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1. アフリカトリパノソーマ症：臨床症状、診断、治療african trypanosomiasis clinical manifestations diagnosis and treatment [show details]
… Another concentration technique involves a mini-anion exchange column; blood is filtered through a resin that retains blood cells but allows trypanosomes… The CDC Drug Service telephone number is (404) 639-3670 or (404) 770-7100. The drugs available for treatment of HAT are toxic and difficult to administer; new drugs are urgently needed.…
2. 遺伝性楕円赤血球症と関連疾患hereditary elliptocytosis and related disorders [show details]
… due to drugs or deficiency of vitamin B12 or folate); inherited megaloblastic anemias may rarely be seen.… 4.1) Band 3 protein (also called AE1 [anion exchange protein 1]) Glycophorin C; Genetic variation affecting the abundance,…
3. 遺伝性球状赤血球症hereditary spherocytosis [show details]
…Erythrocyte ankyrin is encoded by the ANK1 gene; Band 3 (the anion exchanger AE1) – This anion channel is encoded by the solute carrier family 4 anion exchanger (SLC4A1) gene; Band 4.2 (previously called pallidin) …
4. 不安定ヘモグロビン変異体unstable hemoglobin variants [show details]
… increased hemolysis when exposed to oxidant drugs, and it is prudent to discontinue possible offending drugs in patients who appear to have worsening… splenectomy: A disulfide bond between membrane band 3 (also known as anion exchanger [AE]-1) and globin.…
5. 薬物および毒素による溶血性貧血hemolytic anemia due to drugs and toxins [show details]
… Drugs are an uncommon cause of hemolytic anemia, but when a patient develops hemolytic anemia in the setting of a drug, it is important to determine whether the drug is responsible. Additional challenges …

English Journal

Modeling of the static batch desorption and dynamic column elution of geniposidic acid from a porous anion-exchanger.

Qian W, Wang J, Ding H, Xie W.
Journal of chromatography. A. 2019 Jun;1594()1-12.
For several decades, plenty of iridoid glycosides including geniposide (GS) and geniposidic acid (GSA) in the gardenia yellow pigment extraction waste water was not recovered effectively. This study is aimed to supply an efficient GSA recycling route. In this study, a model incorporating a superfici
PMID 30772057

Physical-chemical interactions between pharmaceuticals and biochar in synthetic and real urine.

Solanki A, Boyer TH.
Chemosphere. 2019 Mar;218()818-826.
This research advances the knowledge of the pharmaceutical removal interactions by biochar in synthetic and real urine through the use of reference adsorbents and adsorbate probes. Earlier work has combined biochar and urine for pharmaceutical removal, however, the interactions that influence adsorp
PMID 30508800

Generic anion-exchange chromatography method for analytical and preparative separation of nucleotides in the development and manufacture of drug substances.

Tsay FR, Haidar Ahmad IA, Henderson D, Schiavone N, Liu Z, Makarov AA, Mangion I, Regalado EL.
Journal of chromatography. A. 2019 Feb;1587()129-135.
Nucleotides are among the most frequently used chemical building blocks in the research, development and manufacture of drug substances. They are composed of three highly polar subunit molecules (a nucleobase, a sugar, and at least one phosphate group), which makes their separation and analysis very
PMID 30591245

Japanese Journal

Preparative Separation of High-Purity Dihydroartemisinic Acid from Artemisinin Production Waste by Combined Chromatography

Liu Shuoqian,Ferreira Jorge Freire da Silva,Tian Dongming,Tang Yuwei,Liu Liping,Yang Wei,Liu Zhonghua,Tian Na
ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 66(3), 319-326, 2018
… In order to make full use of artemisinin production waste and thus to reduce the production cost of artemisinin, we developed an efficient and scalable method to isolate high-purity dihydroartemisinic acid from artemisinin production waste by combining anion-exchange resin with silica-gel column chromatography. …
NAID 130006407042

Phosphate as a Determinant of the Difference in Drug Interactions Due to Colestyramine and Colestimide

Oda Masako,Kudo Takehiro,Ichimura Yuichi,Saitoh Hiroshi
医療薬学 41(3), 191-197, 2015
… They cause drug interactions of different extents, with colestyramine decreasing the absorption of various anionic drugs more potently than colestimide. … In the present study, we evaluated the binding characteristics of colestyramine and colestimide to several anionic drugs in the absence or presence of phosphate. … Resin suspension and drug solution were prepared using ultrapure water, the Japanese Pharmacopeia (JP) 1st …
NAID 130005132602

Effect of Colestimide Therapy for Glycemic Control in Type 2 Diabetes Mellitus with Hypercholesterolemia

YAMAKAWA TADASHI,TAKANO TATSURO,UTSUNOMIYA HIROTOSHI,KADONOSONO KAZUAKI,OKAMURA ATUSHI
Endocrine journal 54(1), 53-58, 2007-02-20
… Colestimide is a new anion-exchange resin used to lower serum cholesterol in Japan. … Total cholesterol and LDL-cholesterol decreased significantly (P<0.01) with either medication, with similar reduction rates for both drugs. …
NAID 10019479257