WordNet

a medicine that increases the hemoglobin content of the blood; used to treat iron-deficiency anemia (同)haematinic

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/03 20:42:28」(JST)

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Hemin (trade name Panhematin) is an iron-containing porphyrin.^[1] More specifically, it is Protoporphyrin IX containing a ferric iron ion (Heme B) with a chloride ligand.

It is used in the management of porphyria attacks, particularly in acute intermittent porphyria.

It is sometimes distinguished from Hematin which has a hydroxide ligand in place of the chloride. However, the terms are sometimes equated.^[2]

Hematin is considered the "X factor" required for the growth of Haemophilus influenzae.^[3]

References

^ "hemin" at Dorland's Medical Dictionary
^ "hematin" at Dorland's Medical Dictionary
^ Sherris, John C.; Ryan, Kenneth J.; Ray, C. L. (2004). Sherris medical microbiology: an introduction to infectious diseases. New York: McGraw-Hill. p. 395. ISBN 0-8385-8529-9.

External links

Information from the American Porphyria Foundation, including emergency delivery information
Hemin at RxList
Hemin at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. 急性間欠性ポルフィリン症のマネージメント management of acute intermittent porphyria
2. 子宮内膜アブレーションまたは切除術：切除用内視鏡手技 endometrial ablation or resection resectoscopic techniques
3. ALA脱水酵素欠損性ポルフィリン症 ala dehydratase porphyria
4. 重度または持続性子宮出血のマネージメント managing an episode of severe or prolonged uterine bleeding
5. マラリアにおける貧血 anemia in malaria

English Journal

Interactions of the Antimalarial Drug Methylene Blue with Methemoglobin and Heme Targets in Plasmodium falciparum: A Physico-Biochemical Study.

Blank O, Davioud-Charvet E, Elhabiri M.SourceLaboratoire de Chimie Bioorganique et Médicinale, European School of Chemistry, Polymers and Materials (ECPM), University of Strasbourg and Centre National de la Recherche Scientifique , Strasbourg, France .
Antioxidants & redox signaling.Antioxid Redox Signal.2012 Aug 15;17(4):544-54. Epub 2012 Jan 18.
Abstract Aims: Resistance of Plasmodium falciparum to drugs has led to renewed interest of redox-active methylene blue (MB) for which no resistance has been reported so far. Moreover, MB displays unique interactions with glutathione reductase (GR). However, the mechanisms of action/interaction wit
PMID 22256987

A set of logic gates fabricated with G-quadruplex assembled at an electrode surface.

Wang Z, Ning L, Duan A, Zhu X, Wang H, Li G.SourceDepartment of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China. genxili@nju.edu.cn.
Chemical communications (Cambridge, England).Chem Commun (Camb).2012 Aug 4;48(60):7507-9. Epub 2012 Jun 22.
A G-quadruplex-hemin complex assembled at an electrode surface may exhibit "smart" behaviors under benign conditions, which can be further used in fabricating a set of logic gates. Desirably, these logic gates can be integrated into a logic network with the advantages of integrity, unification and r
PMID 22729247

Japanese Journal

Metal compound analysis by capillary chromatography using an untreated capillary tube and water-hydrophilic-hydrophobic solvent mixture as a carrier solution

Yoshida Kazuma,Jinno Naoya,Hashimoto Masahiko,Tsukagoshi Kazuhiko
同志社大学理工学研究報告 51(4), 8-11, 2011-01
… We examined metal compounds such as copper(II) sulfate, hematin, and hemoglobin using the TRDC system equipped with chemiluminescence detector. … The model mixture solutions of hematin–copper(II), and hemoglobin– … The mixture of hematin–copper(II) as well as hemoglobin–copper(II) was well separated and eluted with the organic solvent-rich carrier solution based on the tube radial distribution and detected by chemiluminescence in the present TRDC system. …
NAID 110008114702

Synthesis of polyarbutin by oxidative polymerization using PEGylated hematin as a biomimetic catalyst

KOHRI Michinari,FUKUSHIMA Haruka,TANIGUCHI Tatsuo,NAKAHIRA Takayuki
Polymer journal 42(12), 952-955, 2010-12-15
NAID 10027447583

Related Pictures

★リンクテーブル★

リンク元	「ヘム」「ヘマチン」
拡張検索	「hematinic」

「ヘム」

Hemin
Systematic (IUPAC) name
	Chloro[3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-dipropanoato(2−)]iron(III)
Clinical data
AHFS/Drugs.com	Consumer Drug Information
Pregnancy cat.	C (US)
Legal status	℞-only (US)
Routes	Intravenous infusion
Identifiers
CAS number	16009-13-5
ATC code	B06AB01
PubChem	CID 5318002
ChemSpider	21160444
UNII	743LRP9S7N
ChEMBL	CHEMBL1628226
Chemical data
Formula	C34H32ClFeN4O4
Mol. mass	651.94 g/mol
	SMILES OC(=O)CCC=5C1=C\C6=N\C(=C/c3n2[Fe](Cl)N1C(=C\C4=N\C(=C/c2c(C=C)c3C)C(/C)=C4/C=C)/C=5C)C(\C)=C6\CCC(O)=O;
	InChI InChI=1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16?;; ; Key:BTIJJDXEELBZFS-UKFHATERSA-K ;
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　　[★]

英: heme
同: プロトヘム protoheme、フェロプロトポルフィリンIX ferroprotoporphyrin IX
関: ヘマチン hematin

ポルフィリンと鉄イオンの錯体

生合成

→ポルフィリン

反応場所						酵素	補酵素	酵素阻害物質	酵素の障害による疾患
ミトコンドリア	サクシニルCoA succinyl-CoA	グリシン glycine	5-アミノレブリン酸 aminolevulinic acid aminolevulinate ALA	CoA	CO2	5-アミノレブリン酸シンターゼ ALA synthase	ビタミンB6
細胞質	5-アミノレブリン酸 aminolevulinic acid aminolevulinate ALA	←2分子	ポルホビリノゲン porphobilinogen PBG	2H2O		ALA dehydratase		Pb
細胞質	ポルホビリノゲン porphobilinogen PBG		ヒドロキシメチルビラン	4NH3		ウロポルフィリゲノンIシンターゼ uroporphyrinogen I synthase			急性間欠性ポルフィリン症 acute intermittent porphyria
細胞質	ヒドロキシメチルビラン		ウロポルフィリノゲンIII			ウロポルフィリゲノンIIIシンターゼ uroporphyrinogen III synthase
細胞質	ウロポルフィリノゲンIII		コプロポルフィリノゲンIII	4CO2		ウロポルフィリノゲンデカルボキシラーゼ			晩発性皮膚ポルフィリン症 porphyria cutanea tarda
ミトコンドリア	コプロポルフィリノゲンIII		プロトポルフィリノゲンIX	2CO2		コプロポルフィリノゲンオキシダーゼ
ミトコンドリア	プロトポルフィリノゲンIX		プロトポルフィリンIX			プロトポルフィリノゲンオキシダーゼ
ミトコンドリア	プロトポルフィリンIX	Fe2+	ヘム			フェロケラターゼ		Pb