同: TSPYL

WordNet

want to have; "Id like a beer now!"
a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
be fond of; "I like my nephews"
feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
undergo a test; "She doesnt test well"
any standardized procedure for measuring sensitivity or memory or intelligence or aptitude or personality etc; "the test was standardized on a large sample of students" (同)mental test, mental testing, psychometric test
the act of undergoing testing; "he survived the great test of battle"; "candidates must compete in a trial of skill" (同)trial
the act of testing something; "in the experimental trials the amount of carbon was measured separately"; "he called each flip of the coin a new trial" (同)trial, run
a hard outer covering as of some amoebas and sea urchins
put to the test, as for its quality, or give experimental use to; "This approach has been tried with good results"; "Test this recipe" (同)prove, try, try out, examine, essay
achieve a certain score or rating on a test; "She tested high on the LSAT and was admitted to all the good law schools"
determine the presence or properties of (a substance)
show a certain characteristic when tested; "He tested positive for HIV"
stated explicitly or in detail; "needed a specific amount"
a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria"
(sometimes followed by `to'
being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements"
relating to or distinguishing or constituting a taxonomic species; "specific characters"
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
one of the two male reproductive glands that produce spermatozoa and secrete androgens; "she kicked him in the balls and got away" (同)testicle, orchis, ball, ballock, bollock, nut, egg

PrepTutorEJDIC

…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
(人の能力などの)『試験』,考査,テスト / (物事の)『試験』,検済,試錬,実験《+of+名》 / 化学分析;試薬 / =test match / …‘を'『試験する』,検査する / …‘を'化学分析する / (…の)試験を受ける,試験をする《+for+名》
《名詞の前にのみ用いて》『特定の』,一定の・『明確な』,明白な・(そのものに)『特有の』,独特の《+『to』+『名』》・〈C〉(…の)特効薬《+『for』+『名』》・《複数形で》明細,細部(details)
遺伝子
=testicle

UpToDate Contents

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1. 原発性免疫不全症に対する遺伝子治療の概要overview of gene therapy for primary immunodeficiency [show details]
… regulation of gene expression is required necessitates vectors containing appropriate control sequences or site-specific gene integration. Limitations of gene editing include: Decrease in rates of gene correction… and transcription activator-like effector nucleases (TALENs) . Gene editing is under investigation for several forms of SCID,…
2. 乳幼児突然死症候群：危険因子およびリスク低減戦略sudden infant death syndrome risk factors and risk reduction strategies [show details]
…transmission . Genes involved in the development of the autonomic nervous system . Partial deletions of complement component C4 . Interleukin-10 promoter gene . Testis-specific Y-like gene , which is expressed …
3. 健常者および患者における胎児性ヘモグロビン（ヘモグロビンF）fetal hemoglobin hemoglobin f in health and disease [show details]
… A₂) and the most common variants affecting globin genes are presented separately. Hemoglobin evolved from ancient hemoproteins by gene duplication, gene conversion (non-reciprocal exchange of genetic …
4. 小児における停留精巣：臨床的特徴および評価undescended testes cryptorchidism in children clinical features and evaluation [show details]
… in the insulin-like factor 3 (INSL3) receptor gene (RXFP2) in five . Other studies have identified mutations in the INSL3 gene and the androgen receptor gene in cryptorchid patients .… nonpalpable testis and enlarged contralateral testis may suggest testicular absence or atrophy, particularly after the onset of puberty . However, enlargement of the contralateral testis is not specific enough…
5. 遺伝子治療、ゲノム編集、遺伝子発現抑制の概要overview of gene therapy gene editing and gene silencing [show details]
… separate vector, gene editing involves directly altering the endogenous genomic sequence of a cell. As its name implies, gene editing is sequence-specific and seeks to make highly specific genomic sequence …

English Journal

Putative molecular mechanism underlying sperm chromatin remodelling is regulated by reproductive hormones.

Gill-Sharma MK1, Choudhuri J, Ansari MA, D'Souza S.Author information 1Department of Neuroendocrinology, National Institute for Research in Reproductive Health, J,M, Street, Parel, Mumbai 400012, India. manjitgill_sharma@hotmail.com.Abstract
Clinical epigenetics.Clin Epigenetics.2012 Dec 17;4(1):23. doi: 10.1186/1868-7083-4-23.
BACKGROUND: The putative regulatory role of the male reproductive hormones in the molecular mechanism underlying chromatin condensation remains poorly understood. In the past decade, we developed two adult male rat models wherein functional deficits of testosterone or FSH, produced after treatments
PMID 23241214

EST analysis and identification of gonad-related genes from the normalized cDNA library of large yellow croaker, Larimichthys crocea.

Zhou P1, Zhang Z, Wang Y, Zou Z, Xie F.Author information 1Key Laboratory of Science and Technology for Aquaculture and Food Safety of Fujian Province University, Fisheries College/Fisheries Biotechnology Institute, Jimei University, Xiamen, China.AbstractOn grounds of the especially limited numbers of identified gonad-specific or gonad-related genes of large yellow croaker Larimichthys crocea which may represent a major obstacle for the study of gonad development and sex differentiation, we initiated a sequencing program of Expressed Sequence Tags (ESTs) in large yellow croaker. In this study, we firstly constructed a normalized gonad cDNA library using the combination of SMART technique and DSN treatment. The titer of amplified cDNA library was 4.8x10(11) and the percentage of unique cDNA sequences of the library was 82.49%. 2916 unique cDNAs were clustered from the 3535 high quality ESTs. Among the 1785 ESTs which had significant homology with known genes in the NCBI database, about 64 significant gonad-related genes were found, accounting for 3.59% of the total unique cDNAs. Specifically, the testis-specific LRR gene and testis-specific chromodomain Y-like protein gene were identified from fish for the first time. Six gonad-related microsatellite-containing ESTs were identified from the 129 ESTs containing 149 microsatellites. Expression patterns of 10 of these gonad-related gene homologues in ovaries and testes were examined by qRT-PCR. The results will be powerful resources for our further investigation to establish the molecular mechanisms of gonad development and sex differentiation in large yellow croaker.
Comparative biochemistry and physiology. Part D, Genomics & proteomics.Comp Biochem Physiol Part D Genomics Proteomics.2010 Jun;5(2):89-97. doi: 10.1016/j.cbd.2010.01.002. Epub 2010 Feb 6.
On grounds of the especially limited numbers of identified gonad-specific or gonad-related genes of large yellow croaker Larimichthys crocea which may represent a major obstacle for the study of gonad development and sex differentiation, we initiated a sequencing program of Expressed Sequence Tags (
PMID 20403775

TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway.

Kim EJ1, Lee SY, Kim TR, Choi SI, Cho EW, Kim KC, Kim IG.Author information 1Department of Radiation Biology, Korea Atomic Energy Research Institute, Yuseong, Daejeon 305-600, Republic of Korea.AbstractTSPYL5, encoding testis-specific Y-like protein, has been postulated to be a tumor suppressor gene, and its hypermethylation is often associated with human disease, especially cancer. In this study, we report that the TSPYL5 gene was less methylated (30%) in A549 lung adenocarcinoma cells, which are relatively resistant to gamma-radiation, than in H460 lung cancer cells, in which the TSPYL5 gene was hypermethylated (95%); thus, the expression level of TSPYL5 is much higher in A549 cells than in H460 cells. We showed that TSPYL5 suppression with silencing RNA in A549 cells up-regulated cellular PTEN, followed by down-regulation of AKT activation. Therefore, blockage of TSPYL5 sensitized A549 cells to cytotoxic agents such as gamma-radiation. In addition, TSPYL5 suppression also showed an increased level of p21(WAF1/Cip1) and subsequently induced inhibition of cell growth in A549 cells. The overexpression of TSPYL5 in H460 cells showed the opposite effects. This study provides the first demonstration that TSPYL5 modulates cell growth and sensitization of cells to the detrimental effects of damaging agents via regulation of p21(WAF1/Cip1) and PTEN/AKT pathway.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2010 Feb 12;392(3):448-53. doi: 10.1016/j.bbrc.2010.01.045. Epub 2010 Jan 15.
TSPYL5, encoding testis-specific Y-like protein, has been postulated to be a tumor suppressor gene, and its hypermethylation is often associated with human disease, especially cancer. In this study, we report that the TSPYL5 gene was less methylated (30%) in A549 lung adenocarcinoma cells, which are
PMID 20079711