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English Journal

Differential effects of ghrelin antagonists on alcohol drinking and reinforcement in mouse and rat models of alcohol dependence.

Gomez JL1, Cunningham CL2, Finn DA3, Young EA2, Helpenstell LK2, Schuette LM2, Fidler TL2, Kosten TA4, Ryabinin AE2.
Neuropharmacology.Neuropharmacology.2015 Jun 4. pii: S0028-3908(15)00207-5. doi: 10.1016/j.neuropharm.2015.05.026. [Epub ahead of print]
An effort has been mounted to understand the mechanisms of alcohol dependence in a way that may allow for greater efficacy in treatment. It has long been suggested that drugs of abuse seize fundamental reward pathways and disrupt homeostasis to produce compulsive drug seeking behaviors. Ghrelin, an
PMID 26051399

Beheshti S1, Shahrokhi S2.
Neuropeptides.Neuropeptides.2015 May 30. pii: S0143-4179(15)00054-2. doi: 10.1016/j.npep.2015.05.003. [Epub ahead of print]
Studies have shown that intracerebral administration of ghrelin hormone affects learning and memory in different experimental models of learning. However, the effect of antagonism of ghrelin receptor type 1a (GHS-R1a) on different stages of learning has not been investigated. In this study the effec
PMID 26072187

Ghrelin signaling is not essential for sugar or fat conditioned flavor preferences in mice.

Sclafani A1, Touzani K2, Ackroff K2.
Physiology & behavior.Physiol Behav.2015 May 21;149:14-22. doi: 10.1016/j.physbeh.2015.05.016. [Epub ahead of print]
The oral and post-oral actions of sugar and fat stimulate intake and condition flavor preferences in rodents through a process referred to as appetition. Ghrelin is implicated in food reward processing, and this study investigated its involvement in nutrient conditioning in mice. In Exp. 1 ghrelin r
PMID 26003495