WordNet

of the transmission gear causing backward movement in a motor vehicle; "in reverse gear"
a relation of direct opposition; "we thought Sue was older than Bill but just the reverse was true" (同)contrary, opposite
the gears by which the motion of a machine can be reversed (同)reverse gear
the side of a coin or medal that does not bear the principal design (同)verso
(American football) a running play in which a back running in one direction hands the ball to a back running in the opposite direction
an unfortunate happening that hinders or impedes; something that is thwarting or frustrating (同)reversal, setback, blow, black_eye
thyroid hormone similar to thyroxine but with one less iodine atom per molecule and produced in smaller quantity; exerts the same biological effects as thyroxine but is more potent and briefer (同)liothyronine, T
a lapel on a womans garment; turned back to show the reverse side (同)revere
turned inside out and resewn; "the reversed collar looked as good as new"

PrepTutorEJDIC

(位置・方向・順序などにおいて)『逆の』;裏側の』 / 逆に動かす(動く),バックの / 〈U〉《the reverse》(…の)『反対』,『逆』《+『of』+『名』(『wh』‐節)》》 / 〈U〉《the reverse》(貨幣・メダルなどの)『裏側』,(一般に)(…の)裏面《+『of』+『名』》 / 〈C〉(運命などの)逆転,不運 / 〈U〉後退[装置],逆転[装置] / …‘を'『逆にする』,反対にする;…‘を'裏返す / 〈機械など〉‘を'逆転させる,逆方向に動かす / 〈判決など〉‘を'取り消す,破棄する / (ダンスで)逆に回る / 〈機械などが〉逆方向に動く
（フランス語）(えりの)裏出し,折り返し
逆にした,反対の,裏返のし;取り消された

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/07 16:56:55」(JST)

wiki en

Reverse triiodothyronine (3,3’,5’-triiodothyronine, reverse T₃, or rT₃) is an isomer of triiodothyronine (3,5,3’ triiodothyronine, T₃).

Reverse T₃ is the third-most common iodothyronine the thyroid gland releases into the bloodstream, of which 0.9% is rT₃; tetraiodothyronine (levothyroxine, T₄) constitutes 90% and T₃ is 9%. However, 95% of rT₃ in human blood is made elsewhere in the body, as enzymes remove a particular iodine atom from T₄.^[1]

The production of hormone by the thyroid gland is controlled by the hypothalamus and pituitary gland. The physiological activity of thyroid hormone is regulated by a system of enzymes that activate, inactivate or simply discard the prohormone T₄ and in turn functionally modify T₃ and rT₃. These enzymes operate under complex direction of systems including neurotransmitters, hormones, markers of metabolism and immunological signals.

The levels of rT3 increase in conditions such as euthyroid sick syndrome because its clearance decreases while its production stays the same. The decreased clearance is possibly from lower 5'-deiodinase activity in the peripheral tissue or decreased liver uptake of rT3.^[2]

Reactions

Synthesis of Reverse T₃ from T₄ via deiodination. Synthesis of T₃ and T₂ is also shown.

References

^ Chopra IJ (July 1976). "An assessment of daily production and significance of thyroidal secretion of 3, 3', 5'-triiodothyronine (reverse T3) in man". J. Clin. Invest. 58 (1): 32–40. doi:10.1172/JCI108456. PMC 333152. PMID 932209.
^ Euthyroid Sick Syndrome at eMedicine

External links

Triiodothyronine, Reverse at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. 甲状腺ホルモンの合成および生理 thyroid hormone synthesis and physiology
2. 非甲状腺疾患における甲状腺機能 thyroid function in nonthyroidal illness
3. 慢性腎疾患における甲状腺機能 thyroid function in chronic kidney disease
4. アミオダロンと甲状腺機能障害 amiodarone and thyroid dysfunction
5. 甲状腺ホルモンの作用 thyroid hormone action

English Journal

Environmental heat stress modulates thyroid status and its response to repeated endotoxin challenge in steers.

Kahl S1, Elsasser TH2, Rhoads RP3, Collier RJ3, Baumgard LH3.
Domestic animal endocrinology.Domest Anim Endocrinol.2015 Jul;52:43-50. doi: 10.1016/j.domaniend.2015.02.001. Epub 2015 Feb 26.
The objective of this study was to evaluate in cattle, the effects of acute exposure to a heat stress (HS) environment on the status of the pituitary (thyrotropin, TSH)-thyroid (thyroxine, T4)-peripheral tissue T4 deiodination (type 1 5'-deiodinase [D1]; triiodothyronine [T3]; reverse-triiodothyroni
PMID 25804834

Relation of thyroid hormone abnormalities with subclinical inflammatory activity in patients with type 1 and type 2 diabetes mellitus.

Moura Neto A1, Parisi MC, Alegre SM, Pavin EJ, Tambascia MA, Zantut-Wittmann DE.
Endocrine.Endocrine.2015 Jun 7. [Epub ahead of print]
Thyroid hormone (TH) abnormalities are common in patients with diabetes mellitus (DM). These thyroid hormone abnormalities have been associated with inflammatory activity in several conditions but this link remains unclear in DM. We assessed the influence of subclinical inflammation in TH metabolism
PMID 26049370

Effects of 3,3',5-triiodothyronine on microglial functions.

Mori Y1, Tomonaga D, Kalashnikova A, Furuya F, Akimoto N, Ifuku M, Okuno Y, Beppu K, Fujita K, Katafuchi T, Shimura H, Churilov LP, Noda M.
Glia.Glia.2015 May;63(5):906-20. doi: 10.1002/glia.22792. Epub 2015 Jan 30.
L-tri-iodothyronine (3, 3', 5-triiodothyronine; T3) is an active form of the thyroid hormone (TH) essential for the development and function of the CNS. Though nongenomic effect of TH, its plasma membrane-bound receptor, and its signaling has been identified, precise function in each cell type of th
PMID 25643925

Japanese Journal

The influence of body mass index and low-grade systemic inflammation on thyroid hormone abnormalities in patients with type 2 diabetes

NETO Arnaldo Moura,PARISI Maria Candida Riberiro,TAMBASCIA Marcos Antonio,ALEGRE Sarah Monte,PAVIN Elizabeth Joao,ENGELBRECHT ZANTUT-WITTMANN Denise
Endocrine journal 60(7), 877-884, 2013-07-01
… We measured total (T) and free (F) thyroxine (T4) and triiodothyronine (T3), reverse T3 (rT3), the ratios FT3/rT3, FT3/FT4 and FT4/rT3, clinical parameters (age, gender, diabetes duration and complications, body mass index, waist circumference, hypertension, HbA1c), and high sensitivity C-reactive protein. …
NAID 10031195756

リン酸アルキルアンモニウムを添加した移動相を用いる逆相高速液体クロマトグラフィーによるヨウ化物イオン及びヨウ素化チロニン類の同時分析

宮下正弘,瀬山義幸,小畑俊男
分析化学 = Japan analyst 60(2), 149-156, 2011-02-05
イオン対（IP）試薬としてリン酸アルキルアンモニウムを添加した移動相を用いる紫外吸光（UV）検出/逆相高速液体クロマトグラフィー（HPLC）で，ヨウ化物イオン（I－）及びヨウ素化チロニン類を同時分析する方法を検討した．本研究では，カラムにSunrise C18を用い，移動相の諸条件（pH，IP試薬の種類など）がI－及びヨウ素チロニン類の保持に及ぼす影響を系統的に調べた．その結果から，分離に至適な移 …
NAID 10027410153

総トリヨードサイロニン(TT3),遊離トリヨードサイロニン(FT3),リバースT3(rT3) (広範囲血液・尿化学検査免疫学的検査(第7版・4)その数値をどう読むか) -- (内分泌学的検査甲状腺・副甲状腺関係)

家入蒼生夫
日本臨床 68(-), 284-289, 2010-07
NAID 40017200742

「リバーストリヨードサイロニン」

Reverse triiodothyronine
Names
	IUPAC name (2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid
Identifiers
CAS Number	5817-39-0
3D model (Jmol)	Interactive image
ChEBI	CHEBI:11684
ChemSpider	559294
ECHA InfoCard	100.150.134
IUPHAR/BPS	2636
KEGG	C07639
MeSH	Reverse+triiodothyronine
PubChem	22069
	InChI InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1 Key: HZCBWYNLGPIQRK-LBPRGKRZSA-N ; InChI=1/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1 Key: HZCBWYNLGPIQRK-LBPRGKRZBV ;
	SMILES C1=CC(=C(C=C1C[C@@H](C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I ;
Properties
Chemical formula	C15H12I3NO4
Molar mass	650.974
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

　　[★]

英: 3,3'5'-triiodothyronine , reverse triiodothyronine, rT3
同: リバースT3
関: 低トリヨードサイロニン症候群

「リバース・トリヨードサイロニン」

　　[★]

英: reverse triiodothyronine, rT3

「逆位トリヨードチロニン」

　　[★]

英: reverse triiodothyronine

「reverse」

　　[★]

v.

逆転させる、逆行する、逆戻りさせる、リバースする

adj.

逆の、逆性の

関: adversely、backward、converse、conversely、inverse、inversely、opposite、oppositely、retro、reversal

「triiodothyronine」

　　[★] トリヨードサイロニン T3 　

[Chopra_1976-1] Chopra IJ (July 1976). "An assessment of daily production and significance of thyroidal secretion of 3, 3', 5'-triiodothyronine (reverse T3) in man". J. Clin. Invest. 58 (1): 32–40. doi:10.1172/JCI108456. PMC 333152. PMID 932209.

[2] Euthyroid Sick Syndrome at eMedicine

v t e Thyroid hormone metabolic intermediates

Tyrosine / iodotyrosine	Monoiodotyrosine Diiodotyrosine

Thyronine / iodothyronine	3'-Monoiodothyronine 3,3'-Diiodothyronine 3,5-Diiodothyronine 3,3',5-Triiodothyronine (T₃) 3,3',5'-Triiodothyronine (Reverse T₃) 3,5,3',5'-Tetraiodothyronine (Thyroxine, T₄)

Thyronamine / iodothyronamine	3-Iodothyronamine 3,3',5-Triiodothyronamine

Iodothyroacetate / iodothyroacetic acid	Triiodothyroacetate (TRIAC)

リンク元	「リバーストリヨードサイロニン」「リバース・トリヨードサイロニン」「逆位トリヨードチロニン」
関連記事	「reverse」「triiodothyronine」

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案内

reverse triiodothyronine