The members of p90 ribosomal S6 kinase (RSK) family of Ser/Thr kinases are downstream effectors of MAPK/ERK pathway that regulate diverse cellular processes including cell growth, proliferation and survival. In carcinogenesis, RSKs are thought to modulate cell motility, invasion and metastasis. Here
Nucleic acids research.Nucleic Acids Res.2014 Nov 1;42(15):10037-49. doi: 10.1093/nar/gku652. Epub 2014 Aug 8.
Low-density lipoprotein receptor (LDLR) mRNA is unstable, but is stabilized upon extracellular signal-regulated kinase (ERK) activation, possibly through the binding of certain proteins to the LDLR mRNA 3'-untranslated region (UTR), although the detailed mechanism underlying this stability control i
Prostaglandin E2 induces retinoic acid receptor-β up-regulation through MSK1.
Fernández-Martínez AB1, Lucio Cazaña FJ2.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Sep;1843(9):1997-2004. doi: 10.1016/j.bbamcr.2014.05.013. Epub 2014 Jun 2.
The pharmacological modulation of putative renoprotective factors hypoxia-inducible factor-1α (HIF-1α) and HIF-1α-regulated vascular endothelial growth factor-A (VEGF-A) in the kidney has therapeutic interest. In human renal proximal tubular HK2 cells, prostaglandin E2 (PGE2) up-regulates HIF-1α
… RSK3, which belongs to the p90-S6K subfamily, was identified as a functional counterpart of Fpk1/2 in mammalian cells as the RSK3 gene functionally complemented the ISP-1-resistant phenotype of fpk1/2∆ cells. …
Expression and Activation of Mitogen-activated Protein Kinases in Matured Porcine Oocytes under Thermal Stress
YEN Shih-Ying,TSENG Jung-Kai,CHUANG Show-Mei,CHEN Shuen-Ei,JU Jyh-Cherng
Journal of Reproduction and Development, 2014
… When MII oocytes were heated, only the phosphorylated p38 levels relative to the total p38 levels decreased (P<0.01) after HS, but no clear relationship with HS treatments was observed in the ERK, JNK and p90rsk expressions of matured oocytes. …
Thank you for your enquiry. Based on sequence analysis of the immunogen, ab32114 RSK1 p90 antibody [E4] would not cross react with other RSK proteins RSK2, RSK3 or RSK4. However, I am sorry this has not been been