growth hormone secretagogue

• 成長ホルモン分泌促進因子

関

GHS

WordNet

1. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
2. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
3. become attached by or as if by the process of growth; "The tree trunks had grown together"
4. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
5. cause to grow or develop; "He grows vegetables in his backyard"
6. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
7. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
8. (pathology) an abnormal proliferation of tissue (as in a tumor)
9. a progression from simpler to more complex forms; "the growth of culture"
10. something grown or growing; "a growth of hair"
11. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
12. the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion

PrepTutorEJDIC

1. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
2. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
3. ホルモン

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/21 23:38:19」(JST)

wiki en

[Wiki en表示]

Growth hormone secretagogues (GSHs) are a class of drugs which act as secretagogues (i.e., induce the secretion) of growth hormone (GH). They include agonists of the ghrelin/growth hormone secretagogue receptor (GHSR), such as ghrelin (lenomorelin), pralmorelin (GHRP-2), GHRP-6, examorelin (hexarelin), ipamorelin, and ibutamoren (MK-677), and agonists of the growth hormone-releasing hormone receptor (GHRHR), such as growth hormone-releasing hormone (GHRH) (somatorelin), CJC-1295, sermorelin, and tesamorelin. Many also induce the secretion of insulin-like growth factor 1 (IGF-1), as well as of other hypothalamic-pituitary hormones such as prolactin and cortisol. The main clinical application of these agents is the treatment of growth hormone deficiency. They also see black market use, similarly to anabolic steroids, for bodybuilding purposes.

References

UpToDate Contents

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• 1. 成長ホルモンの生理学 physiology of growth hormone
• 2. 小児における成長ホルモン欠乏症の治療 treatment of growth hormone deficiency in children
• 3. 成長ホルモン不感受性症候群 growth hormone insensitivity syndromes
• 4. 小児における成長ホルモン欠乏症の診断 diagnosis of growth hormone deficiency in children
• 5. 過渡期における成長ホルモン治療 growth hormone treatment during the transition period

English Journal

• Glucocorticoid-induced skeletal muscle atrophy.

• Schakman O, Kalista S, Barbé C, Loumaye A, Thissen JP.SourceLaboratory of Cell Physiology, Institute of Neuroscience, B-1200 Brussels, Belgium.
• The international journal of biochemistry & cell biology.Int J Biochem Cell Biol.2013 Oct;45(10):2163-72. doi: 10.1016/j.biocel.2013.05.036. Epub 2013 Jun 24.
• Many pathological states characterized by muscle atrophy (e.g., sepsis, cachexia, starvation, metabolic acidosis and severe insulinopenia) are associated with an increase in circulating glucocorticoids (GC) levels, suggesting that GC could trigger the muscle atrophy observed in these conditions. GC-
• PMID 23806868

• Ghrelin amplifies the nicotine-induced dopamine release in the rat striatum.

• Palotai M, Bagosi Z, Jászberényi M, Csabafi K, Dochnal R, Manczinger M, Telegdy G, Szabó G.SourceDepartment of Pathophysiology, Faculty of Medicine, University of Szeged, Hungary.
• Neurochemistry international.Neurochem Int.2013 Oct;63(4):239-43. doi: 10.1016/j.neuint.2013.06.014. Epub 2013 Jul 3.
• The orexigenic peptide ghrelin plays a prominent role in the regulation of energy balance and in the mediation of reward mechanisms and reinforcement for addictive drugs, such as nicotine. Nicotine is the principal psychoactive component in tobacco, which is responsible for addiction and relapse of
• PMID 23831084

• Changes in the ghrelin hormone pathway maybe part of an unusual gastric system in monotremes.

• He C, Tsend-Ayush E, Myers MA, Forbes BE, Grützner F.SourceSchool of Molecular and Biomedical Science, The University of Adelaide, SA 5005, Australia.
• General and comparative endocrinology.Gen Comp Endocrinol.2013 Sep 15;191:74-82. doi: 10.1016/j.ygcen.2013.06.003. Epub 2013 Jun 13.
• Ghrelin is a growth hormone (GH)-releasing and appetite-regulating peptide predominately released from the stomach. Ghrelin is evolutionarily highly conserved and known to have a wide range of functions including the regulation of metabolism by maintaining an insulin-glucose balance. The peptide is
• PMID 23770219

Japanese Journal

• グレリンは視床下部結節乳頭核ニューロンを脱分極する

• 若林 祐次,金 主賢,中島 一樹
• 電子情報通信学会技術研究報告. MBE, MEとバイオサイバネティックス 113(61), 11-13, 2013-05-17
• 胃や脳で産生される内因性ペプチドであるグレリンは摂食行動の亢進や成長ホルモン分泌を促進させる働きで知られる.またグレリンは睡眠・覚醒の制御にも関与することが最近報告され注目を集めている.グレリンの受容体は脳全体に広く分布しており,脳内覚醒系神経核の一つである視床下部結節乳頭核でも発現している.しかしグレリンが結節乳頭核ニューロンに対してどのように作用するのかはまだ明らかにされていない.そこでラット …
• NAID 110009768721

• The physiological significance and potential clinical applications of ghrelin.

• Akamizu Takashi,Kangawa Kenji
• European journal of internal medicine 23(3), 197-202, 2012-04
• … Ghrelin, a natural ligand for the growth hormone (GH)-secretagogue receptor (GHS-R), is now known to play a role in a number of different physiological processes. …
• NAID 120003988362

• イヌのgrowth hormone secretagogue receptor (GHS-R) 1aと血中グレリン動態に関する基礎的研究

• 北澤 多喜雄,石田 祥士,岩 賢,山形 友哉,越智 建太,内田 英二,平賀 武夫,海谷 啓之
• 酪農学園大学紀要. 自然科学編 36(2), 295-310, 2012-04
• NAID 110008923158

Related Links

• Growth hormone secretagogue receptor - Wikipedia, the free ...

This box: view · talk · edit. Growth hormone secretagogue receptor is a G protein- coupled receptor that binds ghrelin and plays a role in energy homeostasis and regulation of body weight. Contents. 1 Function; 2 Transcripts; 3 Selective ligands ...

• Growth Hormone Secretagogues | Iron Man Magazine

21 Sep 2009 ... Growth hormone, produced in the pituitary gland, is one of the body's three major anabolic hormones. The others are testosterone and insulin. A peptide hormone, meaning that it's composed of a long chain of amino acids in a ...

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★リンクテーブル★

リンク元	「成長ホルモン放出ペプチド」「成長ホルモン分泌促進因子」「GHS」
拡張検索	「growth hormone secretagogue receptor」
関連記事	「grow」「growth」

「成長ホルモン放出ペプチド」

　　[★]

英

growth hormone-releasing peptide、GHRP

同

成長ホルモン分泌促進因子 growth hormone secretagogue GHS

商

ＧＨＲＰ

「成長ホルモン分泌促進因子」

　　[★]

英

growth hormone secretagogue、GHS

関

成長ホルモン放出ペプチド

「GHS」

　　[★]

• 成長ホルモン分泌促進因子

関

growth hormone secretagogue

「growth hormone secretagogue receptor」

　　[★] 成長ホルモン分泌促進因子受容体

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「growth」

　　[★]

• n.

• 成長