WordNet
- smear with blood, as in a hunting initiation rite, where the face of a person is smeared with the blood of the kill
- temperament or disposition; "a person of hot blood"
- people viewed as members of a group; "we need more young blood in this organization"
- the fluid (red in vertebrates) that is pumped through the body by the heart and contains plasma, blood cells, and platelets; "blood carries oxygen and nutrients to the tissues and carries away waste products"; "the ancients believed that blood was the sea
- a structure or object that impedes free movement
- any condition that makes it difficult to make progress or to achieve an objective; "intolerance is a barrier to understanding" (同)roadblock
- anything serving to maintain separation by obstructing vision or access
- in or relating to the retina of the eye; "retinal cells"
- the innermost light-sensitive membrane covering the back wall of the eyeball; it is continuous with the optic nerve
PrepTutorEJDIC
- 『血』,『血』液 / 流血(bloodshed);殺人 / 気質,気性,血気,血潮 / 『血統』,血縁(kinship);生まれ,家柄;《the~》王家の血統 / (人種・出身国の)系 / 〈人〉‘に'初めての経験をさせる / 〈猟犬〉‘に'初めて獲物を血を味わわせる
- (通行をはばむ)『さく』,『障壁』;関門;《ふざけて》改札口 / (…の)『難関』,障害《+『to』+『名』》
- (目の)網膜
- 純血の,純種の / 《複合語を作って》「…の血(性質)を持った」の意を表す
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/03/31 12:19:55」(JST)
[Wiki en表示]
The blood–retinal barrier, or the BRB, is part of the blood–ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina.[1] It consists of non-fenestrated capillaries of the retinal circulation and tight-junctions between retinal epithelial cells preventing passage of large molecules from choriocapillaris into the retina.
Contents
- 1 Structure
- 2 Clinical significance
- 3 Other animals
- 4 See also
- 5 References
Structure
The blood retinal barrier has two components: the retinal vascular endothelium and the retinal pigment epithelium.[2] Retinal blood vessels that are similar to cerebral blood vessels maintain the inner blood-ocular barrier. This physiological barrier comprises a single layer of non-fenestrated endothelial cells, which have tight junctions. These junctions are impervious to tracer, so many substances can affect the metabolism of the eyeball. The retinal pigment epithelium maintains the outer blood–retinal barrier.[3]
Clinical significance
Diabetic retinopathy
Diabetic retinopathy, eye damage that frequently occurs as a result of diabetes, is related to the breakdown of the blood–retinal barrier.[4] The barrier becomes more leaky in patients with diabetic retinopathy.[5]
Other animals
Animal models have shown that the blood–retinal barrier becomes more permeable to substances in hypertensive animals (those with high blood pressure).[6]
See also
References
- ^ Biologyonline.org. Blood–retinal barrier. Retrieved on July 19, 2007.
- ^ Vinores, SA (1995). "Assessment of blood–retinal barrier integrity". Histology and histopathology 10 (1): 141–54. PMID 7756735.
- ^ Pardianto, G et al. (2005). "Blood–retinal-barrier". Mimbar Ilmiah Oftalmologi Indonesia 2: 68–69.
- ^ Azza B. El-Remessy, Mohamed Al-Shabrawey, Yousuf Khalifa, Nai-Tse Tsai, Ruth B. Caldwell and Gregory I. Liou. 2006. Neuroprotective and Blood–retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes. American Journal of Pathology, Volume 168, Pages 235-244. Retrieved on July 19, 2007.
- ^ Lobo, CL; Bernardes, RC; Cunha-Vaz, JG. (2000). "Alterations of the Blood–retinal Barrier and Retinal Thickness in Preclinical Retinopathy in Subjects With Type 2 Diabetes". Archives in Ophthalmology 118 (10): 1364–1369. doi:10.1001/archopht.118.10.1364. PMID 11030818.
- ^ S Lightman, E Rechthand, C Latker, A Palestine and S Rapoport. Assessment of the permeability of the blood–retinal barrier in hypertensive rats. Hypertension, Volume 10, Pages 390-395. Retrieved on July 19, 2007.
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Diabetes impairs mobilization of mouse bone marrow-derived Lin(-)/VEGF-R2(+) progenitor cells.
- Barthelmes D, Irhimeh MR, Gillies MC, Karimipour M, Zhou M, Zhu L, Shen WY.SourceSave Sight Institute, Sydney Hospital and Sydney Eye Hospital, The University of Sydney, Sydney, Australia.
- Blood cells, molecules & diseases.Blood Cells Mol Dis.2013 Oct;51(3):163-73. doi: 10.1016/j.bcmd.2013.05.002. Epub 2013 May 25.
- Endothelial progenitor cells circulating in the peripheral blood (PB) contribute to vascular repair. This study aimed to evaluate the potential of a 'cocktail' consisting of erythropoietin, granulocyte colony-stimulating factor and tetrahydrobiopterin to mobilize hematopoietic lineage negative/vascu
- PMID 23714230
- Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats.
- Mysona BA, Al-Gayyar MM, Matragoon S, Abdelsaid MA, El-Azab MF, Saragovi HU, El-Remessy AB.SourceProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, 1120 15th Street HM-1200, Augusta, GA, 30912, USA.
- Diabetologia.Diabetologia.2013 Oct;56(10):2329-39. doi: 10.1007/s00125-013-2998-6. Epub 2013 Aug 7.
- AIMS/HYPOTHESIS: Diabetic retinopathy is characterised by early blood-retina barrier (BRB) breakdown and neurodegeneration. Diabetes causes imbalance of nerve growth factor (NGF), leading to accumulation of the NGF precursor (proNGF), as well as the NGF receptor, p75 neurotrophin receptor (p75(NTR))
- PMID 23918145
- Effects of modified LDL and HDL on retinal pigment epithelial cells: a role in diabetic retinopathy?
- Du M, Wu M, Fu D, Yang S, Chen J, Wilson K, Lyons TJ.SourceHarold Hamm Diabetes Center and Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, HHDC Suite 2900, Oklahoma City, OK, 73104, USA.
- Diabetologia.Diabetologia.2013 Oct;56(10):2318-28. doi: 10.1007/s00125-013-2986-x. Epub 2013 Jul 11.
- AIMS/HYPOTHESIS: Blood-retina barrier leakage in diabetes results in extravasation of plasma lipoproteins. Intra-retinal modified LDLs have been implicated in diabetic retinopathy (DR), but their effects on retinal pigment epithelial (RPE) cells and the added effects of extravasated modified HDLs ar
- PMID 23842729
Japanese Journal
- Amino Acid Residues Involved in the Substrate Specificity of TauT/SLC6A6 for Taurine and γ-Aminobutyric Acid
- Yahara Tohru,Tachikawa Masanori,Akanuma Shin-ichi [他]
- Biological & pharmaceutical bulletin 37(5), 817-825, 2014-05
- NAID 40020048870
- 血液網膜関門の機能特性を利用したドラッグデリバリー
- 久保 義行,赤沼 伸乙,細谷 健一
- Drug Delivery System 27(5), 361-369, 2012
- … 血液網膜関門(blood-retinal barrier; …
- NAID 130003368327
- 高島 由季,土屋 智裕,五十嵐 祐子 [他],金沢 貴憲,岡田 弘晃,Arto Urtti
- YAKUGAKU ZASSHI 132(12), 1365-1370, 2012
- … In addition, the ocular tissue has a blood-retinal barrier which restricts drug delivery thorough systemic administration. … Therefore the invasive intravitreal injection has been generally applied for treatment of retinal diseases. … The liposomes show high pDNA encapsulation efficiency and good cellular uptake ability in human retinal pigment epithelial cells (ARPE-19 cells). …
- NAID 130002489532
Related Links
- The blood–retinal barrier, or the BRB, is part of the blood–ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina. It consists of non-fenestrated capillaries of the ...
Related Pictures
![Mechanism of blood‑retinal barrier](https://1mg.info/0/b/v/2860.jpg)
![Diabetic Retinopathy: Seeing Beyond](https://1mg.info/0/b/v/2861.jpg)
![Blood Retinal Barrier Permeability](https://1mg.info/0/b/v/2862.jpg)
![figure 2 blood retinal barrier brb the brb](https://1mg.info/0/b/v/2863.jpg)
![Orchestrated leukocyte recruitment to](https://1mg.info/0/b/v/2864.jpg)
★リンクテーブル★
[★]
- 英
- blood-retinal barrier, BRB
- 同
- 血液網関門、血液網膜柵
- 関
- 網膜、中心性漿液性網脈絡膜症、網膜色素上皮
[★]
- 関
- damage、difficulty、disorder、disturbance、dysfunction、foe、hindrance、impair、impairment、impediment、lesion、obstacle
[★]
- 関
- 11-cis-retinal、retina、retinae、retinaldehyde, retinol
[★]
血液