WordNet

arrange into a group or groups; "Can you group these shapes together?"
(chemistry) two or more atoms bound together as a single unit and forming part of a molecule (同)radical, chemical group
any number of entities (members) considered as a unit (同)grouping
a set that is closed, associative, has an identity element and every element has an inverse (同)mathematical group
form a group or group together (同)aggroup
the activity of putting things together in groups
a system for classifying things into groups (同)pigeonholing
the univalent radical derived from toluene (同)benzyl_group, benzyl radical
arranged into groups (同)sorted

PrepTutorEJDIC

(…の)『群れ』,集まり,小集団《+of+名》 / (主義・系統・種類などを同じくする人・物の)『派』,『団体』 / (ポミュラーソング歌手の)グループ / (動・植物分類上の)群;(化学の)基,原子団;(地質学上の)界;(数学の)群;(言語学上の)語派 / …‘を'一群に集める,一団にする《+『名』+『together』》 / (系統的に)…‘を'分類する,調和よく配合する《+『名』+『together』》 / 集まる,群(集団)をなす
グループに分けること;分類法 / (集まった物の)配置,配合

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1. 赤血球抗原および抗体のプライマー a primer of red blood cell antigens and antibodies
2. B群レンサ球菌感染症予防のための予防接種 vaccines for the prevention of group b streptococcal disease
3. PANDAS：A群レンサ球菌が関連した小児自己免疫性神経精神疾患 pandas pediatric autoimmune neuropsychiatric disorder associated with group a streptococci
4. 新生児および乳児におけるB群レンサ球菌感染症 group b streptococcal infection in neonates and young infants
5. 連鎖球菌扁桃咽頭炎の治療および予防 treatment and prevention of streptococcal tonsillopharyngitis

English Journal

Phosphatidylcholine and dihydrocaffeic acid amide mixture enhanced the thermo-oxidative stability of canola oil.

Aladedunye F1, Przybylski R2.Author information 1Max Rubner-Institut (MRI), Federal Research Institute for Nutrition and Food, Department for Safety and Quality of Cereals, Working Group for Lipid Research, Schützenberg 12, D-32756 Detmold, Germany. Electronic address: felix.aladedunye@mri.bund.de.2Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.AbstractRecently, we reported the synthesis of a series of dihydrocaffeic acid amides and evaluated their performance as antioxidants for frying applications using a model frying. In the present study, the possibility of a synergy between the amide, N-propyl-N-benzyl-3-(3,4 dihydroxyphenyl)propanamide (DCA) and phosphatidylcholine (PC) was explored in a 6-day actual frying operation. As measured by the amount of polar components (TPC), anisidine value (AnV), changes in fatty acid composition, residual tocopherol and hydroxynonenal (HNE), canola oil containing the formulated antioxidant was twice as stable compared to the regular unfortified oil. At the end of the frying period, the amount of HNE detected in regular canola oil and the fortified sample was at 5.7 and 2.5μg/g, respectively. Thus, the mixture containing phosphatidylcholine and dihydrocaffeic acid amide is a promising antioxidant for frying application.
Food chemistry.Food Chem.2014 May 1;150:494-9. doi: 10.1016/j.foodchem.2013.10.165. Epub 2013 Nov 16.
Recently, we reported the synthesis of a series of dihydrocaffeic acid amides and evaluated their performance as antioxidants for frying applications using a model frying. In the present study, the possibility of a synergy between the amide, N-propyl-N-benzyl-3-(3,4 dihydroxyphenyl)propanamide (DCA)
PMID 24360481

Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy.

Rahn JJ1, Bestman JE1, Josey BJ1, Inks ES1, Stackley KD1, Rogers CE1, Chou CJ2, Chan SS3.Author information 1Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, USA.2Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: chouc@musc.edu.3Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: chans@musc.edu.AbstractEpilepsy is a debilitating disease affecting 1-2% of the world's population. Despite this high prevalence, 30% of patients suffering from epilepsy are not successfully managed by current medication suggesting a critical need for new anti-epileptic drugs (AEDs). In an effort to discover new therapeutics for the management of epilepsy, we began our study by screening drugs that, like some currently used AEDs, inhibit histone deacetylases (HDACs) using a well-established larval zebrafish model. In this model, 7-day post fertilization (dpf) larvae are treated with the widely used seizure-inducing compound pentylenetetrazol (PTZ) which stimulates a rapid increase in swimming behavior previously determined to be a measurable manifestation of seizures. In our first screen, we tested a number of different HDAC inhibitors and found that one, 2-benzamido-1 4-naphthoquinone (NQN1), significantly decreased swim activity to levels equal to that of valproic acid, 2-n-propylpentanoic acid (VPA). We continued to screen structurally related compounds including Vitamin K3 (VK3) and a number of novel Vitamin K (VK) analogs. We found that VK3 was a robust inhibitor of the PTZ-induced swim activity, as were several of our novel compounds. Three of these compounds were subsequently tested on mouse seizure models at the National Institute of Neurological Disorders and Stroke (NINDS) Anticonvulsant Screening Program. Compound 2h reduced seizures particularly well in the minimal clonic seizure (6Hz) and corneal-kindled mouse models of epilepsy, with no observable toxicity. As VK3 affects mitochondrial function, we tested the effects of our compounds on mitochondrial respiration and ATP production in a mouse hippocampal cell line. We demonstrate that these compounds affect ATP metabolism and increase total cellular ATP. Our data indicate the potential utility of these and other VK analogs for the prevention of seizures and suggest the potential mechanism for this protection may lie in the ability of these compounds to affect energy production.
Neuroscience.Neuroscience.2014 Feb 14;259:142-54. doi: 10.1016/j.neuroscience.2013.11.040. Epub 2013 Dec 1.
Epilepsy is a debilitating disease affecting 1-2% of the world's population. Despite this high prevalence, 30% of patients suffering from epilepsy are not successfully managed by current medication suggesting a critical need for new anti-epileptic drugs (AEDs). In an effort to discover new therapeut
PMID 24291671

Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase.

Kim IH1, Lee IH2, Nishiwaki H1, Hammock BD3, Nishi K4.Author information 1Department of Applied Bioscience, Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan.2Department of Medicinal Chemistry, Hyundai Pharm Co., Ltd, Suwon, Gyonggi 443-270, Republic of Korea.3Department of Entomology & UCD Comprehensive Cancer Center, University of California Davis, One Shields Ave, Davis, CA 95616, USA.4Department of Applied Bioscience, Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan. Electronic address: knishi@agr.ehime-u.ac.jp.AbstractWe explored both structure-activity relationships among substituted oxyoxalamides used as the primary pharmacophore of inhibitors of the human sEH and as a secondary pharmacophore to improve water solubility of inhibitors. When the oxyoxalamide function was modified with a variety of alkyls or substituted alkyls, compound 6 with a 2-adamantyl group and a benzyl group was found to be a potent sEH inhibitor, suggesting that the substituted oxyoxalamide function is a promising primary pharmacophore for the human sEH, and compound 6 can be a novel lead structure for the development of further improved oxyoxalamide or other related derivatives. In addition, introduction of substituted oxyoxalamide to inhibitors with an amide or urea primary pharmacophore produced significant improvements in inhibition potency and water solubility. In particular, the N,N,O-trimethyloxyoxalamide group in amide or urea inhibitors (26 and 31) was most effective among those tested for both inhibition and solubility. The results indicate that substituted oxyoxalamide function incorporated into amide or urea inhibitors is a useful secondary pharmacophore, and the resulting structures will be an important basis for the development of bioavailable sEH inhibitors.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2014 Feb 1;22(3):1163-75. doi: 10.1016/j.bmc.2013.12.027. Epub 2014 Jan 3.
We explored both structure-activity relationships among substituted oxyoxalamides used as the primary pharmacophore of inhibitors of the human sEH and as a secondary pharmacophore to improve water solubility of inhibitors. When the oxyoxalamide function was modified with a variety of alkyls or subst
PMID 24433964

Japanese Journal

Syntheses and Catalytic Ability of Sugar-Incorporated N-Heterocyclic Carbene Pincer Pd Complexes Possessing Various N-Substituents

Imanaka Yosuke,Hashimoto Hideki,Nishioka Takanori
Bulletin of the Chemical Society of Japan 88(8), 1135-1143, 2015
… These complexes possess various N-substituents, namely, methyl, isopropyl, benzyl, or D-glucopyranosyl units on the terminal NHC moieties. … The complex possessing an isopropyl group on the terminal NHC moiety exhibited excellent catalytic activity with TON (800000), which is comparable to the best value reported for a similar reaction. …
NAID 130005092055

Solvent Effect on Fluorescence Properties of Stilbene Dendrimer Surrounded by Benzyl-Ether Dendrons

Nakazato Satoshi,Arai Tatsuo
Bulletin of the Chemical Society of Japan advpub(0), 2015
… These results indicated that the core of even higher generation dendrimer was not isolated from solvent molecules and environment of dendrimer core is constructed by both surrounding dendron group and penetrated solvent molecules. …
NAID 130005067227

The Nickel(II)-Catalyzed Direct Benzylation, Allylation, Alkylation, and Methylation of C-H Bonds in Aromatic Amides Containing an 8-Aminoquinoline Moiety as the Directing Group

Aihara Yoshinori,Wuelbern Jendrik,Chatani Naoto
Bulletin of the Chemical Society of Japan advpub(0), 2015
… Direct alkylation via the cleavage of the ortho C-H bonds by a nickel-catalyzed reaction of aromatic amides containing an 8-aminoquinoline moiety as the directing group with alkyl halides is reported. … Various alkyl halides, including benzyl, allyl, alkyl, and methyl halides (or pseudo halides) participate as electrophilic coupling partners. … The reaction shows a high functional group compatibility. …
NAID 130004801859