WordNet

arranged according to size
of many different kinds purposefully arranged but lacking any uniformity; "assorted sizes"; "his disguises are many and various"; "various experiments have failed to disprove the theory"; "cited various reasons for his behavior" (同)various
consisting of a haphazard assortment of different kinds; "an arrangement of assorted spring flowers"; "assorted sizes"; "miscellaneous accessories"; "a mixed program of baroque and contemporary music"; "a motley crew"; "sundry sciences commonly known as social"- I.A.Richards (同)miscellaneous, mixed, motley, sundry
not easy to combine harmoniously (同)incompatible, mismated, unsuited
not arranged according to size
an operation that segregates items into groups according to a specified criterion; "the bottleneck in mail delivery is the process of sorting" (同)sorting
an approximate definition or example; "she wore a sort of magenta dress"; "she served a creamy sort of dessert thing"
a person of a particular character or nature; "what sort of person is he?"; "hes a good sort"

PrepTutorEJDIC

各種取り合わせた / 《複合語を作って》「調和した」の意を表す
不調和,つりあいのとれていない
『種類』,部類(kind) / 性格,性質,タイプ / 《おもに英話》《単数形で》(ある)種類の人 / …‘を'分類する,区分けする;えり分ける,選び出す《+『名』+『out,』+『out』+『名』》

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/15 22:34:10」(JST)

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1. 着床前の男女生み分け技術 techniques for preimplantation sex selection
2. 自己免疫性リンパ増殖症候群(ALPS)：臨床的特徴および診断 autoimmune lymphoproliferative syndrome alps clinical features and diagnosis
3. 下肢末梢動脈疾患の症状を治療するための試験的治療 investigational therapies for treating symptoms of lower extremity peripheral artery disease
4. 急性膵炎の発症機序 pathogenesis of acute pancreatitis
5. 悪性黒色腫に対する補助免疫療法 adjuvant immunotherapy for melanoma

English Journal

Transcriptomic responses in rainbow trout gills upon infection with viral hemorrhagic septicemia virus (VHSV).

Aquilino C1, Castro R1, Fischer U1, Tafalla C2.Author information 1Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos (Madrid), Spain; Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany.2Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos (Madrid), Spain; Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany. Electronic address: tafalla@inia.es.AbstractIt has been previously demonstrated that even though the fin bases constitute the main portal of entry of viral hemorrhagic septicemia virus (VHSV) in rainbow trout (Oncorhynchus mykiss), an important number of chemokine genes are up-regulated in the gills upon bath exposure to the virus. Because chemokines mediate the recruitment of leukocytes through the action of specific chemokine receptors, in the current study, we have studied the transcription of several immune genes in response to a VHSV bath infection in the gills, focusing both on chemokine receptor genes and on genes characteristic of distinct leukocyte populations such as IgM, IgD, IgT, CD4, CD8, perforin and MHC-II. We have studied the response to the virus in naïve fish as well as in fish that had been previously intramuscularly (i.m.) injected with a VHSV DNA vaccine. Additionally, we have sorted both IgM(+) and CD8(+) cells from the gills of naïve and infected animals to study some of these up-regulated genes in specific leukocyte populations. Our results indicate that despite the low replication level, VHSV provokes an up-regulation of IgM, IgT, CD3 and perforin transcription together with the up-regulation of CCR7, CCR9, CXCR3B and CXCR4 mRNA levels. Interestingly, MHC-II mRNA was up-regulated and CCR7 was down-modulated in IgM(+) cells from infected gills, whereas perforin, CCR7 and CXCR4 mRNA levels were higher in sorted CD8(+) cells from infected animals. Surprisingly, when fish had been previously injected with either the empty plasmid or the VHSV DNA vaccine, these up-regulations in immune gene transcription were no longer observed. Our results point to the gills as an important site for innate and acquired viral defense.
Developmental and comparative immunology.Dev Comp Immunol.2014 May;44(1):12-20. doi: 10.1016/j.dci.2013.11.006. Epub 2013 Nov 22.
It has been previously demonstrated that even though the fin bases constitute the main portal of entry of viral hemorrhagic septicemia virus (VHSV) in rainbow trout (Oncorhynchus mykiss), an important number of chemokine genes are up-regulated in the gills upon bath exposure to the virus. Because ch
PMID 24269609

Imatinib sensitizes endometrial cancer cells to cisplatin by targeting CD117-positive growth-competent cells.

Zhang X1, Kyo S2, Nakamura M1, Mizumoto Y1, Maida Y1, Bono Y1, Takakura M1, Fujiwara H1.Author information 1Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan.2Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan. Electronic address: satoruky@med.kanazawa-u.ac.jp.AbstractThe use of molecular target therapy has not been established for endometrial cancer. The present study investigated the potential therapeutic strategy of targeting CD117-positive cancer cells as a novel molecular target therapy. FACS-sorted CD117(+) cells isolated from endometrial cancer cell lines (Ishikawa or MFE280 cells) exhibited higher proliferative capacity in vitro and colony forming activity on soft agar, and decreased sensitivity to cisplatin, compared to CD117(-) cells. Immunohistochemical analyses with surgical specimens of endometrial cancers showed that high CD117 expression was tightly linked to advanced FIGO stages, myometrial invasion and histological grade, and was significantly associated with poor overall survival and relapse-free survival (Kaplan-Meier analysis; p<0.001, log-rank test). The Cox-regression hazard model identified high CD117 expression to be an independent prognostic factor for survival (p<0.05). In vitro assay confirmed that stem cell factor (SCF), a ligand of CD117, was produced specifically in CD117(+) cells of endometrial cancer, and the colony-forming activity were abrogated by adding anti-SCF antibody, indicating an SCF-dependent growth property. Imatinib was confirmed to selectively target CD117(+) cells in vitro, and synergistically enhanced the anti-tumor effect of low dose cisplatin in vivo, which showed only modest effects when used as a single use. These findings suggest that CD117 can be a marker of aggressive behavior of cells as well as an independent prognostic marker in endometrial cancer. Targeting of the SCF/CD117 axis by imatinib sensitized endometrial cancer cells to cisplatin, proposing a novel therapeutic strategy for this tumor type.
Cancer letters.Cancer Lett.2014 Apr 1;345(1):106-14. doi: 10.1016/j.canlet.2013.11.020. Epub 2013 Dec 11.
The use of molecular target therapy has not been established for endometrial cancer. The present study investigated the potential therapeutic strategy of targeting CD117-positive cancer cells as a novel molecular target therapy. FACS-sorted CD117(+) cells isolated from endometrial cancer cell lines
PMID 24333732

Children's thoughts on the social exclusion of peers with intellectual or learning disabilities.

Nowicki EA, Brown J, Stepien M.Author information Faculty of Education, The University of Western Ontario, London, Ontario, Canada.AbstractBACKGROUND: Previous research has shown that children with intellectual or learning disabilities are at risk for social exclusion by their peers but little is known of children's views on this topic. In this study, we used concept mapping to investigate elementary school children's thoughts on why they believe their peers with intellectual or learning disabilities are sometimes socially excluded at school.
Journal of intellectual disability research : JIDR.J Intellect Disabil Res.2014 Apr;58(4):346-57. doi: 10.1111/jir.12019. Epub 2013 Jan 28.
BACKGROUND: Previous research has shown that children with intellectual or learning disabilities are at risk for social exclusion by their peers but little is known of children's views on this topic. In this study, we used concept mapping to investigate elementary school children's thoughts on why t
PMID 23356579

Japanese Journal

Variation and Determinants of Rice Yields among Individual Paddy Fields : Case Study of a Large-Scale Farm in the Kanto Region of Japan

九州大学大学院農学研究院紀要 61(1), 205-214, 2016-02-29
NAID 120005725063

火星のローブ状地形の成因:―土石流堆積物逆解析による予察的検討―

地学雑誌 125(1), 163-170, 2016
NAID 130005138746

腫瘍症例と健常犬における血液検査所見の比較検討

動物臨床医学 23(2), 59-65, 2016
NAID 130005125167

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