methylxanthine

メチルキサンチン


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/06/07 02:44:08」(JST)

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English Journal

  • Glucagon-Like Peptide 1 Stimulates Insulin Secretion via Inhibiting RhoA/ROCK Signaling and Disassembling Glucotoxicity-Induced Stress Fibers.
  • Kong X1, Yan D, Sun J, Wu X, Mulder H, Hua X, Ma X.
  • Endocrinology.Endocrinology.2014 Dec;155(12):4676-85. doi: 10.1210/en.2014-1314. Epub 2014 Sep 22.
  • Chronic hyperglycemia leads to pancreatic β-cell dysfunction characterized by diminished glucose-stimulated insulin secretion (GSIS), but the precise cellular processes involved are largely unknown. Here we show that pancreatic β-cells chronically exposed to a high glucose level displayed substant
  • PMID 25243854
  • X-box binding protein 1 is a novel key regulator of peroxisome proliferator-activated receptor γ2.
  • Cho YM1, Kwak SN, Joo NS, Kim DH, Lee AH, Kim KS, Seo JB, Jeong SW, Kwon OJ.
  • The FEBS journal.FEBS J.2014 Nov;281(22):5132-46. doi: 10.1111/febs.13052. Epub 2014 Oct 7.
  • X-box binding protein 1 (XBP1), a transcription factor of the unfolded protein response, plays various roles in many biological processes. We examined its pro-adipogenic activity and target genes during adipogenic differentiation in wild-type and genetically modified 3T3-L1 cells. Signalling pathwa
  • PMID 25223794
  • Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity.
  • Rouse M1, Younès A1, Egan JM2.
  • The Journal of endocrinology.J Endocrinol.2014 Nov;223(2):107-17. doi: 10.1530/JOE-14-0335.
  • Resveratrol (RES) and curcumin (CUR) are polyphenols that are found in fruits and turmeric, and possess medicinal properties that are beneficial in various diseases, such as heart disease, cancer, and type 2 diabetes mellitus (T2DM). Results from recent studies have indicated that their therapeutic
  • PMID 25297556

Japanese Journal

  • Prematurational Culture with 3-Isobutyl-1-methylxanthine Synchronizes Meiotic Progression of the Germinal Vesicle Stage and Improves Nuclear Maturation and Embryonic Development in In Vitro-grown Bovine Oocytes
  • HUANG Weiping,NAGANO Masashi,KANG Sung-Sik [他]
  • The journal of reproduction and development 60(1), 9-13, 2014-02
  • NAID 40019996986
  • Prematurational culture with 3-isobutyl-1-methylxanthine synchronizes meiotic progression of the germinal vesicle stage and improves nuclear maturation and embryonic development in in vitro-grown bovine oocytes.
  • Huang Weiping,Nagano Masashi,Kang Sung-Sik,Yanagawa Yojiro,Takahashi Yoshiyuki
  • The Journal of reproduction and development 60(1), 9-13, 2014-02
  • … The objective of this study was to clarify the effects of prematurational culture (pre-IVM) supplemented with 3-isobutyl-1-methylxanthine (IBMX) on nuclear and cytoplasmic maturation of in vitro-grown bovine oocytes. …
  • NAID 120005438261
  • Induction of Beige-Like Adipocytes in 3T3-L1 Cells
  • ASANO Hiroki,KANAMORI Yohei,HIGURASHI Satoshi,NARA Takayuki,KATO Ken,MATSUI Tohru,FUNABA Masayuki
  • Journal of Veterinary Medical Science 76(1), 57-64, 2014
  • … Iso-induced Ucp1 expression was significantly higher in the cells treated with a mixture of triiodothyronine (T3) and 3-isobutyl-1-methylxanthine (IBMX) for days 0–8 than in the control cells. …
  • NAID 130003391247

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Related Pictures

Most common methylxanthines. methylxanthine ,1zkl,1zkn,Is-化学物质Methylxanthines caffeine and theophylline Methylxanthines or methylated xanthines Raw Chocolate by Sacred Chocolate Figure 2: Methylxanthine structures of



★リンクテーブル★
リンク元メチルキサンチン」「中枢神経興奮薬
拡張検索isobutylmethylxanthine

メチルキサンチン」

  [★]

methylxanthine


概念

誘導体

構造

  • メチルキサンチン系

作用機序 (SPC.211)

  • 飲料として摂取した場合血中濃度は<50μM
血中濃度 作用
0.5-1.0mM [Ca2+]i
>50μM ホスホジエステラーゼの阻害
<50μM アデノシン受容体の拮抗
  • cAMP↑-(+cAMP)→ホルモン受容体↑、(+cAMP)βアドレナリン受容体↑
  • アデノシン受容体の非特異的拮抗、細胞内Ca2+遊離

薬理作用 (SPC.211,212)

  • 中枢作用   :眠気消失、知的活動↑、興奮、不眠、振戦、神経過敏、けいれん、胃腸障害
  • 心血管系作用 :陽性変力作用、陽性変時作用
  • 気管支拡張作用:気管支平滑筋の弛緩
  • 利尿作用
  • 高濃度:SRからCa2+を放出→骨格筋拘縮、胃酸分泌促進
  カフェイン テオフィリン テオブロミン
中枢作用
心血管系作用
気管支拡張作用
利尿作用

副作用

  • 肝臓で代謝されるので肝不全では中毒症状を呈する

中枢神経興奮薬」

  [★]

cerntral nervous system stimulant, CNS stimulant
中枢興奮薬
薬理学
  • 中枢神経系の機能を亢進する薬物の総称

中枢神経興奮薬

  • 覚醒アミン

isobutylmethylxanthine」

  [★]

イソブチルメチルキサンチン

IBMX