WordNet

place at intervals; "Space the interviews so that you have some time between the different candidates"
an empty area (usually bounded in some way between things); "the architect left space in front of the building"; "they stopped at an open space in the jungle"; "the space between his teeth"
the unlimited expanse in which everything is located; "they tested his ability to locate objects in space"; "the boundless regions of the infinite" (同)infinite
a blank character used to separate successive words in writing or printing; "he said the space is the most important character in the alphabet" (同)blank
a blank area; "write your name in the space provided" (同)blank space, place
an area reserved for some particular purpose; "the laboratorys floor space"
one of the areas between or below or above the lines of a musical staff; "the spaces are the notes F-A-C-E"
the time between occurrences of a repeating event; "some women do not control the spacing of their children"
the property possessed by an array of things that have space between them (同)spatial_arrangement
located or occurring outside a cell or cells; "extracellular fluid"
arranged with spaces between; often used as a combining form; "widely spaced eyes"

PrepTutorEJDIC

〈U〉『空間』,広がり / 〈U〉『宇宙』,地球の大気圏外(outer space) / 〈C〉〈U〉『間隔』,距離;《しばしば複数形で》空地 / 〈C〉(特定目的のための)『場所』 / 〈U〉《しばしばa~》時間 / 〈C〉〈U〉スペース,余白,余地 / 〈C〉線間(譜表において五線の間の部分) / …‘を'間隔をおいて配置する《+『out』+『名,』+『名』+『out』》
スペースをあけること,間隔をとること / (印刷された行・語・文の)スペース,間隔

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/29 22:53:18」(JST)

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In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell". This space is usually taken to be outside the plasma membranes, and occupied by fluid. The term is used in contrast to intracellular (inside the cell).

According to the Gene Ontology database the Extracellular Space is a Cellular Component defined as: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term".^[1]

The composition of the extracellular space includes metabolites, ions, various proteins and non-protein substances (i.e. DNA, RNA, lipids, microbial products etc.) that might affect cellular function. For example, hormones, growth factors, cytokines and chemokines act by travelling the extracellular space towards biochemical receptors on cells. Other proteins that are active outside the cell are various enzymes, including digestive enzymes (Trypsin, Pepsin), extracellular proteinases (Matrix metalloproteinases, ADAMTSs, Cathepsins) and antioxidant enzymes (extracellular superoxide dismutase). Often, proteins present in the extracellular space are stored outside the cells by attaching to various Extracellular matrix components (Collagens, Proteoglycans, etc.).^[2] In addition, Extracellular matrix proteolytic products are also present in the extracellular space, especially in tissues undergoing remodelling [2].

The term 'extracellular' is often used in reference to the extracellular fluid (ECF) compartment which composes about 15 litres of an average adult 70 kg human body which is assumed to contain a total of about 50 litres of water (thus, about 30% of the body's water is in the ECF compartment).

The cell membrane (and, in plants and fungi, the cell wall) is the barrier between the two, and chemical composition of intra- and extracellular milieu can be radically different. In most organisms, for example, a Na⁺/K⁺-ATPase pump maintains a high concentration of sodium ions outside cells while keeping that of potassium low, leading to chemical excitability. Many cold-tolerant plants force water into the extracellular space when the temperature drops below 0 degrees Celsius, so that when it freezes, it does not lyse the plants' cells.^[3]

Two compartments comprise the extracellular space: the vascular space and the interstitial space.^[4]

References [edit]

^ Extracellular Space by Gene Ontology database (EMBL-EBI)
^ Didangelos, A.; Yin, X.; Mandal, K.; Baumert, M.; Jahangiri, M.; Mayr, M. (2010). "Proteomics Characterization of Extracellular Space Components in the Human Aorta". Molecular & Cellular Proteomics 9 (9): 2048–2062. doi:10.1074/mcp.M110.001693. PMC 2938114. PMID 20551380. .
^ Taiz, Lincoln. Plant Physiology, 4th ed. 2006. Sinaeur Associates, Inc.
^ Fleischhauer, J.; Lehmann, L.; Kléber, A. G. (1995). "Electrical resistances of interstitial and microvascular space as determinants of the extracellular electrical field and velocity of propagation in ventricular myocardium". Circulation 92 (3): 587–594. PMID 7634473. Fleischhauer J, Lehmann L, Kléber AG (August 1995). "Electrical resistances of interstitial and microvascular space as determinants of the extracellular electrical field and velocity of propagation in ventricular myocardium". Circulation 92 (3): 587–94.

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