oxatomide

オキサトミド


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/23 18:35:08」(JST)

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English Journal

  • Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases.
  • Tobe M1, Tsuboi K2, Hasegawa F3, Fujiwara N2, Inoue Y2, Isobe M2, Isobe Y4.
  • Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2016 Feb 15;26(4):1292-5. doi: 10.1016/j.bmcl.2016.01.019. Epub 2016 Jan 8.
  • We have designed and efficiently synthesized novel 1-phenyl-6-aminouracils by replacing the chroman moiety in CX-659S, a nonsteroidal dermatologic candidate, with dimethyldihydrobenzofuranol to cancel CX-659S asymmetric center. Medicinal chemistry effort culminated in the discovery of 13d bearing a
  • PMID 26786694
  • The Contribution of National Spontaneous Reporting Systems to Detect Signals of Torsadogenicity: Issues Emerging from the ARITMO Project.
  • Raschi E1, Poluzzi E1, Salvo F2,3,4, Koci A1, Suling M5,6, Antoniazzi S2,7, Perina L1, Hazell L8, Moretti U9, Sturkenboom M10, Garbe E5, Pariente A2,3,4, De Ponti F11.
  • Drug safety.Drug Saf.2016 Jan;39(1):59-68. doi: 10.1007/s40264-015-0353-1.
  • INTRODUCTION: Spontaneous reporting systems (SRSs) are pivotal for signal detection, especially for rare events with a high drug-attributable component, such as torsade de pointes (TdP). Use of different national SRSs is rarely attempted because of inherent difficulties, but should be considered on
  • PMID 26446144
  • P2X7 receptor antagonist activity of the anti-allergic agent oxatomide.
  • Yoshida K1, Ito M2, Matsuoka I3.
  • European journal of pharmacology.Eur J Pharmacol.2015 Nov 15;767:41-51. doi: 10.1016/j.ejphar.2015.10.002. Epub 2015 Oct 16.
  • Activation of the P2X7 receptor by extracellular ATP is associated with various immune responses including allergic inflammation. Anti-allergic agents, such as H1-antihistamines, are known to inhibit the effects of different chemical mediators such as acetylcholine and platelet-activating factor. Th
  • PMID 26463039

Japanese Journal

  • Inverse Agonistic Activity of Antihistamines and Suppression of Histamine H_1 Receptor Gene Expression
  • Mizuguchi Hiroyuki,Ono Shohei,Hattori Masashi [他],FUKUI Hiroyuki
  • Journal of pharmacological sciences 118(1), 117-121, 2012-01-20
  • … Two inverse agonists (carebastine and mepyramine), but not the neutral antagonist oxatomide, decreased inositol phosphate accumulation. … The inverse agonists also decreased H1R gene expression and down-regulated H1R mRNA below basal expression, while basal H1R mRNA expression was maintained after oxatomide treatment. …
  • NAID 10030454416
  • Intact Cell Binding for In Vitro Prediction of Sedative and Non-sedative Histamine H_1-Receptor Antagonists Based on Receptor Internalization
  • Hishinuma Shigeru,Sato Yuko,Kobayashi Yusuke [他],KOMAZAKI Hiroshi,SAITO Masaki
  • Journal of pharmacological sciences 107(1), 66-79, 2008-05-20
  • … Displacement curves for sedative H<sub>1</sub>-receptor antagonists (diphenhydramine, chlorpheniramine, promethazine, ketotifen, azelastine and oxatomide) against [<sup>3</sup>H]mepyramine binding were not changed by histamine pretreatment. …
  • NAID 10024320504
  • 保険薬局における表計算ソフトMicrosoft Excel^[○!R]を用いた薬物血中濃度推移の簡易評価
  • 山本 佳久,鈴木 豊史,深水 啓朗,鎌野 衛,伴野 和夫
  • 医療薬学 33(6), 547-554, 2007-06-10
  • … We found that various drugs, such as aciclovir (Astric^[○!R] dry syrup), oseltamivir phosphate (Tamiflu^[○!R] dry syrup), clarithromycin (Clarith^[○!R] dry syrup), cefditoren pivoxil (Meiact MS^[○!R] fine granules), oxatomide (Celtect^[○!R] dry syrup) and procaterol hydrochloride (Meptin^[○!R] dry syrup), had characteristic concentration patterns that could be understood visually. …
  • NAID 110006290474

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oxatomide
アデコックアトピクトアレトンイワトミドオキサトーワオキサトミドオキロットガーランドスパクリットセキタールセルテクトセルトミドセルマレンデルトーマトーラスタンヒシレタンペペシンメクテクト
  • アレルギー性抗ヒスタミン薬

作用機序

薬理作用

動態

適応

注意

禁忌

  • 妊婦

副作用

  • 眠気、倦怠感、口渇

参考

  • ガーランド錠30mg
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