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1. 小児期に生じる股関節痛へのアプローチapproach to hip pain in childhood [show details]
…Orthopedic – Pain is usually localized to the hip but may be referred to the thigh or knee; may have acute or insidious onset; pain increases with activity and decreases with rest; systemic symptoms are …
2. 慢性非癌性疼痛治療の概要overview of the treatment of chronic non cancer pain [show details]
… agents for the management of pain have several potential advantages over systemic drugs: delivery at the site of insult, lower initial rates of systemic absorption, fewer systemic effects, and patient preference …
3. 小児や骨格発達の未成熟な青年の慢性膝関節痛または損傷に対するアプローチapproach to chronic knee pain or injury in children or skeletally immature adolescents [show details]
… involve only one knee while systemic disease frequently presents with bilateral knee and pain in other joints. How severe is the pain? – Patients should be asked to rate their pain using any one of the age-appropriate …
4. 原因不明の膝痛をきたす成人へのアプローチapproach to the adult with unspecified knee pain [show details]
…knee pain due to infection and inflammation. Systemic rheumatic disease – Systemic rheumatic disease is a group of systemic autoimmune diseases that include: rheumatoid arthritis (RA), systemic lupus …
5. リウマチ性疾患患者に生じる広範囲慢性疼痛（中枢性感作による疼痛）の概要overview of chronic widespread centralized pain in the rheumatic diseases [show details]
… The management of chronic pain in patients with rheumatic disease requires a better understanding of centralized pain in chronic systemic and regional rheumatic and musculoskeletal pain disorders . An overview …

English Journal

Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression: Role of MAPK signaling pathway.

Humo M, Ayazgök B, Becker LJ, Waltisperger E, Rantamäki T, Yalcin I.
Progress in neuro-psychopharmacology & biological psychiatry. 2020 Jun;100()109898.
Chronic pain produces psychologic distress, which often leads to mood disorders such as depression. Co-existing chronic pain and depression pose a serious socio-economic burden and result in disability affecting millions of individuals, which urges the development of treatment strategies targeting t
PMID 32109506

Single injection Quadratus Lumborum block for postoperative analgesia in adult surgical population: A systematic review and meta-analysis.

Jin Z, Liu J, Li R, Gan TJ, He Y, Lin J.
Journal of clinical anesthesia. 2020 Jun;62()109715.
The Quadratus lumborum (QL) block was first reported as a postoperative analgesic technique for abdominoplasty, and since has been used for a variety of surgeries. In this systematic review and meta-analysis, we summarize the current literature on the postoperative analgesic effect of QL block. We s
PMID 31968297

Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib.

Sun X, Cao Z, Mao K, Wu C, Chen H, Wang J, Wang X, Cong X, Li Y, Meng X, Yang X, Yang YG, Sun T.
Biomaterials. 2020 May;240()119845.
Photodynamic therapy (PDT) can destroy local tumor cells and induce effective antitumor immune responses, and has been applied in the treatment of patients with superficial solid tumors. Numerous systemic side effects of PDT, such as pain and skin photosensitivity, however, limit this therapeutic op
PMID 32085974

Japanese Journal

高度な眼窩炎症と髄膜炎を併発した眼部帯状疱疹の1例

佐々木信之,坂本麻里,栗本拓治,盛崇太朗,上田香織,中西裕子,飯島健太,立花久嗣,中村誠
神経眼科 37(1), 38-44, 2020
<p>　眼部帯状疱疹に高度な眼窩炎症と髄膜炎を併発し，重篤な視機能障害を残した症例を経験した．症例は72歳，女性．左眼痛と嘔気を自覚するも前医にて異常認めなかったが症状増悪し，1週間後に当科受診した．左眼瞼下垂，瞳孔不同，上眼瞼腫脹，結膜浮腫および点状角膜炎を認め，3日後に左三叉神経第一枝領域に皮疹が出現し帯状疱疹と診断された．持続する高熱と髄液検査にてウイルス性髄膜炎と診断された．ア …
NAID 130007823730

敗血症性急性肺傷害の病態メカニズムと新たな治療戦略

服部裕一,服部貢士,松田直之
日本薬理学会年会要旨集 93(0), 3-S34-3, 2020
… Given that sepsis can be regarded as a gene-related disorder, the potential usefulness of systemic delivery of decoy oligodeoxynucleotide against some transcription factors may be considered to be a promising novel therapeutic approach for treatment of acute lung injury in sepsis.</p> …
NAID 130007811993

霊長類におけるノシセプチン受容体を標的とした安全なオピオイド鎮痛薬の可能性

木口倫一,Ko Mei-Chuan
日本薬理学会年会要旨集 93(0), 2-S20-4, 2020
… </p><p>Newly developed bifunctional NOP/MOP receptor agonists, which shows partial agonist activity for both NOP and MOP receptors, exerted morphine-comparable antinociception without causing itch sensation following systemic or intrathecal administration in rhesus monkeys. …
NAID 130007811685