塩酸チクロピジン

関: ticlopidine

WordNet

a complex consisting of an organic base in association with hydrogen chloride

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/17 02:31:25」(JST)

wiki en

Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family. Like clopidogrel, it is an adenosine diphosphate (ADP) receptor inhibitor. It is used in patients in whom aspirin is not tolerated, or in whom dual antiplatelet therapy is desirable. Because it has been reported to increase the risk of thrombotic thrombocytopenic purpura (TTP) and neutropenia, its use has largely been supplanted by the newer drug, clopidogrel, which is felt to have a much lower hematologic risk. The usual dose is 250 mg twice daily by the oral route.

Action[edit]

Inhibits platelet aggregation by altering the function of platelet membranes by blocking ADP receptors. This prevents the conformational change of glycoprotein IIb/IIIa which allows platelet binding to fibrinogen.
Prolongs bleeding time.
Decreased incidence of stroke in high-risk patients.

Contraindications[edit]

Hypersensitivity
Bleeding disorders
Active bleeding
Severe liver disease

Precautions[edit]

Risk of bleeding (trauma, surgery, history of peptic ulcer disease)
Renal or hepatic impairment
Geriatric patients (increased sensitivity)
Pregnancy, lactation, or children under 18
Neutropenia
Thrombotic thrombocytopenic purpura

UpToDate Contents

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1. 脳卒中の二次予防のための抗血小板療法 antiplatelet therapy for secondary prevention of stroke
2. 非ST上昇型急性冠症候群における抗血小板薬 antiplatelet agents in acute non st elevation acute coronary syndromes
3. 薬剤誘発性の好中球減少および無顆粒球症 drug induced neutropenia and agranulocytosis
4. 待機的経皮的冠動脈インターベンションのための抗血栓療法：一般的使用 antithrombotic therapy for elective percutaneous coronary intervention general use
5. 待機的経皮的冠動脈インターベンションのための抗血栓療法：臨床研究 antithrombotic therapy for elective percutaneous coronary intervention clinical studies

English Journal

Comparison of the effects of omeprazole and rabeprazole on ticlopidine metabolism in vitro.

Kinoshita Y, Matsumoto N, Watanabe M, Takeba Y, Yoshida Y, Ohba K, Suzuki S, Itoh F, Kumai T, Kobayashi S.SourceDepartment of Pharmacology, St. Marianna University School of Medicine, Japan.
Journal of pharmacological sciences.J Pharmacol Sci.2011 Sep 16;117(1):19-26. Epub 2011 Aug 6.
The thienopyridine derivative ticlopidine (TCL) is an inhibitor of adenosine diphosphate-induced platelet aggregation. Combination therapy with a thienopyridine derivative and aspirin is standard after coronary stenting, although more hemorrhagic complications occur with the combination therapy than
PMID 21821971

Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-rug interactions.

Lee KS, Kim SK.SourceCollege of Pharmacy and RCTCP, Chungnam National University, Daejeon, 305-764, Republic of Korea.
Journal of applied toxicology : JAT.J Appl Toxicol.2011 Sep 14. doi: 10.1002/jat.1720. [Epub ahead of print]
We developed methods for evaluating the ntial inhibition of human cytochrome P450 (CYP) enzymes, including CYP1A2, CYP2A6, CYP2B6, CYP2?C9, CYP2?C19, CYP2D6, CYP2E1 and CYP3A4, using pooled human liver microsomes (HLMs). The CYP inhibition assay used substrate cocktail sets [set A: phenacetin fo
PMID 21915887

Japanese Journal

中心性漿液性網脈絡膜症に対する塩酸チクロピジン内服療法

安藤文隆,笹野久美子,鈴木福江,神谷忠
眼科臨床紀要 = Folia Japonica de ophthalmologica clinica 2(2), 113-119, 2009-02-15
NAID 10024806822

塩酸チクロピジンにより著名な胆汁うっ滞をきたした1例

紺谷忠司,嶋田浩介,岩倉伸次 [他]
和歌山医学 59(2), 76-79, 2008-06
NAID 40016119160

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★リンクテーブル★

リンク元	「チクロピジン」
関連記事	「hydrochloride」

「チクロピジン」

Ticlopidine
Systematic (IUPAC) name
	5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
Clinical data
Trade names	Ticlid
AHFS/Drugs.com	monograph
MedlinePlus	a695036
Pregnancy cat.	B1 (AU) C (US)
Legal status	?
Routes	Oral
Pharmacokinetic data
Bioavailability	>80%
Protein binding	98%
Metabolism	Hepatic
Half-life	*12 hours (single dose)
Excretion	Renal and fecal
Identifiers
CAS number	55142-85-3
ATC code	B01AC05
PubChem	CID 5472
DrugBank	DB00208
ChemSpider	5273
UNII	OM90ZUW7M1
KEGG	D08594
ChEBI	CHEBI:9588
ChEMBL	CHEMBL833
Chemical data
Formula	C14H14ClNS
Mol. mass	263.786 g/mol
	SMILES Clc1ccccc1CN3Cc2c(scc2)CC3;
	InChI InChI=1S/C14H14ClNS/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14/h1-4,6,8H,5,7,9-10H2 ; Key:PHWBOXQYWZNQIN-UHFFFAOYSA-N ;
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　　[★]

英: ticlopidine
化: 塩酸チクロピジン ticlopidine hydrochloride
商: ジルペンダー、ソーパー、ソロゾリン、チクピロン、ニチステート、パチュナ、パナピジン、パナルジン、パラクロジン、ビーチロン、ピエテネール、ヒシミドン、ファルロジン、マイトジン
関: その他の血液・体液用薬

抗血栓薬

血小板中のcAMP濃度を上昇させる薬物

作用機序

血小板膜にあるACを持続的に活性化→細胞内cAMP↑→細胞内Ca増加抑制→血小板活性化抑制 (SPC.293)

「hydrochloride」

　　[★] 塩酸塩、ハイドロクロライド　

匿名

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案内

案内

ticlopidine hydrochloride