WordNet

exciting strong but not unpleasant emotions; "a stirring speech" (同)soul-stirring
agitating a liquid with an implement; "constant stirring prevents it from burning on the bottom of the pan"
move an implement through; "stir the soup"; "stir my drink"; "stir the soil"
a prominent or sensational but short-lived news event; "he made a great splash and then disappeared" (同)splash
emotional agitation and excitement
move very slightly; "He shifted in his seat" (同)shift, budge, agitate
mix or add by stirring; "Stir nuts into the dough"
change the arrangement or position of (同)vex, disturb, commove, shake up, stir up, raise up
try to stir up public opinion (同)foment, stir up
cause to be agitated, excited, or roused; "The speaker charged up the crowd with his inflammatory remarks" (同)rouse, turn_on, charge, commove, excite, charge up
disturbance usually in protest (同)excitement, turmoil, upheaval, hullabaloo
the act of agitating something; causing it to move around (usually vigorously)
a state of agitation or turbulent change or development; "the political ferment produced new leadership"; "social unrest" (同)ferment, fermentation, tempestuousness, unrest
a mental state of extreme emotional disturbance
in a stirring manner; "he talked stirringly about his days during the war"

PrepTutorEJDIC

感動させる,鼓舞させる・活発な;多忙な,繁華な・（感情などが）湧き起こること、動揺・感動的な、奮起させる
…‘を'『かき混ぜる』,かき回す;…‘を'(…に入れて)かき混ぜる《+『名』+『into』+『名』》 / 〈物事〉‘を'『かき立てる』;…‘を'扇動する《+『up』+『名,』+『名』+『up』》 / 〈人〉‘を'奮起させる,‘の'心をかき立てる《+『up』+『名,』+『名』+『up』》 / 《話》…‘の'目を覚まさせる《+『up』+『名』》 / …‘を'軽く動かす / (特に,かすかに)『動く』 / 《話》動き回る,起きて働く;目を覚ます / かき回せる,かき混ぜられる / 〈U〉《しばしばa ~》騒ぎ / 〈C〉《a ~》かすかな動き / 〈C〉(スプーンなどで)かき混ぜること
刑務所
(激しく)〈液体など〉'を'『ゆする』,ゆり動かす;…'を'かき混ぜる / 〈人・世問・心〉'を'『かき乱す』,動揺させる / (政治・社会問題で)(…に反対(賛成)して)『扇動する』,アジる《+『against』(『for』)+『名』》
〈U〉(激しく)ゆり動かすこと,かき混ぜること / 〈U〉(心の)動揺 / 〈C〉〈U〉扇動,アジ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/25 16:45:43」(JST)

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1. 先進国の小児における慢性下痢症の診断へのアプローチ approach to the diagnosis of chronic diarrhea in children in developed countries
2. 炭化水素中毒 hydrocarbon poisoning
3. 錠剤を嚥下できないHIV感染成人患者の治療：液剤、チュアブル、および砕くことができる剤形の薬剤 treatment of hiv infected adults who have trouble swallowing pills liquid chewable and crushable formulations
4. 非ヌクレオシド系逆転写酵素阻害剤の薬理学 pharmacology of non nucleoside reverse transcriptase inhibitors

English Journal

Preparation and characterization of self-assembled chitosan nanoparticles for the sustained delivery of streptokinase: an in vivo study.

Modaresi SM, Ejtemaei Mehr S, Faramarzi MA, Esmaeilzadeh Gharehdaghi E, Azarnia M, Modarressi MH, Baharifar H, Vaez SJ, Amani A.Author information Department of Biology, Faculty of Basic Sciences, Kharazmi University , Tehran , Iran .AbstractAbstract Chitosan (CS) nanoparticles have been extensively studied as carriers for therapeutic proteins in recent years. In this study, streptokinase loaded-CS nanoparticles were prepared and the pharmacokinetic parameters of streptokinase were compared with those of naked streptokinase. The preparation method included stirring the protein with the CS solution. The optimized combination was used for animal experiments to determine the streptokinase activity in rat plasma. Blood samples were collected at specified intervals and the activity assay was performed based on amidolysis activity of the chromogenic substrate, S2251, by streptokinase-plasminogen activator complex. The results demonstrated that streptokinase-loaded CS nanoparticles have more prolonged amidolytic activity in vivo compared to the naked one.
Pharmaceutical development and technology.Pharm Dev Technol.2014 Aug;19(5):593-7. doi: 10.3109/10837450.2013.813542. Epub 2013 Jul 17.
Abstract Chitosan (CS) nanoparticles have been extensively studied as carriers for therapeutic proteins in recent years. In this study, streptokinase loaded-CS nanoparticles were prepared and the pharmacokinetic parameters of streptokinase were compared with those of naked streptokinase. The prepara
PMID 23859703

Determination of nerolidol in teas using headspace solid phase microextraction-gas chromatography.

Ma C1, Qu Y2, Zhang Y2, Qiu B2, Wang Y3, Chen X4.Author information 1Ministry of Education & Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou 350002, China; College of Tea and Food Science, Wuyi University, Wuyishan 354300, China.2Ministry of Education & Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou 350002, China.3State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China.4State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China. Electronic address: xichen@xmu.edu.cn.AbstractNerolidol is an important volatile compound found in tea aroma, consumption of which has been associated with good health. A novel approach for the quantitative determination of nerolidol in teas has been developed using a headspace solid phase microextraction (HS-SPME) and a gas chromatography-flame ionization detector (GC-FID). The experimental parameters relating to the extraction efficiency of the HS-SPME such as fibre types, extraction temperature, extraction time, stirring rate were investigated and optimized. The study results demonstrated that combining GC-FID with HS-SPME was an efficient and flexible extraction approach for the analysis of nerolidol in teas. Using the HS-SPME-GC-FID, the linear range of the determination of nerolidol was found to be 2.7-1360ngg(-1) and the limit of detection was 0.3ngg(-1). The average recoveries were in the range 78.7-106% in spiked tea samples. In addition, the generation and the content change in nerolidol at different manufacturing stages were investigated. Based on the content of nerolidol in Oolong tea samples, grade judgment for the various teas was performed.
Food chemistry.Food Chem.2014 Jun 1;152:285-90. doi: 10.1016/j.foodchem.2013.11.010. Epub 2013 Nov 28.
Nerolidol is an important volatile compound found in tea aroma, consumption of which has been associated with good health. A novel approach for the quantitative determination of nerolidol in teas has been developed using a headspace solid phase microextraction (HS-SPME) and a gas chromatography-flam
PMID 24444938

Combination of submicroemulsion and phospholipid complex for novel delivery of ursodeoxycholic acid.

Ma YQ, Li G, Xu JH, Zhang J, Zhang ZZ, Xiao HY, Li XF.Author information Department of Pharmaceutics, the 94th Hospital of PLA , Nanchang , China.AbstractAbstract The objective of this study was to prepare and characterize ursodeoxycholic acid submicron emulsion (UA-SME) loaded with ursodeoxycholic acid phytosomes (UA-PS) and optimize the process variables. A screening experiment with response surface methodology with Box-Behnken design (BBD) was used to optimize the process parameters of UA-SME. The blood concentrations of UA after oral administration of UA-SME and UA coarse drug were assayed. The optimum process conditions were finally obtained by using a desirability function. It was found that stirring velocity, homogenization pressure and homogenization cycles were the most important variables that affected the particles size, polydispersity index and entrapment efficiency of UA-SME. Results showed that the optimum stirring velocity, homogenization pressure and cycles were 16 000 rpm, 60 MPa and 10 cycles, respectively. The mean diameter, polydispersity index and entrapment efficiency of UA-SME were 251.9 nm, 0.241 and 74.36%, respectively. Pharmacokinetic parameters of UA and UA-SME in rats were Tmax 2.215 and 1.489 h, Cmax 0.0364 and 0.1562 μg/mL, AUC0-∞ 3.682 and 13.756 μg h/mL, respectively. The bioavailability of UA in rats was significantly different (p < 0.05) after oral administration of UA-SME compared to those of UA coarse drug. This was due to improvement of the hydrophilicity and lipophilic property of UA-SME.
Pharmaceutical development and technology.Pharm Dev Technol.2014 May;19(3):363-72. doi: 10.3109/10837450.2013.788517. Epub 2013 May 1.
Abstract The objective of this study was to prepare and characterize ursodeoxycholic acid submicron emulsion (UA-SME) loaded with ursodeoxycholic acid phytosomes (UA-PS) and optimize the process variables. A screening experiment with response surface methodology with Box-Behnken design (BBD) was use
PMID 23634754

Biosensing enhancement using passive mixing structures for microarray-based sensors.

Lynn NS Jr1, Martínez-López JI2, Bocková M1, Adam P1, Coello V3, Siller HR4, Homola J5.Author information 1Institute of Photonics and Electronics, Chaberská 57, 18251 Prague, Czech Republic.2Tecnológico de Monterrey, Eugenio Garza Sada 2501 Sur, C.P. 64849 Monterrey, N.L., México. Electronic address: israel@null.net.3Centro de Investigación Científica y de Educación Superior de Ensenada, Unidad Monterrey, Alianza Sur No. 105, Nueva Carretera Aeropuerto Km 9.5, Apodaca 66629, N.L., México. Electronic address: vcoello@cicese.mx.4Tecnológico de Monterrey, Eugenio Garza Sada 2501 Sur, C.P. 64849 Monterrey, N.L., México. Electronic address: hector.siller@itesm.mx.5Institute of Photonics and Electronics, Chaberská 57, 18251 Prague, Czech Republic. Electronic address: homola@ufe.cz.AbstractThe combination of microarray technologies with microfluidic sample delivery and real-time detection methods has the capability to simultaneously monitor 10-1000s of biomolecular interactions in a single experiment. Despite the benefits that microfluidic systems provide, they typically operate in the laminar flow regime under mass transfer limitations, where large analyte depletion layers act as a resistance to analyte capture. By locally stirring the fluid and delivering fresh analyte to the capture spot, the use of passive mixing structures in a microarray environment can reduce the negative effects of these depletion layers and enhance the sensor performance. Despite their large potential, little attention has been given to the integration of these mixing structures in microarray sensing environments. In this study, we use passive mixing structures to enhance the mass transfer of analyte to a capture spot within a microfluidic flow cell. Using numerical methods, different structure shapes and heights were evaluated as means to increase local fluid velocities, and in turn, rates of mass transfer to a capture spot. These results were verified experimentally via the real-time detection of 20-mer ssDNA for an array of microspots. Both numerical and experimental results showed that a passive mixing structure situated directly over the capture spot can significantly enhance the binding rate of analyte to the sensing surface. Moreover, we show that these structures can be used to enhance mass transfer in experiments regarding an array of capture spots. The results of this study can be applied to any experimental system using microfluidic sample delivery methods for microarray detection techniques.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Apr 15;54:506-14. doi: 10.1016/j.bios.2013.11.027. Epub 2013 Nov 25.
The combination of microarray technologies with microfluidic sample delivery and real-time detection methods has the capability to simultaneously monitor 10-1000s of biomolecular interactions in a single experiment. Despite the benefits that microfluidic systems provide, they typically operate in th
PMID 24321884