WordNet

the 23rd letter of the Roman alphabet (同)w, double-u
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

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1. 急性骨髄性白血病の予後 prognosis of acute myeloid leukemia
2. ウィルムス腫瘍の症状、診断、および病期分類 presentation diagnosis and staging of wilms tumor
3. 先天性乳児ネフローゼ症候群 congenital and infantile nephrotic syndrome
4. 小児におけるステロイド抵抗性特発性ネフローゼ症候群 steroid resistant idiopathic nephrotic syndrome in children
5. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia

Multigene Measurable Residual Disease Assessment Improves Acute Myeloid Leukemia Relapse Risk Stratification in Autologous Hematopoietic Cell Transplantation.

Mulé MP1, Mannis GN2, Wood BL3, Radich JP3, Hwang J2, Ramos NR1, Andreadis C2, Damon L2, Logan AC2, Martin TG2, Hourigan CS4.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant.2016 Nov;22(11):1974-1982. doi: 10.1016/j.bbmt.2016.08.014. Epub 2016 Aug 17.
We report here the largest study to date of adult patients with acute myeloid leukemia (AML) tested for measurable residual disease (MRD) at the time of autologous hematopoietic cell transplantation (auto-HCT). Seventy-two adult patients who underwent transplantation between 2004 and 2013 at a singl
PMID 27544285

Clinical Utility of Next-Generation Sequencing for Oncogenic Mutations in Patients with Acute Myeloid Leukemia Undergoing Allogeneic Stem Cell Transplantation.

Luskin MR1, Carroll M1, Lieberman D2, Morrissette JJ2, Zhao J2, Crisalli L1, Roth DB2, Luger SM1, Porter DL1, Reshef R3.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant.2016 Nov;22(11):1961-1967. doi: 10.1016/j.bbmt.2016.07.018. Epub 2016 Jul 28.
To determine the association of somatic mutations in acute myeloid leukemia (AML) with risk of relapse after allogeneic hematopoietic stem cell transplantation (alloHSCT), we retrospectively studied pre-transplantation genetic profiles obtained from next-generation sequencing of 26 genes in 112 adul
PMID 27478011

Human blood cell levels of 5-hydroxymethylcytosine (5hmC) decline with age, partly related to acquired mutations in TET2.

Buscarlet M1, Tessier A2, Provost S3, Mollica L4, Busque L5.
Experimental hematology.Exp Hematol.2016 Nov;44(11):1072-1084. doi: 10.1016/j.exphem.2016.07.009. Epub 2016 Jul 27.
Epigenetic alteration may play a role in age-associated dysfunction of stem cells and predispose to the development of hematological cancers. We analyzed global levels of hematopoietic 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) in a cross-sectional study comprising 198 unrelated indiv
PMID 27475703