接合因子受容体、接合因子レセプター、交配因子受容体、交配因子レセプター
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- =sense organ / 受信装置
UpToDate Contents
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English Journal
- Detection of ligand-receptor binding using microfluidic frontal affinity chromatography on proteoliposomes derived directly from native cell membranes.
- Olesen K, Karlsson R, Lind U, Davidson M, Blomberg A, Karlsson A.Author information Nanoxis Consulting AB, Lennart Torstenssongatan 5, Gothenburg SE-400 16, Sweden.AbstractA method for characterization of ligand binding to membrane receptors in their native cell membrane is presented. The methodology is based on microfluidic frontal affinity chromatography coupled to mass spectrometry (FAC-MS). Proteoliposomes with receptor of interest are prepared directly from cell membranes and serve as a stationary phase in a microfluidic flow cell for frontal analysis. The G-Protein-Coupled Receptor (GPCR) Ste2 involved in the pheromone-induced yeast mating pathway is used as a model receptor for proof of principle characterization. The ligand affinity of the natural pheromone peptide, the α-factor, is compared to a set of pheromone analogs having different receptor affinities. With short preparation time, preserved lipid composition and the ability to immobilize proteoliposomes from any cell membrane, we propose that our methodology with immobilized proteoliposomes together with microfluidics FAC-MS can be an important improvement for ligand-receptor studies in native membranes.
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2013 Jul 15;931:84-9. doi: 10.1016/j.jchromb.2013.05.010. Epub 2013 May 22.
- A method for characterization of ligand binding to membrane receptors in their native cell membrane is presented. The methodology is based on microfluidic frontal affinity chromatography coupled to mass spectrometry (FAC-MS). Proteoliposomes with receptor of interest are prepared directly from cell
- PMID 23770737
- Functional and physical interactions among Saccharomyces cerevisiae α-factor receptors.
- Gehret AU, Connelly SM, Dumont ME.Author information Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.AbstractThe α-factor receptor Ste2p is a G protein-coupled receptor (GPCR) expressed on the surface of MATa haploid cells of the yeast Saccharomyces cerevisiae. Binding of α-factor to Ste2p results in activation of a heterotrimeric G protein and of the pheromone response pathway. Functional interactions between α-factor receptors, such as dominant-negative effects and recessive behavior of constitutive and hypersensitive mutant receptors, have been reported previously. We show here that dominant-negative effects of mutant receptors persist over a wide range of ratios of the abundances of G protein to receptor and that such effects are not blocked by covalent fusion of G protein α subunits to normal receptors. In addition, we detected dominant effects of mutant C-terminally truncated receptors, which had not been previously reported to act in a dominant manner. Furthermore, coexpression of C-terminally truncated receptors with constitutively active mutant receptors results in enhancement of constitutive signaling. Together with previous evidence for oligomerization of Ste2p receptors, these results are consistent with the idea that functional interactions between coexpressed receptors arise from physical interactions between them rather than from competition for limiting downstream components, such as G proteins.
- Eukaryotic cell.Eukaryot Cell.2012 Oct;11(10):1276-88. doi: 10.1128/EC.00172-12. Epub 2012 Aug 24.
- The α-factor receptor Ste2p is a G protein-coupled receptor (GPCR) expressed on the surface of MATa haploid cells of the yeast Saccharomyces cerevisiae. Binding of α-factor to Ste2p results in activation of a heterotrimeric G protein and of the pheromone response pathway. Functional interactions b
- PMID 22923047
- Comparison of fragments comprising the first two helices of the human Y4 and the yeast Ste2p G-protein-coupled receptors.
- Shao X, Zou C, Naider F, Zerbe O.Author information Institute of Organic Chemistry, University of Zurich, Zurich, Switzerland.AbstractSolution NMR techniques are used to determine the structure and the topology of micelle integration of a large fragment of the Y4 receptor, a human G-protein-coupled receptor, that contains the entire N-terminal domain plus the first two transmembrane (TM) segments. The structure calculations reveal that the putative TM helices are indeed helical to a large extent, but that interruptions of secondary structure occur close to internal polar or charged residues. This view is supported by (15)N relaxation data, amide-water exchange rates, and attenuations from micelle-integrating spin labels. No contacts between different helices are observed. This is in contrast to a similar TM1-TM2 fragment from the yeast Ste2p receptor for which locations of the secondary and the tertiary structure agreed well with the predictions from a homology model. The difference in structure is discussed in terms of principal biophysical properties of residues within central regions of the putative TM helices. Overall, using the biophysical scale of Wimley and White the TM regions of Ste2p display much more favorable free energies for membrane integration. Accordingly, the full secondary structure and the tertiary structure in TM1-TM2 of the Y4 receptor is likely to be formed only when tertiary contacts with other TM segments are created during folding of the receptor.
- Biophysical journal.Biophys J.2012 Aug 22;103(4):817-26. doi: 10.1016/j.bpj.2012.07.012.
- Solution NMR techniques are used to determine the structure and the topology of micelle integration of a large fragment of the Y4 receptor, a human G-protein-coupled receptor, that contains the entire N-terminal domain plus the first two transmembrane (TM) segments. The structure calculations reveal
- PMID 22947943
Japanese Journal
- 炭酸ガス経皮吸収がラットの運動パフォーマンスと筋肉に及ぼす影響について
- The Japanese Journal of Rehabilitation Medicine 50(3), 195-201, 2013
- NAID 130003368046
- アンチエイジングとDDS : アンチエイジングの標的臓器としての小腸機能
- Effects of Vertically Transferred 3,3',4,4',5-Pentachlorobiphenyl on Gene Expression in the Ovaries of Immature Sprague-Dawley Rats
- The Journal of reproduction and development 53(4), 937-943, 2007-08-01
- NAID 10020004331
Related Links
- Mating Factor Receptor A (n.) 1. (MeSH) A family of pheromone receptors that were initially discovered in SACCHAROMYCES CEREVISIAE as proteins necessary for fungal ... Webmaster Solution Alexandria A windows (pop-into ...
- Receptors, Mating Factor information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Receptors, Mating Factor Description of Receptors, Mating Factor ...
★リンクテーブル★
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- 英
- mating factor receptor
- 関
- 接合因子受容体、接合因子レセプター、交配因子レセプター
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- 英
- mating factor receptor
- 関
- 接合因子レセプター、交配因子受容体、交配因子レセプター
[★]
- 英
- mating factor receptor
- 関
- 接合因子受容体、接合因子レセプター、交配因子受容体
[★]
- 英
- mating factor receptor
- 関
- 接合因子受容体、交配因子受容体、交配因子レセプター
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- 関
- actual、actually、in fact、in practice、indeed、practically
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- 関
- coitus、conjugate、conjugation、copulation、copulatory、interbreed、juncture、mate
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- 関
- element、elementary、factorial、parameter