感染性脳炎
- 関
- brain inflammation、encephalitis、Rasmussen's syndrome
WordNet
- of or relating to infection; "infectious hospital"; "infectious disease"
- caused by infection or capable of causing infection; "viruses and other infective agents"; "a carrier remains infective without himself showing signs of the disease" (同)infective
- easily spread; "fear is exceedingly infectious; children catch it from their elders"- Bertrand Russell
- inflammation of the brain usually caused by a virus; symptoms include headache and neck pain and drowsiness and nausea and fever (`phrenitis is no longer in scientific use) (同)cephalitis, phrenitis
PrepTutorEJDIC
- (病気が)伝染する,伝染性の / (影響などが)感化しやすい,うつりやすい
- 脳炎
UpToDate Contents
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English Journal
- MRI and planimetric CT follow-up study of patients with severe tick-borne encephalitis.
- Czupryna P1, Tarasow E2, Moniuszko-Malinowska A1, Pancewicz S1, Zajkowska O3, Targoński A4, Chorąży M5, Rutkowski K6, Dunaj J1, Grygorczuk S1, Kondrusik M1, Zajkowska J1.
- Infectious diseases (London, England).Infect Dis (Lond).2016 Jan 2;48(1):1-8. doi: 10.3109/23744235.2015.1083119.
- BACKGROUND: The aim of the study was to evaluate the magnetic resonance imaging (MRI) and planimetric computed tomography (CT) of brain lesions in patients with a history of tick-borne encephalitis (TBE); to assess the influence of steroid treatment on the brain and whether lesions were age-dependen
- PMID 26414745
- Experimental Autoimmune Encephalomyelitis in Mice.
- Terry RL1, Ifergan I, Miller SD.
- Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1304:145-60. doi: 10.1007/7651_2014_88.
- Experimental autoimmune encephalitis (EAE), the animal model of multiple sclerosis (MS), has provided significant insight into the mechanisms that initiate and drive autoimmunity. Several central nervous system proteins and peptides have been used to induce disease, in a number of different mouse st
- PMID 25005074
- Next-generation sequencing (NGS) in the identification of encephalitis-causing viruses: Unexpected detection of human herpesvirus 1 while searching for RNA pathogens.
- Perlejewski K1, Popiel M2, Laskus T3, Nakamura S4, Motooka D5, Stokowy T6, Lipowski D7, Pollak A8, Lechowicz U9, Caraballo Cortés K10, Stępień A11, Radkowski M12, Bukowska-Ośko I13.
- Journal of virological methods.J Virol Methods.2015 Dec 15;226:1-6. doi: 10.1016/j.jviromet.2015.09.010. Epub 2015 Sep 28.
- BACKGROUND: Encephalitis is a severe neurological syndrome usually caused by viruses. Despite significant progress in diagnostic techniques, the causative agent remains unidentified in the majority of cases. The aim of the present study was to test an alternative approach for the detection of putati
- PMID 26424618
Japanese Journal
- Prospective Safety Monitoring of Haemophilus influenzae Type b and Heptavalent Pneumococcal Conjugate Vaccines in Kagoshima, Japan
- Nishi Junichiro,Tokuda Koichi,Imuta Naoko,Minami Taketsugu,Kawano Yoshifumi
- Japanese Journal of Infectious
- … Objective severe adverse events included anaphylactoid reaction, encephalitis/encephalopathy, neurological events, severe focal reactions, systemic eruption/urticaria, fever above 39℃ within 2 days after inoculation, and other complications requiring hospitalization. …
- NAID 130003381678
- 術後に急性散在性脳脊髄炎を発症した心室中隔欠損症の1例
- 安東 勇介,深江 宏治,小野 友行,梶原 隆,小江 雅弘,八浪 浩一,中村 紳二
- Pediatric Cardiology and Cardiac Surgery 29(4), 204-208, 2013
- 急性散在性脳脊髄炎（acute disseminated encephalomyelitis ： ADEM）は先行感染または予防接種後に発症する大脳白質の炎症性脱髄疾患であり，髄鞘構成蛋白に対する自己免疫反応によって発症すると考えられている．散在性多発性病巣に基づく多彩な神経症状を呈するが，炎症は一過性で予後は比較的良い．開心術に合併した報告は稀であり，われわれは心室中隔欠損閉鎖術後にADEMを発 …
- NAID 130003380039
- Prevalence of Swine Viral and Bacterial Pathogens in Rodents and Stray Cats Captured around Pig Farms in Korea
- TRUONG Quang Lam,SEO Tae Won,YOON Byung-Il,KIM Hyeon-Cheol,HAN Jeong Hee,HAHN Tae-Wook
- Journal of Veterinary Medical Science, 2013
- … South Korea were used to determine the prevalence of the following selected swine pathogens: ten viral pathogens [porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), rotavirus, classical swine fever virus (CSFV), porcine circovirus type 2 (PCV2), encephalomyocarditis virus (EMCV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine parvovirus (PPV), pseudorabies virus (PRV) and Japanese encephalitis virus (JEV)] and four bacterial pathogens (Brucella, Leptospira, Salmonella and Lawsonia intracellularis). …
- NAID 130003362266
Related Links
- ... and Epstein-Barr virus (the cause of infectious mononucleosis) are herpes viruses. All herpes viruses may cause encephalitis occasionally, but herpes simplex virus 1 is the most common culprit. The herpes simplex virus 1 ...
- The National Center for Infectious Diseases (NCID) has been officially reorganized and as a result its former divisions and programs have been realigned into multiple new national centers. Any reference in this site to ...
★リンクテーブル★
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- 英
- Rasmussen's syndrome, Rasmussen syndrome
- 同
- Rasmussen症候群
- 関
- 脳炎 encephalitis brain inflammation、感染性脳炎 infectious encephalitis、コジェヴニコフてんかん、難治性てんかん
[show details]
概念
- 小児の慢性進行持続性部分てんかん
- 感染などをきっかけに発病する自己免疫性の難治なてんかん発作を主体とする疾患。
- グルタミン酸受容体等に対する自己免疫によりてんかん発作重積・知的退行・片麻痺が起こる進行性の中枢神経疾患。
疫学
- 難治てんかんの1/1000、日本では250人程度と推定されている。
- 発病年齢：平均7.2±6.4歳。成人の発病例あり
病因
臨床像
発症時
- 誘因暴露(上気道炎、扁桃炎、ワクチン接種)から2週間後に発症する例は40%。残りはてんかん発作で発症。
- てんかんの型は部分起始性の全般性強直間代発作や 焦点運動発作。
- 頻度は最初は月に1～数回。徐々に頻度は増加。
- 薬物によるてんかん発作のコントロールは不良。
発作頻度増加
- 発症から数ヶ月の経過で発作の頻度が徐々に増加し、発症後2年程度で発作が持続的となる。
- 半数以上の例で、本疾患に特徴的な持続性部分てんかんが出現。
- 局所のミオクロニーが何ヶ月～何年にも渡って持続。初期では1肢にとどまるが、次第に同側他肢に広がり、ついには対側肢にも出現してくる。
症状固定
- 片麻痺や知的障害が出現して6ヶ月程度で症状が固定。てんかん発作は減少傾向。
- 成人期には精神症状も出現しうる。
診断
- 1. 感染の後発症
- 2. 徐々にてんかん発作の頻度が増加
- 3. 一側の半球障害に基づく片麻痺や視野障害
- 4. 脳波検査：一側の半球の徐波
- 5. MRI：病変部の消退、移動がみられる
- 6. 髄液検査：Granzyme B濃度(細胞傷害性T細胞が放出)。神経自己抗体(グルタミン酸受容体抗体など)
治療
- 薬物療法
- 1.ステロイドパルス治療
- 2.ガンマグロブリン療法
- 3.タクロリムス
- 4.血漿交換療法
- 手術療法
- 機能的半球切除：focusが言語優位半球側の反対側で全麻痺となっている場合。
参考文献
- 1. Focal seizures due to chronic localized encephalitis.
- RASMUSSEN T, OLSZEWSKI J, LLOYDSMITH D.
- Neurology.Neurology.1958 Jun;8(6):435-45.
- PMID 13566382
- http://child-neuro-jp.org/visitor/qa2/a33.html
- http://child-neuro-jp.org/visitor/iken2/rasmussen.html
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脳炎、脳炎症
- 関
- cerebritis、encephalitic、encephalitides、encephalitis、infectious encephalitis、Rasmussen's syndrome
[★]
- 英
- infectious encephalitis
- 関
- 脳炎、ラスムッセン症候群
[★]
- 関
- communicability、communicable、contagious、epidemic、infectiosity、infectiousness、infective、infectivity、transmissibility、transmissible