太いヘンレループ上行脚
WordNet
- move in loops; "The bicycle looped around the tree"
- anything with a round or oval shape (formed by a curve that is closed and does not intersect itself)
- a flight maneuver; aircraft flies a complete circle in the vertical plane (同)loop-the-loop
- an intrauterine device in the shape of a loop
- a computer program that performs a series of instructions repeatedly until some specified condition is satisfied
- an inner circle of advisors (especially under President Reagan); "hes no longer in the loop"
- the basic pattern of the human fingerprint
- make a loop in; "loop a rope" (同)intertwine
- fasten or join with a loop; "He looped the watch through his belt"
- fly loops, perform a loop; "the stunt pilot looped his plane"
- relatively dense in consistency; "thick cream"; "thick soup"; "thick smoke"; "thick fog"
- (of darkness) very intense; "thick night"; "thick darkness"; "a face in deep shadow"; "deep night" (同)deep
- in quick succession; "misfortunes come fast and thick" (同)thickly
- abounding; having a lot of; "the top was thick with dust"
- having component parts closely crowded together; "a compact shopping center"; "a dense population"; "thick crowds"; "a thick forest"; "thick hair"
- not thin; of a specific thickness or of relatively great extent from one surface to the opposite usually in the smallest of the three solid dimensions; "an inch thick"; "a thick board"; "a thick sandwich"; "spread a thick layer of butter"; "thick coating of dust"; "thick warm blankets"
- any of the main branches arising from the trunk or a bough of a tree (同)tree branch
- either of the two halves of a bow from handle to tip; "the upper limb of the bow"
- the graduated arc that is attached to an instrument for measuring angles; "the limb of the sextant"
- (astronomy) the circumferential edge of the apparent disc of the sun or the moon or a planet
- one of the jointed appendages of an animal used for locomotion or grasping: arm; leg; wing; flipper
- moving or going or growing upward; "the ascending plane"; "the ascending staircase"; "the ascending stems of chickweed"
PrepTutorEJDIC
- (糸・ひも・針金などで作った)『輪』・輪状のもの;(輪状の)湾曲部・(宙返り飛行・スケートなどで描く)輪・ループ (ある条件が成立するまで繰り返し実行される，プログラム中に記述された一連の命令のこと)・仲間、影響｝を受け合う間柄・同列の立場・「keep誰々in the loop」として、「keep誰々informed：情報を（人）に絶えず提供し続ける、報告を（人）に欠かさない、（人）に逐次連絡する、（人）に常に通知する」・避妊リング; (鉄道・電線などの)環状線(loop line)・…‘を'輪にする,輪で囲む・…‘を'輪で結ぶ,輪で締める《+『up』+『名,』+『名』+『up』》・輪になる,輪を描く
- 『厚い』,分厚い;『太い』 / 《数量を表す名詞の後に用いて》『厚さ…の』,太さ…の / (液体・気体が)『濃い』,濃厚な / 『密な』,密生した,密集した / (なまりが)著しい,ひどい / (声が)はっきりしない,かすれた / (頭が)重い,ぼんやりした / 《話》ばかな,愚かな / 《話》親密な;(…と)親して《+with+名》 / 《補語にのみ用いて》(…で)いっぱいの,満ちた《+with+名》 / 『厚く』,分厚く,濃く,密に / 《the ~》(…)最も厚い(太い,濃い,密な)部分《+of+名》 / 《the ~》(活動などの)たけなわ,まっただ中《+of+名》
- 《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
- (動物の)『手足』;(鳥の)翼 / (木の)大枝
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/21 17:57:49」(JST)
[Wiki en表示]
| Ascending limb of loop of Henle |
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Scheme of renal tubule and its vascular supply. (Labeled at center left.)
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Nephron ion flow diagram
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| Details |
| Latin |
tubulus rectus distalis |
| Identifiers |
| Gray's |
p.1223 |
Dorlands
/Elsevier |
t_22/12830078 |
| Anatomical terminology |
The ascending limb of loop of Henle is a segment of the nephron in the kidney divided into a thin and thick ascending limb (also known as distal straight tubule).
Contents
- 1 Structure
- 2 Function
- 2.1 Thin ascending limb
- 2.2 Thick ascending limb
- 3 Clinical significance
- 4 See also
- 5 References
- 6 External links
Structure
The ascending limb of the loop of Henle is a direct continuation from the descending limb of loop of Henle, and one of the structures in the nephron of the kidney. The ascending limb has a thin and a thick segment. The ascending limb drains urine into the distal convoluted tubule.
The thin ascending limb is found in the medulla of the kidney, and the thick ascending limb can be divided into a part that is in the renal medulla and a part that is in the renal cortex. The ascending limb is much thicker than the descending limb.
Histology
As in the descending limb, the epithelium is simple cuboidal epithelium.[citation needed]
Function
Thin ascending limb
The thin ascending limb is impermeable to water and ions, except sodium and chloride which cross by diffusion.
Thick ascending limb
Functionally, the parts of the ascending limb in the medulla and cortex are very similar.[citation needed]
The medullary ascending limb remains impermeable to water. Sodium, potassium (K+) and chloride (Cl-) ions are reabsorbed by active transport. K+ is passively transported along its concentration gradient through a K+ leak channel in the apical aspect of the cells, back into the lumen of the ascending limb. This K+ "leak" generates a positive electrochemical potential difference in the lumen. This drives more paracellular reabsorption of Na+, as well as other cations such as magnesium (Mg2+) and importantly calcium Ca2+ due to charge repulsion.
This is also the part of the tubule that generates Tamm-Horsfall protein. The function of this protein is not well understood, but is responsible for creating urinary casts.
Clinical significance
The thick ascending limb is the site of action of Loop diuretics such as furosemide block the K+/Na+/2Cl- co-transporter.
See also
- Descending limb of loop of Henle
References
External links
- Physiology at MCG 7/7ch07/7ch07p11
- Histology image: 15804loa - Histology Learning System at Boston University
- Overview at vet.cornell.edu
This article incorporates text from a public domain edition of Gray's Anatomy.
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Anatomy: urinary system (TA A08, TH H3.06, GA 11.1215)
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| Abdomen |
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Kidneys
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Layers
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- Renal fascia
- Renal capsule
- Renal cortex
- Renal medulla
- Renal sinus
- Renal pyramids
- medullary interstitium
- Renal lobe
- Cortical lobule
- Medullary ray
- Nephron
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Intrarenal arteries
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- Renal artery
- Segmental arteries
- Interlobar arteries
- Arcuate arteries
- Interlobular arteries
- Afferent arterioles
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Renal tubule
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- Renal corpuscle
- Glomerulus
- Bowman's capsule
- Proximal convoluted tubule
- Loop of Henle
- Descending
- Thin ascending
- Thick ascending
- Distal convoluted tubule
- Connecting tubule
- Collecting ducts aka Duct of Belini
- Renal papilla
- Minor calyx
- Major calyx
- Renal pelvis
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Intrarenal veins
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- Efferent arterioles
- Peritubular capillaries/Vasa recta
- Arcuate vein
- Interlobar veins
- Renal vein
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JGA
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- Macula densa
- Juxtaglomerular cells
- Mesangium/Extraglomerular mesangial cell
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Filtration
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- Glomerular basement membrane
- Podocyte
- Filtration slits
- Mesangium/Intraglomerular mesangial cell
- Tubular fluid
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Ureters
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- Orifice of ureter
- Adventitia
- Muscular layer
- Mucosa
- Ureteropelvic junction
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| Pelvis |
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Bladder
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- Apex
- Uvula
- Neck
- Median umbilical ligament
- Muscular layer
- Mucosa
- Submucosa
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Urethra
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- Urethral sphincters
- External sphincter muscle of male urethra
- External sphincter muscle of female urethra
- Internal sphincter muscle of urethra
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noco/acba/cong/tumr, sysi/epon, urte
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proc/itvp, drug (G4B), blte, urte
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UpToDate Contents
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English Journal
- P2X Receptors Inhibit NaCl Absorption in mTAL Independently of Nitric Oxide.
- Svendsen SL1, Isidor S1, Praetorius HA1, Leipziger J1.
- Frontiers in physiology.Front Physiol.2017 Jan 24;8:18. doi: 10.3389/fphys.2017.00018. eCollection 2017.
- Activation of basolateral P2X receptors markedly reduces NaCl absorption in mouse medullary thick ascending limb (mTAL). Here we tested the role of nitric oxide (NO) in the ATP-mediated (P2X) transport inhibition. We used isolated, perfused mTALs from mice to electrically measure NaCl absorption. By
- PMID 28174542
- A novel SLC12A1 gene mutation associated with hyperparathyroidism, hypercalcemia, nephrogenic diabetes insipidus, and nephrocalcinosis in four patients.
- Wongsaengsak S1, Vidmar AP1, Addala A2, Kamil ES3, Sequeira P4, Fass B5, Pitukcheewanont P6.
- Bone.Bone.2017 Jan 14;97:121-125. doi: 10.1016/j.bone.2017.01.011. [Epub ahead of print]
- Solute Carrier Family 12 member 1 (SLC12A1) gene encodes the sodium-potassium-chloride co-transporter (NKCC2) at the apical membrane of the thick ascending loop of Henle (TAL). Bartter's syndrome (BS) type I is a rare, autosomal recessive, renal tubular disorder associated with mutation of the SLC12
- PMID 28095294
- Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport.
- Milatz S1, Himmerkus N2, Wulfmeyer VC2,3, Drewell H4, Mutig K4, Hou J5, Breiderhoff T6, Müller D7, Fromm M6, Bleich M2, Günzel D6.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2017 Jan 10;114(2):E219-E227. doi: 10.1073/pnas.1611684114. Epub 2016 Dec 27.
- The thick ascending limb (TAL) of Henle's loop drives paracellular Na+, Ca2+, and Mg2+ reabsorption via the tight junction (TJ). The TJ is composed of claudins that consist of four transmembrane segments, two extracellular segments (ECS1 and -2), and one intracellular loop. Claudins interact within
- PMID 28028216
Japanese Journal
- 森本 哲司
- 日本小児腎臓病学会雑誌 26(1), 70-75, 2013
- 腎臓は，水・電解質の調節機構の主役として，さまざまな生理的役割を果たしているが，胎生期は，その役割の多くの部分を胎盤が担っている。しかし，出生とともに著しい体外環境変化が生じるため，腎機能はこれにすばやく対応する必要がある。例えば，出生時の体表面積あたりの糸球体濾過率(GFR)は成人の20%，生後2週間で40%，生後2か月には50%となり，1～2歳ごろにほぼ成人レベルに達することが知られている。 …
- NAID 130003384541
- The Effects of γ-tocopherol Administration on Pretibial Edema in Young Women with Premenstrual Syndrome
- Kato Shigeko,Koshida Sayo,Mune Masatoshi. et.al.
- Acta medica Nagasakiensia 53(3), 59-64, 2009-03
- … Gamma-tocopherol is largely metabolized to 2,7,8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (γ-CEHC), which has natriuretic activity that is mediated via inhibition of 70 pS ATP-sensitive K+ channels in the thick ascending limb of the loop of Henle. … However, the effects of γ-tocopherol administration on edema are unclear. …
- NAID 110007027359
- The Effects of .GAMMA.-tocopherol Administration on Pretibial Edema in Young Women with Premenstrual Syndrome
- KATO Shigeko,SHIRAISHI Keiko,KOSHIDA Sayo,MUNE Masatoshi,OMAGARI Katsuhisa
- Acta Medica Nagasakiensia 53(3), 59-64, 2009
- … Gamma-tocopherol is largely metabolized to 2,7,8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (γ-CEHC), which has natriuretic activity that is mediated via inhibition of 70 pS ATP-sensitive K+ channels in the thick ascending limb of the loop of Henle. … However, the effects of γ-tocopherol administration on edema are unclear. …
- NAID 130004450968
Related Links
- 1. Kidney Int. 1982 Nov;22(5):454-64. Thick ascending limb of Henle's loop. Burg MB. Thick ascending limbs of Henle's loop have at least three major roles: (1) They reabsorb sodium chloride which dilutes the urine. (2) The ...
- Anatomy and Morphology The loop of Henle encompasses the thin descending limb, the thin ascending limb, and the TAL. Short-looped nephrons that originate from superficial and midcortical nephrons have a short ...
★リンクテーブル★
[★]
- 英
- thick ascending limb, TAL
- 同
- 太いヘンレループ上行脚 ascending thick limb of Henle's loop thick ascending limb of loop of Henle
- 関
- 遠位尿細管、ヘンレ係蹄、ヘンレループ、尿細管
[★]
太い上行脚。太いヘンレループ上行脚 thick ascending limb of loop of Henle
[★]
- 関
- ascent、elevate、elevation、increase、raise、rise、rose、upward
[★]
- 関
- ansa、ring、wheel
[★]
- 関
- dark、dense
[★]
- 関
- extremities