リボソームS6キナーゼ、リボソームタンパク質S6キナーゼ、S6リボソームキナーゼ、S6プロテインキナーゼ
- 関
- RSK、S6 kinase
WordNet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- the 19th letter of the Roman alphabet (同)s
- an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
- the basic unit of money in Papua New Guinea
PrepTutorEJDIC
- 蛋白(たんばく)質
- sulfurの化学記号 / {略}South[ern]
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/04/18 15:13:13」(JST)
[Wiki en表示]
Some of the signalling events involving rsk.
In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90rsk in humans, rsk 1-3. Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway. There are two known mammalian homologues of S6 Kinase: S6K1 and S6K2.
Contents
- 1 Substrates
- 2 Genomics
- 3 Proteomics
- 4 Research history
- 5 References
- 6 External links
Substrates
Rsk is named for ribosomal protein s6, part of the translational machinery, but several other substrates have been identified, including other ribosomal proteins. Cytosolic substrates of p90rsk include protein phosphatase 1; glycogen synthase kinase 3 (GSK3); L1 CAM, a neural cell adhesion molecule; Son of Sevenless, the Ras exchange factor; and Myt1, an inhibitor of cdc2.[1]
p90rsk also regulates transcription factors including cAMP response element-binding protein (CREB); estrogen receptor-α (ERα); IκBα/NF-κB; and c-Fos.[1]
Genomics
p90 Rsk-1 is located at 1p.[2]
p90 Rsk-2 is located at Xp22.2 and contains 22 exons. Mutations in this gene have been associated with Coffin-Lowry syndrome, a disease characterised by severe psychomotor retardation and other developmental abnormalities.[3]
p90 Rsk-3 is located at 6q27.[4]
Proteomics
The main distinguishing feature between p90rsk and p70rsk is that the 90 kDa family contain two non-identical kinase domains, while the 70 kDa family contain only one kinase domain.
Domain structure of rsk. Numbers refer to amino acid residues of p90 rsk-1 from rat.
[5]
Research history
Rsk was first identified in Xenopus laevis eggs by Erikson and Maller in 1985.[6]
References
- ^ a b Morten Frödin and Steen Gammeltoft. 1999. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Molecular and Cellular Endocrinology 151(1-2):Pages 65-77 (PMID 10411321 doi:10.1016/S0303-7207(99)00061-1 DOI)
- ^ GenBank, Entrez Gene
- ^ Online 'Mendelian Inheritance in Man' (OMIM) 300075
- ^ Y Zhao, C Bjørbaek, S Weremowicz, C C Morton, and D E Moller. 1993. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Mol Cell Biol. 15(8):4353–4363.
- ^ Based on figure 2 and 5 in Frödin and Gammeltoft, 1999.
- ^ Eleanor Erikson and James L. Maller. 1985. A Protein Kinase from Xenopus Eggs Specific for Ribosomal Protein S6. PNAS 82(3):742-746
External links
- Ribosomal Protein S6 Kinases, 90-kDa at the US National Library of Medicine Medical Subject Headings (MeSH)
- Ribosomal Protein S6 Kinases, 70-kDa at the US National Library of Medicine Medical Subject Headings (MeSH)
Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)
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Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)
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Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
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Polo kinase (EC 2.7.11.21) |
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Cyclin-dependent kinase (EC 2.7.11.22) |
- CDK1
- CDK2
- CDKL2
- CDK3
- CDK4
- CDK5
- CDKL5
- CDK6
- CDK7
- CDK8
- CDK9
- CDK10
- CDC2L5
- CRKRS
- PCTK1
- PCTK2
- PCTK3
- PFTK1
- CDC2L1
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(RNA-polymerase)-subunit kinase (EC 2.7.11.23) |
- RPS6KA5
- RPS6KA4
- P70S6 kinase
- P70-S6 Kinase 1
- RPS6KB2
- RPS6KA2
- RPS6KA3
- RPS6KA1
- RPS6KC1
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Mitogen-activated protein kinase (EC 2.7.11.24) |
- Extracellular signal-regulated
- MAPK1
- MAPK3
- MAPK4
- MAPK6
- MAPK7
- MAPK12
- MAPK15
- C-Jun N-terminal
- P38 mitogen-activated protein
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MAP3K (EC 2.7.11.25) |
- MAP kinase kinase kinases
- MAP3K1
- MAP3K2
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAP3K7
- MAP3K8
- RAFs
- MLKs
- MAP3K12
- MAP3K13
- MAP3K9
- MAP3K10
- MAP3K11
- MAP3K7
- ZAK
- CDC7
- MAP3K14
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Tau-protein kinase (EC 2.7.11.26) |
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(acetyl-CoA carboxylase) kinase (EC 2.7.11.27) |
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Tropomyosin kinase (EC 2.7.11.28) |
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29) |
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Receptor protein serine/threonine kinase (EC 2.7.11.30) |
- Bone morphogenetic protein receptors
- BMPR1
- BMPR1A
- BMPR1B
- BMPR2
- ACVR1
- ACVR1B
- ACVR1C
- ACVR2A
- ACVR2B
- ACVRL1
- Anti-Müllerian hormone receptor
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Dual-specificity kinases (EC 2.7.12)
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MAP2K |
- MAP2K1
- MAP2K2
- MAP2K3
- MAP2K4
- MAP2K5
- MAP2K6
- MAP2K7
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- Biochemistry overview
- Enzymes overview
- By EC (Enzyme Commission number): 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- The antidepressant-like effect of alarin is related to TrkB-mTOR signaling and synaptic plasticity.
- Zhuang F1, Li M2, Gao X2, Wang Y2, Wang D3, Ma X2, Ma T2, Gu S4.
- Behavioural brain research.Behav Brain Res.2016 Oct 15;313:158-71. doi: 10.1016/j.bbr.2016.06.057. Epub 2016 Jun 30.
- Alarin is a newly derived neuropeptide from a splice variant of the galanin-like peptide gene. We previously showed that alarin has an antidepressant-like effect by increasing the activity of the extracellular signal-regulated kinase (ERK) and protein kinase B (AKT) pathways, mediated by the tropomy
- PMID 27374162
- Different dietary energy intake affects skeletal muscle development through an Akt-dependent pathway in Dorper × Small Thin-Tailed crossbred ewe lambs.
- Zhao JX1, Liu XD1, Li K1, Liu WZ1, Ren YS1, Zhang JX2.
- Domestic animal endocrinology.Domest Anim Endocrinol.2016 Oct;57:63-70. doi: 10.1016/j.domaniend.2016.05.010. Epub 2016 May 27.
- The objective of this experiment was to investigate the mechanisms through which different levels of dietary energy affect postnatal skeletal muscle development in ewe lambs. Twelve Dorper × Small Thin-Tailed crossbred ewe lambs (100 d of age; 20 ± 0.5 kg BW) were selected randomly and divided i
- PMID 27565232
- Effects of dietary protein levels on the disease resistance, immune function and physical barrier function in the gill of grass carp (Ctenopharyngodon idella) after challenged with Flavobacterium columnare.
- Xu J1, Feng L2, Jiang WD2, Wu P2, Liu Y2, Jiang J2, Kuang SY3, Tang L3, Tang WN3, Zhang YA4, Zhou XQ5.
- Fish & shellfish immunology.Fish Shellfish Immunol.2016 Oct;57:1-16. doi: 10.1016/j.fsi.2016.08.024. Epub 2016 Aug 15.
- The effects of dietary protein levels on the disease resistance, gill immune function and physical barrier function of grass carp (Ctenopharyngodon idella) were investigated in this study. A total of 540 grass carp (264.11 ± 0.76 g) were fed six diets containing graded levels of protein (143.1,
- PMID 27539702
Japanese Journal
- Ferulic Acid Induces Mammalian Target of Rapamycin Inactivation in Cultured Mammalian Cells
- Bian Zehua,Furuya Norihiko,Zheng Dong-Mei [他]
- Biological & pharmaceutical bulletin 36(1), 120-124, 2013-01-00
- NAID 40019536185
- Relationship between ATM and Ribosomal Protein S6 Revealed by the Chemical Inhibition of Ser/Thr Protein Phosphatase Type 1
- LI Ying,MITSUHASHI Shinya,IKEJO Makoto [他],MIURA Nobuaki,KAWAMURA Takeshi,HAMAKUBO Takao,UBUKATA Makoto
- Bioscience, biotechnology, and biochemistry 76(3), 486-494, 2012-03-23
- … The optimal cellular responses to DNA damage are modulated by kinase and phosphatase. … The ataxia telangiectasia mutated (ATM) is a Ser/Thr kinase which is the core of the DNA damage signaling apparatus. … The Ser/Thr protein phosphatase type 1 (PP1) inhibitor, tautomycetin (TC) and an antibody to the phospho-(S/T)Q sites of the ATM substrate were used to identify the common substrates for PP1 and ATM in regulating the pathway for DNA damage response. …
- NAID 10030750481
Related Links
- This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell ...
- This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the ...
- Ribosomal protein s6 kinases; S6 Kinase. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is ...
Related Pictures
★リンクテーブル★
[★]
- 英
- ribosomal protein S6 kinase
- 関
- リボソームタンパク質S6キナーゼ、S6リボソームキナーゼ、S6プロテインキナーゼ、S6キナーゼ
[★]
- 英
- ribosomal protein S6 kinase、RSK
- 関
- リボソームS6キナーゼ、S6リボソームキナーゼ、S6プロテインキナーゼ、S6キナーゼ
[★]
- 英
- ribosomal protein S6 kinase
- 関
- リボソームタンパク質S6キナーゼ、リボソームS6キナーゼ、S6リボソームキナーゼ
[★]
- 英
- ribosomal protein S6 kinase
- 関
- リボソームタンパク質S6キナーゼ、リボソームS6キナーゼ、S6プロテインキナーゼ
[★]
リボソームタンパク質S6キナーゼ
- 関
- ribosomal protein S6 kinase
[★]
90-kDaリボソームS6キナーゼ
- MAPキナーゼで活性化される細胞内シグナリング酵素
- 関
- p90 ribosomal S6 kinase
[★]
70-kDaリボソームS6キナーゼ
- 翻訳調節に関与するリン酸化酵素
- 関
- p70 S6 kinase、p70S6K
[★]
- 関
- 肺区域
- 肺区域の一つ。下葉に属する。背側の中等度高位を占める。上-下葉区。S6に向かう気管支は前後軸に沿って背側に向かうため、胸部単純X線写真上 ○ が見える。
[★]
キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase
[★]
- 関
- ribosomally、ribosome
[★]
S6キナーゼ
- 関
- ribosomal protein S6 kinase
[★]