WordNet

a medicine that increases the hemoglobin content of the blood; used to treat iron-deficiency anemia (同)haematinic

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/27 17:46:19」(JST)

An alternative reaction for heme degradation catalyzed by the Escherichia coli O157:H7 ChuS protein: Release of hematinic acid, tripyrrole and Fe(III).

Ouellet YH1, Ndiaye CT1, Gagné SM1, Sebilo A1, Suits MD2, Jubinville É1, Jia Z2, Ivancich A3, Couture M4.
Journal of inorganic biochemistry.J Inorg Biochem.2016 Jan;154:103-13. doi: 10.1016/j.jinorgbio.2015.11.002. Epub 2015 Nov 10.
As part of the machinery to acquire, internalize and utilize heme as a source of iron from the host, some bacteria possess a canonical heme oxygenase, where heme plays the dual role of substrate and cofactor, the later catalyzing the cleavage of the heme moiety using O2 and electrons, and resulting
PMID 26598215

Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice.

Nogueira E, Lager F, Le Roux D, Nogueira P, Freitas J, Charvet C, Renault G, Loureiro A, Almeida CR, Ohradanova-Repic A, Machacek C, Bernardes GJ, Moreira A, Stockinger H, Burnet M, Carmo AM, Gomes AC, Preto A, Bismuth G, Cavaco-Paulo A.
Journal of biomedical nanotechnology.J Biomed Nanotechnol.2015 Dec;11(12):2243-52.
Methotrexate is the first line of treatment of rheumatoid arthritis. Since many patients become unresponsive to methotrexate treatment, only very expensive biological therapies are effective and increased methotrexate tolerance strategies need to be identified. Here we propose the encapsulation of m
PMID 26510317

Comparative Risk of Anaphylactic Reactions Associated With Intravenous Iron Products.

Wang C1, Graham DJ1, Kane RC2, Xie D3, Wernecke M4, Levenson M3, MaCurdy TE4, Houstoun M5, Ryan Q5, Wong S4, Mott K6, Sheu TC4, Limb S7, Worrall C8, Kelman JA8, Reichman ME1.
JAMA.JAMA.2015 Nov 17;314(19):2062-8. doi: 10.1001/jama.2015.15572.
IMPORTANCE: All intravenous (IV) iron products are associated with anaphylaxis, but the comparative safety of each product has not been well established.OBJECTIVE: To compare the risk of anaphylaxis among marketed IV iron products.DESIGN, SETTING, AND PARTICIPANTS: Retrospective new user cohort stud
PMID 26575062

町田晴市,長谷川篤彦
動物臨床医学 12(2), 99-104, 2003
5歳齢、体重5.6kgの去勢済み、FeLV抗原陽性の雑種猫において貧血と血小板の減少症、および赤血球と血小板の形態異常と芽球の出現が認められた。骨髄検査においても芽球比率の増加と2系統の造血細胞に異形成所見が認めらたことから、骨髄異形成症候群（MDS）と診断した。ブスルファン（BU）とサイクロフォスファマイド（CY)の２剤のアルキル化剤を用いた治療によって血球減少症と全身状態の改善が約100日間得 …
NAID 130004493303

Detection of Chlorophyll Breakdown Products in the Senescent Leaves of Higher Plants

Suzuki Yasuo,Shioi Yuzo
Plant and cell physiology 40(9), 909-915, 1999-09
… In the senescent cotyledons of barley, three degradation products, hematinic acid, methyl ethyl maleimide, and the putative degraded C-E-ring derivative, methyl vinyl maleimide dialdehyde, were detected. …
NAID 110003721534

Production of Hematinic Acid by the Reaction of Hemoglobin with Phenylhydrazine : Evidence for the Oxidative Cleavage of Heme

廣田和弘,佐々木健二
Biological and Pharmaceutical Bulletin 17(6), 856-858, 1994-06-15
… Incubation of hemoglobin (Hb, 2 mM as heme) with phenylhydrazine (PH, 5-20 mM) under aerobic conditions produced hematinic acid (HA), one of the oxidatively degraded pyrroles derived from protoporphyrin in Hb. …
NAID 110003640660