dose fractionation

線量分割

WordNet

1. travel or traverse (a distance); "This car does 150 miles per hour"; "We did 6 miles on our hike every day"
2. the syllable naming the first (tonic) note of any major scale in solmization (同)doh, ut
3. proceed or get along; "How is she doing in her new job?"; "How are you making out in graduate school?"; "Hes come a long way" (同)fare, make_out, come, get along
4. create or design, often in a certain way; "Do my room in blue"; "I did this piece in wood to express my love for the forest" (同)make
5. carry on or function; "We could do with a little more help around here" (同)manage
6. get (something) done; "I did my job" (同)perform
7. treat with an agent; add (an agent) to; "The ray dosed the paint"
8. the quantity of an active agent (substance or radiation) taken in or absorbed at any one time (同)dosage
9. a measured portion of medicine taken at any one time (同)dosage
10. a process that uses heat to separate a substance into its components (同)fractional process
11. separation into portions
12. treated with some kind of application; "a mustache dosed with bear grease"

PrepTutorEJDIC

1. 《疑問文・否定文を作る》 / 《否定命令文を作る》 / 《助動詞とbe動詞のどちらも含まない文に用いて付加疑問を作る》 / 《強意語として》 / 《文》《助動詞とbe動詞のどちらも含まない文に用いて倒置文を作る》 / 《あいづちを打つ場合に》 / 《先行する動詞またはそれを含む述部の代用》 / 《so,nor,neitherで始まる簡略文で》 / …‘を'『する』,行う,果たす / 《通例have done,時にbe doneの形で》…‘を'『終える』,済ませる / …‘を'作る,作り出す / …‘を'『処理する』,整える,片付ける / 〈学課〉‘を'『勉強する』,専攻する / 〈利益・害など〉‘を'与える,もたらす / 〈人〉‘に'『役立つ』,用が足りる(serve) / …の速度で進む,距離を行く / …‘を'見物する / 〈劇〉‘を'上演する;…‘の'役を演じる / …の役目(仕事)をする / 《おもに英》…‘を'だます,かつぐ / 《話》…をへとへとにさせる / 『する』;活動する / 《通例have done,時にbe doneの形で》(…を)『終える』,済ます《+『with』+『名』》 / 〈事が〉『運ぶ』;〈人が〉暮らしていく,健康である / 〈物が〉(…に)『間に合う』,十分である;〈人が〉(…に)役に立つ,向く《+『for』+『名』》 / 《複数形で》すべきこと / 〈C〉《おもに英》大宴会,大パーティー / 〈C〉《英話》詐欺,ぺてん
2. ド(全音階の第1音)
3. (おもに飲み薬1回分の)『服用量』 / (痛いこと・いやなことの)1回分,一定量 / (人などが受ける放射線の)線量 / 性病 / (…を)…‘に'投薬する,服用させる《+『名』+『with』+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/09/01 08:19:03」(JST)

wiki en

[Wiki en表示]

Experiments in radiation biology have found that as the absorbed dose of radiation increases, the number of cells which survive decreases. They have also found that if the radiation is fractionated into smaller doses, with one or more rest periods in between, fewer cells die. This is because of self-repair mechanisms which repair the damage to DNA and other biomolecules such as proteins. These mechanisms can be over expressed in cancer cells, so caution should be used in using results for a cancer cell line to make predictions for healthy cells if the cancer cell line is known to be resistant to cytotoxic drugs such as cisplatin. The DNA self repair processes in some organisms is exceptionally good; for instance, the bacterium Deinococcus radiodurans can tolerate a 15 000 Gy (1.5 MRad) dose.

In the graph below, called a cell survival curve, the dose vs. surviving fraction have been drawn for a hypothetical group of cells with and without a rest time for the cells to recover. Other than the recovery time partway through the irradiation, the cells would have been treated identically.

The human body contains many types of cells, and the human can be killed by the loss of a single type of cells in a vital organ. For many short-term radiation deaths due to what is commonly known as radiation sickness (3 to 30 days after exposure), it is the loss of bone marrow cells (which produce blood cells), and the loss of other cells in the wall of the intestines, that is fatal.

Radiation fractionation as cancer treatment

Fractionation also refers to a method of treating cancer with radiation therapy. When the total dose of radiation is divided into several, smaller doses over a period of several days, there are fewer toxic effects on healthy cells. This maximizes the effect of radiation on cancer and minimizes the negative side effects. Typical fractionation schemes divide the dose into 30 units delivered every weekday over six weeks, though current research is considering the benefits of accelerated fractionation (two deliveries per day and/or deliveries on weekends as well). Hypofractionation is a treatment regimen that delivers higher doses of radiation in fewer visits. The logic behind this treatment is that applying greater amounts of radiation works to lower the effects of accelerated tumor growth that typically occurs during the later stages of radiotherapy.

UpToDate Contents

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• 1. 進行頭頸部癌に対する根治的放射線療法：線量および分割スケジュール definitive radiotherapy for advanced head and neck cancer dose and fractionation schedule
• 2. 予後不良の患者における脳転移の治療 treatment of brain metastases in poor prognosis patients
• 3. 非転移性新規乳癌女性に対する術後放射線療法 adjuvant radiation therapy for women with newly diagnosed non metastatic breast cancer
• 4. ステージIII非小細胞肺癌のマネージメント management of stage iii non small cell lung cancer
• 5. Initial management of limited stage small cell lung cancer

English Journal

• Polysaccharides from Arctium lappa L.: Chemical structure and biological activity.

• Carlotto J1, de Souza LM2, Baggio CH3, Werner MF3, Maria-Ferreira D3, Sassaki GL1, Iacomini M1, Cipriani TR4.
• International journal of biological macromolecules.Int J Biol Macromol.2016 Oct;91:954-60. doi: 10.1016/j.ijbiomac.2016.06.033. Epub 2016 Jun 14.
• The plant Arctium lappa L. is popularly used to relieve symptoms of inflammatory disorders. A crude polysaccharide fraction (SAA) resulting of aqueous extraction of A. lappa leaves showed a dose dependent anti-edematogenic activity on carrageenan-induced paw edema, which persisted for up to 48h. Seq
• PMID 27311502

• Effects of different ligands on epidermal growth factor receptor (EGFR) nuclear translocation.

• Faria JA1, de Andrade C1, Goes AM1, Rodrigues MA2, Gomes DA3.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 Sep 9;478(1):39-45. doi: 10.1016/j.bbrc.2016.07.097. Epub 2016 Jul 25.
• The epidermal growth factor receptor (EGFR) is activated through binding to specific ligands and generates signals for proliferation, differentiation, migration, and cell survival. Recent data show the role of nuclear EGFR in tumors. Although many EGFR ligands are upregulated in cancers, little is k
• PMID 27462018

• The impact of the introduction of a palliative Macmillan consultant radiographer at one UK cancer centre.

• Goldfinch R1, Allerton R1, Khanduri S2, Pettit L2.
• The British journal of radiology.Br J Radiol.2016 Sep;89(1065):20160286. doi: 10.1259/bjr.20160286. Epub 2016 Jul 5.
• OBJECTIVE: The UK radiotherapy (RT) workforce needs novel strategies to manage increasing demand. The appointment of a palliative RT (PRT) consultant radiographer (CR) offers a potential solution to enhance patient pathways providing timely RT. This article examined the impact of one such appointmen
• PMID 27377241

Japanese Journal

• Radiation-induced Liver Injury after 3D-conformal Radiotherapy for Hepatocellular Carcinoma: Quantitative Assessment Using Gd-EOB-DTPA-enhanced MRI

• Acta Medica Okayama 71(1), 25-29, 2017-02
• NAID 120005971552

• Biological dose representation for carbon-ion radiotherapy of unconventional fractionation

• Physics in Medicine and Biology 62(3), 1062-1075, 2017-01
• NAID 120005951784

• 頭蓋咽頭腫に対する通常分割高精度放射線外部照射療法の長期成績

• 脳神経外科ジャーナル 25(8), 646-653, 2016
• NAID 130005406741

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★リンクテーブル★

リンク元	「分割」
関連記事	「fractionation」「do」「dose」「dosing」

「分割」

　　[★]

英

fractionation

同

線量分割 dose fractionation

関

卵割 cleavage

「fractionation」

　　[★]

• n.

• 分画、分取、分割

関

cleavage、cleave、contingency、divide、division、fraction、fractional、fractionate、mince、parcellated、part、parted、partition、resolution、split

　 　

「do」

　　[★]

• v.

• する、行う

関

carry out、conduct、execute、make、perform、practice、undertake

　 　 　 　 　 　 　 　

「dose」

　　[★]

• n.

• 用量、投与量、服用量、薬物用量、線量

関

dosage、ID、injected dose、input

　 　 　 　

「dosing」

　　[★]

• n.

• 投薬

関

administration、medicate、prescription