requiring attention or action; "as nuclear weapons proliferate, preventing war becomes imperative"; "requests that grew more and more imperative"
some duty that is essential and urgent
relating to verbs in the imperative mood
in a manner that cannot be evaded; "the ministry considers that contributions to such a fund should be met from voluntary donations rather than from rates compulsorily levied." (同)obligatorily, mandatorily
required by rule; "in most schools physical education is compulsory"; "attendance is mandatory"; "required reading" (同)mandatory, required
produced by or subjected to forcing; "forced-air heating"; "furnaces of the forced-convection type"; "forced convection in plasma generators"
forced or compelled; "promised to abolish forced labor"
made necessary by an unexpected situation or emergency; "a forced landing"
Role of NPxY motif in Draper-mediated apoptotic cell clearance in Drosophila.
Fujita Y, Nagaosa K, Shiratsuchi A, Nakanishi Y.SourceGraduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Drug discoveries & therapeutics.Drug Discov Ther.2012 Dec;6(6):291-7.
Draper, a receptor responsible for the phagocytosis of apoptotic cells in Drosophila, possesses atypical epidermal growth factor (EGF)-like sequences in the extracellular region and the two phosphorylatable motifs NPxY and YxxL in the intracellular portion. We previously suggested that Pretaporter,
Effect of an MCM4 mutation that causes tumours in mouse on human MCM4/6/7 complex formation.
Watanabe E, Ohara R, Ishimi Y.SourceCollege of Science, Ibaraki University, 2-1-1 Bunkyo, Mito, Ibaraki 351-8511, Japan.
Journal of biochemistry.J Biochem.2012 Aug;152(2):191-8. doi: 10.1093/jb/mvs060. Epub 2012 Jun 4.
It has been reported that a point mutation of minichromosome maintenance (MCM)4 causes mammary carcinoma, and it deregulates DNA replication to produce abnormal chromosome structures. To understand the effect of this mutation at level of MCM2-7 interaction, we examined the effect of the same mutatio
A survey on the experience with dental tourism in a sample of Italian patients.
Carmagnola D, Filippucci L, Celestino S, Carrassi A, Delia S, Lodi G.SourceUnit of Medicine and Oral Pathology, Department of Surgical Medicine and Dentistry, University of Milan, Milan, Italy 2 Altroconsumo, Milan, Italy. daniela.carmagnola@unimi.it
AIM: Dentistry in Italy is mainly private and therefore perceived as forcedly expensive. Dental tourism is becoming popular in order to get cheap dental care. The aim of this study was to carry out a survey aimed at investigating the perception of dental tourism by Italian patients who have recently
In the present study, the authors conduct a series of numerical analyses on the forced-oscillation-frequency responses of the convection in a cubic cavity heated below in the gravitational field with …
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it is imperative for clinicians to appreciate the pathophysiology, etiologic classification, diagnostic strategies, and principles of management of diarrhea and constipation.(HIM.246)