WordNet

characteristic of or containing alcohol; "alcoholic drinks"
a person who drinks alcohol to excess habitually (同)alky, dipsomaniac, boozer, lush, soaker, souse
addicted to alcohol; "alcoholic expatriates in Paris"- Carl Van Doren (同)alcohol-dependent
any of a series of volatile hydroxyl compounds that are made from hydrocarbons by distillation
a liquor or brew containing alcohol as the active agent; "alcohol (or drink) ruined him" (同)alcoholic drink, alcoholic_beverage, intoxicant, inebriant

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1. アルコール性脂肪性肝炎およびアルコール性肝硬変の臨床症状および診断 clinical manifestations and diagnosis of alcoholic fatty liver disease and alcoholic cirrhosis
2. アルコール性肝炎：自然経過およびマネージメント alcoholic hepatitis natural history and management
3. アルコール性脂肪性肝疾患およびアルコール性肝硬変の予後および治療 prognosis and management of alcoholic fatty liver disease and alcoholic cirrhosis
4. アルコール性肝炎：臨床症状および診断 alcoholic hepatitis clinical manifestations and diagnosis
5. 肝肥大：鑑別診断および評価 hepatomegaly differential diagnosis and evaluation

CX3CR1-expressing inflammatory dendritic cells contribute to the progression of steatohepatitis.

Sutti S1, Locatelli I1, Bruzzì S1, Jindal A1, Vacchiano M1, Bozzola C1, Albano E2.
Clinical science (London, England : 1979).Clin Sci (Lond).2015 Nov 1;129(9):797-808. doi: 10.1042/CS20150053. Epub 2015 Jun 25.
Liver monocytes play a major role in the development of NASH (non-alcoholic steatohepatitis). In inflamed tissues, monocytes can differentiate in both macrophages and dendritic cells. In the present study, we investigated the role of moDCs (monocyte-derived inflammatory dendritic cells) in experimen
PMID 26253086

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis.

Afonso MB1, Rodrigues PM1, Carvalho T2, Caridade M1, Borralho P3, Cortez-Pinto H4, Castro RE1, Rodrigues CM5.
Clinical science (London, England : 1979).Clin Sci (Lond).2015 Oct 1;129(8):721-39. doi: 10.1042/CS20140732. Epub 2015 Jun 15.
Hepatocyte cell death, inflammation and oxidative stress constitute key pathogenic mechanisms underlying non-alcoholic fatty liver disease (NAFLD). We aimed to investigate the role of necroptosis in human and experimental NAFLD and its association with tumour necrosis factor α (TNF-α) and oxidativ
PMID 26201023

Penke M1, Larsen PS2, Schuster S3, Dall M2, Jensen BA4, Gorski T5, Meusel A6, Richter S5, Vienberg SG2, Treebak JT2, Kiess W3, Garten A5.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Sep 5;412:65-72. doi: 10.1016/j.mce.2015.05.028. Epub 2015 May 29.
Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme for NAD salvage and the abundance of Nampt has been shown to be altered in non-alcoholic fatty liver disease. It is, however, unknown how hepatic Nampt is regulated in response to accumulation of lipids in the liver of mice f
PMID 26033245

A case of glycogenic hepatopathy developed in a patient with new-onset fulminant type 1 diabetes: the role of image modalities in diagnosing hepatic glycogen deposition including gradient-dual-echo MRI

Murata Fumi,Horie Ichiro,Ando Takao,Isomoto Eriko,Hayashi Hideyuki,Akazawa Satoru,Ueki Ikuko,Nakamura Kan,Kobayashi Masakazu,Kuwahara Hironaga,Abiru Norio,Kawasaki Eiji,Yamasaki Hironori,Kawakami Atsushi
Endocrine Journal 59(8), 669-676, 2012
… Glycogenic hepatopathy (GH) has been reported as a very rare and under recognized complication in long-standing poorly controlled type 1 diabetes (T1D) patients. … It has been reported that GH is indistinguishable from non-alcoholic fatty liver disease, which is more commonly seen in diabetic patients, even after a history is taken and a physical examination or imaging studies have been performed. …
NAID 130004443828

Hirose Akiko,Okada Yosuke,Morita Emiko,Tanaka Yoshiya
Internal Medicine 45(17), 1001-1005, 2006
… In addition, the relevance of alcohol in the onset of BSL is strongly suggested based on alcoholic hepatopathy and the history of the development of grotesque physical appearance associated with increased alcohol consumption. …
NAID 130000076450

Tanji Yoshiyuki
Yonago Acta medica 48(4), 101-106, 2005-12
Benign symmetric lipomatosis (BSL) is a disease characterized by symmetrical and diffuse adipose tissue deposits on the neck, shoulder, chest, abdomen and groin. It is comparatively common in the Medi …
NAID 110003495518

組織型により分類。

アルコール代謝の過程でNADHが蓄積し、脂肪の合成が亢進()、血糖低下(糖新生抑制、ATPが必要だから？)、乳酸の増加(NADH増加のため。また、おそらくTCA回路がNADH増加のために回しにくくなっているため)
ミトコンドリア機能活性化により酸素消費の増大　＋　アルコール脱水素酵素ADH、アルデヒド脱水素酵素ALDHは、zone3(肝小葉中心部)に存在　→　虚血による障害を受けやすい　→　zone3はAST優位なのでAST>ALT、と思われる。

トランスアミナーゼ↑(AST　＞　ALT)、γ-GTP　↑、ALP↑、TG↑、尿酸↑
IgA↑ (小腸のパイエル板におけるリンパ球の活性が亢進するため？。急性アルコール性肝炎では65 kDaの熱ショック蛋白に対するIgA抗体の産生が増加するという報告がある(参考4))

1. [charged] Pathogenesis of alcoholic liver disease - uptodate [1]
2. [charged] Clinical manifestations and diagnosis of alcoholic liver disease - uptodate [2]
3. [charged]Prognosis and treatment of alcoholic liver disease and alcoholic hepatitis - uptodate [3]
4. Circulating IgA antibody against a 65 kDa heat shock protein in acute alcoholic hepatitis.

Winrow VR, Bird GL, Koskinas J, Blake DR, Williams R, Alexander GJ.SourceARC Bone and Joint Research Unit, London Hospital Medical College, UK.
Journal of hepatology.J Hepatol.1994 Mar;20(3):359-63.
Heat shock proteins are known to be immunogenic in a number of diverse conditions and can be induced by hypoxia, tumour necrosis factor and alcohol--all potential triggers in patients with acute alcoholic hepatitis. In the present study, sera from 23 patients with acute alcoholic hepatitis, 18 liver
PMID 8014447