WordNet

natural process that causes something to form; "the formation of gas in the intestine"; "the formation of crystals"; "the formation of pseudopods"
the act of fabricating something in a particular shape (同)shaping
a particular spatial arrangement
creation by mental activity; "the formation of sentences"; "the formation of memories"
an arrangement of people or things acting as a unit; "a defensive formation"; "a formation of planes"
smear with blood, as in a hunting initiation rite, where the face of a person is smeared with the blood of the kill
temperament or disposition; "a person of hot blood"
people viewed as members of a group; "we need more young blood in this organization"
the fluid (red in vertebrates) that is pumped through the body by the heart and contains plasma, blood cells, and platelets; "blood carries oxygen and nutrients to the tissues and carries away waste products"; "the ancients believed that blood was the sea

PrepTutorEJDIC

〈U〉(…の)『形成』,構成,育成《+『of』+『名』》 / 〈C〉形成されたもの,構成物;(その)構造,組織 / 〈U〉〈C〉隊形,陣形
『血』,『血』液 / 流血(bloodshed);殺人 / 気質,気性,血気,血潮 / 『血統』,血縁(kinship);生まれ,家柄;《the~》王家の血統 / (人種・出身国の)系 / 〈人〉‘に'初めての経験をさせる / 〈猟犬〉‘に'初めて獲物を血を味わわせる
純血の,純種の / 《複合語を作って》「…の血(性質)を持った」の意を表す

UpToDate Contents

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1. 胎児の採血 fetal blood sampling
2. 赤血球抗原および抗体のプライマー a primer of red blood cell antigens and antibodies
3. 新生児における赤血球輸血 red blood cell transfusions in the newborn
4. 赤血球細胞膜の動態および機構 red blood cell membrane dynamics and organization
5. 成人における24時間携帯血圧測定および白衣高血圧症 ambulatory blood pressure monitoring and white coat hypertension in adults

English Journal

A Novel p.G112E Mutation in BFSP2 Associated with Autosomal Dominant Pulverulent Cataract with Sutural Opacities.

Liu Q1, Wang KJ, Zhu SQ.Author information 1Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab , Beijing , China.AbstractAbstract Purpose: To identify the genetic defect in a Chinese family with bilateral pulverulent sutural cataract. Materials and methods: A three-generation family with congenital cataract was recruited in the study. The study protocol followed the principles of the Declaration of Helsinki. Detailed family history and clinical data were recorded. Genomic DNA was extracted from peripheral blood leukocytes. Candidate gene sequencing was performed to identify the disease-causing mutation. The effects of amino acid changes on the structure and function of proteins were predicted by bioinformatics analysis. Results: All affected individuals presented pulverulent opacities in the embryonal nucleus and sutures. Direct candidate gene sequencing revealed a heterozygous c. 335 G>A variation in the beaded filament structural protein 2(BFSP2) gene, which resulted in the replacement of a highly conserved glycine by glutamic at codon 112 (p. G112E). Haplotype analysis indicated that the affected members shared a common haplotype with markers near BFSP2. This mutation co-segregated with all affected individuals and was not observed in unaffected members or in 120 ethnically matched controls. Bioinformatic analyses confirmed that the mutation altered the hydrophobic and secondary structure of the protein around the substitution site. Conclusions: We report a novel mutation (p.G112E) in the BFSP2 gene, underscoring the physiological importance of the beaded filament protein and supporting its role in human cataract formation.
Current eye research.Curr Eye Res.2014 Mar 21. [Epub ahead of print]
Abstract Purpose: To identify the genetic defect in a Chinese family with bilateral pulverulent sutural cataract. Materials and methods: A three-generation family with congenital cataract was recruited in the study. The study protocol followed the principles of the Declaration of Helsinki. Detailed
PMID 24654948

Aberrant activation, nuclear localization, and phosphorylation of Yes-associated protein-1 in the embryonic kidney and Wilms tumor.

Murphy AJ1, Pierce J, de Caestecker C, Libes J, Neblett D, de Caestecker M, Perantoni AO, Tanigawa S, Anderson JR, Dome JS, Das A, Carroll TJ, Lovvorn HN 3rd.Author information 1Department of Pediatric Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee.AbstractBACKGROUND: The Yes-associated-protein-1 (YAP1) is a novel, direct regulator of stem cell genes both in development and cancer. FAT4 is an upstream regulator that induces YAP1 cytosolic sequestering by phosphorylation (p-Ser 127) and therefore inhibits YAP1-dependent cellular proliferation. We hypothesized that loss of FAT4 signaling would result in expansion of the nephron progenitor population in kidney development and that YAP1 subcellular localization would be dysregulated in Wilms tumor (WT), an embryonal malignancy that retains gene expression profiles and histologic features reminiscent of the embryonic kidney.
Pediatric blood & cancer.Pediatr Blood Cancer.2014 Feb;61(2):198-205. doi: 10.1002/pbc.24788. Epub 2013 Sep 20.
BACKGROUND: The Yes-associated-protein-1 (YAP1) is a novel, direct regulator of stem cell genes both in development and cancer. FAT4 is an upstream regulator that induces YAP1 cytosolic sequestering by phosphorylation (p-Ser 127) and therefore inhibits YAP1-dependent cellular proliferation. We hypot
PMID 24115727

Initial testing (Stage 1) of TAK-701, a humanized hepatocyte growth factor binding antibody, by the Pediatric Preclinical Testing Program.

Houghton PJ1, Kurmasheva RT, Kolb EA, Wu J, Gorlick R, Maris JM, Smith MA.Author information 1Nationwide Children's Hospital, Columbus, Ohio.AbstractTAK-701 is a humanized antibody that binds hepatocyte growth factor (HGF), thus suppressing c-Met transduced signaling and c-Met dependent proliferation and migration of tumor cells. Six childhood solid tumor xenografts were selected for evaluating TAK-701 based on immunochemical detection of HGF/c-Met autocrine signaling [i.e., pMet(Tyr1349) and HGF positive]. TAK-701 was tested using a dose of 30 mg/kg administered by the intraperitoneal (IP) route twice weekly for 4 weeks. TAK-701 did not induce significant differences in EFS distribution in treated tumors compared to control tumors. Objective responses were not observed in any of the tested solid tumor xenografts.
Pediatric blood & cancer.Pediatr Blood Cancer.2014 Feb;61(2):380-2. doi: 10.1002/pbc.24756. Epub 2013 Sep 9.
TAK-701 is a humanized antibody that binds hepatocyte growth factor (HGF), thus suppressing c-Met transduced signaling and c-Met dependent proliferation and migration of tumor cells. Six childhood solid tumor xenografts were selected for evaluating TAK-701 based on immunochemical detection of HGF/c-
PMID 24019233