αクリスタリンA鎖

WordNet

fasten or secure with chains; "Chain the chairs together"
a unit of length
a necklace made by a stringing objects together; "a string of beads"; "a strand of pearls"; (同)string, strand
a linked or connected series of objects; "a chain of daisies"
a series of (usually metal) rings or links fitted into one another to make a flexible ligament
anything that acts as a restraint
(chemistry) a series of linked atoms (generally in an organic molecule) (同)chemical chain
a series of things depending on each other as if linked together; "the chain of command"; "a complicated concatenation of circumstances" (同)concatenation
(business) a number of similar establishments (stores or restaurants or banks or hotels or theaters) under one ownership
connect or arrange into a chain by linking
first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
British biochemist (born in Germany) who isolated and purified penicillin, which had been discovered in 1928 by Sir Alexander Fleming (1906-1979) (同)Ernst Boris Chain, Sir Ernst Boris Chain
bound with chains; "enchained demons strained in anger to gnaw on his bones"; "prisoners in chains" (同)enchained

PrepTutorEJDIC

『鎖』;(装飾用の)鎖 / 《複数形で》『束縛』,拘束;囚人をつなぐ鎖 / (物事の)『連続』,つながり《+『of』+『名』》 / (商店・銀行・ホテルなどの)チェーン(一連の店が同一資本のもとで連携して経営される方式;その店) / チェーン(測量で用いられる単位;約21.7m) / …'を'『鎖でつなぐ』《+『up』(『together』)+『名,』+『名』+『up』(『together』)》
アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
answer / ampere

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 重度複合型免疫不全（SCID）：特定の欠損 severe combined immunodeficiency scid specific defects
2. 複合免疫不全 combined immunodeficiencies
3. 肥大型心筋症の遺伝学 genetics of hypertrophic cardiomyopathy
4. αサラセミアの病態生理 pathophysiology of alpha thalassemia
5. 重鎖病 the heavy chain diseases

English Journal

Pharmacological chaperone for α-crystallin partially restores transparency in cataract models.

Makley LN1, McMenimen KA1, DeVree BT2, Goldman JW3, McGlasson BN3, Rajagopal P4, Dunyak BM1, McQuade TJ5, Thompson AD1, Sunahara R2, Klevit RE4, Andley UP6, Gestwicki JE7.
Science (New York, N.Y.).Science.2015 Nov 6;350(6261):674-7. doi: 10.1126/science.aac9145.
Cataracts reduce vision in 50% of individuals over 70 years of age and are a common form of blindness worldwide. Cataracts are caused when damage to the major lens crystallin proteins causes their misfolding and aggregation into insoluble amyloids. Using a thermal stability assay, we identified a cl
PMID 26542570

Species-Specific Structural and Functional Divergence of α-Crystallins: Zebrafish αBa- and Rodent αA(ins)-Crystallin Encode Activated Chaperones.

Koteiche HA1, Claxton DP1, Mishra S1, Stein RA1, McDonald ET1, Mchaourab HS1.
Biochemistry.Biochemistry.2015 Sep 29;54(38):5949-58. doi: 10.1021/acs.biochem.5b00678. Epub 2015 Sep 17.
In addition to contributing to lens optical properties, the α-crystallins are small heat shock proteins that possess chaperone activity and are predicted to bind and sequester destabilized proteins to delay cataract formation. The current model of α-crystallin chaperone mechanism envisions a trans
PMID 26378715

A conserved role of αA-crystallin in the development of the zebrafish embryonic lens.

Zou P1, Wu SY1, Koteiche HA1, Mishra S1, Levic DS2, Knapik E2, Chen W1, Mchaourab HS3.
Experimental eye research.Exp Eye Res.2015 Sep;138:104-13. doi: 10.1016/j.exer.2015.07.001. Epub 2015 Jul 4.
αA- and αB-crystallins are small heat shock proteins that bind thermodynamically destabilized proteins thereby inhibiting their aggregation. Highly expressed in the mammalian lens, the α-crystallins have been postulated to play a critical role in the maintenance of lens optical properties by sequ
PMID 26149094

Japanese Journal

Light scattering studies on .ALPHA.-crystallin from bovine eye lens.

SANO Yoh
The Journal of Biochemistry 87(1), 15-21, 1980
… Using the usual angular light scattering technique, we have measured the concentration de-pendence of reduced scattering intensity of fractionated bovine lens α-crystallin (αA-chain) in the presence of 30mM calcium chloride and 0.1M sodium chloride. … The inverse intensity of scattered light at zero angle per unit concentration of α-crystallin has a significant upward curvature with increasing α-crystallin concentration. …
NAID 130003541262