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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/18 22:21:29」(JST)

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English Journal

  • Enhancement of tacrolimus productivity in Streptomyces tsukubaensis by the use of novel precursors for biosynthesis.
  • Turło J, Gajzlerska W, Klimaszewska M, Król M, Dawidowski M, Gutkowska B.SourceDepartment of Drug Technology and Pharmaceutical Biotechnology, Medical University of Warsaw, 1 Banacha St, 02-097 Warsaw, Poland. Electronic address: jadwiga.turlo@wum.edu.pl.
  • Enzyme and microbial technology.Enzyme Microb Technol.2012 Dec 10;51(6-7):388-95. doi: 10.1016/j.enzmictec.2012.08.008. Epub 2012 Aug 30.
  • In this report the optimization of biosynthesis of tacrolimus, the immunosupressant widely used in transplantology and dermatology was described. The enhancement of the productivity of Streptomyces tsukubaensis strain was achieved by development of new precursors of tacrolimus biosynthesis, which sh
  • PMID 23040396
  • Extracellular factors and immunosuppressive drugs influencing insulin secretion of murine islets.
  • Auer VJ, Janas E, Ninichuk V, Eppler E, Weiss TS, Kirchner S, Otto AM, Stangl MJ.SourceInstitute of Medical Engineering, Technische Universität München (IMETUM), Garching Center for Liver Cell Research, Department of Pediatrics and Adolescent Medicine, University of Regensburg Hospital Hepacult GmbH, Biopark Regensburg, Regensburg Chirurgische Klinik und Poliklinik, Transplantationszentrum, Klinikum Großhadern, Ludwig-Maximilians-Universität, München, Germany Research Group Neuro-endocrine-immune Interactions, Anatomisches Institut, Zentrum für Integrative Humanphysiologie (ZIHP), Universität Zürich, Zürich, Switzerland.
  • Clinical and experimental immunology.Clin Exp Immunol.2012 Nov;170(2):238-247. doi: 10.1111/j.1365-2249.2012.04645.x.
  • Approximately 60% of transplanted islets undergo apoptosis within the first week post-transplantation into the liver attributed to poor engraftment, immune rejection and toxicity of immunosuppressive drugs. Understanding how extracellular matrix (ECM) components, immunosuppressive drugs and proinfla
  • PMID 23039895

Japanese Journal

  • Preparation of High-Payload, Prolonged-Release Biodegradable Poly(lactic-co-glycolic acid)-Based Tacrolimus Microspheres Using the Single-Jet Electrospray Method
  • Preparation of High-Payload, Prolonged-Release Biodegradable Poly(lactic-co-glycolic acid)-Based Tacrolimus Microspheres Using the Single-Jet Electrospray Method
  • タクロリムス固体分散体製剤の効率的な0.1 mg希釈散調製方法の確立

Related Links

Tacrolimus comes as a capsule to take by mouth. It is usually taken twice a day. Space your doses 12 hours apart, and take tacrolimus at the same times every day. Follow the directions on your prescription label carefully, and ask ...
INTRODUCTION Cyclosporine and tacrolimus selectively inhibit calcineurin, thereby impairing the transcription of interleukin (IL)-2 and several other cytokines in T lymphocytes. Calcineurin inhibitors have been mainstays of ...

Related Pictures

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拡張検索tacrolimus-binding protein」「tacrolimus hydrate」「tacrolimus ointment」「tacrolimus-binding protein 1A



immunosuppressive drug, immunosuppressant



56kDa immunophilinに結合 (GOO.1596)
56kDa immunophilinはHSP70, HSP90と共にglucocorticoid receptosに結合している。




プログラフタリムスプロトピック Protopicグラセプター
tacrolimus ointment
  • 放線菌から分離されたマクロライド系の物質
  • シクロスポリンより低濃度で免疫抑制の作用をもつ
  • 腎毒性がある

tacrolimus-binding protein」


FK506-binding proteinFKBP

tacrolimus hydrate」



tacrolimus ointment」

  [★] タクロリムス。タクロリムス水和物軟膏

tacrolimus-binding protein 1A」