多形性低悪性度腺癌
WordNet
- unrefined in character; "low comedy"
- an air mass of lower pressure; often brings precipitation; "a low moved in over night bringing sleet and snow" (同)depression
- a low level or position or degree; "the stock market fell to a new low"
- used of sounds and voices; low in pitch or frequency (同)low-pitched
- very low in volume; "a low murmur"; "the low-toned murmur of the surf" (同)low-toned
- in a low position; near the ground; "the branches hung low"
- less than normal in degree or intensity or amount; "low prices"; "the reservoir is low"
- literal meanings; being at or having a relatively small elevation or upward extension; "low ceilings"; "low clouds"; "low hills"; "the sun is low"; "low furniture"; "a low bow"
- level to the right gradient
- a relative position or degree of value in a graded group; "lumber of the highest grade" (同)level, tier
- the height of the ground on which something stands; "the base of the tower was below grade" (同)ground level
- a variety of cattle produced by crossbreeding with a superior breed
- the gradient of a slope or road or other surface; "the road had a steep grade"
- a degree of ablaut (同)gradation
- assign a grade or rank to, according to ones evaluation; "grade tests"; "score the SAT essays"; "mark homework" (同)score, mark
- determine the grade of or assign a grade to
- relating to the crystallization of a compound in two or more different forms; "polymorphous crystallization" (同)polymorphic
- arranged in a sequence of grades or ranks; "stratified areas of the distribution" (同)ranked, stratified
- British political cartoonist (born in New Zealand) who created the character Colonel Blimp (1891-1963) (同)David Low, Sir David Low, Sir David Alexander Cecil Low
PrepTutorEJDIC
- (高さ・位置が)『低い』,低い所にある / (価格・数量・程度などが)『低い』,少ない / (身分・地位などが)『低い』,卑しい / (人格・行為などが)『卑しい』,下劣な,下品な / 《補語にのみ用いて》(体が)『弱った』;元気のない,憂うつな / (供給が)不十分な;(…が)乏しい《+『in』(『on』)+『名』》 / (音・声が)低い,小さい / (生物が)下等な / 『低く』,低い所に / (価格・程度などが)『安く』,低く / 低い声(調子)で;静かに / 最低点,最低水準
- (牛の)モーという鳴き声 / (牛が)モーと鳴く
- 《米》(小・中・高校の)『学年』(小学校から12年まで通算する) / 《おもに米》(学業の)『成績』,評点 / (位階・品質・価値などの)『階級』,『等級』 / 《米》(道路・線路などの)傾斜,勾配(こうばい)(《英》gradient) / …‘を'『等級分けする』,‘の'格づけをする / 《米》…‘の'採点をする / 〈道路など〉‘の'勾配(こうばい)をゆるくする / 等級別になる,徐々に変わる,〈色彩などが〉次第に他の色に移る
- 多形の,多様な
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/28 23:03:31」(JST)
[Wiki en表示]
Polymorphous low-grade adenocarcinoma |
Low magnification micrograph of a polymorphous low-grade adenocarcinoma, showing the typical variation of architectural arrangement. H&E stain.
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Classification and external resources |
Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing malignant salivary gland tumor.[1] It is most commonly found in the palate.[2]
The name of the tumor derives from the fact that:
- It has a varied microscopic architectural appearance, i.e. it is polymorphous.
- It is non-aggressive when compared to other oral cavity tumors, i.e. it is a low-grade tumor.[1]
- It forms glands, i.e. it is an adenocarcinoma.
It is the second most common malignant tumor of the salivary glands, after Mucoepidermoid Carcinoma. It affects the minor salivary glands in the area between the hard and the soft palate. Male to female ratio is 3:1, and the average age is 56 years.
Contents
- 1 Histology
- 2 Treatment
- 3 Additional images
- 4 Additional reading
- 5 References
- 6 External links
Histology
Micrograph of a
polymorphous low-grade adenocarcinoma. H&E stain.
PLGAs consist of a monomorphous cell population that has a varied histologic morphology.
Microscopically, its histology can be confused with an adenoid cystic carcinoma and a pleomorphic adenoma.
Treatment
PLGAs are treated with wide local surgical excision and long-term follow-up.[2] There is a recurrence rate of 14% (Peterson, contemporary of oral and maxillofacial surgery).
Additional images
-
Polymorphous low-grade adenocarcinoma. H&E stain.
Additional reading
- Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.
References
- ^ a b Arathi N, Bage AM (2009). "Polymorphous low-grade adenocarcinoma of parotid gland: a rare occurrence". Indian J Pathol Microbiol 52 (1): 103–5. doi:10.4103/0377-4929.44985. PMID 19136798.
- ^ a b Paleri V, Robinson M, Bradley P (April 2008). "Polymorphous low-grade adenocarcinoma of the head and neck". Curr Opin Otolaryngol Head Neck Surg 16 (2): 163–9. doi:10.1097/MOO.0b013e3282f70441. PMID 18327037.
External links
- Polymorphous Low-Grade Adenocarcinoma (Head & Neck) Support
Tumors of lip, oral cavity and pharynx / head and neck cancer (C00–C14/D10–D11, 140–149/210)
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Oral cancer |
Salivary gland |
malignant epithelial tumors |
- Acinic cell carcinoma
- Mucoepidermoid carcinoma
- Adenoid cystic carcinoma
- Salivary duct carcinoma
- Epithelial-myoepithelial carcinoma
- Polymorphous low-grade adenocarcinoma
- Hyalinizing clear cell carcinoma
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benign epithelial tumors |
- Pleomorphic adenoma
- Warthin's tumor
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ungrouped: |
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Tongue |
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Index of the mouth
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Description |
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Disease |
- Congenital
- face and neck
- cleft
- digestive system
- Neoplasms and cancer
- Other
- Symptoms and signs
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Treatment |
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 頭頸部腫瘍の病理 pathology of head and neck neoplasms
- 2. 悪性唾液腺腫瘍:再発性および転移性疾患の治療 malignant salivary gland tumors treatment of recurrent and metastatic disease
English Journal
- Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin.
- Weinreb I1, Zhang L, Tirunagari LM, Sung YS, Chen CL, Perez-Ordonez B, Clarke BA, Skalova A, Chiosea SI, Seethala RR, Waggott D, Boutros PC, How C, Liu FF, Irish JC, Goldstein DP, Gilbert R, Ud Din N, Assaad A, Hornick JL, Thompson LD, Antonescu CR.
- Genes, chromosomes & cancer.Genes Chromosomes Cancer.2014 Oct;53(10):845-56. doi: 10.1002/gcc.22195. Epub 2014 Jun 18.
- Polymorphous low-grade adenocarcinoma (PLGA) and cribriform adenocarcinoma of minor salivary gland (CAMSG) are low-grade carcinomas arising most often in oral cavity and oropharynx, respectively. Controversy exists as to whether these tumors represent separate entities or variants of one spectrum, a
- PMID 24942367
- Head and Neck Pathology: SY13-3 HIGH-GRADE TRANSFORMATION IN SALIVARY GLAND CARCINOMAS.
- Nagao T.
- Pathology.Pathology.2014 Oct;46 Suppl 2:S20. doi: 10.1097/01.PAT.0000454116.19061.fd.
- High-grade transformation (HGT) has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous low-grade adenocarcinoma, myoepithelial carcinoma, low-grade mucoepidermoid carcinoma, hyalinizing
- PMID 25188090
- Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.
- Weinreb I1, Piscuoglio S2, Martelotto LG2, Waggott D3, Ng CK2, Perez-Ordonez B1, Harding NJ4, Alfaro J5, Chu KC4, Viale A6, Fusco N7, da Cruz Paula A8, Marchio C2, Sakr RA9, Lim R2, Thompson LD10, Chiosea SI11, Seethala RR11, Skalova A12, Stelow EB13, Fonseca I14, Assaad A15, How C16, Wang J4, de Borja R4, Chan-Seng-Yue M4, Howlett CJ17, Nichols AC17, Wen YH2, Katabi N2, Buchner N18, Mullen L18, Kislinger T19, Wouters BG19, Liu FF20, Norton L21, McPherson JD22, Rubin BP23, Clarke BA1, Weigelt B2, Boutros PC24, Reis-Filho JS25.
- Nature genetics.Nat Genet.2014 Sep 21. doi: 10.1038/ng.3096. [Epub ahead of print]
- Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activat
- PMID 25240283
Japanese Journal
- 耳下腺原発 Polymorphous low-grade adenocarcinoma 症例
- 小林 健二,成瀬 陽,原 寛 [他],中西 亮人,伏木 宏彰,渡辺 行雄
- 耳鼻咽喉科臨床. 補冊 = Practica otologica. Suppl. (134), 101-104, 2012-07-01
- NAID 10030774035
Related Links
- Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic,slow-growing malignant salivary gland tumor. It is most commonly found in the palate. The name of the tumor derives from the fact that: It has a varied ...
Related Pictures
★リンクテーブル★
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- polymorphous low-grade adenocarcinoma
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