変形性関節症
WordNet
- inflammation of a joint or joints
PrepTutorEJDIC
- 関節炎
UpToDate Contents
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English Journal
- Epidemiology of Paget's disease of bone: a systematic review and meta-analysis of secular changes.
- Corral-Gudino L1, Borao-Cengotita-Bengoa M, Del Pino-Montes J, Ralston S.Author information 1Servicio de Medicina Interna, Hospital El Bierzo, Ponferrada, Leon, Spain. lcorral@saludcastillayleon.esAbstractCONTEXT: Several studies have suggested that the prevalence and severity of PDB have fallen in recent years. The magnitude of this trend and its globalization have not been well established.
- Bone.Bone.2013 Aug;55(2):347-52. doi: 10.1016/j.bone.2013.04.024. Epub 2013 May 1.
- CONTEXT: Several studies have suggested that the prevalence and severity of PDB have fallen in recent years. The magnitude of this trend and its globalization have not been well established.OBJECTIVE: The objective of this study is to estimate the pooled magnitude of the changes in the prevalence of
- PMID 23643679
- [Paget's disease of bone: new therapeutic strategies].
- D'Amore M, Lisi S, Sisto M, De Marino AV.AbstractPaget's disease of bone is a chronic disorder of unknown etiology that can result in enlarged and misshapen bones. The excessive breakdown and formation of bone tissue cause affected bones to weaken, resulting in pain, misshapen bones, fractures, and arthritis in the joints. In most cases the diagnosis is achieved casually, as only 5% of patients develop burning pain at the level of affected bones. As regards therapy, the use of anti-reabsorbing drugs, such as bisphosphonates and calcitonin, appears reasonable. Given the disease pathogenesis, the administration of denosumab and tocilizumab may be a valuable alternative to inhibit RANK expression, and thus osteoclast formation, and interleukin-6 production.
- Recenti progressi in medicina.Recenti Prog Med.2013 Mar;104(3):89-92. doi: 10.1701/1255.13854.
- Paget's disease of bone is a chronic disorder of unknown etiology that can result in enlarged and misshapen bones. The excessive breakdown and formation of bone tissue cause affected bones to weaken, resulting in pain, misshapen bones, fractures, and arthritis in the joints. In most cases the diagno
- PMID 23548950
- The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.
- Wright T1, Rea SL, Goode A, Bennett AJ, Ratajczak T, Long JE, Searle MS, Goldring CE, Park BK, Copple IM, Layfield R.Author information 1School of Biomedical Sciences, University of Nottingham, UK.AbstractMutations affecting the Sequestosome 1 (SQSTM1) gene commonly occur in patients with the skeletal disorder Paget's disease of bone (PDB), a condition characterised by defective osteoclast differentiation and function. Whilst most mutations cluster within the ubiquitin-associated (UBA) domain of the SQSTM1 protein, and are associated with dysregulated NFκB signalling, several non-UBA domain mutations have also been identified. Keap1 is a SQSTM1-interacting protein that regulates the levels and activity of the Nrf2 transcription factor. This in turn controls the expression of numerous cytoprotective genes that contribute to the cell's capacity to defend itself against chemical and oxidative stress, through binding to the antioxidant response element (ARE). The PDB-associated S349T mutation maps to the Keap1-interacting region (KIR) of SQSTM1, however the effects of PDB mutant SQSTM1 on Keap1 function have not been investigated. Here we show that unlike other SQSTM1 mutations, the S349T mutation results in neither impaired ubiquitin-binding function in pull-down assays, nor dysregulated NFκB signalling in luciferase reporter assays. Keap1 is expressed in differentiating osteoclast-like cells and the S349T mutation selectively impairs the SQSTM1-Keap1 interaction in co-immunoprecipitations, which molecular modelling indicates results from effects on critical hydrogen bonds required to stabilise the KIR-Keap1 complex. Further, S349T mutant SQSTM1, but not other PDB-associated mutants, showed reduced ability to activate Nrf2 signalling as assessed by ARE-luciferase reporter assays. Thus, SQSTM1-mediated dysregulation of the Keap1-Nrf2 axis, which could potentially lead to aberrant production of oxidative response genes, may contribute to disease aetiology in a subset of PDB patients.
- Bone.Bone.2013 Feb;52(2):699-706. doi: 10.1016/j.bone.2012.10.023. Epub 2012 Oct 29.
- Mutations affecting the Sequestosome 1 (SQSTM1) gene commonly occur in patients with the skeletal disorder Paget's disease of bone (PDB), a condition characterised by defective osteoclast differentiation and function. Whilst most mutations cluster within the ubiquitin-associated (UBA) domain of the
- PMID 23117207
Japanese Journal
- 温泉による運動器疼痛の治療効果に関する非ランダム化比較試験のシステマティック・レビュー
- 上岡 洋晴,津谷 喜一郎,奥泉 宏康 [他],岡田 真平,半田 秀一,北湯口 純,鎌田 真光
- 日本温泉気候物理医学会雑誌 72(3), 179-192, 2009-05-01
- … Their individual results showed that hot springs treatment in combination with a comprehensive fitness class was more effective than hot springs treatment alone, and that balneotherapy had therapeutic effects on arthrosis deformans, psoriatic arthritis, and lumbago. …
- NAID 10024797609
- 慢性関節リウマチに併発した変形性顎関節症, 咬合不全の治療 : 関節鏡視下手術と顎間牽引療法
- ゼラチンの抗原性およびヒト血清中にみられる抗ゼラチン抗体様因子について
Related Links
- arthritis /ar·thri·tis/ (ahr-thri´tis) pl. arthri´tides inflammation of a joint. acute arthritis arthritis marked by pain, heat, redness, and swelling. chronic inflammatory arthritis inflammation of joints in chronic disorders such as rheumatoid arthritis.
- A chronic disease marked by stiffness and inflammation of the joints, weakness, loss of mobility, and deformity. click for a larger image. rheumatoid arthritis. top: normal finger joint. bottom: arthritic finger joint ...
★リンクテーブル★
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- 英
- osteoarthritis, OA
- ラ
- arthritis deformans
- 同
- 変性関節疾患, degenerative joint disease, DJD、degenerative arthritis, hypertrophic arthritis、骨関節症 osteoarthrosis
- 関
- 変形性股関節症
概念
- 慢性関節疾患(変性・退行性)
- 関節軟骨、半月などの退行変性を基盤に、軟骨破壊と同時に骨軟骨の再造成を来し、関節形態が変化する疾患。
疫学
- 発症頻度：女性＞男性
- 加齢に伴い罹患頻度が上昇。60歳以降で10-18%(SOR.233)
- 60歳以上では関節にX線上の変化が認められる → X線上の変化があっても無症状な場合もある
- 頻度：変形性膝関節症 > 変形性股関節症
病型
- 一次性変形性関節症：原疾患不明
- 二次性変形性関節症：続発症として(関節外傷、形態異常、代謝異常、他の関節疾患など)
病因
疾患感受性遺伝子
- 1. secreted frizzled-related protein 3 gene(FRZB)
- 軟骨成熟を制御する糖タンパクであるWntのシグナルを阻害
- small leucine-rich proteoglycanに属するマトリックス蛋白
- TGFβと結合してTGFβシグナルを阻害し、アグリカンやII型コラーゲン発現を抑制
- Ca2+を結合する細胞内蛋白。アグリカンやII型コラーゲンの発現を増大させる
- 軟骨の分化誘導に関わるTGFβ family member
- 軟骨マトリックス産生の増大
病態生理
身体所見
症状
- 関節のこわばり、疼痛、腫脹で、
- 進行例：可動域制限、関節変形
検査
単純X線写真
*関節裂隙の狭小化、消失
治療
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- 変性半月切除関節内debridement
- 高位脛骨骨切り術(HTO)
- 人工膝関節置換術(TKA)
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地方病性変形性骨関節炎