WordNet
- enter (data or a program) into a computer
- a component of production; something that goes into the production of output
- a card or badge used to identify the bearer; "you had to show your ID in order to get in" (同)I.D.
- travel or traverse (a distance); "This car does 150 miles per hour"; "We did 6 miles on our hike every day"
- the syllable naming the first (tonic) note of any major scale in solmization (同)doh, ut
- proceed or get along; "How is she doing in her new job?"; "How are you making out in graduate school?"; "Hes come a long way" (同)fare, make_out, come, get along
- create or design, often in a certain way; "Do my room in blue"; "I did this piece in wood to express my love for the forest" (同)make
- carry on or function; "We could do with a little more help around here" (同)manage
- get (something) done; "I did my job" (同)perform
- take by injection; "inject heroin"
- give an injection to; "We injected the glucose into the patients vein" (同)shoot
- to introduce (a new aspect or element); "He injected new life into the performance"
- force or drive (a fluid or gas) into by piercing; "inject hydrogen into the balloon" (同)shoot
- feed intravenously
- treat with an agent; add (an agent) to; "The ray dosed the paint"
- the quantity of an active agent (substance or radiation) taken in or absorbed at any one time (同)dosage
- a measured portion of medicine taken at any one time (同)dosage
- treated with some kind of application; "a mustache dosed with bear grease"
PrepTutorEJDIC
- 投入,投入量 / (機械・電気)などの入力 / インプット(電子計算機の入力)
- 〈C〉《通例a~》1回分の投薬量 / 〈U〉《まれ》投薬
- 《疑問文・否定文を作る》 / 《否定命令文を作る》 / 《助動詞とbe動詞のどちらも含まない文に用いて付加疑問を作る》 / 《強意語として》 / 《文》《助動詞とbe動詞のどちらも含まない文に用いて倒置文を作る》 / 《あいづちを打つ場合に》 / 《先行する動詞またはそれを含む述部の代用》 / 《so,nor,neitherで始まる簡略文で》 / …‘を'『する』,行う,果たす / 《通例have done,時にbe doneの形で》…‘を'『終える』,済ませる / …‘を'作る,作り出す / …‘を'『処理する』,整える,片付ける / 〈学課〉‘を'『勉強する』,専攻する / 〈利益・害など〉‘を'与える,もたらす / 〈人〉‘に'『役立つ』,用が足りる(serve) / …の速度で進む,距離を行く / …‘を'見物する / 〈劇〉‘を'上演する;…‘の'役を演じる / …の役目(仕事)をする / 《おもに英》…‘を'だます,かつぐ / 《話》…をへとへとにさせる / 『する』;活動する / 《通例have done,時にbe doneの形で》(…を)『終える』,済ます《+『with』+『名』》 / 〈事が〉『運ぶ』;〈人が〉暮らしていく,健康である / 〈物が〉(…に)『間に合う』,十分である;〈人が〉(…に)役に立つ,向く《+『for』+『名』》 / 《複数形で》すべきこと / 〈C〉《おもに英》大宴会,大パーティー / 〈C〉《英話》詐欺,ぺてん
- ド(全音階の第1音)
- (…に)〈液体など〉‘を'注射する,注入する《+『名』+『into』+『名』》;(…を)…‘に'注射する《+『名』+『with』+『名』》 / (話などに)…‘を'動入する,さしはさむ《+『名』+『into』+『名』》
- (おもに飲み薬1回分の)『服用量』 / (痛いこと・いやなことの)1回分,一定量 / (人などが受ける放射線の)線量 / 性病 / (…を)…‘に'投薬する,服用させる《+『名』+『with』+『名』》
UpToDate Contents
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- 1. Prevention of lethal opioid overdose in the community
- 2. 産婦人科における硬膜外・脊椎麻酔の副作用 adverse effects of neuraxial analgesia and anesthesia for obstetrics
- 3. インスリン低血糖試験 insulin induced hypoglycemia test
- 4. 負荷時の放射性核種心筋血流イメージングの概要 overview of stress radionuclide myocardial perfusion imaging
- 5. 胸部PET thoracic positron emission tomography
English Journal
- Dualistic evolution of liver damage in mice triggered by a single sublethal exposure to Microcystin-LR.
- Mattos LJ1, Valença SS2, Azevedo SM1, Soares RM3.Author information 1Laboratory of Ecophysiology and Toxicology of Cyanobacteria, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.2Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.3Laboratory of Ecophysiology and Toxicology of Cyanobacteria, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Federal University of Rio de Janeiro, Campus Xerem, Duque de Caxias, Rio de Janeiro, Brazil. Electronic address: rmsoares@xerem.ufrj.br.AbstractMicrocystins (MCYST) are the most frequently reported cyanotoxins in human poisoning incidents. Despite the well-described mechanism of acute and lethal injury, the sublethal effects of this toxin require further investigation. The aim of this study was to contribute to the knowledge of the variant MCYST-LR effects at sublethal doses by investigating biochemical changes and tissue damage in a murine model. For this purpose, mice were intraperitoneally injected with 45 μg of MCYST-LR/kg body weight. Their organs were collected at 2, 8, 24, 48 or 96 h after injection. Control animals received saline solution. We detected oxidative imbalance in the liver, particularly at 8 h after exposure. Furthermore, biomarkers of liver injury were detected in high concentration in the serum of the exposed animals. Stereological analyses of the liver indicated two different phases in the intoxication process: an initial phase characterized by an increase in steatosis was followed by a second, later phase characterized by increased inflammation and hepatocyte binucleation. Formation of areas of necrosis and increased blood vessel diameter were observed throughout the experimental period. The number of hepatocytes per area unit also decreased. However, these parameters recovered over the period of exposure. MCYST accumulated in liver and was detectable until the end of the monitoring period. These results confirm the necessity for further studies of processes involved in sublethal exposure to MCYST.
- Toxicon : official journal of the International Society on Toxinology.Toxicon.2014 Jun;83:43-51. doi: 10.1016/j.toxicon.2014.02.015. Epub 2014 Mar 1.
- Microcystins (MCYST) are the most frequently reported cyanotoxins in human poisoning incidents. Despite the well-described mechanism of acute and lethal injury, the sublethal effects of this toxin require further investigation. The aim of this study was to contribute to the knowledge of the variant
- PMID 24593963
- Advanced cancer therapy by integrative antitumor actions via systemic administration of miR-499.
- Ando H1, Asai T1, Koide H2, Okamoto A1, Maeda N3, Tomita K3, Dewa T4, Minamino T5, Oku N6.Author information 1Department of Medical Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.2Department of Medical Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan; University of California Irvine, Irvine 92697, USA.3Nippon Fine Chemical Co. Ltd., 5-1-1 Umei, Takasago, Hyogo 676-0074, Japan.4Department of Life and Materials Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan.5Department of Cardiovascular Medicine, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.6Department of Medical Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address: oku@u-shizuoka-ken.ac.jp.AbstractPreviously, we developed tetraethylenepentamine-based polycation liposomes (TEPA-PCL) as a vector for the delivery of small RNAs. In the present research, we attempted tumor-targeted delivery of miR-499 via systemic administration and evaluated the potency of this system as a therapeutic strategy to treat cancer. Lipoplexes were formed by mixing cholesterol-grafted miR-499 (miR-499-C) with TEPA-PCL. Firstly, human umbilical endothelial cells (HUVECs) and Colon 26 NL-17 mouse carcinoma cells were transfected with these lipoplexes in vitro. The results showed that miR-499 had antiangiogenic effects on the HUVECs and suppressed the secretion of vascular endothelial growth factor (VEGF) from the Colon 26 NL-17 cells. In addition, the growth of the latter cells was inhibited by transfection with miR-499-C/TEPA-PCL. For in vivo delivery of miR-499 to tumors via systemic injection, miR-499-C/TEPA-PCL were decorated with Ala-Pro-Arg-Pro-Gly (APRPG) peptide-conjugated polyethylene glycol (PEG) to prepare APRPG-PEG-modified lipoplexes carrying miR-499 (APRPG-miR-499). APRPG-miR-499 were injected into tumor-bearing mice via a tail vein, and these lipoplexes accumulated sufficiently in both angiogenic vessels and cancer cells. In addition, the expression of miR-499-target proteins and VEGF in the tumor cells was clearly suppressed by the treatment with APRPG-miR-499. Finally, the therapeutic effect of miR-499 on tumor growth was evaluated in mice. The tumor growth was significantly inhibited by the intravenous injection of APRPG-miR-499 at such a low dose as 0.5mg/kg. These results suggest that miR-499 delivered by the present system has excellent potency to treat cancer via integrative anticancer actions.
- Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2014 May 10;181:32-9. doi: 10.1016/j.jconrel.2014.02.019. Epub 2014 Mar 2.
- Previously, we developed tetraethylenepentamine-based polycation liposomes (TEPA-PCL) as a vector for the delivery of small RNAs. In the present research, we attempted tumor-targeted delivery of miR-499 via systemic administration and evaluated the potency of this system as a therapeutic strategy to
- PMID 24593893
- Forced swim stress but not exogenous corticosterone could induce the reinstatement of extinguished morphine conditioned place preference in rats: Involvement of glucocorticoid receptors in the basolateral amygdala.
- Karimi S1, Attarzadeh-Yazdi G1, Yazdi-Ravandi S2, Hesam S2, Azizi P2, Razavi Y3, Haghparast A4.Author information 1Molecular Medicine Research Centre, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.2Neuroscience Research Center, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, P.O. Box 19615-1178, Tehran, Iran.3Neurobiology Research Center, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.4Neuroscience Research Center, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, P.O. Box 19615-1178, Tehran, Iran; Neurobiology Research Center, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Haghparast@yahoo.com.AbstractAddiction is a common psychiatric disease and stress has an important role in the drug seeking and relapse behaviors. The involvement of basolateral amygdala (BLA) in the effects of stress on reward pathway is discussed in several studies. In this study, we tried to find out the involvement of glucocorticoid receptors (GRs) in the BLA in stress-induced reinstatement of extinguished morphine-induced conditioned place preference (CPP) in rats. The CPP paradigm was done in adult male Wistar rats weighing 220-320g, and conditioning score and locomotor activity were recorded by Ethovision software. Animals received effective dose of morphine (5mg/kg) daily, during the 3-day conditioning phase. In extinction phase, rats were put in the CPP box for 30min a day for 8 days. After extinction, animals were injected by corticosterone (10m/kg) or exposed to forced swim stress (FSS) 10min before subcutaneous administration of ineffective dose of morphine (0.5mg/kg) in order to reinstate the extinguished morphine-CPP. To block the glucocorticoid receptors in the BLA, after stereotaxic surgery and placing two cannulae in this area bilaterally, animals received GR antagonist mifepristone (RU38486; 0.3, 3 and 30ng/0.3μl DMSO per side) prior to exposure to FSS then each animal received ineffective dose of morphine (0.5mg/kg) as drug-induced reinstatement. The results revealed that physical stress (FSS) but not exogenous corticosterone can significantly induce reinstatement of extinguished morphine-CPP, and intra-BLA mifepristone prevents the stress-induced reinstatement. It can be proposed that stress partially exerts its effect on the reward pathway via glucocorticoid receptors in the BLA.
- Behavioural brain research.Behav Brain Res.2014 May 1;264:43-50. doi: 10.1016/j.bbr.2014.01.045. Epub 2014 Feb 5.
- Addiction is a common psychiatric disease and stress has an important role in the drug seeking and relapse behaviors. The involvement of basolateral amygdala (BLA) in the effects of stress on reward pathway is discussed in several studies. In this study, we tried to find out the involvement of gluco
- PMID 24508237
Japanese Journal
- A novel drug delivery system of intraperitoneal chemotherapy for peritoneal carcinomatosis using gelatin microspheres incorporating cisplatin.
- Gunji Shutaro,Obama Kazukata,Matsui Makoto,Tabata Yasuhiko,Sakai Yoshiharu
- Surgery 154(5), 991-999, 2013-11-00
- … For the treatment of peritoneal carcinomatosis with high-dose CDDP, it is necessary to design a new delivery system of CDDP that can decrease systemic toxicity and achieve a better targeted, high-dose chemotherapy. … The gelatin microspheres incorporating CDDP (GM-CDDP) were injected intraperitoneally into a mouse model of peritoneal carcinomatosis; …
- NAID 120005347135
- Consecutive Acquisition of Time-resolved Contrast-enhanced MR Angiography and Perfusion MR Imaging with Added Dose of Gadolinium-based Contrast Agent Aids Diagnosis of Suspected Brain Metastasis
- TSUCHIYA Kazuhiro,AOKI Shigeki,SHIMOJI Keigo,MORI Harushi,KUNIMATSU Akira
- Magnetic Resonance in Medical Sciences, 2013
- … When findings were negative or equivocal, we injected an additional 0.1-mmol/kg dose of gadoteridol and obtained PWI and second postcontrast T1-weighted images. …
- NAID 130003366413
- Effects of Intracerebroventricularly Administered Carbetocin on Social Behavior in Holstein Steers
- YAYOU Ken-ichi,ITO Shuichi,KASUYA Etsuko,SUTOH Madoka,YAMAMOTO Naoyuki
- Journal of Veterinary Medical Science, 2013
- … In the first experiment, we determined the dose response of intracerebroventricularly administered CBT (0.5, 5 or 50 nmol) on plasma cortisol level and behavior using 7 steers aged from 6 to 10 months. … CBT (50 or 200 nmol/200μl) in artificial cerebrospinal fluid (aCSF) or aCSF (200 μl) was injected into the third ventricle. …
- NAID 130003362192
Related Links
- Definition of Injected Dose per Gram of Tissue in the list of acronyms and abbreviations provided by the Free Online Dictionary and Thesaurus. Printer Friendly Dictionary, Encyclopedia and Thesaurus - The Free Dictionary forum ? ...
- ID,Injected Dose,injection dose,injected doses,injection doses,injections dose,injecting doses,injectable doses,injections Doses,injection dosing Injected Dose - ID Publications: 1,123 | Citation Count: 10,491 injection dose (1123) ...
Related Pictures
![[Full text] Ultrastructural localization of intravenously injected carbon nanohorn | IJN](https://1mg.info/0/k/t/1137.jpg)
★リンクテーブル★
| リンク元 | 「投与量」「dosage」「input」「ID」「注入量」 |
| 関連記事 | 「inject」「do」「dose」「dosing」 |
「投与量」
「dosage」
「input」
「ID」
- n.
「注入量」
- 英
- injected dose、ID
- 関
- 投与量、身分証明
「inject」
- v.
- 注射する、注入する、インジェクトする
「do」
- v.
- する、行う
「dose」
- n.
「dosing」
- n.