WordNet
- travel or traverse (a distance); "This car does 150 miles per hour"; "We did 6 miles on our hike every day"
- the syllable naming the first (tonic) note of any major scale in solmization (同)doh, ut
- proceed or get along; "How is she doing in her new job?"; "How are you making out in graduate school?"; "Hes come a long way" (同)fare, make_out, come, get along
- create or design, often in a certain way; "Do my room in blue"; "I did this piece in wood to express my love for the forest" (同)make
- carry on or function; "We could do with a little more help around here" (同)manage
- get (something) done; "I did my job" (同)perform
- treat with an agent; add (an agent) to; "The ray dosed the paint"
- the quantity of an active agent (substance or radiation) taken in or absorbed at any one time (同)dosage
- a measured portion of medicine taken at any one time (同)dosage
- the largest possible quantity (同)upper_limit
- the point on a curve where the tangent changes from positive on the left to negative on the right
- a saying that is widely accepted on its own merits (同)axiom
- treated with some kind of application; "a mustache dosed with bear grease"
PrepTutorEJDIC
- 《疑問文・否定文を作る》 / 《否定命令文を作る》 / 《助動詞とbe動詞のどちらも含まない文に用いて付加疑問を作る》 / 《強意語として》 / 《文》《助動詞とbe動詞のどちらも含まない文に用いて倒置文を作る》 / 《あいづちを打つ場合に》 / 《先行する動詞またはそれを含む述部の代用》 / 《so,nor,neitherで始まる簡略文で》 / …‘を'『する』,行う,果たす / 《通例have done,時にbe doneの形で》…‘を'『終える』,済ませる / …‘を'作る,作り出す / …‘を'『処理する』,整える,片付ける / 〈学課〉‘を'『勉強する』,専攻する / 〈利益・害など〉‘を'与える,もたらす / 〈人〉‘に'『役立つ』,用が足りる(serve) / …の速度で進む,距離を行く / …‘を'見物する / 〈劇〉‘を'上演する;…‘の'役を演じる / …の役目(仕事)をする / 《おもに英》…‘を'だます,かつぐ / 《話》…をへとへとにさせる / 『する』;活動する / 《通例have done,時にbe doneの形で》(…を)『終える』,済ます《+『with』+『名』》 / 〈事が〉『運ぶ』;〈人が〉暮らしていく,健康である / 〈物が〉(…に)『間に合う』,十分である;〈人が〉(…に)役に立つ,向く《+『for』+『名』》 / 《複数形で》すべきこと / 〈C〉《おもに英》大宴会,大パーティー / 〈C〉《英話》詐欺,ぺてん
- ド(全音階の第1音)
- (おもに飲み薬1回分の)『服用量』 / (痛いこと・いやなことの)1回分,一定量 / (人などが受ける放射線の)線量 / 性病 / (…を)…‘に'投薬する,服用させる《+『名』+『with』+『名』》
- (量・数・程度の)『最大限』 / (数学で)極大;最大値;極大点 / 最高の,最大の
- 格言,金言,処世訓
UpToDate Contents
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- 1. ループ利尿剤：最大有効量および主な副作用 loop diuretics maximum effective dose and major side effects
- 2. コリスチン：概要 colistin an overview
- 3. アシクロビル：概要 acyclovir an overview
- 4. ピラジンアミド：概要 pyrazinamide an overview
- 5. 乳児および小児における低血糖に対するアプローチ approach to hypoglycemia in infants and children
English Journal
- Paclitaxel nanosuspensions for targeted chemotherapy - nanosuspension preparation, characterization, and use.
- Lee SE, Bairstow SF, Werling JO, Chaubal MV, Lin L, Murphy MA, Diorio JP, Gass J, Rabinow B, Wang X, Zhang Y, Yang Z, Hoffman RM.Author information Baxter Healthcare Corporation , Round Lake, IL , USA and.AbstractAbstract Objective: The purpose of this work was to prepare a stable paclitaxel nanosuspension and test it for potential use as a targeted chemotherapeutic. Different particle coatings were employed to assess their impact on cellular uptake in vitro. In vivo work was then performed to demonstrate efficacy in tumor-bearing mouse models. Materials and method: Paclitaxel nanosuspensions were prepared using a homogenization process and coated with excipients. Surface charge was measured by zeta potential, potency by high-performance liquid chromatography, and solubility using an in-line UV probe. Cellular uptake studies were performed via flow cytometry. In vivo experiments were performed to determine residence time, maximum tolerated dose, and the efficacy of paclitaxel nanosuspensions (Paclitaxel-NS). Results: A stable paclitaxel nanosuspension was prepared and coated with various excipients. Studies in mice showed that the nanosuspension was well-tolerated and at least as effective as the IV Taxol control in prolonging mouse survival in a head and neck cancer model as well as an ovarian cancer model with a lower overall drug dose than the traditional IV administration route. Conclusions: The paclitaxel nanosuspension is suitable for cellular uptake. The nanosuspension was effective in prolonging life in two separate xenograft orthotopic murine cancer models through two separate routes of administration.
- Pharmaceutical development and technology.Pharm Dev Technol.2014 Jun;19(4):438-53. doi: 10.3109/10837450.2013.789911. Epub 2013 Apr 25.
- Abstract Objective: The purpose of this work was to prepare a stable paclitaxel nanosuspension and test it for potential use as a targeted chemotherapeutic. Different particle coatings were employed to assess their impact on cellular uptake in vitro. In vivo work was then performed to demonstrate ef
- PMID 23617261
- Sinoporphyrin sodium: a novel sensitizer in sonodynamic therapy.
- Hu J, Wang X, Zhang K, Wang P, Su X, Li Y, Huang Z, Liu Q.Author information Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, Ministry of Education, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Shaanxi, China.AbstractThe aim of this paper was to investigate whether sinoporphyrin sodium (DVDMS) could be a novel sonosensitizer in sonodynamic therapy. We used two kinds of leukemia cells (K562, U937) as main tumor cell models and cells (peripheral blood mononuclear cells, spleen lymphocytes) separated from healthy ICR mice as normal cell models. The multivolume spectrophotometer system and fluorescence spectrophotometer were used to determine the spectral characteristics of DVDMS. The uptake of DVDMS by tumor cells and normal cells was measured by flow cytometry. The MTT assay was used to examine the cytotoxicity and sonotoxicity of DVDMS. The absorption spectra showed that DVDMS had five distinct peaks at 359, 514, 548, 580, and 631 nm, respectively, and the maximum peak was at ∼359 nm. The fluorescence emission spectra showed that DVDMS fluorescence emission was at 642 nm. DVDMS showed an advantage of quick cellular uptake and selectively accumulated in tumor cells compared with normal healthy cells. The cytotoxicity of DVDMS by the MTT method was dose dependent, and DVDMS had little cytotoxicity to normal cells. The sonotoxicity of DVDMS showed that in the presence of DVDMS, under appropriate conditions, the cell-damaging effect of ultrasound was significantly enhanced. The present study showed that the newly synthesized sensitizer, DVDMS, under appropriate experiment conditions, can act as a potential sonosensitizer for tumors in sonodynamic therapy.
- Anti-cancer drugs.Anticancer Drugs.2014 Feb;25(2):174-82. doi: 10.1097/CAD.0000000000000031.
- The aim of this paper was to investigate whether sinoporphyrin sodium (DVDMS) could be a novel sonosensitizer in sonodynamic therapy. We used two kinds of leukemia cells (K562, U937) as main tumor cell models and cells (peripheral blood mononuclear cells, spleen lymphocytes) separated from healthy I
- PMID 24100280
- Interaction between serum BDNF and aerobic fitness predicts recognition memory in healthy young adults.
- Whiteman AS1, Young DE2, He X3, Chen TC3, Wagenaar RC4, Stern CE1, Schon K5.Author information 1Department of Psychology and Center for Memory & Brain, Boston University, 2 Cummington Mall, Boston, MA 02215, USA.2Exercise and Health Sciences Department, College of Nursing and Health Sciences, University of Massachusetts Boston, 100 Morrissey Blvd., Boston, MA 02125, USA.3Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA.4Sargent College of Health and Rehabilitation Sciences, Boston University, 635 Commonwealth Avenue, Boston, MA 02215, USA.5Department of Psychology and Center for Memory & Brain, Boston University, 2 Cummington Mall, Boston, MA 02215, USA; Department of Anatomy and Neurobiology, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA. Electronic address: kschon@bu.edu.AbstractConvergent evidence from human and non-human animal studies suggests aerobic exercise and increased aerobic capacity may be beneficial for brain health and cognition. It is thought growth factors may mediate this putative relationship, particularly by augmenting plasticity mechanisms in the hippocampus, a brain region critical for learning and memory. Among these factors, glucocorticoids, brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF), hormones that have considerable and diverse physiological importance, are thought to effect normal and exercise-induced hippocampal plasticity. Despite these predictions, relatively few published human studies have tested hypotheses that relate exercise and fitness to the hippocampus, and none have considered the potential links to all of these hormonal components. Here we present cross-sectional data from a study of recognition memory; serum BDNF, cortisol, IGF-1, and VEGF levels; and aerobic capacity in healthy young adults. We measured circulating levels of these hormones together with performance on a recognition memory task, and a standard graded treadmill test of aerobic fitness. Regression analyses demonstrated BDNF and aerobic fitness predict recognition memory in an interactive manner. In addition, IGF-1 was positively associated with aerobic fitness, but not with recognition memory. Our results may suggest an exercise adaptation-related change in the BDNF dose-response curve that relates to hippocampal memory.
- Behavioural brain research.Behav Brain Res.2014 Feb 1;259:302-12. doi: 10.1016/j.bbr.2013.11.023. Epub 2013 Nov 21.
- Convergent evidence from human and non-human animal studies suggests aerobic exercise and increased aerobic capacity may be beneficial for brain health and cognition. It is thought growth factors may mediate this putative relationship, particularly by augmenting plasticity mechanisms in the hippocam
- PMID 24269495
Japanese Journal
- Measurements of Individual Radiation Doses in Residents Living Around the Fukushima Nuclear Power Plant
- Nagataki Shigenobu,Takamura Noboru,Kamiya Kenji,Akashi Makoto
- Radiation Research 180(5), 439-447, 2013-11
- … The individual external radiation doses, determined by a behavior survey in the "evacuation and deliberate evacuation area" in the first 4 months, were <5 mSv in 97.4% of residents (maximum: 15 mSv). … External doses in Fukushima City determined by personal dosimeters were <1 mSv/3 months (September-November, 2011) in 99.7% of residents (maximum: 2.7 mSv). …
- NAID 120005353321
- Contribution of tap water to chlorate and perchlorate intake: A market basket study
- Asami Mari,Yoshida Nobue,Kosaka Koji,Ohno Koichi,Matsui Yoshihiko
- Science of The Total Environment 463, 199-208, 2013-10-01
- … For perchlorate, daily intake from water was 0.7 (0.1-4.4) mu g/day, which is not high compared to the average total intake of 14 (2.5-84) mu g/day, while the reference dose (RfD) is 35 mu g/day and the provisional maximum tolerable daily intake (PMTDI) is 500 mu g/day for body weight of 50 kg. …
- NAID 120005350095
- Influence of Acidosis on Cardiotonic Effects of Colforsin and Epinephrine: A Dose-Response Study
- Hagiya Keiichi,Takahashi Hiroshi,Isaka Yumi,Inomata Shinichi,Tanaka Makoto,高橋 宏,猪股 伸一,田中 誠
- Journal of cardiothoracic and vascular anesthesia 27(5), 925-932, 2013-10
- … The hearts were assigned randomly to the control (pH 7.4), mild acidosis (pH 7.0), or severe acidosis (pH 6.6) group (n = 8 per group) and were perfused continuously with colforsin 10−7, 10−6, and 10−5 mol/L.Measurements and Main ResultsMaximum dP/dt was determined, and the concentration-response relation was evaluated at each pH. Colforsin at 10−6 mol/L increased the maximum dP/dt from 2,592 ± 557 to 5,189 ± 721 mmHg/s (p < …
- NAID 120005345618
Related Links
- 世界大百科事典 第2版 - maximum doseの用語解説 - 中毒量は物質によって異なり，ごく微量で中毒作用を起こすものから，相当多量に用いなければ作用を現さないものまである。医薬品の場合には〈極量maximum dose〉といって，それ ...
- "maximum dose" への豊富な翻訳例文 – 和英辞書と日本語翻訳サーチエンジン ... 試験は薬剤の少なくとも二回投与する必要があります、1つ は推 奨 最大用 量 で ある 、ケースなどの別の 用量 は、 傷害が発生しない場合、1.5〜2倍の推奨 ...
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★リンクテーブル★
| リンク元 | 「極量」「最高用量」「最大投与量」「最高投与量」「maximal dose」 |
| 関連記事 | 「maximum」「do」「dose」「dosing」 |
「極量」
「最高用量」
- 英
- maximum dose
- 関
- 極量、最大投与量、最高投与量
「最大投与量」
- 英
- maximum dose
- 関
- 極量、最高投与量、最高用量
「最高投与量」
- 英
- maximum dose
- 関
- 極量、最大投与量、最高用量
「maximal dose」
「maximum」
- n.
「do」
- v.
- する、行う
「dose」
- n.
「dosing」
- n.