WordNet

pursue a positive and satisfying existence; "You must accept yourself and others if you really want to live"
actually being performed at the time of hearing or viewing; "a live television program"; "brought to you live from Lincoln Center"; "live entertainment involves performers actually in the physical presence of a live audience" (同)unrecorded
abounding with life and energy; "the club members are a really live bunch"
charged with an explosive; "live ammunition"; "a live bomb"
exerting force or containing energy; "live coals"; "tossed a live cigarette out the window"; "got a shock from a live wire"; "live ore is unmined ore"; "a live bomb"; "a live ball is one in play"
highly reverberant; "a live concert hall"
in current use or ready for use; "live copy is ready to be set in type or already set but not yet proofread"
lead a certain kind of life; live in a certain style; "we had to live frugally after the war"
not recorded; "the opera was broadcast live"
of current relevance; "a live issue"; "still a live option"
small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
a person who has a special life style; "a high liver"
large and complicated reddish-brown glandular organ located in the upper right portion of the abdominal cavity; secretes bile and functions in metabolism of protein and carbohydrate and fat; synthesizes substances involved in the clotting of the blood; sy
liver of an animal used as meat
someone who lives in a place; "a liver in cities"
a benign epithelial tumor of glandular origin

PrepTutorEJDIC

『生きている』,生命がある / 《副詞[句]を伴って》〈人などが〉『生き続ける』 / 〈物事が〉長く続く,存続する / 《場所を表す副詞[句]を伴って》〈人などが〉『住む』,居住する / 《副詞[句]を伴って》『生活する』,暮らす / 生人を楽しむ,おもしろく桟らす / 《a+形容詞癌lifeを目的語にして》〈…を生活〉‘を'する / 〈思想など〉‘を'実銭する
《名詞の前にのみ用いて》『生きている』 / 『活気のある』 / (問題などが)当面の / 燃えている / (弾丸などが)まだ爆発してない,未発の / まだ動いている(働いている),有効な / 電流が通じている / (放走が)生の,実況の
(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
(ある態度で)生活する人;居住者
〈C〉『肝臓』 / 〈U〉(食用にする)動物の肝臓,レバー

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/17 21:16:51」(JST)

wiki en

Hepatocellular adenoma, also hepatic adenoma, or rarely hepadenoma, is an uncommon benign liver tumor which is associated with the use of hormonal contraception with a high estrogen content.^[1] Patients taking higher potency hormones, patients of advanced age, or patients with prolonged duration of use have a significantly increased risk of developing hepatocellular adenomas.^[2]

Signs and Symptoms

About 25-50% of hepatic adenomas cause pain in the right upper quadrant or epigastric region of the abdomen.^[2] Since hepatic adenomas can be large (8–15 cm), patients may notice a palpable mass. However, hepatic adenomas are usually asymptomatic, and may be discovered incidentally on imaging ordered for some unrelated reason.^[2] If not treated, there is a 30% risk of bleeding.^[3] Bleeding may lead to hypotension, tachycardia, and sweating (diaphoresis).

Diagnosis

It is important to distinguish hepatic adenoma from other benign liver tumors, such as hemangiomas and focal nodular hyperplasia, because hepatic adenomas have a small but meaningful risk of progressing into a malignancy.^[3] MRI is the most useful investigation in the diagnosis and work-up.^[4] A poly-phasic CT scan is another useful test for diagnosing hepatic adenoma.^[3]

Large hepatic adenomas have a tendency to rupture and bleed massively inside the abdomen.

Radiologic differential diagnosis

Echinococcal cyst
Focal fatty change
Focal nodular hyperplasia
Hepatoblastoma
Infiltrative liver disease
Inflammatory pseudotumor
Leiomyosarcoma
Lymphoma
Nodular regenerative hyperplasia

Pathologic diagnosis

Micrograph of a hepatic adenoma demonstrating a regular reticulin scaffold. Reticulin stain.

Hepatic adenomas are, typically, well-circumscribed nodules that consist of sheets of hepatocytes with a bubbly vacuolated cytoplasm. The hepatocytes are on a regular reticulin scaffold and less or equal to three cell thick.

The histologic diagnosis of hepatic adenomas can be aided by reticulin staining. In hepatic adenomas, the reticulin scaffold is preserved and hepatocytes do not form layers of four or more hepatocytes, as is seen in hepatocellular carcinoma.

Cells resemble normal hepatocytes and are traversed by blood vessels but lack portal tracts or central veins.

Etiology

Ninety percent of hepatic adenomas arise in women aged 20–40, most of whom use oral contraceptives.

Related Conditions

Hepatic adenomas are related to glycogen storage diseases, type 1, as well as anabolic steroid use.

Treatment

Some authors feel that all hepatocellular adenoma should be resected, because of the risk of rupture causing bleeding and because they may contain malignant foci.^[5] Current recommendations are that all hepatic adenomas should be resected, as long as they are surgically accessible and the patient is a reasonable operative candidate.^[6] Patients with adenomas should avoid oral contraceptives or hormonal replacement therapy.

Pregnancy could cause the adenoma to grow faster, so patients with hepatic adenomas should avoid pregnancy.^[7]

Additional images

Micrograph of hepatic adenoma. H&E stain.
Micrograph of hepatic adenoma. Reticulin stain.

References

^ Rooks J, Ory H, Ishak K, Strauss L, Greenspan J, Hill A, Tyler C (1979). "Epidemiology of hepatocellular adenoma. The role of oral contraceptive use.". JAMA 242 (7): 644–8. doi:10.1001/jama.242.7.644. PMID 221698.
^ ^a ^b ^c "Hepatocellular Adenoma: eMedicine Gastroenterology".
^ ^a ^b ^c Anthony S. Fauci , Eugene Braunwald, Dennis L. Kasper, Stephen L. Hauser, Dan L. Longo, J. Larry Jameson, Joseph Loscalzo (2008). Harrison's principles of internal medicine (17th ed.). New York: McGraw-Hill Medical. pp. Chapter 92 (benign liver tumors). ISBN 978-0071466332.
^ Hussain S, van den Bos I, Dwarkasing R, Kuiper J, den Hollander J (2006). "Hepatocellular adenoma: findings at state-of-the-art magnetic resonance imaging, ultrasound, computed tomography and pathologic analysis.". Eur Radiol 16 (9): 1873–86. doi:10.1007/s00330-006-0292-4. PMID 16708218.
^ Toso C, Majno P, Andres A, Rubbia-Brandt L, Berney T, Buhler L, Morel P, Mentha G (2005). "Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors.". World J Gastroenterol 11 (36): 5691–5. PMID 16237767. Full text
^ Cho, S; Marsh J; Steel J et al. (2008). "Surgical management of hepatocellular adenoma: take it or leave it?". Ann Surg Oncol (15): 2795–2803.
^ "Hepatocellular Adenoma Treatment & Management". WebMD. Medscape. Retrieved 11 July 2012.

External links

University of Utah - Pathology Images

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 肝線維症の新しい治療法 emerging therapies for hepatic fibrosis
2. 肝線維症の病因 pathogenesis of hepatic fibrosis
3. 肝線維症の非侵襲的評価：血清学的検査および画像診断 noninvasive assessment of hepatic fibrosis overview of serologic and radiographic tests
4. HIV感染患者におけるC型肝炎の疫学、自然経過、および診断 epidemiology natural history and diagnosis of hepatitis c in the hiv infected patient
5. アルコール性肝疾患の病因 pathogenesis of alcoholic liver disease

English Journal

Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms.

Baeg MK1, Choi MG1, Jung YD1, Ko SH1, Lim CH1, Kim HH1, Kim JS1, Cho YK1, Park JM1, Lee IS1, Kim SW1.
Gut and liver.Gut Liver.2016 Jan 23;10(1):76-82. doi: 10.5009/gnl14381.
BACKGROUND/AIMS: Esophageal squamous cell carcinoma (ESCC) and colorectal neoplasms (CRNs) share risk factors. We aimed to investigate whether the CRN risk is increased in ESCC patients.METHODS: ESCC patients who underwent a colonoscopy within 1 year of diagnosis were retrospectively analyzed. Patie
PMID 25963088

Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats.

Jo W1, Yu ES1, Chang M2, Park HK1, Choi HJ1, Ryu JE1, Jang S1, Lee HJ1, Jang JJ3, Son WC1.
Molecular medicine reports.Mol Med Rep.2016 Jan;13(1):146-52. doi: 10.3892/mmr.2015.4513. Epub 2015 Nov 6.
Antitumor effects of metformin have recently emerged despite its original use for type II diabetes. In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC. Tum
PMID 26548419

A case of inflammatory hepatocellular adenoma displaying an unusual histological pattern.

Kanda H1, Furuta R2,3, Motoi N2,4, Kakita T2, Sugiura Y2, Unno T5, Matsueda K5, Saiura A6, Sugitani M7, Ishikawa Y2.
Clinical journal of gastroenterology.Clin J Gastroenterol.2015 Dec;8(6):426-34. doi: 10.1007/s12328-015-0614-7. Epub 2015 Nov 20.
Hepatocellular adenoma (HCA) is a rare type of liver tumor. Here, we report a variant case of HCA in a 56-year-old Japanese man which displayed unusual histological features. The patient had undergone surgery for esophageal and gastric cancer 2 years prior. A computed tomography scan performed in t
PMID 26589902

Japanese Journal

若年女性の正常肝に発生した高分化型肝細胞癌の1例

日本臨床外科学会雑誌 75(1), 190-196, 2014
NAID 130004679186

異時性肝転移を切除した食道類基底細胞癌の1例

日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 74(6), 1488-1494, 2013-06-25
NAID 10031190861

胆管腺腫内に発生した肝内胆管癌の1例

日本消化器外科学会雑誌 46(5), 356-361, 2013
NAID 130004560947

Related Pictures

Gastrointestinal Neoplasms - Meta Hepatic adenoma | Image | Radiopaedia.org Adenoma, liver cell; Adenoma, Hepatocellular; Hepatoma, Benign Gastro Path at College of Medicine State University - StudyBlue File:Hepatic adenoma high mag.jpg - Wikimedia Commons Webpathology.com: A Collection of Surgical Pathology Images Hepatic adenoma causes, symptoms, diagnosis, treatment & prognosis Adenoma, liver cell; Adenoma, Hepatocellular; Hepatoma, Benign

★リンクテーブル★

リンク元	「肝細胞腺腫」「LCA」
関連記事	「liver cell」「live」「adeno」「cell」「liver」

「肝細胞腺腫」

Hepatocellular adenoma
	Micrograph of a hepatic adenoma (bottom of image). H&E stain.
Classification and external resources
ICD-O	M8170/0
DiseasesDB	5726
eMedicine	med/48
MeSH	D018248

　　[★]

英: hepatocellular adenoma HCA, liver cell adenoma LCA, hepatic adenoma HA
関: 肝腫瘍

疫学

女性に多い。男女比=1:9 (NSU.618)。好発年齢20-40 (NSU.618)。
経口避妊薬や蛋白同化ホルモンの長期服用の既往があることが多い

病理

線維性被膜を有し、灰黄色・褐色、孤立性が多い。(NSU.618)
肝細胞が索状または管腔状に配列し、中心静脈も門脈域も認めない。(NSU.618)　←　顕微鏡的には正常肝細胞に似た細胞からなる(APT.212)
腺腫は胆汁を産生するので、固定標本では緑色に見える(APT.212)

治療

NSU.618

経口避妊薬を服用している場合にはこれを中止。
腫瘍が小さく、増大傾向無ければ経過観察。
収容が増大し、腫瘍内での出血、壊死、腹腔内は列の可能性のある場合や、肝細胞との鑑別が困難な場合には切除。

「LCA」

　　[★]

「liver cell」

　　[★]

肝細胞、肝臓細胞

関: hepatic cell、hepatic parenchymal cell、hepatocellular、hepatocyte、hepatocytic

「live」

　　[★]

[liv]

vt.
vi.

[laiv]

adj.

同: LAIV

「adeno」

　　[★]

comb form.
アデノ、腺の

関: gland、glandular

「cell」

　　[★] 細胞　　　　　　　

「liver」

　　[★] 肝臓　　　　　　

[1] Rooks J, Ory H, Ishak K, Strauss L, Greenspan J, Hill A, Tyler C (1979). "Epidemiology of hepatocellular adenoma. The role of oral contraceptive use.". JAMA 242 (7): 644–8. doi:10.1001/jama.242.7.644. PMID 221698.

[urlHepatocellular_Adenoma:_eMedicine_Gastroenterology-2] "Hepatocellular Adenoma: eMedicine Gastroenterology".

[HarrisonsInternal-3] Anthony S. Fauci , Eugene Braunwald, Dennis L. Kasper, Stephen L. Hauser, Dan L. Longo, J. Larry Jameson, Joseph Loscalzo (2008). Harrison's principles of internal medicine (17th ed.). New York: McGraw-Hill Medical. pp. Chapter 92 (benign liver tumors). ISBN 978-0071466332.

[4] Hussain S, van den Bos I, Dwarkasing R, Kuiper J, den Hollander J (2006). "Hepatocellular adenoma: findings at state-of-the-art magnetic resonance imaging, ultrasound, computed tomography and pathologic analysis.". Eur Radiol 16 (9): 1873–86. doi:10.1007/s00330-006-0292-4. PMID 16708218.

[5] Toso C, Majno P, Andres A, Rubbia-Brandt L, Berney T, Buhler L, Morel P, Mentha G (2005). "Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors.". World J Gastroenterol 11 (36): 5691–5. PMID 16237767. Full text

[6] Cho, S; Marsh J; Steel J et al. (2008). "Surgical management of hepatocellular adenoma: take it or leave it?". Ann Surg Oncol (15): 2795–2803.

[7] "Hepatocellular Adenoma Treatment & Management". WebMD. Medscape. Retrieved 11 July 2012.

匿名

検索

案内

案内

liver cell adenoma