asporin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/07/27 13:03:21」(JST)

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Asporin
Identifiers
Symbols	ASPN; OS3; PLAP-1; PLAP1; SLRR1C
External IDs	OMIM: 608135 MGI: 1913945 HomoloGene: 32357 GeneCards: ASPN Gene
Gene Ontology Molecular function • calcium ion binding Cellular component • proteinaceous extracellular matrix • extracellular matrix Biological process • bone mineralization • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of tooth mineralization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54829	66695
Ensembl	ENSG00000106819	ENSMUSG00000021388
UniProt	Q9BXN1	Q99MQ4
RefSeq (mRNA)	NM_001193335.1	NM_001172481.1
RefSeq (protein)	NP_001180264.1	NP_001165952.1
Location (UCSC)	Chr 9: 95.22 – 95.24 Mb	Chr 13: 49.64 – 49.66 Mb
PubMed search	[1]	[2]

Asporin is a protein that in humans is encoded by the ASPN gene.

ASPN belongs to a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and the overall similarity to decorin (MIM 125255) (Lorenzo et al., 2001).[supplied by OMIM]

References

Further reading

• Lorenzo P, Aspberg A, Onnerfjord P et al. (2001). "Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan". J. Biol. Chem. 276 (15): 12201–11. DOI:10.1074/jbc.M010932200. PMID 11152692. 
• Henry SP, Takanosu M, Boyd TC et al. (2001). "Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family". J. Biol. Chem. 276 (15): 12212–21. DOI:10.1074/jbc.M011290200. PMID 11152695. 
• Yamada S, Murakami S, Matoba R et al. (2001). "Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene". Gene 275 (2): 279–86. DOI:10.1016/S0378-1119(01)00683-7. PMID 11587855. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Clark HF, Gurney AL, Abaya E et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. DOI:10.1101/gr.1293003. PMC 403697. PMID 12975309. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
• Kizawa H, Kou I, Iida A et al. (2005). "An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis". Nat. Genet. 37 (2): 138–44. DOI:10.1038/ng1496. PMID 15640800. 
• Rodriguez-Lopez J, Pombo-Suarez M, Liz M et al. (2006). "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians". Arthritis Res. Ther. 8 (3): R55. DOI:10.1186/ar1920. PMC 1526645. PMID 16542493. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1526645. 
• Yamada S, Ozawa Y, Tomoeda M et al. (2006). "Regulation of PLAP-1 expression in periodontal ligament cells". J. Dent. Res. 85 (5): 447–51. DOI:10.1177/154405910608500510. PMID 16632759. 
• Jiang Q, Shi D, Yi L et al. (2007). "Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese". J. Hum. Genet. 51 (12): 1068–72. DOI:10.1007/s10038-006-0065-6. PMID 17024313. 
• Nakamura T, Shi D, Tzetis M et al. (2007). "Meta-analysis of association between the ASPN D-repeat and osteoarthritis". Hum. Mol. Genet. 16 (14): 1676–81. DOI:10.1093/hmg/ddm115. PMID 17517696. 
• Shi D, Nakamura T, Dai J et al. (2007). "Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population". J. Hum. Genet. 52 (8): 664–7. DOI:10.1007/s10038-007-0166-x. PMID 17603749. 
• Kou I, Nakajima M, Ikegawa S (2007). "Expression and regulation of the osteoarthritis-associated protein asporin". J. Biol. Chem. 282 (44): 32193–9. DOI:10.1074/jbc.M706262200. PMID 17804408. 
• Nakajima M, Kizawa H, Saitoh M et al. (2007). "Mechanisms for asporin function and regulation in articular cartilage". J. Biol. Chem. 282 (44): 32185–92. DOI:10.1074/jbc.M700522200. PMID 17827158. 

UpToDate Contents

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• 1. 変形性関節症の危険因子および考えられる原因 risk factors for and possible causes of osteoarthritis

English Journal

• Proteomics Analysis of Cardiac Extracellular Matrix Remodeling in a Porcine Model of Ischemia-Reperfusion Injury.

• Barallobre-Barreiro J, Didangelos A, Schoendube FA, Drozdov I, Yin X, Fernández-Caggiano M, Willeit P, Puntmann VO, Aldama-López G, Shah AM, Doménech N, Mayr M.Source1 Unidad de Investigación - INIBIC-CHU A Coruña, A Coruña, Spain;
• Circulation.Circulation.2012 Jan 18. [Epub ahead of print]
• BACKGROUND: Following myocardial ischemia, extracellular matrix (ECM) deposition occurs at the site of the focal injury and at the border region.METHODS AND RESULTS: We have applied a novel proteomic method for the analysis of ECM in cardiovascular tissues to a porcine model of ischemia-reperfusion
• PMID 22261194

• The sclerostin-bone protein interactome.

• Devarajan-Ketha H, Craig TA, Madden BJ, Robert Bergen H 3rd, Kumar R.SourceDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2012 Jan 13;417(2):830-5. Epub 2011 Dec 22.
• The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-malt
• PMID 22206666

• Candidate Serum Biomarkers for Prostate Adenocarcinoma Identified by mRNA Differences in Prostate Tissue and Verified with Protein Measurements in Tissue and Blood.

• Klee EW, Bondar OP, Goodmanson MK, Dyer RB, Erdogan S, Bergstralh EJ, Bergen HR 3rd, Sebo TJ, Klee GG.SourceDepartment of Health Sciences Research.
• Clinical chemistry.Clin Chem.2012 Jan 12. [Epub ahead of print]
• BACKGROUND: Improved tests are needed for detection and management of prostate cancer. We hypothesized that differential gene expression in prostate tissue could help identify candidate blood biomarkers for prostate cancer and that blood from men with advanced prostate disease could be used to verif
• PMID 22247499

Japanese Journal

• TGP-β1及び活性型ビタミンDがヒト歯根膜由来細胞の分化へ及ぼす影響

• 福井 稔子
• 日本歯周病学会会誌 52(4), 391-400, 2010-12-28
• … 石灰化誘導培地でのTGF-β1と活性型ビタミンDに対するHPdLFの反応性は, 歯根膜細胞に特徴的マーカーとされるPLAP-1/asporin遺伝子発現は減弱し, 骨芽細胞に特徴的マーカーとされるオステオカルシン遺伝子発現は上昇した。 …
• NAID 10027692058

• Binding characteristics of the osteoarthritis-associated protein asporin

• KOU Ikuyo,NAKAJIMA Masahiro,IKEGAWA Shiro
• Journal of bone and mineral metabolism 28(4), 395-402, 2010-07-30
• NAID 10027208115

Related Links

• Asporin - Wikipedia, the free encyclopedia

Asporin is a protein that in humans is encoded by the ASPN gene. ASPN belongs to a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and the ...

• Anti-Asporin antibody (ab31303) | Abcam

Goat polyclonal to Asporin Primary antibodies datasheet (ab31303).

Related Pictures

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★リンクテーブル★

リンク元

「変形性関節症」

「変形性関節症」

　　[★]

英

osteoarthritis, OA

ラ

arthritis deformans

同

変性関節疾患, degenerative joint disease, DJD、degenerative arthritis, hypertrophic arthritis、骨関節症 osteoarthrosis

関

変形性股関節症

概念

• 慢性関節疾患(変性・退行性)
• 関節軟骨、半月などの退行変性を基盤に、軟骨破壊と同時に骨軟骨の再造成を来し、関節形態が変化する疾患。

疫学

• 発症頻度：女性＞男性
• 加齢に伴い罹患頻度が上昇。60歳以降で10-18%(SOR.233)
• 60歳以上では関節にX線上の変化が認められる　→　X線上の変化があっても無症状な場合もある
• 頻度：変形性膝関節症 > 変形性股関節症

病型

• 一次性変形性関節症：原疾患不明
• 二次性変形性関節症：続発症として(関節外傷、形態異常、代謝異常、他の関節疾患など)

病因

疾患感受性遺伝子

• 1. secreted frizzled-related protein 3 gene(FRZB)

• 軟骨成熟を制御する糖タンパクであるWntのシグナルを阻害

• 2. asporin(ASPN)

• small leucine-rich proteoglycanに属するマトリックス蛋白
• TGFβと結合してTGFβシグナルを阻害し、アグリカンやII型コラーゲン発現を抑制

• 3. calmodulin(CALM1)

• Ca2+を結合する細胞内蛋白。アグリカンやII型コラーゲンの発現を増大させる

• 4. GDF5(CDMP1)

• 軟骨の分化誘導に関わるTGFβ family member
• 軟骨マトリックス産生の増大

病態生理

• アグリカンの単分子化

身体所見

• 遠位指節間関節(DIP)の結節：ヘバーデン結節 (典型的)
• 近位指節間関節(PIP)の結節：ブシャール結節

症状

• 関節のこわばり、疼痛、腫脹で、
• 進行例：可動域制限、関節変形

検査

単純X線写真

• ローゼンバーグ撮影肢位で行う

*関節裂隙の狭小化、消失

• 軟骨下骨の硬化、骨棘形成
• 時には骨嚢胞像、関節内の遊離体出現
• 傍関節性の骨萎縮像、軟骨下骨の著明な骨びらんなどは出現しない。

治療

• 保存的治療

• 生活療法
• 運動療法
• 薬物療法

• アセトアミノフェン
• NSAIDs
• ステロイド関節内注射　→　ステロイド関節症

• 装具療法

• 足底板挿入

• 手術療法

• 変性半月切除関節内debridement
• 高位脛骨骨切り術(HTO)
• 人工膝関節置換術(TKA)