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1. 神経有棘赤血球症neuroacanthocytosis [show details]
…magnetic resonance imaging (MRI), iron deposition in the globus pallidus creates a hallmark "eye of the tiger" sign in these patients, which can be diagnostic . Sequence analysis of the PANK2 gene is commercially…
2. 小児における運動減少性運動障害bradykinetic movement disorders in children [show details]
…patients without PANK2 mutations. While considered a characteristic feature of PKAN, the eye of the tiger sign has also been reported in a minority of patients with neuroferritinopathy . In addition to …
3. 舞踏病の概要overview of chorea [show details]

English Journal

Novel PANK2 mutation discovered among South East Asian children living in Thailand affected with pantothenate kinase associated neurodegeneration.

Sakpichaisakul K, Saengow VE, Suwanpratheep P, Rongnoparat K, Panthan B, Trachoo O.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2019 May;().
Pantothenate kinase-associated neurodegeneration (PKAN) is linked to brain iron accumulation caused by PANK2 gene mutation. Despite the importance of genetic testing to confirm PKAN and identify at risk parents, genetic screening is financially burdensome for developing countries like Thailand. Beca
PMID 31088771

The "eye of the tiger" in a patient with multiple sclerosis.

, B B, S S, S S, .
Journal of the neurological sciences. 2019 Apr;399()1-2.
PMID 30735883

Amelioration of Dystonic Opisthotonus in Pantothenate Kinase-Associated Neurodegeneration Syndrome with Absent "Eye-of-the-Tiger" Sign Following Bilateral Pallidal Deep Brain Stimulation.

Mohd Fauzi NA, Mohamed Ibrahim N, Mohamed Mukari SA, Jegan T, Abdul Aziz Z.
Movement disorders clinical practice. 2019 Apr;6(4)332-334.
PMID 31061845

Japanese Journal

ＰＡＮＫ２およびＰＬＡ２Ｇ６に変異をみとめない成人発症のｉｄｉｏｐａｔｈｉｃ　ｎｅｕｒｏｄｅｇｅｎｅｒａｔｉｏｎ　ｗｉｔｈ　ｂｒａｉｎ　ｉｒｏｎ　ａｃｃｕｍｕｌａｔｉｏｎの４７歳男性例

斉木臣二,関根威,上野祐司,吉野浩代,高橋順子,谷慶彦,神戸泰紀,本井ゆみ子,服部信孝
臨床神経学 49(8), 474-478, 2009
症例は47歳男性．32歳，36歳，37歳時に双極性感情障害で精神科病院に入院歴あり．36歳頃から歩行困難，嚥下困難が出現，進行した．神経学的に認知症，パーキンソニズム，水平性注視眼振，痙性対麻痺，小脳性運動失調をみとめ，末梢血に有棘赤血球をみとめたが，赤血球chorein発現，赤血球Kell抗原発現，血中βリポ蛋白は正常であった．MRIで脳萎縮（前頭側頭葉・基底核・脳幹・小脳），両側淡蒼 …
NAID 130004504568

Related Links

Eye of the tiger sign (globus pallidus) | Radiology Reference ...

The eye of the tiger sign refers to abnormal low T2 signal on MRI (due to abnormal accumulation of iron) in the globus pallidus with a longitudinal stripe of high signal (due to gliosis and spongiosis). The eye of the tiger sign is most ...

Eye-of-the-Tiger sign is not Pathognomonic of Pantothenate ...

An eye-of-the-tiger sign is a specific magnetic resonance imaging (MRI) pattern, a key diagnostic feature of pantothenate kinase associated neurodegeneration (PKAN). It is low-signal intensity rings surrounding the ...

Survivor - Eye Of The Tiger (Official Music Video) - YouTube

Survivor's official music video for 'Eye Of The Tiger'. Click to listen to Survivor on Spotify: http://smarturl.it/SurvSpot?IQid=Surv... As featured on Ultimate Survivor. Click to buy the track or album ...