実験的神経自己免疫疾患

WordNet

(physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"
instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"
a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going" (同)scheme
a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender" (同)system of rules
a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"
a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"
the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"
to conduct a test or investigation; "We are experimenting with the new drug in order to fight this disease"
the act of conducting a controlled test or investigation (同)experimentation
a venture at something new or different; "as an experiment he decided to grow a beard"
the testing of an idea; "it was an experiment in living"; "not all experimentation is done in laboratories" (同)experimentation
try something new, as in order to gain experience; "Students experiment sexually"; "The composer experimented with a new style" (同)try out
an impairment of health or a condition of abnormal functioning
relating to or based on experiment; "experimental physics"
relying on observation or experiment; "experimental results that supported the hypothesis" (同)data-based, observational
of the nature of or undergoing an experiment; "an experimental drug"
easily agitated; "a nervous addict"; "a nervous thoroughbred"
of or relating to the nervous system; "nervous disease"; "neural disorder" (同)neural

PrepTutorEJDIC

〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身
(…の)『実験』,試み《+『in』(『on, with』)+『名』》 / (…の)実験をする《+『on(upon, with)』+『名』》
(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
女性の話術芸人 =diseur
実験の,実験に基づく: / 実験に使われる,実験用の / 実験的な,試験的な
『神経の』 / 『神経質な』,神経過敏な / 『心配な』,不安な

UpToDate Contents

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1. 自己免疫の概要 overview of autoimmunity
2. 混合性結合組織病の臨床症状 clinical manifestations of mixed connective tissue disease
3. 成人における中枢神経系の原発性血管炎 primary angiitis of the central nervous system in adults
4. 未分化型の全身性リウマチ性（結合組織）疾患およびオーバーラップ症候群 undifferentiated systemic rheumatic connective tissue diseases and overlap syndromes
5. 小児における中枢神経系の急性脱髄の鑑別診断 differential diagnosis of acute central nervous system demyelination in children

English Journal

The importance of studying sex differences in disease: The example of multiple sclerosis.

Golden LC1,2, Voskuhl R1.
Journal of neuroscience research.J Neurosci Res.2017 Jan 2;95(1-2):633-643. doi: 10.1002/jnr.23955.
To date, scientific research has often focused on one sex, with assumptions that study of the other sex would yield similar results. However, many diseases affect males and females differently. The sex of a patient can affect the risk for both disease susceptibility and progression. Such differences
PMID 27870415

Mesoscopic model of neuronal system deficits in Multiple Sclerosis.

Safarbali B1, Hadaeghi F1, Gharibzadeh S2.
Journal of theoretical biology.J Theor Biol.2016 Dec 21;411:6-15. doi: 10.1016/j.jtbi.2016.07.013. Epub 2016 Jul 13.
Multiple Sclerosis (MS) is a devastating autoimmune disease which deteriorates the connections in central nervous system (CNS) through the attacks to oligodendrocytes. Studying its origin and progression, in addition to clinical developments such as MRI brain images, cerebrospinal fluid (CSF) variat
PMID 27422137

Prolactin: Friend or Foe in Central Nervous System Autoimmune Inflammation?

Costanza M1, Pedotti R2.
International journal of molecular sciences.Int J Mol Sci.2016 Dec 2;17(12). pii: E2026.
The higher prevalence of multiple sclerosis (MS) in females, along with the modulation of disease activity observed during pregnancy and the post-partum period, has suggested a hormonal influence in MS. Even if prolactin (PRL) does not belong to the sex hormones family, its crucial role in female re
PMID 27918427

Japanese Journal

Immunotoxic Effects of Trichloroethylene and Tetrachloroethylene

Seo Makoto,Kobayashi Ryo,Nagase Hisamitsu
Journal of Health Science 57(6), 488-496, 2011
… Generally, TCE and PCE exposure causes organ toxicological effects on the liver, kidney, and the central nervous system; … In this review, we summarize research into immunotoxic effects, such as allergy hypersensitivity, autoimmune disease, and immunosuppression, of TCE and PCE from experimental animal studies and human epidemiological studies. …
NAID 130001869865

多発性硬化症の病態解析から治療標的の同定へ

大木伸司,山村隆
日本臨床免疫学会会誌 = Japanese journal of clinical immunology 32(4), 214-222, 2009-08-31
… れた．我々は，自己免疫病態形成に関わる病原性T細胞の機能解析を目的として，寛解期MS患者由来の末梢血T細胞を対象に，DNAマイクロアレイ法を用いた網羅的遺伝子発現解析を施行し，新たなMS治療標的候補分子として，オーファン核内受容体NR4A2を同定した．RNAi法を用いたT細胞のNR4A2発現抑制により，炎症性サイトカイン産生抑制と，実験的自己免疫性脳脊髄炎（Experimental Autoimmune Encephalomyelitis …
NAID 10026352065

スフィンゴシン１－リン酸受容体調節薬，フィンゴリモド（ＦＴＹ７２０）の自己免疫疾患治療への応用

千葉健治
YAKUGAKU ZASSHI 129(6), 655-665, 2009
… FTY720 has been shown to be highly effective in experimental allograft models and autoimmune disease models such as autoimmune encephalomyelitis, collagen-induced arthritis, and lupus nephritis. … Patients who received FTY720 orally had a significant reduction in the clinical disease activity, the number of lesions in the central nervous system, and the relapse rates. …
NAID 130000136171