- embryonal、embryonic、embryonic stage、fetal、fetal stage
- of or relating to a fetus; "fetal development" (同)foetal
- the time after sunrise and before sunset while it is light outside; "the dawn turned night into day"; "it is easier to make the repairs in the daytime" (同)daytime, daylight
- time for Earth to make a complete rotation on its axis; "two days later they left"; "they put on two performances every day"; "there are 30,000 passengers per day" (同)twenty-four hours, twenty-four hour period, 24-hour interval, solar day, mean solar day
- a day assigned to a particular purpose or observance; "Mothers Day"
- a period of opportunity; "he deserves his day in court"; "every dog has his day"
- an era of existence or influence; "in the day of the dinosaurs"; "in the days of the Roman Empire"; "in the days of sailing ships"; "he was a successful pianist in his day"
- some point or period in time; "it should arrive any day now"; "after that day she never trusted him again"; "those were the days"; "these days it is not unusual"
- the period of time taken by a particular planet (e.g. Mars) to make a complete rotation on its axis; "how long is a day on Jupiter?"
- the recurring hours when you are not sleeping (especially those when you are working); "my day began early this morning"; "it was a busy day on the stock exchange"; "she called it a day and went to bed"
- in an early stage of development; "the embryonic government staffed by survivors of the massacre"; "an embryonic nation, not yet self-governing" (同)embryotic
- of an organism prior to birth or hatching; "in the embryonic stage"; "embryologic development" (同)embryologic, embryonal
- the time during which someones life continues; "the monarchs last days"; "in his final years" (同)years
- United States writer best known for his autobiographical works (1874-1935) (同)Clarence Day, Clarence Shepard Day Jr.
- 〈U〉〈C〉『昼間』,『日中』 / 〈C〉『1日』,1昼夜,日 / 〈C〉(労働や勉強の単位の)1日 / 〈C〉(物事が予定された)日・期日;《しばしばD-》祝日 / 〈C〉《しばしば複数形で》(過去・現在・未来いずれかの)『時代』;現代 / 〈C〉《しばしば複数形で》『一生』,生涯;《所有格の旧詞・代名詞とともに槻数形で》(…の)『全先宗代』,活動期 / 〈U〉《the ~》戦い,勝負
- (おもに人称代名詞・固有名詞(人名),thereの後で)had, wouldの短縮形 / (疑問文でwhere,what,whenの後で)didの短縮形;Where'd he go?=Where did he go?
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- Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats.
- Lin YL1, Wang S2.Author information 1Division of Mental Health and Addiction Medicine, Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, ROC; Graduate Institute of Life Sciences, National Defense Medical Center, 161, Section 6, Minquan E. Road, Neihu District, Taipei 114, Taiwan, ROC.2Division of Mental Health and Addiction Medicine, Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, ROC; Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, 155, Section 2, Li-Nung Street, Beitou District, Taipei 112, Taiwan, ROC; Department of Education and Research, Taipei City Hospital, 145 Zhengzhou Road, Datong District, Taipei 103, Taiwan, ROC. Electronic address: email@example.com.AbstractMajor depression is one of the most prevalent mental disorders in the population. In addition to genetic influences, disturbances in fetal nervous system development might be a contributing factor. Maternal infection during pregnancy may affect fetal brain development and consequently lead to neurological and mental disorders. Previously, we used low-dose lipopolysaccharide (LPS) exposure on embryonic day 10.5 to mimic mild maternal infection in rats and found that dopaminergic and serotonergic neurons were reduced in the offspring. The offspring also showed more anxiety-like behavior and an enhanced stress response. In the present study we used forced swim test and chronic mild stress challenge to assess depression-like behaviors in the affected offspring and examined their adult hippocampal neurogenesis and brain-derived neurotrophic factor (BDNF) concentration. Our results showed that prenatally LPS-exposed rats (LPS rats) displayed more depression-like behaviors and had reduced adult neurogenesis and BDNF. The behavioral abnormalities and reduction in adult neurogenesis could be reversed by chronic fluoxetine (FLX) treatment. This study demonstrates that during the critical time of embryonic development LPS exposure can produce long-term behavioral changes and reduction in adult neurogenesis. The findings of enhanced depression-like behaviors, reduced adult neurogenesis, and their responsiveness to chronic antidepressant treatment suggest that prenatal LPS exposure could serve as an animal model of depression.
- Behavioural brain research.Behav Brain Res.2014 Feb 1;259:24-34. doi: 10.1016/j.bbr.2013.10.034. Epub 2013 Oct 28.
- Major depression is one of the most prevalent mental disorders in the population. In addition to genetic influences, disturbances in fetal nervous system development might be a contributing factor. Maternal infection during pregnancy may affect fetal brain development and consequently lead to neurol
- PMID 24177209
- Human Wharton's Jelly Stem Cells and Its Conditioned Medium Enhance Healing of Excisional and Diabetic Wounds.
- Fong CY, Tam K, Cheyyatraivendran S, Gan SU, Gauthaman K, Armugam A, Jeyaseelan K, Choolani M, Biswas A, Bongso A.Author information Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, 119228, Singapore.AbstractWound healing is a major problem in diabetic patients and current treatments have met with limited success. We evaluated the treatment of excisional and diabetic wounds using a stem cell isolated from the human umbilical cord Wharton's jelly (hWJSC) that shares unique properties with embryonic and adult mesenchymal stem cells. hWJSCs are non-controversial, available in abundance, hypo-immunogenic, non-tumorigenic, differentiate into keratinocytes, and secrete important molecules for tissue repair. When human skin fibroblasts (CCD) in conventional scratch-wound assays were exposed to hWJSC-conditioned medium (hWJSC-CM) the fibroblasts at the wound edges migrated and completely covered the spaces by day 2 compared to controls. The number of invaded cells, cell viability, total collagen, elastin, and fibronectin levels were significantly greater in the hWJSC-CM treatment arm compared to controls (P < 0.05). When a single application of green fluorescent protein (GFP)-labeled hWJSCs (GFP-hWJSCs) or hWJSC-CM was administered to full-thickness murine excisional and diabetic wounds, healing rates were significantly greater compared to controls (P < 0.05). Wound biopsies collected at various time points showed the presence of green GFP-labeled hWJSCs, positive human keratinocyte markers (cytokeratin, involucrin, filaggrin) and expression of ICAM-1, TIMP-1, and VEGF-A. On histology, the GFP-hWJSCs and hWJSC-CM treated wounds showed reepithelialization, increased vascularity and cellular density and increased sebaceous gland and hair follicle numbers compared to controls. hWJSCs showed increased expression of several miRNAs associated with wound healing compared to CCDs. Our studies demonstrated that hWJSCs enhance healing of excisional and diabetic wounds via differentiation into keratinocytes and release of important molecules. J. Cell. Biochem. 115: 290-302, 2014. © 2013 Wiley Periodicals, Inc.
- Journal of cellular biochemistry.J Cell Biochem.2014 Feb;115(2):290-302. doi: 10.1002/jcb.24661.
- Wound healing is a major problem in diabetic patients and current treatments have met with limited success. We evaluated the treatment of excisional and diabetic wounds using a stem cell isolated from the human umbilical cord Wharton's jelly (hWJSC) that shares unique properties with embryonic and a
- PMID 24038311
- Distinctive population of Gfap-expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus.
- Seki T, Sato T, Toda K, Osumi N, Imura T, Shioda S.Author information Department of Histology and Neuroanatomy, Tokyo Medical University, Tokyo, 160-8402, Japan.AbstractIn the adult hippocampus, granule cells continue to be generated from astrocyte-like progenitors expressing glial fibrillary acidic protein (GFAP) that differ from embryonic neocortical progenitors. However, during the embryonic period, dentate granule neurons and neocortical pyramidal neurons are derived from the ventricular zone (VZ) of the pallium. Our question is when do GFAP+ progenitors of granule neurons appear in the developing hippocampus during the embryonic period, and how do they form the granule cell layer. The present analysis using Gfap-GFP transgenic mice shows that the GFP+ distinct cell population first appears in the VZ of the medial pallium at the dorsal edge of the fimbria on embryonic day 13.5. During the perinatal period, they form a migratory stream from the VZ to the developing dentate gyrus, and establish the germinal zones in the migratory stream, and the marginal and hilar regions in the developing dentate gyrus. GFP+ cells in these regions were positive for Sox2 and Ki67, but negative for BLBP. GFP+ cells with Neurogenin2 expression were largely distributed in the VZ, whereas GFP+ cells with Tbr2 and NeuroD expressions were seen in the migratory stream and developing dentate gyrus. Prox1-expressing GFP+ cells were restricted to the developing dentate gyrus. These results suggest that distinctive Gfap-expressing progenitors arising around the dentate notch form germinal regions in the migratory stream and the developing dentate gyrus where they differentiate into granule neurons, indicating that distinct astrocyte-like neural progenitors continue to generate granule neurons, from the beginning of dentate development and throughout life. J. Comp. Neurol. 522:261-283, 2014. © 2013 Wiley Periodicals, Inc.
- The Journal of comparative neurology.J Comp Neurol.2014 Feb;522(2):Spc1. doi: 10.1002/cne.23508.
- In the adult hippocampus, granule cells continue to be generated from astrocyte-like progenitors expressing glial fibrillary acidic protein (GFAP) that differ from embryonic neocortical progenitors. However, during the embryonic period, dentate granule neurons and neocortical pyramidal neurons are d
- PMID 24311322
- Runx1 promotes neuronal differentiation in dorsal root ganglion
- Kobayashi Azusa,Senzaki Kouji,Ozaki Shigeru,Yoshikawa Masaaki,Shiga Takashi,先崎 浩次,尾崎 繁,吉川 雅朗,志賀 隆
- Molecular and cellular neuroscience 49(1), 23-31, 2012-01
- … Transcription factor Runx1 controls the cell type specification of peptidergic and nonpeptidergic nociceptive dorsal root ganglion (DRG) neurons by repressing TrkA and calcitonin gene-related peptide (CGRP) expression and activating Ret expression during late embryonic and early postnatal periods (Chen et al., 2006b; … We used transgenic Runx1-deficient (Runx1−/−::Tg) mice which are rescued from early embryonic lethality by selective expression of Runx1 in hematopoietic cells under the control of GATA-1 promoter. …
- NAID 120003825042
- Trp53 Activity Is Repressed in Radio-adapted Cultured Murine Limb Bud Cells
- VARES Guillaume,WANG Bing,TANAKA Kaoru,SHANG Yi,FUJITA Kazuko,HAYATA Isamu,NENOI Mitsuru
- Journal of radiation research 52(6), 727-734, 2011-11-16
- … Murine fetuses were exposed to whole-body priming irradiation of 0.3 Gy or 0.5 Gy at embryonic day 11 (E11). …
- NAID 10029652907
- 期 11.5 日目（embryonic day（E））（受精が確認されたとき. を 0.5 日目とする），12.5 日目，13.5 日目に行った。E11.5. では視床の外側の核（主に dLGN:dorsal lateral geniculate nucleus や VB:ventro basal nucleus）に取込みが見られた。 dLGN は 網膜 ...
- The embryo becomes embedded in the endometrium in a process called implantation. In most successful pregnancies, the embryo implants 8 to 10 days after ovulation (Wilcox et al. 1999). The embryo, the extra-embryonic membranes, and ...
- embryo、embryonal、embryonic、embryonic day、embryonic form、embryonic stage、fetal stage、feto、fetus、foetal、foetus
- embryonic day、embryonic stage、fetal stage、embryonic、fetal、embryonal
- embryonal、embryonic、embryonic day、embryonically、fetal、fetal stage
- embryonal、embryonic、embryonic day、embryonic stage、embryonically、fetal
- embryonic、embryonic day、embryonic stage、embryonically、fetal、fetal stage
- embryo、embryonal、embryonic day、embryonic stage、embryonically、fetal、fetal stage、fetus、germ、germinal