adj.

必須の、急を要する、肝要の、避けられない、厳然たる、やむを得ない、緊急の、絶対に必要な、欠かせない

it is imperative for clinicians to appreciate the pathophysiology, etiologic classification, diagnostic strategies, and principles of management of diarrhea and constipation.(HIM.246)

命令的な、威圧的な、強制的な、高圧的な、有無を言わさぬ
(文法)命令法の

n.

緊急になすべきこと、命令、要請、規則、規範、義務、責務
(文法)命令法

関: compulsorily、compulsory、forced、forcedly、inescapable、inevitable、obligatory、unavoidable

WordNet

requiring attention or action; "as nuclear weapons proliferate, preventing war becomes imperative"; "requests that grew more and more imperative"
some duty that is essential and urgent
relating to verbs in the imperative mood
required by obligation or compulsion or convention; "he made all the obligatory apologies"
morally or legally constraining or binding; "attendance is obligatory"; "an obligatory contribution"
invariably occurring or appearing; "the inevitable changes of the seasons"
an unavoidable event; "dont argue with the inevitable"
incapable of being avoided or prevented; "the inevitable result"
produced by or subjected to forcing; "forced-air heating"; "furnaces of the forced-convection type"; "forced convection in plasma generators"
forced or compelled; "promised to abolish forced labor"
made necessary by an unexpected situation or emergency; "a forced landing"
in a manner that cannot be evaded; "the ministry considers that contributions to such a fund should be met from voluntary donations rather than from rates compulsorily levied." (同)obligatorily, mandatorily
required by rule; "in most schools physical education is compulsory"; "attendance is mandatory"; "required reading" (同)mandatory, required
the state of demanding notice or attention; "the insistence of their hunger"; "the press of business matters" (同)insistence, insistency, press, pressure
the quality of being insistent; "he pressed his demand with considerable instancy" (同)instancy
a mood that expresses an intention to influence the listeners behavior (同)imperative, jussive mood, imperative form
a principle stating the action required to attain a desired goal
the moral principle that behavior should be determined by duty
in an imperative and commanding manner (同)peremptorily

PrepTutorEJDIC

『命令的な』,断固とした / (行動などが)‐避けられない』,のっぴきならない / (文法で動詞が)命令法の / (文法で)命令法;〈C〉命令文
(道徳上・法律上)義務のある,強制的な;(課目など)必修の;(・・・に)必須の《+『on』(『upon』)+『 / 名』》
『避けがたい』,免れられない,必然的な
強いられた,強制的な / 強いて作った,不自然な
強制的に,義務的に
強制的な,無理じいの / 義務的な,必修の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/12 23:48:13」(JST)

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1. 中手骨基部骨折 metacarpal base fractures
2. 後頭神経痛 occipital neuralgia
3. 腎不全における心膜炎 pericarditis in renal failure
4. 中毒性結膜炎 toxic conjunctivitis
5. 癌生存者における禁酒および禁煙 alcohol and smoking cessation for cancer survivors

English Journal

[Autophagic vacuolar myopathies: what we have learned from the differential diagnosis of vacuoles in muscle biopsy].

Zámečník J, Dahmen RA.AbstractEstablishing the correct etiological diagnosis of autophagic vacuolar myopathies (AVM) is an imperative since the recent availability of the enzyme replacement therapy for the treatment of Pompe disease. Recent recognition of the complex functional pathology of these disorders dramatically changed the view on their pathogenesis and it may lead to identification of new approaches in the therapy. Muscle biopsy is a useful tool for the differential diagnosis of the AVM; however, in some cases it may fail. Through a series of five short case studies we aim at demonstrating the histopathological findings and differential diagnosis of some AVM (Pompe disease, Danon disease and chloroquine myopathy) in muscle biopsy. We also want to address the fact that the way to the correct diagnosis of these disorders can be quite complicated. Awareness of these diseases and the availability of a dry blood spot test for the non-invasive diagnosis of Pompe disease represent a good basis for detecting patients who are still kept under other diagnoses and thus escaping treatment.Keywords: autophagic myopathies - vacuoles - Pompe disease - Danon disease - chloroquine myopathy.
Ceskoslovenská patologie.Cesk Patol.2013 Dec;49(1):39-45.
Establishing the correct etiological diagnosis of autophagic vacuolar myopathies (AVM) is an imperative since the recent availability of the enzyme replacement therapy for the treatment of Pompe disease. Recent recognition of the complex functional pathology of these disorders dramatically changed t
PMID 23432075

Engineering multi-stage nanovectors for controlled degradation and tunable release kinetics.

Martinez JO, Chiappini C, Ziemys A, Faust AM, Kojic M, Liu X, Ferrari M, Tasciotti E.SourceDepartment of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave., Houston, TX 77030, USA; Graduate School of Biomedical Sciences, University of Texas Health Science Center, 6767 Bertner Ave., Houston, TX 77030, USA.
Biomaterials.Biomaterials.2013 Nov;34(33):8469-77. doi: 10.1016/j.biomaterials.2013.07.049. Epub 2013 Jul 30.
Nanovectors hold substantial promise in abating the off-target effects of therapeutics by providing a means to selectively accumulate payloads at the target lesion, resulting in an increase in the therapeutic index. A sophisticated understanding of the factors that govern the degradation and release
PMID 23911070

Impartiality in humans is predicted by brain structure of dorsomedial prefrontal cortex.

Baumgartner T, Schiller B, Hill C, Knoch D.SourceSocial and Affective Neuroscience, Department of Psychology, University of Basel, Birmannsgasse 8, CH-4055 Basel, Switzerland. Electronic address: t.baumgartner@unibas.ch.
NeuroImage.Neuroimage.2013 Nov 1;81:317-24. doi: 10.1016/j.neuroimage.2013.05.047. Epub 2013 May 18.
The moral force of impartiality (i.e. the equal treatment of all human beings) is imperative for providing justice and fairness. Yet, in reality many people become partial during intergroup interactions; they demonstrate a preferential treatment of ingroup members and a discriminatory treatment of o
PMID 23689015

Stimulus-driven attention modulates the release of anticipatory postural adjustments during step initiation.

Tard C, Dujardin K, Bourriez JL, Derambure P, Defebvre L, Delval A.SourceUniversity of Lille Nord de France, UDSL, France; Neurology and Movement Disorders Department, Lille University Medical Center, EA 4559, France.
Neuroscience.Neuroscience.2013 Sep 5;247:25-34. doi: 10.1016/j.neuroscience.2013.05.015. Epub 2013 May 17.
OBJECTIVE: Step initiation can be modified by environmental stimulations, suggesting the involvement of stimulus-driven attention. Therefore, we assessed the influence of attentional status during step preparation.METHODS: Fourteen healthy, young subjects were presented with an auditory oddball para
PMID 23688436

Japanese Journal

森勇太「近世上方における連用形命令の成立」に対する所感・反論

村上謙
日本語の研究 10(1), 72-76, 2014-01
NAID 40019920423

大規模自然災害時における薬剤師の役割　—被災地，石巻からの報告—

丹野佳郎
YAKUGAKU ZASSHI 134(1), 19-23, 2014
… Apart from the establishment of an adoptive management system for large-scale natural disasters, a coordinated system for disaster medical assistance team (DMAT), Japanese Red Cross (JRC), Self-Defense Force (SDF), and other relief work organizations was imperative. …
NAID 130003382301

無限小定数と限量子除去法によるハイブリッドシステムの検証に向けて

岩塚卓弥,寺内多智弘,結縁祥治
情報処理学会論文誌. プログラミング 6(3), 20-32, 2013-12-20
ハイブリッドシステムの形式的検証における課題の1つは,連続的な値の変化を離散的な値の変化と同一のフレームワーク上で扱う方法である.連続的変化を超準解析に由来する無限小定数を用いて表現し,ホーア論理でハイブリッドシステムを検証するフレームワークとして末永らによるHOAREdtが提案されている.本研究では,限量子除去法を適用することでHOAREdtによるハイブリッドシステムの検証を支援する手法を提案す …
NAID 110009656444

On the physics of multidrug efflux through a biomolecular complex.

Mishima Hirokazu,Oshima Hiraku,Yasuda Satoshi,Amano Ken-Ichi,Kinoshita Masahiro
The Journal of chemical physics 139(20), 2013-11-27
… In earlier works, we showed that the spatial distribution of the solute-vessel potential of mean force (PMF) induced by the solvent plays imperative roles in the insertion∕release process. …
NAID 120005353514