- 関
- signal pathway、signal transduction、signal transduction pathway、signal transduction system
WordNet
- place signs, as along a road; "sign an intersection"; "This road has been signed"
- (medicine) any objective evidence of the presence of a disorder or disease; "there were no signs of asphyxiation"
- a perceptible indication of something not immediately apparent (as a visible clue that something has happened); "he showed signs of strain"; "they welcomed the signs of spring" (同)mark
- a character indicating a relation between quantities; "dont forget the minus sign"
- a fundamental linguistic unit linking a signifier to that which is signified; "The bond between the signifier and the signified is arbitrary"--de Saussure
- a gesture that is part of a sign language
- a public display of a message; "he posted signs in all the shop windows"
- engage by written agreement; "They signed two new pitchers for the next season" (同)contract, sign on, sign_up
- approve and express assent, responsibility, or obligation; "All parties ratified the peace treaty"; "Have you signed your contract yet?" (同)ratify
- communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" (同)signal, signalize, signalise
- mark with ones signature; write ones name (on); "She signed the letter and sent it off"; "Please sign here" (同)subscribe
- be engaged by a written agreement; "He signed to play the casino on Dec. 18"; "The soprano signed to sing the new opera"
- communicate in sign language; "I dont know how to sign, so I could not communicate with my deaf cousin"
- notably out of the ordinary; "the year saw one signal triumph for the Labour party"
- an electric quantity (voltage or current or field strength) whose modulation represents coded information about the source from which it comes
- any nonverbal action or gesture that encodes a message; "signals from the boat suddenly stopped" (同)signaling, sign
- any incitement to action; "he awaited the signal to start"; "the victory was a signal for wild celebration"
- occupy an intermediate or middle position or form a connecting link or stage between two others; "mediate between the old and the new"
- acting through or dependent on an intervening agency; "the disease spread by mediate as well as direct contact"
- (genetics) the process of transfering genetic material from one cell to another by a plasmid or bacteriophage
- the process whereby a transducer accepts energy in one form and gives back related energy in a different form; "the transduction of acoustic waves into voltages by a microphone"
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- (ある事実・状態・感情などの)『表れ』,印,気配,徴侯(indication);(…の)こん跡,計跡《+『of』+『名』》・『身ぶり』,手まね,合図 / 『標識』,看板 / (数学・音楽などの)記号 / (…の)『象徴』,シンボル(symbol)《+『of』+『名』》・《文》(…の)『前兆』,きざし《+『of』+『名』》・宮(きゅう)(黄道12区分の一つ) ・〈手紙・書類・作品など〉‘に'『署名する』・(…に)〈名前など〉‘を'書く《+『名』+『on』(『to』)+『名』》 / …‘を'雇う契約に署名する・…‘を'合図する,知らせる;…に合図する・署名する・契約書に署名して雇われる
- (警告・指示・情報などを伝える)『信号』,合図 / (…の)きっかけ,動機,導火線《+『for』+『名』》 / 〈人・車など〉‘に'『合図する』,信号を送る / …‘を'『合図』(信号)『で知らせる』 / 『合図する』,信号する / 合図の,信号の / めざましい,顕著な
- 〈紛争・相違点など〉‘を'調停する,仲裁する / 〈妥協・和解・同意など〉‘を'仲裁して成立させる / (両者の)調停をする《+『between』+『名』》 / 仲介者(媒介物)を通じての,間接の
- =sense organ / 受信装置
UpToDate Contents
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- 1. 肥満細胞：表面受容体とシグナル伝達 mast cells surface receptors and signal transduction
- 2. ペプチドホルモンのシグナル伝達および調節 peptide hormone signal transduction and regulation
- 3. インスリン受容体の構造および機能 structure and function of the insulin receptor
- 4. T細胞受容体シグナル伝達 t cell receptor signaling
- 5. 甲状腺ホルモンの作用 thyroid hormone action
English Journal
- PPP2R5B, a regulatory subunit of PP2A, contributes to adipocyte insulin resistance.
- Beg M1, Srivastava A2, Shankar K1, Varshney S1, Rajan S2, Gupta A1, Kumar D2, Gaikwad AN3.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2016 Dec 5;437:97-107. doi: 10.1016/j.mce.2016.08.016. Epub 2016 Aug 10.
- Insulin resistance is associated with deregulation of insulin signaling owing to the chronic exposure of insulin (hyperinsulinemia) to the tissues. Phosphorylation and dephosphorylation events in insulin signaling pathway play an essential role in signal transduction and glucose uptake. Amongst all,
- PMID 27521959
- The broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance.
- Ruvolo PP1.
- BBA clinical.BBA Clin.2016 Aug 3;6:87-99. doi: 10.1016/j.bbacli.2016.08.002. eCollection 2016.
- Aberrant activation of signal transduction pathways can transform a normal cell to a malignant one and can impart survival properties that render cancer cells resistant to therapy. A diverse set of cascades have been implicated in various cancers including those mediated by serine/threonine kinases
- PMID 27556014
- Plant protein phosphatases 2C: from genomic diversity to functional multiplicity and importance in stress management.
- Singh A1, Pandey A1, Srivastava AK2, Tran LP3, Pandey GK1.
- Critical reviews in biotechnology.Crit Rev Biotechnol.2016 Dec;36(6):1023-1035. Epub 2015 Sep 18.
- Protein phosphatases (PPs) counteract kinases in reversible phosphorylation events during numerous signal transduction pathways in eukaryotes. Type 2C PPs (PP2Cs) represent the major group of PPs in plants, and recent discovery of novel abscisic acid (ABA) receptors (ABARs) has placed the PP2Cs at t
- PMID 26380928
Japanese Journal
- (Pro)renin Receptor and Vacuolar H^+-ATPase
- ICHIHARA Atsuhiro
- Keio journal of medicine 61(3), 73-78, 2012-09-01
- … The (pro)renin receptor [(P)RR] is a molecule that binds prorenin and renin in tissues, leading not only to their activation, but also carrying out intracellular signaling. … V-ATPase is a multi-subunit proton pump involved in diverse and fundamental aspects of cellular physiology, including receptor-mediated endocytosis and recycling, processing of proteins and signaling molecules, membrane sorting and trafficking, and activation of lysosomal/autophagosomal enzymes. …
- NAID 10031117716
- (Pro)renin Receptor and Vacuolar H+−ATPase
- Ichihara Atsuhiro
- The Keio Journal of Medicine 61(3), 73-78, 2012
- … The (pro)renin receptor [(P)RR] is a molecule that binds prorenin and renin in tissues, leading not only to their activation, but also carrying out intracellular signaling. … V-ATPase is a multi-subunit proton pump involved in diverse and fundamental aspects of cellular physiology, including receptor-mediated endocytosis and recycling, processing of proteins and signaling molecules, membrane sorting and trafficking, and activation of lysosomal/autophagosomal enzymes. …
- NAID 130003366385
- The Inhibitory G Protein Gi Identified as Pertussis Toxin-Catalyzed ADP-Ribosylation
- Katada Toshiaki
- Biological and Pharmaceutical Bulletin 35(12), 2103-2111, 2012
- … Pertussis toxin (PTX) produced by Bordetella pertussis was first introduced by Ui and his colleagues in research on signal transduction under the name islet-activating protein in 1979, when the mechanism of toxin-induced stimulation of insulin release from pancreatic islets was reported in the rat. … The stimulatory effect of PTX in vivo results from the blockage of α2-adrenergic receptor-mediated inhibition of insulin release. …
- NAID 130002480519
Related Links
- 1. Crit Rev Toxicol. 1997 Mar;27(2):109-34. Aryl hydrocarbon receptor-mediated signal transduction. Rowlands JC, Gustafsson JA. The aryl hydrocarbon (or dioxin) receptor (AhR) is a ligand-activated basic helix-loop-helix ...
- Int J Biol Sci 2013; 9(5):435-443. doi:10.7150/ijbs.6087 Review The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases Jing Liang 1, Yan-Ling Wu 2 , Bing-Jia Chen 1, Wen Zhang 1 , Yoshimasa Tanaka 3, Hiroshi Sugiyama ...
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| 関連記事 | 「sign」「signaling」「mediate」「signal」 |
「sign」
- n.
「signaling」
- n.
「mediate」
- 仲介する、媒介する
「signal」
- n.