膠様滴状角膜変性症
WordNet
- utter with seeming casualness; "drop a hint"; drop names"
- a shape that is spherical and small; "he studied the shapes of low-viscosity drops"; "beads of sweat on his forehead" (同)bead, pearl
- a small indefinite quantity (especially of a liquid); "he had a drop too much to drink"; "a drop of each sample was analyzed"; "there is not a drop of pity in that man"; "years afterward, they would pay the blood-money, driblet by driblet"--Kipling (同)drib, driblet
- stop pursuing or acting; "drop a lawsuit"; "knock it off!" (同)knock off
- fall or sink into a state of exhaustion or death; "shop til you drop"
- give birth; used for animals; "The cow dropped her calf this morning"
- a sudden sharp decrease in some quantity; "a drop of 57 points on the Dow Jones index"; "there was a drop in pressure in the pulmonary artery"; "a dip in prices"; "when that became known the price of their stock went into free fall" (同)dip, fall, free_fall
- a central depository where things can be left or picked up
- the act of dropping something; "they expected the drop would be successful"
- a free and rapid descent by the force of gravity; "it was a miracle that he survived the drop from that height" (同)fall
- a predetermined hiding place for the deposit and distribution of illicit goods (such as drugs or stolen property)
- leave or unload; "unload the cargo"; "drop off the passengers at the hotel" (同)drop_off, set_down, put down, unload, discharge
- change from one level to another; "She dropped into army jargon"
- go down in value; "Stock prices dropped"
- let fall to the ground; "Dont drop the dishes"
- lose (a game); "The Giants dropped 11 of their first 13"
- omit (a letter or syllable) in speaking or writing; " New Englanders drop their post-vocalic rs"
- take (a drug, especially LSD), by mouth; "She dropped acid when she was a teenager"
- terminate an association with; "drop him from the Republican ticket"
- to fall vertically; "the bombs are dropping on enemy targets"
- want to have; "Id like a beer now!"
- a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
- a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
- equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
- resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
- be fond of; "I like my nephews"
- feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
- find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
- any degenerative disorder resulting from inadequate or faulty nutrition
- a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"
- the transparent dome-shaped anterior portion of the outer covering of the eye; it covers the iris and pupil and is continuous with the sclera
PrepTutorEJDIC
- 〈しずくが〉『したたる』,垂れる《+『down』》 / 〈物が〉『落ちる』,落下する《+『down』》 / 〈人が〉『ばったり倒れる』,崩れ落ちる / 『下落する』,減少する《+『off』(『away』)》 / 終わる,やめになる / 《副詞[句]を伴って》引き離される,落後する / (…から)手を引く,やめる《+『from』(『out of』)+『名』》 / (…に)ちょっと立ち寄る,(…を)ひょっこり訪ねる《+『in』(『by,over,round』)『at』(『on』)+『名』》 / …‘を'『したたらせる』,垂らす / (…へ)…‘を'『落とす』,落下させる《+『名』+『into』(『on』)+『名』》 / …‘を'降ろす,下げる / …‘を'減少させる / …‘を'漏らす,ふと口にする / 〈人〉に〈短い手紙・伝言〉‘を'送る / 《話》…‘を'なぐり倒す,撃ち落とす / 《話》《副詞[句]を伴って》〈人〉‘を'乗り物から降ろす / (…から)〈ある音・文字〉‘を'落とす,抜かす,省く《+『名』+『from』+『名』》 / 〈人〉‘と'関係を絶つ;〈問題など〉‘を'打ち切る / …‘を'やめさせる;(…から)…‘を'追い出す《+『名from』+『名』》 / (ばくちなどで)〈金〉‘を'なくす / 〈C〉(…の)『しずく』,したたり《+『of』+『名』》 / 〈C〉(液体・事物の)少量,微量《+『of』+『名』》 / 〈C〉あめ玉,ドロップ / 《a ~》落下,降下(fall);落下距離 / 《a ~》(…の)下落,減少《+『in』+『名』》 / 《複数形で》点滴薬 / 《話》《a ~》少量の酒 / 〈C〉《おもに米》(郵便箱などの)落とし口,差し入れ口
- …‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
- (外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
- 栄養障害 / 筋萎縮症,筋ジストロフィー(筋肉の退化・萎縮・運動障害などが起こる病気)
- (…の)『好み』,趣味《+『for』(『to』)+『名』》
- (眼球の)角膜
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/18 10:55:45」(JST)
[Wiki en表示]
Gelatinous drop-like corneal dystrophy |
Classification and external resources |
A completely opaque cornea with multiple drop-like nodular opacities. Some blood vessels are present in the opaque cornea
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OMIM |
204870 |
Apple green dichroism of subepithelial deposition of amyloid viewed under polarized light. Congo red stain.
Gelatinous drop-like corneal dystrophy, also known as amyloid corneal dystrophy, is a rare form of corneal dystrophy. The disease was described by Nakaizumi as early as 1914.[1]
Contents
- 1 Genetics
- 2 Clinical presentation
- 3 Treatment
- 4 References
Genetics
A number of mutations causing this disease have been described in the M1S1 (TACSTD2) gene encoding Tumor-associated calcium signal transducer 2, but not all patients have these mutations, suggesting involvement of other genes.[2]
Clinical presentation
The main pathological features in this dystrophy are mulberry-shaped gelatinous masses beneath the corneal epithelium. Patients suffer from photophobia, foreign body sensation in the cornea. The loss of vision is severe. The amyloid nodules have been found to contain lactoferrin, but the gene encoding lactoferrin is unaffected.
This form of corneal amyloidosis appears to be more frequent in Japan.[3]
Treatment
Recurrence within a few years occurs in all patients following corneal transplantation. Soft contact lenses are effective in decreasing recurrences.
References
- ^ Nakaizumi, K. : A rare case of corneal dystrophy. Acta. Soc. Ophthal. Jpn. 18: 949-950, 1914
- ^ Klintworth GK (2009). "Corneal dystrophies". Orphanet J Rare Dis 4 (1): 7. doi:10.1186/1750-1172-4-7. PMC 2695576. PMID 19236704.
- ^ Online 'Mendelian Inheritance in Man' (OMIM) 204870
Media related to Gelatinous droplike corneal dystrophy at Wikimedia Commons
Types of corneal dystrophy (H18.5, 371.5)
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Epithelial and subepithelial |
- Epithelial basement membrane dystrophy
- Gelatinous drop-like corneal dystrophy
- Lisch epithelial corneal dystrophy
- Meesmann corneal dystrophy
- Subepithelial mucinous corneal dystrophy
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Bowman's membrane |
- Reis–Bucklers corneal dystrophy
- Thiel-Behnke dystrophy
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Stroma |
- Congenital stromal corneal dystrophy
- Fleck corneal dystrophy
- Granular corneal dystrophy
- Lattice corneal dystrophy
- Macular corneal dystrophy
- Posterior amorphous corneal dystrophy
- Schnyder crystalline corneal dystrophy
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Descemet's membrane and
endothelial |
- Congenital hereditary endothelial dystrophy
- Fuchs' dystrophy
- Posterior polymorphous corneal dystrophy
- X-linked endothelial corneal dystrophy
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anat (g/a/p)/phys/devp/prot
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proc, drug (S1A/1E/1F/1L)
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UpToDate Contents
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English Journal
- Trop2: From development to disease.
- McDougall AR1, Tolcos M, Hooper SB, Cole TJ, Wallace MJ.
- Developmental dynamics : an official publication of the American Association of Anatomists.Dev Dyn.2014 Dec 19. doi: 10.1002/dvdy.24242. [Epub ahead of print]
- Background: Trop2 was first discovered as a biomarker of invasive trophoblast cells. Since then most research has focused on its role in tumourigenesis because it is highly expressed in the vast majority of human tumours and animal models of cancer. It is also highly expressed in stem cells and in m
- PMID 25523132
- Clinico-histopathological and biochemical analyses of corneal amyloidosis in gelatinous drop-like corneal dystrophy.
- Tasaki M1, Ueda M, Matsumoto K, Kawaji T, Misumi Y, Eiki D, Suenaga G, Obayashi K, Yamashita T, Tanihara H, Ando Y.
- Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.Amyloid.2014 Nov 17:1-3. [Epub ahead of print]
- PMID 25402568
- [Gelatinous drop-like corneal dystrophy.]
- Lezrek O1, Daoudi C2, Handor H2, Belmokhtar A2, Naciri K2, Hafidi Z2, Laghmari M2, Lezrek M2, Daoudi R2.
- Journal francais d'ophtalmologie.J Fr Ophtalmol.2014 Nov 14. pii: S0181-5512(14)00301-5. doi: 10.1016/j.jfo.2014.05.009. [Epub ahead of print]
- PMID 25455555
Japanese Journal
- Chromosomal Sharing in Atypical Cases of Gelatinous Drop-like Corneal Dystrophy
- Tsujikawa Motokazu,Maeda Naoyuki,Tsujikawa Kaoru [他],HORI Yuichi,INOUE Tomoyuki,NISHIDA Kohji
- Japanese journal of ophthalmology 54(5), 494-498, 2010-09-01
- NAID 10027666035
- 織地 宣嘉,山本 祐介,田 聖花 [他],辻川 元一,田中 陽一,島崎 潤
- あたらしい眼科 = Journal of the eye 27(3), 361-365, 2010-03-30
- NAID 10026924420
Related Links
- corneal dystrophy, gelatinous drop-like corneal dystrophy, gelatinous drop-like An autosomal recessive disorder (OMIM:204870) characterised by severe corneal amyloidosis leading to blindness. Clinical findings In the first decade of ...
- 1. Cornea. 2012 Nov;31 Suppl 1:S37-40. doi: 10.1097/ICO.0b013e31826a066a. Gelatinous drop-like corneal dystrophy. Tsujikawa M. Department of Ophthalmology, Osaka University Medical School, Osaka, Japan. moto@ophthal.med ...
- ... the Bowman layer also. The appearance of fusiform deposits in the stroma in some patients has led some to categorize gelatinous drop-like corneal dystrophy as a lattice dystrophy and have designated it as type III. GDLD ...
Related Pictures
★リンクテーブル★
[★]
- 英
- gelatinous drop-like corneal dystrophy
[★]
- (液体が)したたる、ぼたぼた落ちる
- (物が)(急に、思いがけなく)落ちる(down)。(花が)散る。(人が)(車などから)ひらりと(飛び)降りる(off)。(正式)(川・丘などが)下る(down)
- (人が)(疲れて・傷ついて)急に倒れる。死ぬ。(意識的に)身を伏せる
- (程度・数量・価値などが)下がる(fall)、落ちる(away)。健康や病状が悪化する
- (事が)やめになる。(~から)手を引く、やめる(from)。(視界から)見えなくなる(out of, from)。(交通・話などが)とだえる(off)
- 急に(ある状態に)なる、陥る(into, to)
- (略式)ひょいと(~に)立ち寄る(in, by, over, round)(on, at, into)。(人に)偶然であう(in)(across, on, with)
- 落後(後退)する、遅れる(away, back, off, behind)
- (動物が)生まれる
- (猟犬が)獲物を見て伏せる
- (言葉・ため息などが)(~から)ふともれる(from)
- (水・空気の流れに沿って)穏やかに動く
- (トランプ)(ブリッジなどで)(特定の札が)出るはめになる、死ぬ
- (球技)(球が)ホール(ポケット、ゴール)に入る(転がり込む)
- 逮捕される
- 関
- decline, decrease, depression, droplet, dropping, dropwise, fall, instill, instillation, lower, lowering, reduction
[★]
- 関
- alike、as well as、care for、correspond、correspondingly、equally、favor、identically、likewise、prefer、resemble、same、similar、similarly、such
[★]
- (医)栄養失調、栄養失調症。(医)異栄養、異栄養症、ジフトロフィー
- 栄養障害。細胞や組織の物質代謝障害によって変性・萎縮などの起こること。
[★]
- 関
- gelatine
[★]
- 関
- cornea