナトリウム再吸収、カリウム排泄亢進により体液量貯留、低カリウムによるインスリン作用低下

参考

1. 糖尿病の分類

http://www.uemura-clinic.com/dmlecture/newcriteria.htm

2. 糖尿病の新診断基準2010

http://d.hatena.ne.jp/bonbokorin/20100608/p1

3. 糖尿病の新しい診断基準を7月に施行　日本糖尿病学会-糖尿病NET-資料室

http://www.dm-net.co.jp/calendar/2010/010167.php

4. 委員会報告糖尿病の分類と診断基準に関する委員会報告 2010

http://www.jds.or.jp/jds_or_jp0/uploads/photos/635.pdf

「スルホニル尿酸系薬」

　　[★]

同: スルフォニル尿酸系薬、SU剤、スルホニル尿素系血糖降下薬
関: 糖尿病治療薬、薬理学

分類

スルフォニル尿酸系薬 sulfonylurea

-作用弱

トルブタミド tolbutamide -第一世代
グリクラジド gliclazide -第二世代

-作用中

クロルプロパミド clorpropamide

-作用強

グリベンクラミド glibenclamide -第二世代

-新薬

グリメピリド glimepiride -第三世代

スルホンアミド系薬

作用機序

GOO.1634
ATP感受性KチャネルのSUR1サブユニットに結合し、チャネルを阻害する。膜が脱分極し、電位依存性Ca2+チャネルが開口する。

薬理作用

動態

適応

以下の全てを満たす場合
1. NIDDM
2. 高度の肥満がない
3. 食事療法、運動療法で満足な血糖コントロールが得られない
4. 膵インスリン分解能をある程度保持 (尿中Cペプチド>20μg/day)
5. 低血糖を理解し対応できる
6. 妊婦ではない

注意

禁忌

1. IDDM
2. 重篤な感染症を繰り返す場合
3. 大きな外科手術を受ける場合
4. 高度の肝・腎障害がある場合
5. 妊婦
6. アレルギーなど副作用の発現を満たすもの

「インシュリン非依存性糖尿病」

　　[★]

英: non-insulin-dependent diabetes mellitus、NIDDM
関: 若年発症型成人型糖尿病、II型糖尿病、インスリン非依存性糖尿病、2型糖尿病、インスリン非依存型糖尿病、成人発症型糖尿病

「adult-onset diabetes mellitus」

　　[★]

成人発症型糖尿病

関: maturity-onset diabetes、maturity-onset diabetes mellitus、MODY、NIDDM、non-insulin-dependent diabetes mellitus、type 2 diabetes mellitus、type II diabetes mellitus

「maturity-onset diabetes mellitus」

　　[★]

成人発症型糖尿病

関: adult-onset diabetes mellitus、maturity-onset diabetes、MODY、NIDDM、non-insulin-dependent diabetes mellitus、type 2 diabetes mellitus、type II diabetes mellitus

[WHO2015-1] ^ ^a ^b ^c ^d ^e ^f "Diabetes Fact sheet N°312". World Health Organization. August 2011. Archived from the original on 26 August 2013. Retrieved 2012-01-09.

[2] "Diabetes Blue Circle Symbol". International Diabetes Federation. 17 March 2006. Archived from the original on 5 August 2007.

[NIH2014Cause-3] "Causes of Diabetes". National Institute of Diabetes and Digestive and Kidney Diseases. June 2014. Archived from the original on 2 February 2016. Retrieved 10 February 2016.

[NIH2014Diag-4] "Diagnosis of Diabetes and Prediabetes". National Institute of Diabetes and Digestive and Kidney Diseases. June 2014. Archived from the original on 6 March 2016. Retrieved 10 February 2016.

[5] Pasquel, FJ; Umpierrez, GE (November 2014). "Hyperosmolar hyperglycemic state: a historic review of the clinical presentation, diagnosis, and treatment.". Diabetes Care. 37 (11): 3124–31. doi:10.2337/dc14-0984. PMC 4207202. PMID 25342831.

[6] Fasanmade, OA; Odeniyi, IA; Ogbera, AO (June 2008). "Diabetic ketoacidosis: diagnosis and management". African journal of medicine and medical sciences. 37 (2): 99–105. PMID 18939392.

[Green2011-7] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r Gardner, David G.; Shoback, Dolores, eds. (2011). "Chapter 17: Pancreatic hormones & diabetes mellitus". Greenspan's basic & clinical endocrinology (9th ed.). New York: McGraw-Hill Medical. ISBN 0-07-162243-8. OCLC 613429053.

[8] Saenz A, Fernandez-Esteban I, Mataix A, Ausejo M, Roque M, Moher D (20 July 2005). "Metformin monotherapy for type 2 diabetes mellitus.". The Cochrane database of systematic reviews (3): CD002966. doi:10.1002/14651858.CD002966.pub3. PMID 16034881. (subscription required (help)).

[Ann2016-9] Maruthur, NM; Tseng, E; Hutfless, S; Wilson, LM; Suarez-Cuervo, C; Berger, Z; Chu, Y; Iyoha, E; Segal, JB; Bolen, S (19 April 2016). "Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis". Annals of Internal Medicine. 164: 740–51. doi:10.7326/M15-2650. PMID 27088241. (subscription required (help)).

[10] Krentz AJ, Bailey CJ (February 2005). "Oral antidiabetic agents: current role in type 2 diabetes mellitus.". Drugs. 65 (3): 385–411. doi:10.2165/00003495-200565030-00005. PMID 15669880. (subscription required (help)).

[11] Malanda UL, Welschen LM, Riphagen II, Dekker JM, Nijpels G, Bot SD (18 January 2012). "Self-monitoring of blood glucose in patients with type 2 diabetes mellitus who are not using insulin.". The Cochrane database of systematic reviews. 1: CD005060. doi:10.1002/14651858.CD005060.pub3. PMID 22258959. (subscription required (help)).

[12] Cetinkunar, S; Erdem, H; Aktimur, R; Sozen, S (16 June 2015). "Effect of bariatric surgery on humoral control of metabolic derangements in obese patients with type 2 diabetes mellitus: How it works.". World journal of clinical cases. 3 (6): 504–9. doi:10.12998/wjcc.v3.i6.504. PMC 4468896. PMID 26090370.

[13] Ganguly, S; Tan, HC; Lee, PC; Tham, KW (April 2015). "Metabolic bariatric surgery and type 2 diabetes mellitus: an endocrinologist's perspective.". Journal of biomedical research. 29 (2): 105–11. doi:10.7555/JBR.29.20140127. PMC 4389109. PMID 25859264.

[14] Moscou, Susan (2013). "Getting the word out: advocacy, social marketing, and policy development and enforcement". In Truglio-Londrigan, Marie; Lewenson, Sandra B. Public health nursing: practicing population-based care (2nd ed.). Burlington, MA: Jones & Bartlett Learning. p. 317. ISBN 978-1-4496-4660-8. OCLC 758391750.

[Epi2006-15] Smyth, S; Heron, A (January 2006). "Diabetes and obesity: the twin epidemics". Nature Medicine. 12 (1): 75–80. doi:10.1038/nm0106-75. PMID 16397575. (subscription required (help)).

[16] Global Burden of Disease Study 2013 Collaborators (22 August 2015). "Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013". The Lancet. 386 (9995): 743–800. doi:10.1016/S0140-6736(15)60692-4. PMC 4561509. PMID 26063472.

[17] Tfayli, H; Arslanian, S (March 2009). "Pathophysiology of type 2 diabetes mellitus in youth: the evolving chameleon". Arquivos brasileiros de endocrinologia e metabologia. 53 (2): 165–74. doi:10.1590/s0004-27302009000200008. PMC 2846552. PMID 19466209.

[18] Imperatore, Giuseppina; Boyle, James P.; Thompson, Theodore J.; Case, Doug; Dabelea, Dana; Hamman, Richard F.; Lawrence, Jean M.; Liese, Angela D.; Liu, Lenna L. (December 2012). "Projections of Type 1 and Type 2 Diabetes Burden in the U.S. Population Aged <20 Years Through 2050". Diabetes Care. 35 (12): 2515–2520. doi:10.2337/dc12-0669. ISSN 0149-5992. PMC 3507562. PMID 23173134.

[Will2011-19] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r Melmed, Shlomo; Polonsky, Kenneth S.; Larsen, P. Reed; Kronenberg, Henry M. (eds.). Williams textbook of endocrinology. (12th ed.). Philadelphia: Elsevier/Saunders. pp. 1371–1435. ISBN 978-1-4377-0324-5.

[Rip2011-20] Leutholtz, Brian C.; Ripoll, Ignacio (2011). "Diabetes". Exercise and disease management (2nd ed.). Boca Raton: CRC Press. p. 25. ISBN 978-1-4398-2759-8. OCLC 725919496.

[21] Zaccardi F, Webb DR, Yates T, Davies MJ (February 2016). "Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective.". Postgraduate Medical Journal. 92 (1084): 63–9. doi:10.1136/postgradmedj-2015-133281. PMID 26621825. (subscription required (help)).

[Vij2010-22] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Vijan, S (2010-03-02). "Type 2 diabetes". Annals of Internal Medicine. 152 (5): ITC31–15; quiz ITC316. doi:10.7326/0003-4819-152-5-201003020-01003. PMID 20194231.

[AFP09-23] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Ripsin CM, Kang H, Urban RJ (January 2009). "Management of blood glucose in type 2 diabetes mellitus". Am Fam Physician. 79 (1): 29–36. PMID 19145963.

[24] Pasquier, F (October 2010). "Diabetes and cognitive impairment: how to evaluate the cognitive status?". Diabetes & metabolism. 36 Suppl 3: S100–5. doi:10.1016/S1262-3636(10)70475-4. PMID 21211730.

[Fat2009-25] Risérus U, Willett WC, Hu FB (January 2009). "Dietary fats and prevention of type 2 diabetes". Progress in Lipid Research. 48 (1): 44–51. doi:10.1016/j.plipres.2008.10.002. PMC 2654180. PMID 19032965.

[Sleep2011-26] Touma, C; Pannain, S (August 2011). "Does lack of sleep cause diabetes?". Cleveland Clinic journal of medicine. 78 (8): 549–58. doi:10.3949/ccjm.78a.10165. PMID 21807927.

[27] Christian, P; Stewart, CP (March 2010). "Maternal micronutrient deficiency, fetal development, and the risk of chronic disease". The Journal of Nutrition. 140 (3): 437–45. doi:10.3945/jn.109.116327. PMID 20071652.

[28] Pedersen HK, Gudmundsdottir V, Nielsen HB, et al. (21 July 2016). "Human gut microbes impact host serum metabolome and insulin sensitivity". Nature. 535 (7612): 376–381. doi:10.1038/nature18646. PMID 27409811.

[29] Abdullah, A; Peeters, A; de Courten, M; Stoelwinder, J (September 2010). "The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of prospective cohort studies.". Diabetes research and clinical practice. 89 (3): 309–19. doi:10.1016/j.diabres.2010.04.012. PMID 20493574.

[30] Pan, A; Wang, Y; Talaei, M; Hu, FB; Wu, T (17 September 2015). "Relation of active, passive, and quitting smoking with incident type 2 diabetes: a systematic review and meta-analysis.". The Lancet. Diabetes & endocrinology. 3: 958–67. doi:10.1016/S2213-8587(15)00316-2. PMID 26388413.

[SSB2010-31] Malik, VS; Popkin, BM; Bray, GA; Després, JP; Hu, FB (2010-03-23). "Sugar Sweetened Beverages, Obesity, Type 2 Diabetes and Cardiovascular Disease risk". Circulation. 121 (11): 1356–64. doi:10.1161/CIRCULATIONAHA.109.876185. PMC 2862465. PMID 20308626.

[32] Malik, VS; Popkin, BM; Bray, GA; Després, JP; Willett, WC; Hu, FB (November 2010). "Sugar-Sweetened Beverages and Risk of Metabolic Syndrome and Type 2 Diabetes: A meta-analysis". Diabetes Care. 33 (11): 2477–83. doi:10.2337/dc10-1079. PMC 2963518. PMID 20693348.

[33] Hu, EA; Pan, A; Malik, V; Sun, Q (2012-03-15). "White rice consumption and risk of type 2 diabetes: meta-analysis and systematic review". BMJ (Clinical research ed.). 344: e1454. doi:10.1136/bmj.e1454. PMC 3307808. PMID 22422870.

[34] Lee, I-Min; Shiroma, Eric J; Lobelo, Felipe; Puska, Pekka; Blair, Steven N; Katzmarzyk, Peter T (1 July 2012). "Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy". The Lancet. 380 (9838): 219–29. doi:10.1016/S0140-6736(12)61031-9. PMC 3645500. PMID 22818936.

[35] Lind, L; Lind, PM (Jun 2012). "Can persistent organic pollutants and plastic-associated chemicals cause cardiovascular disease?". Journal of internal medicine. 271 (6): 537–53. doi:10.1111/j.1365-2796.2012.02536.x. PMID 22372998.

[Genetic2011-36] Herder, C; Roden, M (June 2011). "Genetics of type 2 diabetes: pathophysiologic and clinical relevance". European journal of clinical investigation. 41 (6): 679–92. doi:10.1111/j.1365-2362.2010.02454.x. PMID 21198561.

[37] "Monogenic Forms of Diabetes: Neonatal Diabetes Mellitus and Maturity-onset Diabetes of the Young". National Diabetes Information Clearinghouse (NDIC). National Institute of Diabetes and Digestive and Kidney Diseases, NIH. March 2007. Retrieved 2008-08-04.

[BookDM2008-38] Funnell, Martha M.; Anderson, Robert M. (2008). "Influencing self-management: from compliance to collaboration". In Feinglos, Mark N.; Bethel, M. Angelyn. Type 2 diabetes mellitus: an evidence-based approach to practical management. Contemporary endocrinology. Totowa, NJ: Humana Press. p. 462. ISBN 978-1-58829-794-5. OCLC 261324723.

[39] Izzedine, H; Launay-Vacher, V; Deybach, C; Bourry, E; Barrou, B; Deray, G (November 2005). "Drug-induced diabetes mellitus". Expert opinion on drug safety. 4 (6): 1097–109. doi:10.1517/14740338.4.6.1097. PMID 16255667. (subscription required (help)).

[40] Sampson, UK; Linton, MF; Fazio, S (July 2011). "Are statins diabetogenic?". Current Opinion in Cardiology. 26 (4): 342–7. doi:10.1097/HCO.0b013e3283470359. PMC 3341610. PMID 21499090.

[pmid19444934-41] Saad F, Gooren L (March 2009). "The role of testosterone in the metabolic syndrome: a review". The Journal of Steroid Biochemistry and Molecular Biology. 114 (1–2): 40–3. doi:10.1016/j.jsbmb.2008.12.022. PMID 19444934. (subscription required (help)).

[pmid18832284-42] Farrell JB, Deshmukh A, Baghaie AA (2008). "Low testosterone and the association with type 2 diabetes". The Diabetes Educator. 34 (5): 799–806. doi:10.1177/0145721708323100. PMID 18832284.

[43] Diabetes mellitus a guide to patient care. Philadelphia: Lippincott Williams & Wilkins. 2007. p. 15. ISBN 978-1-58255-732-8.

[who2006-44] Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation (PDF). Geneva: World Health Organization. 2006. p. 21. ISBN 978-92-4-159493-6.

[45] Vijan, S (March 2010). "Type 2 diabetes". Annals of Internal Medicine. 152 (5): ITC31-15. doi:10.7326/0003-4819-152-5-201003020-01003. PMID 20194231.

[who-99-46] World Health Organization. "Definition, diagnosis and classification of diabetes mellitus and its complications: Report of a WHO Consultation. Part 1. Diagnosis and classification of diabetes mellitus". Retrieved 2007-05-29.

[Expert2009-47] International Expert, Committee (July 2009). "International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes". Diabetes Care. 32 (7): 1327–34. doi:10.2337/dc09-9033. PMC 2699715. PMID 19502545.

[48] "Diagnosis and classification of diabetes mellitus". Diabetes Care. American Diabetes Association. 33 Suppl 1 (Supplement_1): S62–9. January 2010. doi:10.2337/dc10-S062. PMC 2797383. PMID 20042775.

[49] "Diagnosis and classification of diabetes mellitus". Diabetes Care. American Diabetes Association. 35 Suppl 1 (Suppl 1): S64–71. January 2012. doi:10.2337/dc12-s064. PMC 3632174. PMID 22187472.

[Pathologic_Basis_of_Disease-50] Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Cotran, Ramzi S.; Robbins, Stanley L. (2005). Robbins and Cotran Pathologic Basis of Disease (7th ed.). Philadelphia, Pa.: Saunders. pp. 1194–1195. ISBN 0-7216-0187-1.

[51] Diabetes mellitus a guide to patient care. Philadelphia: Lippincott Williams & Wilkins. 2007. p. 201. ISBN 978-1-58255-732-8.

[52] Vivian, Eva M.; Blackorbay, Brady (2013). "Chapter 13: Endocrine Disorders". In Lee, Mary. Basic Skills in Interpreting Laboratory Data (5th ed.). Bethesda, MD: American Society of Health-System Pharmacists. ISBN 978-1-58528-345-3. OCLC 859778842.

[Screen09-53] Valdez R (2009). "Detecting Undiagnosed Type 2 Diabetes: Family History as a Risk Factor and Screening Tool". J Diabetes Sci Technol. 3 (4): 722–6. doi:10.1177/193229680900300417. PMC 2769984. PMID 20144319.

[Selph_et_al-2015-54] Selph, S; Dana, T; Blazina, I; Bougatsos, C; Patel, H; Chou, R (22 June 2015). "Screening for Type 2 Diabetes Mellitus: A Systematic Review for the U.S. Preventive Services Task Force". Annals of Internal Medicine. 162 (11): 765–76. doi:10.7326/M14-2221. PMID 25867111.

[US08-55] "Archived: Diabetes Mellitus (Type 2) in Adults: Screening". U.S. Preventive Services Task Force. June 2008. Retrieved 2014-03-16.

[56] Siu, AL (27 October 2015). "Screening for Abnormal Blood Glucose and Type 2 Diabetes Mellitus: U.S. Preventive Services Task Force Recommendation Statement.". Annals of Internal Medicine. 163: 861–8. doi:10.7326/M15-2345. PMID 26501513.

[57] "Draft Recommendation Statement Screening for Abnormal Glucose and Type 2 Diabetes Mellitus". U.S. Preventive Services Task Force. Archived from the original on 9 October 2014. Retrieved 7 October 2014.

[ADA21015-58] "Standards of Medical Care in Diabetes—2015: Summary of Revisions". Diabetes Care. 54 (38): S4. 2015. doi:10.2337/dc15-S003. PMID 25537706.

[59] Raina Elley C, Kenealy T (December 2008). "Lifestyle interventions reduced the long-term risk of diabetes in adults with impaired glucose tolerance". Evid Based Med. 13 (6): 173. doi:10.1136/ebm.13.6.173. PMID 19043031.

[60] Orozco LJ, Buchleitner AM, Gimenez-Perez G, Roqué I Figuls M, Richter B, Mauricio D (2008). Mauricio, Didac, ed. "Exercise or exercise and diet for preventing type 2 diabetes mellitus". Cochrane Database Syst Rev (3): CD003054. doi:10.1002/14651858.CD003054.pub3. PMID 18646086.

[Schellenberg2013-61] Schellenberg, ES.; Dryden, DM.; Vandermeer, B.; Ha, C.; Korownyk, C. (October 2013). "Lifestyle Interventions for Patients With and at Risk for Type 2 Diabetes: A Systematic Review and Meta-analysis". Ann Intern Med. 159 (8): 543–51. doi:10.7326/0003-4819-159-8-201310150-00007. PMID 24126648.

[62] O'Gorman, DJ; Krook, A (September 2011). "Exercise and the treatment of diabetes and obesity". The Medical clinics of North America. 95 (5): 953–69. doi:10.1016/j.mcna.2011.06.007. PMID 21855702.

[BMJ2016-63] Kyu, Hmwe H.; Bachman, Victoria F.; Alexander, Lily T.; Mumford, John Everett; Afshin, Ashkan; Estep, Kara; Veerman, J. Lennert; Delwiche, Kristen; Iannarone, Marissa L.; Moyer, Madeline L.; Cercy, Kelly; Vos, Theo; Murray, Christopher J.L.; Forouzanfar, Mohammad H. (9 August 2016). "Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013". BMJ. 354: i3857. doi:10.1136/bmj.i3857. PMC 4979358. PMID 27510511.

[64] Nield L, Summerbell CD, Hooper L, Whittaker V, Moore H (2008). Nield, Lucie, ed. "Dietary advice for the prevention of type 2 diabetes mellitus in adults". Cochrane Database Syst Rev (3): CD005102. doi:10.1002/14651858.CD005102.pub2. PMID 18646120.

[65] Carter, P; Gray, LJ; Troughton, J; Khunti, K; Davies, MJ (2010-08-18). "Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis". BMJ (Clinical research ed.). 341: c4229. doi:10.1136/bmj.c4229. PMC 2924474. PMID 20724400.

[AHRQ05-66] Santaguida PL, Balion C, Hunt D, et al. (August 2005). "Diagnosis, prognosis, and treatment of impaired glucose tolerance and impaired fasting glucose" (PDF). Evid Rep Technol Assess (Summ) (128): 1–11. PMID 16194123.

[67] Seida, Jennifer C.; Mitri, Joanna; Colmers, Isabelle N.; Majumdar, Sumit R.; Davidson, Mayer B.; Edwards, Alun L.; Hanley, David A.; Pittas, Anastassios G.; Tjosvold, Lisa; Johnson, Jeffrey A. (Oct 2014). "Effect of Vitamin D3 Supplementation on Improving Glucose Homeostasis and Preventing Diabetes: A Systematic Review and Meta-Analysis". The Journal of Clinical Endocrinology & Metabolism. 99 (10): 3551–3560. doi:10.1210/jc.2014-2136. PMC 4483466. PMID 25062463.

[NICE2009Self-68] "Type 2 diabetes: The management of type 2 diabetes". May 2009.

[69] Farmer, AJ; Perera, R; Ward, A; Heneghan, C; Oke, J; Barnett, AH; Davidson, MB; Guerci, B; Coates, V; Schwedes, U; O'Malley, S (27 February 2012). "Meta-analysis of individual patient data in randomised trials of self monitoring of blood glucose in people with non-insulin treated type 2 diabetes". BMJ (Clinical research ed.). 344: e486. doi:10.1136/bmj.e486. PMID 22371867.

[70] Emdin, CA; Rahimi, K; Neal, B; Callender, T; Perkovic, V; Patel, A (10 February 2015). "Blood pressure lowering in type 2 diabetes: a systematic review and meta-analysis.". JAMA. 313 (6): 603–15. doi:10.1001/jama.2014.18574. PMID 25668264.

[71] McBrien, K; Rabi, DM; Campbell, N; Barnieh, L; Clement, F; Hemmelgarn, BR; Tonelli, M; Leiter, LA; Klarenbach, SW; Manns, BJ (6 August 2012). "Intensive and Standard Blood Pressure Targets in Patients With Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis". Archives of Internal Medicine. 172 (17): 1–8. doi:10.1001/archinternmed.2012.3147. PMID 22868819.

[72] Boussageon, R; Bejan-Angoulvant, T; Saadatian-Elahi, M; Lafont, S; Bergeonneau, C; Kassaï, B; Erpeldinger, S; Wright, JM; Gueyffier, F; Cornu, C (2011-07-26). "Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials". BMJ (Clinical research ed.). 343: d4169. doi:10.1136/bmj.d4169. PMC 3144314. PMID 21791495.

[73] Webster, MW (July 2011). "Clinical practice and implications of recent diabetes trials". Current Opinion in Cardiology. 26 (4): 288–93. doi:10.1097/HCO.0b013e328347b139. PMID 21577100.

[ADA2015-74] Inzucchi, SE; Bergenstal, RM; Buse, JB; Diamant, M; Ferrannini, E; Nauck, M; Peters, AL; Tsapas, A; Wender, R; Matthews, DR (March 2015). "Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes.". Diabetologia. 58 (3): 429–42. doi:10.1007/s00125-014-3460-0. PMID 25583541.

[75] Makam, AN; Nguyen, OK (10 January 2017). "An Evidence-Based Medicine Approach to Antihyperglycemic Therapy in Diabetes Mellitus to Overcome Overtreatment.". Circulation. 135 (2): 180–195. doi:10.1161/CIRCULATIONAHA.116.022622. PMID 28069712.

[76] Simpson, TC.; Needleman, I.; Wild, SH.; Moles, DR.; Mills, EJ. (2010). Simpson, Terry C, ed. "Treatment of periodontal disease for glycaemic control in people with diabetes". Cochrane Database Syst Rev (5): CD004714. doi:10.1002/14651858.CD004714.pub2. PMID 20464734.

[Exercise10-77] Zanuso S, Jimenez A, Pugliese G, Corigliano G, Balducci S (March 2010). "Exercise for the management of type 2 diabetes: a review of the evidence". Acta Diabetol. 47 (1): 15–22. doi:10.1007/s00592-009-0126-3. PMID 19495557.

[Diet09-78] Davis N, Forbes B, Wylie-Rosett J (June 2009). "Nutritional strategies in type 2 diabetes mellitus". Mt. Sinai J. Med. 76 (3): 257–68. doi:10.1002/msj.20118. PMID 19421969.

[79] Thomas D, Elliott EJ (2009). Thomas, Diana, ed. "Low glycaemic index, or low glycaemic load, diets for diabetes mellitus". Cochrane Database Syst Rev (1): CD006296. doi:10.1002/14651858.CD006296.pub2. PMID 19160276.

[80] Feinman, RD; Pogozelski, WK; Astrup, A; Bernstein, RK; Fine, EJ; Westman, EC; Accurso, A; Frassetto, L; Gower, BA; McFarlane, SI; Nielsen, JV; Krarup, T; Saslow, L; Roth, KS; Vernon, MC; Volek, JS; Wilshire, GB; Dahlqvist, A; Sundberg, R; Childers, A; Morrison, K; Manninen, AH; Dashti, HM; Wood, RJ; Wortman, J; Worm, N (January 2015). "Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base.". Nutrition (Burbank, Los Angeles County, Calif.). 31 (1): 1–13. doi:10.1016/j.nut.2014.06.011. PMID 25287761.

[81] Hawthorne, K.; Robles, Y.; Cannings-John, R.; Edwards, A. G. K.; Robles, Yolanda (2008). Robles, Yolanda, ed. "Culturally appropriate health education for Type 2 diabetes mellitus in ethnic minority groups". Cochrane Database Syst Rev (3): CD006424. doi:10.1002/14651858.CD006424.pub2. PMID 18646153. CD006424.

[GlickBauerYeh2014-82] Glick-Bauer M, Yeh MC (2014). "The health advantage of a vegan diet: exploring the gut microbiota connection". Nutrients (Review). 6 (11): 4822–38. doi:10.3390/nu6114822. PMC 4245565. PMID 25365383.

[83] Leach, Matthew J.; Kumar, Saravana (2012-09-12). "Cinnamon for diabetes mellitus". The Cochrane Database of Systematic Reviews (9): CD007170. doi:10.1002/14651858.CD007170.pub2. ISSN 1469-493X. PMID 22972104.

[84] Palmer, Suetonia C.; Mavridis, Dimitris; Nicolucci, Antonio; Johnson, David W.; Tonelli, Marcello; Craig, Jonathan C.; Maggo, Jasjot; Gray, Vanessa; De Berardis, Giorgia; Ruospo, Marinella; Natale, Patrizia; Saglimbene, Valeria; Badve, Sunil V.; Cho, Yeoungjee; Nadeau-Fredette, Annie-Claire; Burke, Michael; Faruque, Labib; Lloyd, Anita; Ahmad, Nasreen; Liu, Yuanchen; Tiv, Sophanny; Wiebe, Natasha; Strippoli, Giovanni F.M. (19 July 2016). "Comparison of Clinical Outcomes and Adverse Events Associated With Glucose-Lowering Drugs in Patients With Type 2 Diabetes". JAMA. 316 (3): 313–24. doi:10.1001/jama.2016.9400. PMID 27434443.

[85] Boussageon, R; Supper, I; Bejan-Angoulvant, T; Kellou, N; Cucherat, M; Boissel, JP; Kassai, B; Moreau, A; Gueyffier, F; Cornu, C (2012). Groop, Leif, ed. "Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials". PLOS Medicine. 9 (4): e1001204. doi:10.1371/journal.pmed.1001204. PMC 3323508. PMID 22509138.

[86] Richter, B; Bandeira-Echtler, E; Bergerhoff, K; Clar, C; Ebrahim, SH (18 July 2007). Richter, Bernd, ed. "Rosiglitazone for type 2 diabetes mellitus". The Cochrane database of systematic reviews (3): CD006063. doi:10.1002/14651858.CD006063.pub2. PMID 17636824.

[87] Chen, X; Yang, L; Zhai, SD (December 2012). "Risk of cardiovascular disease and all-cause mortality among diabetic patients prescribed rosiglitazone or pioglitazone: a meta-analysis of retrospective cohort studies". Chinese medical journal. 125 (23): 4301–6. PMID 23217404.

[88] Lv, J; Perkovic, V; Foote, CV; Craig, ME; Craig, JC; Strippoli, GF (12 December 2012). Strippoli, Giovanni FM, ed. "Antihypertensive agents for preventing diabetic kidney disease". The Cochrane database of systematic reviews. 12: CD004136. doi:10.1002/14651858.CD004136.pub3. PMID 23235603.

[Cheng2014-89] Cheng, J; Zhang, W; Zhang, X; Han, F; Li, X; He, X; Li, Q; Chen, J (May 2014). "Effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on all-cause mortality, cardiovascular deaths, and cardiovascular events in patients with diabetes mellitus: a meta-analysis.". JAMA internal medicine. 174 (5): 773–85. doi:10.1001/jamainternmed.2014.348. PMID 24687000.

[90] Brunström, Mattias; Carlberg, Bo (24 February 2016). "Effect of antihypertensive treatment at different blood pressure levels in patients with diabetes mellitus: systematic review and meta-analyses". BMJ. 352: i717. doi:10.1136/bmj.i717. PMC 4770818. PMID 26920333.

[91] Swinnen, SG.; Simon, AC.; Holleman, F.; Hoekstra, JB.; Devries, JH. (2011). Simon, Airin CR, ed. "Insulin detemir versus insulin glargine for type 2 diabetes mellitus". Cochrane Database Syst Rev (7): CD006383. doi:10.1002/14651858.CD006383.pub2. PMID 21735405.

[92] Waugh, N; Cummins, E; Royle, P; Clar, C; Marien, M; Richter, B; Philip, S (July 2010). "Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation". Health technology assessment (Winchester, England). 14 (36): 1–248. doi:10.3310/hta14360. PMID 20646668.

[93] Picot, J; Jones, J; Colquitt, JL; Gospodarevskaya, E; Loveman, E; Baxter, L; Clegg, AJ (September 2009). "The clinical effectiveness and cost-effectiveness of bariatric (weight loss) surgery for obesity: a systematic review and economic evaluation". Health technology assessment (Winchester, England). 13 (41): 1–190, 215–357, iii–iv. doi:10.3310/hta13410. PMID 19726018.

[94] Frachetti, KJ; Goldfine, AB (April 2009). "Bariatric surgery for diabetes management". Current Opinion in Endocrinology, Diabetes and Obesity. 16 (2): 119–24. doi:10.1097/MED.0b013e32832912e7. PMID 19276974.

[Schum2009-95] Schulman, AP; del Genio, F; Sinha, N; Rubino, F (September–October 2009). ""Metabolic" surgery for treatment of type 2 diabetes mellitus". Endocrine Practice. 15 (6): 624–31. doi:10.4158/EP09170.RAR. PMID 19625245.

[96] Colucci, RA (January 2011). "Bariatric surgery in patients with type 2 diabetes: a viable option". Postgraduate Medicine. 123 (1): 24–33. doi:10.3810/pgm.2011.01.2242. PMID 21293081.

[97] Dixon, JB; le Roux, CW; Rubino, F; Zimmet, P (16 June 2012). "Bariatric surgery for type 2 diabetes". Lancet. 379 (9833): 2300–11. doi:10.1016/S0140-6736(12)60401-2. PMID 22683132.

[98] Rubino, F; Nathan, DM; Eckel, RH; Schauer, PR; Alberti, KG; Zimmet, PZ; Del Prato, S; Ji, L; Sadikot, SM; Herman, WH; Amiel, SA; Kaplan, LM; Taroncher-Oldenburg, G; Cummings, DE; Delegates of the 2nd Diabetes Surgery, Summit (June 2016). "Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations.". Diabetes Care. 39 (6): 861–77. doi:10.2337/dc16-0236. PMID 27222544.

[Mee2007-99] Meetoo, D; McGovern, P; Safadi, R (13–27 September 2007). "An epidemiological overview of diabetes across the world". British journal of nursing (Mark Allen Publishing). 16 (16): 1002–7. PMID 18026039.

[100] Abate N, Chandalia M (2001). "Ethnicity and type 2 diabetes: focus on Asian Indians". J. Diabetes Complicat. 15 (6): 320–7. doi:10.1016/S1056-8727(01)00161-1. PMID 11711326.

[101] Carulli, L; Rondinella, S; Lombardini, S; Canedi, I; Loria, P; Carulli, N (November 2005). "Review article: diabetes, genetics and ethnicity". Alimentary pharmacology & therapeutics. 22 Suppl 2: 16–9. doi:10.1111/j.1365-2036.2005.02588.x. PMID 16225465.

[Wild_2004-102] Wild S, Roglic G, Green A, Sicree R, King H (May 2004). "Global prevalence of diabetes: estimates for the year 2000 and projections for 2030". Diabetes Care. 27 (5): 1047–53. doi:10.2337/diacare.27.5.1047. PMID 15111519.

[History2010-103] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Zajac, Jacek; Shrestha, Anil; Patel, Parini; Poretsky, Leonid (2009). "The Main Events in the History of Diabetes Mellitus". In Poretsky, Leonid. Principles of diabetes mellitus (2nd ed.). New York: Springer. pp. 3–16. ISBN 978-0-387-09840-1. OCLC 663097550.

v t e Diabetes (E10–E14, 250)

Types	Type 1 Type 2 LADA Gestational diabetes Diabetes and pregnancy Prediabetes Impaired fasting glucose Impaired glucose tolerance Insulin resistance KPD MODY Neonatal Transient Permanent Type 3c (Pancreatogenic)

Blood tests	Blood sugar Glycosylated hemoglobin Glucose tolerance test Postprandial glucose test Fructosamine Glucose test C-peptide Noninvasive glucose monitor Insulin tolerance test

Management	Diabetic diet Anti-diabetic drugs Insulin therapy intensive conventional pulsatile Cure Embryonic stem cells Artificial pancreas Other Gastric bypass surgery

Complications	Diabetic comas Hypoglycemia Ketoacidosis Hyperosmolar hyperglycemic state Diabetic foot ulcer Neuropathic arthropathy Organs in diabetes Blood vessels Muscle Kidney Nerves Retina Heart Diabetic skin disease Diabetic dermopathy Diabetic bulla Diabetic cheiroarthropathy Neuropathic ulcer Hyperglycemia Hypoglycemia

Other	Glossary of diabetes

匿名

検索

案内

NIDDM

Wikipedia preview

wiki en

Contents

Signs and symptoms

Complications

Cause

Lifestyle

Genetics

Medical conditions

Pathophysiology

Diagnosis

Screening

Prevention

Management

Lifestyle

Medications

Surgery

Epidemiology

History

References

External links

UpToDate Contents

English Journal

Japanese Journal

Related Links

Related Pictures

★リンクテーブル★

「糖尿病」

定義

病型

参考1

症状

合併症

医療系の雑誌より(日経カデット11月？)

表5 糖尿病患者にみられる筋骨格系症状を呈する疾患と臨床的特徴

診断

血糖値検査による分類

診断基準

予後

USMLE

高血圧と糖尿病を合併する病態

参考

「スルホニル尿酸系薬」

分類

スルフォニル尿酸系薬 sulfonylurea

スルホンアミド系薬

作用機序

薬理作用

動態

適応

注意

禁忌

「インシュリン非依存性糖尿病」

「adult-onset diabetes mellitus」

「maturity-onset diabetes mellitus」

表5　糖尿病患者にみられる筋骨格系症状を呈する疾患と臨床的特徴