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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/04 14:01:42」(JST)

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TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene.^[1]

Function

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors.^[2]

Interactions

TRAF1 has been shown to interact with:

BIRC2,^[3]^[4]^[5]
Baculoviral IAP repeat-containing protein 3,^[3]^[4]
CFLAR,^[6]^[7]
Caspase 8,^[8]^[9]
HIVEP3,^[10]
RANK^[11]^[12]
TNFAIP3,^[13]^[14]
TRAF interacting protein,^[15] and
TRAF2.^[16]^[17]

References

^ Rothe M, Wong SC, Henzel WJ, Goeddel DV (September 1994). "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor". Cell 78 (4): 681–92. doi:10.1016/0092-8674(94)90532-0. PMID 8069916.
^ "Entrez Gene: TRAF1 TNF receptor-associated factor 1".
^ ^a ^b Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (Dec 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. PMC 1170295. PMID 9384571.
^ ^a ^b Li X, Yang Y, Ashwell JD (March 2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature 416 (6878): 345–7. doi:10.1038/416345a. PMID 11907583.
^ Shu HB, Takeuchi M, Goeddel DV (November 1996). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13973–8. doi:10.1073/pnas.93.24.13973. PMC 19479. PMID 8943045.
^ Shu HB, Halpin DR, Goeddel DV (June 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity 6 (6): 751–63. doi:10.1016/s1074-7613(00)80450-1. PMID 9208847.
^ Kataoka T, Budd RC, Holler N, Thome M, Martinon F, Irmler M et al. (June 2000). "The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways". Curr. Biol. 10 (11): 640–8. doi:10.1016/s0960-9822(00)00512-1. PMID 10837247.
^ Micheau O, Tschopp J (July 2003). "Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes". Cell 114 (2): 181–90. doi:10.1016/s0092-8674(03)00521-x. PMID 12887920.
^ Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR et al. (March 2001). "TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis". J. Biol. Chem. 276 (11): 8087–93. doi:10.1074/jbc.M009450200. PMID 11098060.
^ Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH (January 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Mol. Cell 9 (1): 121–31. doi:10.1016/s1097-2765(01)00434-8. PMID 11804591.
^ Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC (Dec 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". J. Biol. Chem. 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. PMID 9852070.
^ Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH et al. (January 1999). "Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase". FEBS Lett. 443 (3): 297–302. doi:10.1016/s0014-5793(98)01731-1. PMID 10025951.
^ Song HY, Rothe M, Goeddel DV (June 1996). "The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6721–5. doi:10.1073/pnas.93.13.6721. PMC 39093. PMID 8692885.
^ Heyninck K, Beyaert R (January 1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Lett. 442 (2-3): 147–50. doi:10.1016/s0014-5793(98)01645-7. PMID 9928991.
^ Lee SY, Lee SY, Choi Y (April 1997). "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation". J. Exp. Med. 185 (7): 1275–85. doi:10.1084/jem.185.7.1275. PMC 2196258. PMID 9104814.
^ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
^ Takeuchi M, Rothe M, Goeddel DV (August 1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. 271 (33): 19935–42. doi:10.1074/jbc.271.33.19935. PMID 8702708.

UpToDate Contents

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English Journal

Pilot study on "pericytic mimicry" and potential embryonic/stem cell properties of angiotropic melanoma cells interacting with the abluminal vascular surface.

Lugassy C, Wadehra M, Li X, Corselli M, Akhavan D, Binder SW, Péault B, Cochran AJ, Mischel PS, Kleinman HK, Barnhill RL.SourceDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles (UCLA) Medical Center, Los Angeles, CA, USA, clugassy@mednet.ucla.edu.
Cancer microenvironment : official journal of the International Cancer Microenvironment Society.Cancer Microenviron.2013 Apr;6(1):19-29. doi: 10.1007/s12307-012-0128-5. Epub 2012 Dec 29.
The interaction of tumor cells with the tumor vasculature is mainly studied for its role in tumor angiogenesis and intravascular metastasis of circulating tumor cells. In addition, a specific interaction of tumor cells with the abluminal surfaces of vessels, or angiotropism, may promote the migratio
PMID 23275074

Inducible TNF Receptor Associated Factor-1 Expression Couples to the Canonical to the Non-Canonical NF-κB pathway in TNF stimulation.

Choudhary S, Kalita M, Fang L, Patel K, Tian B, Zhao Y, Edeh CB, Brasier AR.SourceUTMB, Galveston, United States.
The Journal of biological chemistry.J Biol Chem.2013 Mar 29. [Epub ahead of print]
The NF-kB transcription factor mediates the inflammatory response through distinct (canonical and non-canonical) signaling pathways. The mechanisms controlling utilization of either of these pathways are largely unknown. Here we observe that TNF stimulation induces delayed NF-kB2/p100 processing and
PMID 23543740

Independent replication analysis of genetic loci with previous evidence of association with juvenile idiopathic arthritis.

Ellis JA, Chavez RA, Pezic A, Ponsonby AL, Akikusa JD, Allen RC, Munro JE.SourceGenes, Environment & Complex Disease, Murdoch Childrens Research Institute, 50 Flemington Rd, Parkville, Vic, 3052, Australia. justine.ellis@mcri.edu.au.
Pediatric rheumatology online journal.Pediatr Rheumatol Online J.2013 Mar 18;11(1):12. doi: 10.1186/1546-0096-11-12.
BACKGROUND: Over the last five years, there have been numerous reports of association of juvenile idiopathic arthritis with single nucleotide polymorphisms (SNPs) at various loci outside the major histocompatibility complex (MHC) region. However, the majority of these association findings have been
PMID 23506417

Japanese Journal

TNF Receptor-Associated Factor (TRAF) Signaling Network in CD4+ T-Lymphocytes

So Takanori,Nagashima Hiroyuki,Ishii Naoto
The Tohoku Journal of Experimental Medicine 236(2), 139-154, 2015
… Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs), which are composed of six TRAF proteins (TRAF1-TRAF6) with a conserved C-terminal TRAF domain, are intracellular signaling adaptors that mediate the link between receptor-proximal activation events and intracellular signaling proteins. …
NAID 130005075699

Variant Translocation Partners of the Anaplastic Lymphoma Kinase (ALK) Gene in Two Cases of Anaplastic Large Cell Lymphoma, Identified by Inverse cDNA Polymerase Chain Reaction

Takeoka Kayo,Okumura Atsuko,Honjo Gen,Ohno Hitoshi
Journal of Clinical and Experimental Hematopathology 54(3), 225-235, 2014
… Nucleotide sequencing of the PCR products and a database search revealed that the sequences of ATIC in case 1 and TRAF1 in case 2 appeared to follow those of ALK. … We subsequently confirmed ATIC-ALK and TRAF1-ALK fusions by reverse transcriptase PCR and nucleotide sequencing. … ATIC is the second most common partner of variant ALK rearrangements, while the TRAF1-ALK fusion gene was first reported in 2013, and this is the second reported case of ALK+ ALCL carrying TRAF1-ALK. …
NAID 130004705270

Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese

NISHIMOTO K
ANNALS OF THE RHEUMATIC DISEASES 69(2), 368-373, 2010
NAID 120004738407

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★リンクテーブル★

リンク元	「TNF受容体関連因子1」「TNF receptor-associated factor 1」
関連記事	「TRAF」

「TNF受容体関連因子1」

TNF receptor-associated factor 1
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	3M0D
Identifiers
Symbols	TRAF1 ; EBI6; MGC:10353
External IDs	OMIM: 601711 MGI: 101836 HomoloGene: 4138 GeneCards: TRAF1 Gene
Gene ontology
Molecular function	• tumor necrosis factor receptor binding; • protein binding; • zinc ion binding; • ubiquitin protein ligase binding; • thioesterase binding;
Cellular component	• cytoplasm;
Biological process	• protein complex assembly; • apoptotic process; • signal transduction; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of NF-kappaB transcription factor activity; • regulation of extrinsic apoptotic signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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