WordNet

part with a possession or right; "I am relinquishing my bedroom to the long-term house guest"; "resign a claim to the throne" (同)relinquish, resign, free, give_up
a process that liberates or discharges something; "there was a sudden release of oxygen"; "the release of iodine from the thyroid gland"
a device that when pressed will release part of a mechanism (同)button
activity that frees or expresses creative energy or emotion; "she had no other outlet for her feelings"; "he gave vent to his anger" (同)outlet, vent
(music) the act or manner of terminating a musical phrase or tone (同)tone ending
a formal written statement of relinquishment (同)waiver, discharge
merchandise issued for sale or public showing (especially a record or film); "a new release from the London Symphony Orchestra"
release (gas or energy) as a result of a chemical reaction or physical decomposition (同)free, liberate
be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"

PrepTutorEJDIC

(束縛・義務などから)〈人・動物など〉‘を'『自由にする』,解放する《+『名』+『from』+『名』》 / 〈矢など〉‘を'放つ,〈爆弾〉‘を'投下する;〈締めつけた物〉‘を'ゆるめて放す / 〈ニュースなど〉‘を'発表する;〈レコード・書籍など〉‘を'発売する,〈映画〉‘を'封切りする / (人に)〈権利など〉‘を'譲渡する《+『名』+『to』+『名』》 / (束縛・義務などからの)『解放』,放免,免除《+『from』+『名』》 / (ガスなどの)放出;(爆弾の)投下;(感情の)吐露《+『of』(『to』)+『名』》 / (ニュースなどの)発表;(映画などの)封切り,(レコードなどの)発表 / (機械の)作動装置,レリーズ
(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/03 23:38:36」(JST)

wiki en

A release factor is a protein that allows for the termination of translation by recognizing the termination codon or stop codon in an mRNA sequence.

During translation of mRNA, most codons are recognized by "charged" tRNA molecules, called aminoacyl-tRNAs because they are adhered to specific amino acids corresponding to each tRNA's anticodon.

In the standard genetic code, there are three mRNA stop codons: UAG ("amber"), UAA ("ochre"), and UGA ("opal" or "umber").

Although these stop codons are triplets just like ordinary codons, they are not decoded by tRNAs. It was discovered by Mario Capecchi in 1967 that, instead, tRNAs do not ordinarily recognize stop codons at all, and that what he named "release factor" was not a tRNA molecule but a protein.^[1] Later, it was demonstrated that different release factors recognize different stop codons.^[2]

Prokaryotic translation termination is mediated by three prokaryotic release factors: RF1, RF2, and RF3.^[3]

RF1 recognizes the termination codons UAA and UAG
RF2 recognizes UAA and UGA
RF3 is a GTP-binding protein that leads to the dissociation of RF1/RF2 after peptide release

Likewise, eukaryotic translation termination involves two eukaryotic release factors: eRF1 and eRF3.^[3]

eRF1 recognizes all three termination codons
eRF3 is a ribosome-dependent GTPase that helps eRF1 release the completed polypeptide

References

^ Capecchi, M. R. (1967). Polypeptide chain termination in vitro: Isolation of a release factor. Proc. Natl. Acad. Sci. USA 58:1144-1151.
^ Scolnick, E., R. Tompkins, T. Caskey, and M. Nirenberg (1968). Release factors differing in specificity for terminator codons, Proceedings of National Academy of Sciences USA 61:772.
^ ^a ^b Weaver, Robert F. (2005). Molecular Biology, p.616-621. McGraw-Hill, New York, NY. ISBN 0-07-284611-9.

External links

Termination Release Factor at the US National Library of Medicine Medical Subject Headings (MeSH)

This protein-related article is a stub. You can help Wikipedia by expanding it.

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English Journal

Magnetic-fluorescent-targeting multifunctional aptasensorfor highly sensitive and one-step rapid detection of ochratoxin A.

Wang C1, Qian J2, Wang K2, Wang K3, Liu Q2, Dong X2, Wang C4, Huang X5.
Biosensors & bioelectronics.Biosens Bioelectron.2015 Jun 15;68:783-90. doi: 10.1016/j.bios.2015.02.008. Epub 2015 Feb 7.
A multifunctional aptasensor for highly sensitive and one-step rapid detection of ochratoxin A (OTA), has been developed using aptamer-conjugated magnetic beads (MBs) as the recognition and concentration element and a heavy CdTe quantum dots (QDs) as the label. Initially, the thiolated aptamer was c
PMID 25682508

Mechanisms by which the N-terminal 24 amino acids of the p55 regulatory subunit of phosphatidylinositol 3-kinase affect endotoxin-induced cytokine release in human keratinocytes.

Lv F1, Yu Y1, Wang G2, Hu J2, Zhang B1, You W1, Wang J3.
Molecular medicine reports.Mol Med Rep.2015 May;11(5):3753-9. doi: 10.3892/mmr.2015.3184. Epub 2015 Jan 12.
To understand the association between the cytokine network and psoriasis, the present study cultured human keratinocytes (HaCaT cells) and investigated the effects of the phosphatidylinositol‑3‑kinase (PI3K) p55 regulatory subunit (p55PIK), and its N‑terminal 24 amino acids (N24) on the regula
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Japanese Journal

Lifetime amelioration of release-agent-free antireflection-structured replica molds by partial-filling ultraviolet nanoimprint lithography

Abu Talip[a]Yusof Nurhafizah,Hayashi Tatsuya,Taniguchi Jun,Hiwasa Shin
Jpn. J. Appl. Phys. 54(6S1), 06FM04, 2015-05-22
… In ultraviolet nanoimprint lithography (UV-NIL), the presence of fluorinated components in a release-agent-free antireflection-structured (RAF-ARS) replica mold is an important factor preventing the adhesion of resin on its surface. … Nevertheless, a strong release force (RF), which results from the complete filling of resin in a high-aspect-ratio RAF-ARS replica mold during UV-NIL, degrades its fluorinated components and consequently shortens its lifetime. …
NAID 150000110792

Modest Attenuation of HIV-1 Vpu Alleles Derived from Elite Controller Plasma

Chen Jingyan,Tibroni Nadine,Sauter Daniel,Galaski Johanna,Miura Toshiyuki,Alter Galit,Mueller Birthe,Haller Claudia,Walker Bruce D.,Kirchhoff Frank,Brumme Zabrina L.,Ueno Takamasa,Fackler Oliver T.
PLOS ONE 10(3), e0120434, 2015-03-20
… Antagonism of the HIV particle release restriction by the intrinsic immunity factor CD317/tetherin was well conserved among EC and CP Vpu alleles, underscoring the selective advantage of this Vpu function in HIV-1 infected individuals. …
NAID 120005602608

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皆川直凡
鳴門教育大学研究紀要 30, 1-15, 2015-03-13
… As for the mold release motive, as for the school year difference and the sex differences, the thing that was highly individual than contents participation type motive was suggested not clarity for contents whereas I was enhancement?oriented, and a first grader was high as for the contents participation type motive consisting of training intention and the practical use intention, and it was shown in motivational quality as a result of inventory survey for junior high students that a girl was high. …
NAID 110009895521