probucol

プロブコール


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/02/16 18:18:40」(JST)

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English Journal

  • Structural evaluation of probucol nanoparticles in water by atomic force microscopy.
  • Moribe K, Limwikrant W, Higashi K, Yamamoto K.SourceGraduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
  • International journal of pharmaceutics.Int J Pharm.2012 May 10;427(2):365-71. Epub 2012 Feb 20.
  • Structural evaluation of probucol nanoparticles coground with polyvinylpyrrolidone K17 and sodium dodecyl sulfate for 90min was performed by solid-state nuclear magnetic resonance (NMR) spectroscopy and atomic force microscopy (AFM) with force-distance curve analysis. The results of solid-state NMR
  • PMID 22370474
  • Development of a probucol-releasing antithrombogenic drug eluting stent.
  • Vedantham K, Chaterji S, Kim SW, Park K.SourceDepartment of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907.
  • Journal of biomedical materials research. Part B, Applied biomaterials.J Biomed Mater Res B Appl Biomater.2012 May;100(4):1068-77. doi: 10.1002/jbm.b.32672. Epub 2012 Feb 14.
  • The success of drug eluting stents (DESs) has been challenged by the manifestation of late stent thrombosis after DES implantation. The incomplete regeneration of the endothelial layer poststenting triggers adverse signaling processes precipitating in thrombosis. Various approaches have been attempt
  • PMID 22331580

Japanese Journal

  • ニコチン酸誘導体とプロブコール (特集 脂質異常症診療のエビデンスと将来展望) -- (脂質異常症の治療薬--エビデンスと選択基凖)
  • プロブコール-ポリビニルピロリドン固体分散体の安定性
  • 久保 儀忠,八木 直美,関川 彬
  • YAKUGAKU ZASSHI 131(4), 629-634, 2011
  • …   After solid dispersion systems of probucol-polyvinylpyrrolidone K30 (1 : 9 in weight ratio) were exposed to light (10000 lx) for 7 days, 84% of the probucol remained. … Commercial probucol fine granules were thus fairly stable under light exposure. … When these solid dispersion systems were dissolved in water, the probucol concentration decreased with the duration of storage. …
  • NAID 130000678844

Related Links

Probucol is used to lower levels of cholesterol (a fat-like substance) in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels. Probucol was available only with your doctor's ...
Probucol Drug Information from Drugs.com. Includes Probucol side effects, interactions and indications. ... Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter ...


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★リンクテーブル★
リンク元プロブコール

プロブコール」

  [★]

probucol
クラフェデンサクベルコートシンレスタールダウンオイールピヨコールフッコラートプロスエードライドラースロレルコワニール


  • 高脂血症治療薬
  • 家族性高コレステロール血症(FHホモ)にも適応可能
  • 黄色腫・動脈硬化巣の退縮作用がある
  • 強い抗酸化作用→酸化LDL産生を抑制
産生LDLの産生抑制により、マクロファージの貪食を抑制する→CETP活性亢進→コレステロールの逆転送活性化

薬理作用

  • 血症TG↓、血症TC↓
  • LDL受容体非依存的にLDL異化→胆汁への排泄作用↑
→家族性高コレステロール血症の適応となる

作用機序

副作用

CETP活性亢進による