late infantile metachromatic leukodystrophy

遅発乳児型異染性白質ジストロフィー

WordNet

1. of a later stage in the development of a language or literature; used especially of dead languages; "Late Greek"
2. later than usual or than expected; "the train arrived late"; "we awoke late"; "the children came late to school"; "notice came so tardily that we almost missed the deadline"; "I belatedly wished her a happy birthday" (同)belatedly, tardily
3. at or toward an end or late period or stage of development; "the late phase of feudalism"; "a later symptom of the disease"; "later medical science could have saved the child" (同)later
4. of the immediate past or just previous to the present time; "a late development"; "their late quarrel"; "his recent trip to Africa"; "in recent months"; "a recent issue of the journal" (同)recent
5. at an advanced age or stage; "she married late"; "undertook the project late in her career"
6. being or occurring at an advanced period of time or after a usual or expected time; "late evening"; "late 18th century"; "a late movie"; "took a late flight"; "had a late breakfast"
7. having died recently; "her late husband"
8. of or relating to infants or infancy; "infantile paralysis"
9. being or befitting or characteristic of an infant; "infantile games"
10. the syllable naming the sixth (submediant) note of a major or minor scale in solmization (同)lah

PrepTutorEJDIC

1. (定刻・通常・予定の時間より)『遅れた』,遅い / (時刻が)『遅い』,遅く始まる,遅くまで続く;夜更けの / (時期が)『遅い』,終りごろの,後期の / 『最近の』,最新の(recent) / 《the~,one's~》『前の』,先の,前任の(former) / 《the~,one's~》『故』…,つい先ごろ死んだ / (定刻などより)『遅れて』,遅く / (時刻が)『遅く』,遅くまで,(特に)夜更けに;(時期が)遅く,終りごろに / 『最近』,近ごろ(recently)
2. 《名詞の前にのみ用いて》幼時の / 子供じみた;子供らしい
3. ラ(全音階の第6音)

UpToDate Contents

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• 1. 異染性白質ジストロフィー metachromatic leukodystrophy
• 2. 全身疾患と関連した遺伝性ニューロパチー hereditary neuropathies associated with generalized disorders
• 3. ペリツェウス・メルツバッハー病 pelizaeus merzbacher disease
• 4. 消失性白質疾患（Vanishing white matter disease） vanishing white matter disease
• 5. 遺伝性運動失調の概要 overview of the hereditary ataxias

English Journal

• Anti-inflammatory Therapy With Simvastatin Improves Neuroinflammation and CNS Function in a Mouse Model of Metachromatic Leukodystrophy.

• Stein A1, Stroobants S2, Gieselmann V1, D'Hooge R2, Matzner U1.
• Molecular therapy : the journal of the American Society of Gene Therapy.Mol Ther.2015 Jul;23(7):1160-8. doi: 10.1038/mt.2015.69. Epub 2015 Apr 21.
• Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by a functional deficiency of the lysosomal enzyme arylsulfatase A. The prevailing late-infantile variant of MLD is characterized by widespread and progressive demyelination of the central nervous system (CNS) causing death dur
• PMID 25896249

• Sulfatide levels correlate with severity of neuropathy in metachromatic leukodystrophy.

• Dali CÍ1, Barton NW2, Farah MH3, Moldovan M4, Månsson JE5, Nair N2, Dunø M1, Risom L1, Cao H2, Pan L2, Sellos-Moura M2, Corse AM3, Krarup C4.
• Annals of clinical and translational neurology.Ann Clin Transl Neurol.2015 May;2(5):518-33. doi: 10.1002/acn3.193. Epub 2015 Mar 27.
• OBJECTIVE: Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disorder due to deficient activity of arylsulfatase A (ASA) that causes accumulation of sulfatide and lysosulfatide. The disorder is associated with demyelination and axonal loss in the central and peripheral n
• PMID 26000324

• Metachromatic leukodystrophy: Disease spectrum and approaches for treatment.

• van Rappard DF1, Boelens JJ2, Wolf NI3.
• Best practice & research. Clinical endocrinology & metabolism.Best Pract Res Clin Endocrinol Metab.2015 Mar;29(2):261-73. doi: 10.1016/j.beem.2014.10.001. Epub 2014 Oct 16.
• Metachromatic leukodystrophy is an inherited lysosomal disorder caused by recessive mutations in ARSA encoding arylsulfatase A. Low activity of arylsulfatase A results in the accumulation of sulfatides in the central and peripheral nervous system leading to demyelination. The disease is classified i
• PMID 25987178

Japanese Journal

• Two novel mutations in a Japanese patient with the late-infantile form of metachromatic leukodystrophy

• Brain & development 18(5), 400-403, 1996-09
• NAID 10005961271

• 日本人異染性脳白質変性症の遺伝子解析

• 日本先天代謝異常学会雑誌 11(2), 151, 1995-10-05
• NAID 10018923194

• 神経変性疾患にみられる皮膚汗腺組織の病態

• 脳と発達 23(1), 20-25, 1991
• NAID 130004182582

Related Links

• Metachromatic Leukodystrophy Information Page: National ...

There is no cure for MLD. Bone marrow transplantation may delay progression of the disease in some infantile-onsetcases. Other treatment is symptomatic and supportive. Considerable ...

• Metachromatic Leukodystrophy - Diseases & Conditions ...

Four types of metachromatic leukodystrophy occur with varying ages of onset and courses (ie, late infantile, early juvenile, late juvenile, adult). [1] All forms of the disease involve a progressive deterioration of motor and neurocognitive function. The typing is somewhat arbitrary because the types ...

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★リンクテーブル★

リンク元	「遅発乳児型異染性白質ジストロフィー」
関連記事	「late」「infantile」「metachromatic leukodystrophy」「leukodystrophy」

「遅発乳児型異染性白質ジストロフィー」

　　[★]

英

late infantile metachromatic leukodystrophy

「late」

　　[★]

• adv.

• (比較級later-最上級latest)遅い、遅発の、遅発型の、晩発の、後の、後期の

関

after、afterward、afterwards、anaphase、behind、delayed、following、late-stage、post、posterior、slow、subsequent

　 　 　 　 　 　 　 　

「infantile」

　　[★]

• adj.

• 乳児性の、乳児の、小児性の、小児型の

関

baby、infant、newborn infant、puerility、suckling、sucklings

　 　 　

「metachromatic leukodystrophy」

　　[★] 異染性白質ジストロフィー

「leukodystrophy」

　　[★] 白質ジストロフィー