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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/16 17:16:37」(JST)

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TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.^[1]^[2]^[3]

TRAF4 is a member of the TNF receptor associated factor (TRAF) family, a family of scaffold proteins.^[4] TRAF proteins connect IL-1R/Toll and TNF receptors with signaling factors that lead to the activation of NF-κB and mitogen-activated protein kinases. However, TRAF4 is not known to interact with TNF receptors and its cellular functions are not well understood.^[5]

Protein interactions

TRAF4 has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1),^[6]^[7] and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.^[3]

A recent report indicates that TRAF4 binds to NOD-Like Receptors NOD1 and NOD2, and specifically inhibits activation of NF-κB by the activated NOD2-RIP2 complex ^[8]

References

^ Regnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC (Dec 1995). "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma". J Biol Chem 270 (43): 25715–21. doi:10.1074/jbc.270.43.25715. PMID 7592751.
^ Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.
^ ^a ^b "Entrez Gene: TRAF4 TNF receptor-associated factor 4".
^ Wajant H, Henkler F, Scheurich P (June 2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. Signal. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837.
^ Kedinger V, Rio MC (2007). "TRAF4, the unique family member". Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology 597: 60–71. doi:10.1007/978-0-387-70630-6_5. ISBN 978-0-387-70629-0. PMID 17633017.
^ Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE (October 1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. PMID 10514511.
^ Krajewska M, Krajewski S, Zapata JM, Van Arsdale T, Gascoyne RD, Berern K, McFadden D, Shabaik A, Hugh J, Reynolds A, Clevenger CV, Reed JC (June 1998). "TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues". Am. J. Pathol. 152 (6): 1549–61. PMC 1858434. PMID 9626059.
^ Marinis JM, Homer CR, McDonald C, Abbott DW (2011). "A Novel Motif in the Crohn's Disease Susceptibility Protein, NOD2, Allows TRAF4 to Down-regulate Innate Immune Responses". J. Biol. Chem. 286 (3): 1938–1950. doi:10.1074/jbc.M110.189308. PMC 3023490. PMID 21097508.

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English Journal

A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis.

Wu L1, Chen X2, Zhao J1, Martin B1, Zepp JA1, Ko JS2, Gu C2, Cai G3, Ouyang W4, Sen G2, Stark GR2, Su B5, Vines CM6, Tournier C7, Hamilton TA2, Vidimos A2, Gastman B8, Liu C9, Li X9.
The Journal of experimental medicine.J Exp Med.2015 Sep 21;212(10):1571-87. doi: 10.1084/jem.20150204. Epub 2015 Sep 7.
Although IL-17 is emerging as an important cytokine in cancer promotion and progression, the underlining molecular mechanism remains unclear. Previous studies suggest that IL-17 (IL-17A) sustains a chronic inflammatory microenvironment that favors tumor formation. Here we report a novel IL-17-mediat
PMID 26347473

Immunohistochemical and molecular profiling of histologically defined apocrine carcinomas of the breast.

Vranic S1, Marchiò C2, Castellano I2, Botta C2, Scalzo MS2, Bender RP3, Payan-Gomez C4, di Cantogno LV2, Gugliotta P2, Tondat F5, di Celle PF5, Mariani S5, Gatalica Z3, Sapino A6.
Human pathology.Hum Pathol.2015 Sep;46(9):1350-9. doi: 10.1016/j.humpath.2015.05.017. Epub 2015 Jun 5.
Despite the marked improvement in the understanding of molecular mechanisms and classification of apocrine carcinoma, little is known about its specific molecular genetic alterations and potentially targetable biomarkers. In this study, we explored immunohistochemical and molecular genetic character
PMID 26208846

Expression, correlation, and prognostic value of TRAF2 and TRAF4 expression in malignant plural effusion cells in human breast cancer.

Zhao ZJ1, Ren HY1, Yang F1, Wang J1, Wu GP1, Mi XY1.
Diagnostic cytopathology.Diagn Cytopathol.2015 Aug 31. doi: 10.1002/dc.23330. [Epub ahead of print]
BACKGROUND: TRAF2 and TRAF4, members of the tumor necrosis factor receptor- associated factor family of intracellular signal transduction proteins, are associated with breast cancer progression and metastasis.METHODS: We collected malignant serous effusion cells from the patients with breast cancer
PMID 26331901

Related Pictures

TRAF4 (TNF receptor-associated factor 4) TRAF4 - Wikipedia, the free encyclopedia IUCr) TRAF4 TRAF domain www.biomedcentral.com - Figure 图片自动搜索结果请不要搜索 Tumor necrosis factor receptor associated Download]

★リンクテーブル★

リンク元	「TNF受容体関連因子4」「TNF receptor-associated factor 4」
関連記事	「TRAF」

「TNF受容体関連因子4」

TNF receptor-associated factor 4
	; Rendering based on PDB 2EOD.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2EOD, 2YUC
Identifiers
Symbols	TRAF4; CART1; MLN62; RNF83
External IDs	OMIM: 602464 MGI: 1202880 HomoloGene: 3173 GeneCards: TRAF4 Gene
Gene Ontology
Molecular function	• DNA binding; • ubiquitin-protein ligase activity; • protein binding; • zinc ion binding; • protein kinase binding; • ubiquitin protein ligase binding; • thioesterase binding; • metal ion binding; • WW domain binding;
Cellular component	• nucleus; • cytoplasm; • cytoskeleton; • plasma membrane; • tight junction; • perinuclear region of cytoplasm;
Biological process	• apoptotic process; • signal transduction; • respiratory gaseous exchange; • respiratory tube development; • regulation of apoptotic process; • positive regulation of protein kinase activity; • positive regulation of JNK cascade; • positive regulation of protein homodimerization activity;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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