cystic medial necrosis

嚢胞性中膜壊死

WordNet

1. dividing an animal into right and left halves (同)median
2. of or relating to or resembling a cyst
3. of or relating to a normal cyst (as the gallbladder or urinary bladder)
4. the localized death of living cells (as from infection or the interruption of blood supply) (同)mortification, gangrene, sphacelus
5. a closed sac that develops abnormally in some body structure

PrepTutorEJDIC

1. 中間の,中間に位置する / 平均の,並なみの
2. 胞嚢(ほうのう)性の
3. 壊疽(えそ)
4. 胞嚢(ほうのう)
5. mediumの複数形

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/01 11:19:56」(JST)

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[Wiki en表示]

Familial thoracic aortic aneurysm
Micrograph showing cystic medial degeneration, the histologic correlate of familial thoracic aortic aneurysms. The image shows abundant basophilic ground substance in the tunica media (blue at top of image) and disruption of the elastic fibers. The tunica adventitia (yellow at bottom of image) with vaso vasorum is also seen. Movat's stain.
Classification and external resources
ICD-9-CM	441.00
OMIM	607086
DiseasesDB	30073
eMedicine	emerg/28

Familial thoracic aortic aneurysm (also referred to as familial aortic dissection or cystic medial necrosis of aorta) is an autosomal dominant disorder of large arteries.

There is an association between familial thoracic aortic aneurysm, Marfan syndrome and massive baclofen overdose as well as other hereditary connective tissue disorders.

Presentation

A degenerative breakdown of collagen, elastin, and smooth muscle caused by aging contributes to weakening of the wall of the artery.

In the aorta, this can result in the formation of a fusiform aneurysm. There is also increased risk of aortic dissection.

Genetics

Types include:

Type	OMIM	Gene	Locus
AAT1	607086		11q23.3-q24
AAT4	132900	MYH11	16p
AAT6	611788	ACTA2	10q

Terminology

It is sometimes called "Erdheim cystic medial necrosis of aorta", after Jakob Erdheim.

The term "cystic medial degeneration" is sometimes used instead of "cystic medial necrosis", because necrosis is not always found.

See also

• Aneurysm

References

External links

• GeneReview/NCBI/NIH/UW entry on Thoracic Aortic Aneurysms and Aortic Dissections
• 1449852953 at GPnotebook

UpToDate Contents

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• 1. マルファン症候群および関連疾患の遺伝学、臨床的特徴、および診断 genetics clinical features and diagnosis of marfan syndrome and related disorders
• 2. 急性大動脈解離の臨床的特徴および診断 clinical features and diagnosis of acute aortic dissection
• 3. 内臓動脈瘤および偽動脈瘤の概要 overview of visceral artery aneurysm and pseudoaneurysm
• 4. 孤立性上腸間膜動脈解離 spontaneous mesenteric arterial dissection
• 5. 特発性脳動脈および頚動脈の解離：臨床的特徴および診断 spontaneous cerebral and cervical artery dissection clinical features and diagnosis

English Journal

• Spontaneous Coronary Artery Dissection: New Insights from the Tip of the Iceberg?

• Alfonso F.SourceClínico San Carlos University Hospital, Madrid, Spain.
• Circulation.Circulation.2012 Jul 16. [Epub ahead of print]
• Spontaneous coronary artery dissection (SCAD) is a rare clinical entity of unknown etiology that typically affects young women without coronary risk factors(1-5). Initial reports were scarce and based on autopsy findings after episodes of sudden cardiac death suggesting that the condition had a dism
• PMID 22800852

• Signalling from dead cells drives inflammation and vessel remodelling.

• Bennett M, Yu H, Clarke M.SourceDivision of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge, United Kingdom. mrb@mole.bio.cam.ac.uk
• Vascular pharmacology.Vascul Pharmacol.2012 May-Jun;56(5-6):187-92. Epub 2012 Jan 28.
• Death of vascular smooth muscle cells (VSMCs) has been demonstrated in vessel development and in disease, most notably in atherosclerosis, but also after injury and remodelling. VSMC death promotes multiple features of vulnerable plaques, but also induces features of normal vessel ageing and cystic
• PMID 22306421

Japanese Journal

• 症例 大動脈二尖弁に合併した弓部大動脈瘤兼急性大動脈解離の1例

• 長田 裕明,中島 博之,鄒 貴光 [他]
• 胸部外科 64(13), 1193-1196, 2011-12
• NAID 40019078458

• Congenital-idiopathic superficial femoral artery aneurysm in a 7-year-old child

• Matsubara Muneaki,Hiramatsu Yuji,Sugita Shintaro,Atsumi Naotaka,Terada Masatsugu,Sakakibara Yuzuru,松原 宗明,平松 祐司,榊原 謙
• Journal of vascular surgery 53(6), 1699-1701, 2011-06
• … Histologic examination revealed intimal thickening with fibroplasia without severe inflammatory infiltrates or cystic medial necrosis, suggesting a congenital-idiopathic arterial aneurysm. …
• NAID 120003163731

Related Pictures

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★リンクテーブル★

リンク元	「嚢胞性中膜壊死」
関連記事	「medial」「media」「cystic」

「嚢胞性中膜壊死」

　　[★]

英

cystic medial necrosis

関

大動脈弁輪拡張症

「medial」

　　[★]

• adj.

• 内側の、中心の、中央の、内側性の

関

center、central、centre、centro、centrum、hub、inner、inside、interior、medialis、medially、middle

　 　

「media」

　　[★]

• n.

関

culture、culture media、culture medium、culture solution、medium

　

「cystic」

　　[★]

• adj.

• 嚢胞性の