complement factor B

補体B因子、B因子、補体因子B

関

factor B

WordNet

1. make complete or perfect; supply what is wanting or form the complement to; "I need some pepper to complement the sweet touch in the soup"
2. a complete number or quantity; "a full complement"
3. one of a series of enzymes in the blood serum that are part of the immune response
4. something added to complete or embellish or make perfect; "a fine wine is a perfect complement to the dinner"; "wild rice was served as an accompaniment to the main dish" (同)accompaniment
5. number needed to make up a whole force; "a full complement of workers" (同)full complement
6. a word or phrase used to complete a grammatical construction
7. either of two parts that mutually complete each other
8. be a contributing factor; "make things factor into a companys profitability"
9. any of the numbers (or symbols) that form a product when multiplied together
10. an independent variable in statistics
11. anything that contributes causally to a result; "a number of factors determined the outcome"
12. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
13. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
14. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
15. a concept whose truth can be proved; "scientific hypotheses are not facts"
16. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
17. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
18. the 2nd letter of the Roman alphabet (同)b
19. the blood group whose red cells carry the B antigen (同)type_B, group B

PrepTutorEJDIC

1. (あるものを完全にするため)(…を)補う物(事)《+『of』+『名』》 / 補語(文法で文の成分の一つ) / (必要な)全数,全量;(船の)定員 / …を補足する,補う
2. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
3. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/16 14:12:06」(JST)

wiki en

[Wiki en表示]

Complement factor B
PDB rendering based on 1dle.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1DLE, 1Q0P, 1RRK, 1RS0, 1RTK, 2OK5, 2WIN, 2XWB, 2XWJ, 3HRZ, 3HS0
Identifiers
Symbols	CFB ; AHUS4; ARMD14; BF; BFD; CFAB; CFBD; FB; FBI12; GBG; H2-Bf; PBF2
External IDs	OMIM: 138470 MGI: 105975 HomoloGene: 1292 ChEMBL: 5731 GeneCards: CFB Gene
EC number	3.4.21.47
Gene ontology Molecular function • complement binding • serine-type endopeptidase activity Cellular component • extracellular region • extracellular space • plasma membrane • extracellular exosome • blood microparticle Biological process • proteolysis • complement activation • complement activation, alternative pathway • regulation of complement activation • innate immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	629	14962
Ensembl	ENSG00000204359	ENSMUSG00000090231
UniProt	P00751	P04186
RefSeq (mRNA)	NM_001710	NM_001142706
RefSeq (protein)	NP_001701	NP_001136178
Location (UCSC)	Chr 6: 31.95 – 31.95 Mb	Chr 17: 34.86 – 34.86 Mb
PubMed search	[1]	[2]

Alternative pathway. (Some labels are in Polish.)

Complement factor B is a protein that in humans is encoded by the CFB gene.

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

Complement tests

C4 (C)	FB (A)	C3	CH50	Conditions
·	↓	↓	↓	PSG, C3 NeF AA
↓	·	↓	·	HA, C4D
·	·	·	↓	TCPD
↓	· /↓	↓	↓	SLE
↑	↑	↑	↑	inflammation

References

Further reading

• Bradley, D T; Zipfel, P F; Hughes, A E (2011). "Complement in age-related macular degeneration: a focus on function". Eye 25 (6). doi:10.1038/eye.2011.37. PMC 3178140. PMID 21394116. 
• Campbell RD (1988). "The molecular genetics and polymorphism of C2 and factor B". Br. Med. Bull. 43 (1): 37–49. PMID 3315100. 
• Campbell RD, Bentley DR, Morley BJ (1984). "The factor B and C2 genes". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 306 (1129): 367–78. doi:10.1098/rstb.1984.0097. PMID 6149579. 
• Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213–30. doi:10.1159/000019075. PMID 10072631. 
• Rawal N, Pangburn MK (2001). "Structure/function of C5 convertases of complement". Int. Immunopharmacol. 1 (3): 415–22. doi:10.1016/S1567-5769(00)00039-4. PMID 11367526. 
• Arnason A, Larsen B, Marshall WH et al. (1977). "Very close linkage between HLA-B and Bf inferred from allelic association". Nature 268 (5620): 527–8. doi:10.1038/268527a0. PMID 889587. 
• Barnum SR, Ishii Y, Agrawal A, Volanakis JE (1992). "Production and interferon-gamma-mediated regulation of complement component C2 and factors B and D by the astroglioma cell line U105-MG". Biochem. J. 287. ( Pt 2): 595–601. PMC 1133207. PMID 1445220. 
• Yancey KB, Overholser O, Domloge-Hultsch N et al. (1992). "Human keratinocytes and A-431 cells synthesize and secrete factor B, the major zymogen protease of the alternative complement pathway". J. Invest. Dermatol. 98 (3): 379–83. doi:10.1111/1523-1747.ep12499812. PMID 1545147. 
• Niemann MA, Bhown AS, Miller EJ (1991). "The principal site of glycation of human complement factor B". Biochem. J. 274. ( Pt 2): 473–80. PMC 1150163. PMID 2006911. 
• Davrinche C, Abbal M, Clerc A (1991). "Molecular characterization of human complement factor B subtypes". Immunogenetics 32 (5): 309–12. doi:10.1007/bf00211644. PMID 2249879. 
• Farries TC, Lachmann PJ, Harrison RA (1988). "Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complement". Biochem. J. 253 (3): 667–75. PMC 1149358. PMID 3140783. 
• Wu LC, Morley BJ, Campbell RD (1987). "Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements". Cell 48 (2): 331–42. doi:10.1016/0092-8674(87)90436-3. PMID 3643061. 
• Campbell RD, Porter RR (1983). "Molecular cloning and characterization of the gene coding for human complement protein factor B". Proc. Natl. Acad. Sci. U.S.A. 80 (14): 4464–8. doi:10.1073/pnas.80.14.4464. PMC 384059. PMID 6308626. 
• Morley BJ, Campbell RD (1984). "Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen". EMBO J. 3 (1): 153–7. PMC 557312. PMID 6323161. 
• Christie DL, Gagnon J (1983). "Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major cyanogen bromide-cleavage peptide (CB-II) and completion of the sequence of the Bb fragment". Biochem. J. 209 (1): 61–70. PMC 1154056. PMID 6342610. 
• Mole JE, Anderson JK, Davison EA, Woods DE (1984). "Complete primary structure for the zymogen of human complement factor B". J. Biol. Chem. 259 (6): 3407–12. PMID 6546754. 
• Woods DE, Markham AF, Ricker AT et al. (1982). "Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product". Proc. Natl. Acad. Sci. U.S.A. 79 (18): 5661–5. doi:10.1073/pnas.79.18.5661. PMC 346964. PMID 6957884. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Mejía JE, Jahn I, de la Salle H, Hauptmann G (1994). "Human factor B. Complete cDNA sequence of the BF*S allele". Hum. Immunol. 39 (1): 49–53. doi:10.1016/0198-8859(94)90100-7. PMID 8181962. 

External links

• GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
• OMIM entries on Atypical Hemolytic-Uremic Syndrome
• The MEROPS online database for peptidases and their inhibitors: S01.196
• Complement Factor B at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 補体系の後天性疾患 acquired disorders of the complement system
• 2. 小児における非典型的溶血性尿毒症症候群 atypical hemolytic uremic syndrome in children
• 3. 血液-血液透析膜の相互作用に関与する生化学的機序 biochemical mechanisms involved in blood hemodialysis membrane interactions
• 4. 補体経路 complement pathways
• 5. 補体系の遺伝性疾患 inherited disorders of the complement system

English Journal

• Splenic RNA and MicroRNA Mimics Promote Complement Factor B Production and Alternative Pathway Activation via Innate Immune Signaling.

• Zou L1, Feng Y1, Xu G2, Jian W2, Chao W3.
• Journal of immunology (Baltimore, Md. : 1950).J Immunol.2016 Mar 15;196(6):2788-98. doi: 10.4049/jimmunol.1502106. Epub 2016 Feb 17.
• Complement factor B (cfB) is an essential component of the alternative pathway (AP) and plays an important role in the pathogenesis of polymicrobial sepsis. However, the mechanism leading to cfB production and AP activation during sepsis remains poorly understood. In this study, we found that plasma
• PMID 26889043

• Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study.

• Merle BM1, Silver RE1, Rosner B2, Seddon JM3.
• The American journal of clinical nutrition.Am J Clin Nutr.2016 Mar 9. pii: ajcn117606. [Epub ahead of print]
• BACKGROUND: There is growing evidence of the importance of nutrition in age-related macular degeneration (AMD), but few studies have explored associations with folate and B vitamins. No effective therapeutic strategy for geographic atrophy (GA) is available, and prevention could be of great value.OB
• PMID 26961928

• Diabetic ketoacidosis presenting with atypical hemolytic uremic syndrome associated with a variant of complement factor B in an adult: a case report.

• Zhu Z1, Chen H2, Gill R3, Wang J4, Spitalewitz S5, Gotlieb V6.
• Journal of medical case reports.J Med Case Rep.2016 Feb 24;10(1):38. doi: 10.1186/s13256-016-0825-7.
• BACKGROUND: Non-Shiga toxin-associated hemolytic uremic syndrome is known to be caused by dysregulation of the alternative complement pathway. Infections, drugs, pregnancy, bone marrow transplantation, malignancy, and autoimmune disorders have all been reported to trigger episodes of atypical hemoly
• PMID 26911616

Japanese Journal

• モチベーションの分析から見た英語コミュニケーションと国際理解に関する研究

• ゴルシコフ ビクトル,ランギ エリザベス
• 紀要 14, 107-119, 2015-03-01
• 本論文は, 英語コミュニケーションと国際理解の動機付け問題に焦点を当てている。近年、グローバル化に対応した英語教育に関する文部科学省の政策を概観し,その政策は「トップダウン」の性格を持ちながらも、日本人の英語学習者にとって,手段的動機付け(instrumental motivation)と統合的動機付け(integrative motivation)両方のモチベーション要素が含まれていることを指摘 …
• NAID 110009889781

• 再生医療としてiPS細胞が応用される網膜色素上皮細胞

• 岩田 光浩
• 臨床免疫・アレルギー科 63(3), 271-277, 2015-03
• NAID 40020393392

• 競技スポーツの試合場面における円陣行動に対する実践者の認識<BR>-大学女子バスケットボールチームを事例として-

• 日比 千里,青柳 健隆,荒井 弘和,守屋 志保,岡 浩一朗
• スポーツ産業学研究 25(1), 1_11-1_24, 2015
• … A team' s psychological wellbeing is often the deciding factor in team sport success. … However, additional studies involving several teams, games, events, and genders are required to complement these results. …
• NAID 130005073377

Related Links

• CFB - Complement factor B precursor - Homo sapiens (Human ...

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It ...

• Complement factor Bとは - goo Wikipedia (ウィキペディア)

Complement factor Bとは？goo Wikipedia (ウィキペディア) 。出典：Wikipedia（ウィキペディア）フリー百科事典。 Complement factor Bとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ ...

---

★リンクテーブル★

リンク元	「補体B因子」「補体因子B」
関連記事	「B」「complement」「fact」「factor」

「補体B因子」

　　[★]

英

complement factor B

関

B因子、補体因子B

「補体因子B」

　　[★]

英

complement factor B

関

補体B因子、B因子

「B」

　　[★]

• 気管分岐部下緑
• 補体のalternative pathwayに関わる蛋白質

• Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

　 　

「complement」

　　[★]

• n.

• 補って完全にする物、補完物。(免疫)補体
• (必要な)全数、善良

• vt.

• 補って完全にする。補完する。～の補足となる。

　 　 　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter